CN104255773B - A kind of containing MTI-446 with the composition pesticide of fluazinam - Google Patents
A kind of containing MTI-446 with the composition pesticide of fluazinam Download PDFInfo
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- CN104255773B CN104255773B CN201410544537.4A CN201410544537A CN104255773B CN 104255773 B CN104255773 B CN 104255773B CN 201410544537 A CN201410544537 A CN 201410544537A CN 104255773 B CN104255773 B CN 104255773B
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Abstract
The invention discloses a kind of containing MTI-446 with the composition pesticide of fluazinam, including active component, described active component is MTI-446 and fluazinam；Described active component is calculated by weight as: MTI-446 1 30 parts；Fluazinam 1 60 parts.The present invention can overcome and delay that pest resistance to insecticide, preventive effect are better than single dose, resistance of rainwater washing against, quick-acting is good, the lasting period is long, reduces access times, saves time, laborsaving, can prevent and treat various pests and disease simultaneously, reduce drug cost.
Description
Technical field
The invention belongs to pesticide field, be specifically related to a kind of containing MTI-446 with the composition pesticide of fluazinam.
Background technology
Due to the single use of pesticide and medication not science, unreasonable, increase the weight of insect rapidly to currently used agriculture
The resistance of medicine so that high cost, long-time some the pesticide new components developed that put into shorten service life, access times simultaneously
Many, also increase the weight of environmental pollution and increased drug cost.Citrus psylla is unique medium that yellow twig is propagated, and has the tender tip in the same year
In the case of, in 11～14 generations, can occur for 1 year, field generations is overlapping, and single wood louse passes sick rate and is up to 70-80%, and adult can fly,
Difficulty of prevention and cure is high.Meanwhile, at each growth period of Citrus, except wood louse, the also worm such as red spider, blister mite, leaf miner, aleyrodid
Occur while the diseases such as evil and resin sick (rubber is sick), anthrax, so this type of pest and disease damage problem in the urgent need to address.At present
For being agriculturally easily generated the Pest control of resistance, main way is exploitation and the new composition of existing kind no interactions resistance or
Having compounding between pesticide species, the former is owing to required development cost is high, the cycle is long, and current development rate ratio far away is not
The speed that upper pest resistance to insecticide produces.
MTI-446, english common name dinotefuran, chemical name: (RS)-1-methyl-2-nitro-3-(tetrahydrochysene-3-
Furfuryl) guanidine, be a kind of insecticide in anabasine, this medical instrument have tag, absorption height strong, quick-acting in stomach toxicity and root,
The features such as lasting period long 3-4 all (theoretical lasting effect 43 days), insecticidal spectrum are wide, and sucking insect is had excellent preventive effect, and
The lowest dosage i.e. shows the highest insecticidal activity.It is mainly used in preventing and treating Semen Tritici aestivi, Oryza sativa L., Cotton Gossypii, vegetable, fruit tree, Nicotiana tabacum L. etc.
Aphid, leafhopper, plant hopper, thrips, aleyrodid and resistant strain thereof in various crop, simultaneously to coleoptera, Diptera and Lepidoptera,
Diptera, beetle mesh and total wing mesh insect have efficiently, and to cockroach, have efficiently from the sanitary insect pest such as ant, housefly.
Fluazinam, the chloro-N-of english common name fluazinam, chemical name 3-(3-chloro-5-trifluoromethyl-2-pyridine
Base)-α, α, α-three fluoro-2,6-dinitro-ρ-toluidines, belong to 2,6-dinitroanilines, is prevention & protection sterilization
Agent, prevention in advance can ensure that fruit, quality of vegetable are good, is mainly used in downy mildew, gray mold, anthrax and the fruit preventing and treating on vegetable
The diseases such as shot hole on tree, anthrax, scab.
Above-mentioned insect pest all creates certain Drug resistance to MTI-446 or fluazinam, is used alone not reach and preferably prevents
Control effect.At present, we not yet find Patents MTI-446 and fluazinam being applied in combination and document report.
Summary of the invention
The purpose of the present invention solves above-mentioned technical problem, it is provided that a kind of containing MTI-446 with the composition pesticide of fluazinam, energy
Overcome and delayed that pest resistance to insecticide, preventive effect are better than single dose, resistance of rainwater washing against, quick-acting is good, the lasting period is long, reduce using time
Number, saves time, laborsaving, can prevent and treat various pests and disease simultaneously, reduce drug cost.
For realizing above-mentioned purpose, the technical scheme is that
A kind of containing MTI-446 with the composition pesticide of fluazinam, including active component, described active component be MTI-446 and
Fluazinam, is calculated by weight as:
MTI-446 1-30 part；
Fluazinam 1-60 part.
This composition pesticide also includes that auxiliary agent, described auxiliary agent include dispersant, emulsifying agent, antifreezing agent, thickening agent, froth breaking
One or more in agent, solvent, wetting agent, disintegrating agent and filler.
The parts by weight that the above auxiliary agent adds are:
The above emulsifying agent is calcium dodecyl benzene sulfonate, alkylpolyoxyethylene, styrylphenol polyoxy
Vinyl Ether, NPE, thermally coupled distillation columns, aliphatic acid polyethenoxy base ester, polyoxyethylene fat
One or more in fat alcohol ether, dodecyl polyoxyethylene sulfonic acid sodium salt and phenethyl phenol polyethenoxy ether；
The above solvent is dimethylbenzene, diesel oil, toluene, Hexalin, methanol, soybean oil, Oleum Terebinthinae, methyl oleate, molten
One or more in agent oil, dimethylformamide, ethanol, N-ketopyrrolidine, ethyl acetate and aqueous solvent；
The above wetting agent is sodium lauryl sulphate, calcium dodecyl benzene sulfonate, the condensation of methyl naphthalene sulfonic acid sodium formaldehyde
Thing, one or more pulled open in powder, Negel and spaonin powder；
The above dispersant is sodium lignin sulfonate, calcium lignosulfonate, alkylphenol polyoxyethylene formaldehyde condensation products
Sodium sulfate, alkyl benzene calcium sulfonate, alkylphenol polyoxyethylene, polycarboxylic acids sodium, aliphatic amine polyoxyethylene ether and glycerine fatty acid fat
One or more in acid ester polyoxyethylene ether；
The above antifreezing agent is one or more in ethylene glycol, propylene glycol, glycerol and carbamide；
The above thickening agent is one or more in xanthan gum, Magnesiumaluminumsilicate, hydroxymethyl cellulose and polyvinyl alcohol；
The above defoamer is one or more in silicone oil, organic silicone and polypropylene glycerol aether；
The above disintegrating agent is one or more in bentonite, ammonium sulfate, sodium bicarbonate, aluminum chloride and succinic acid；
The above filler is one or more in white carbon, Kaolin, kieselguhr, precipitated calcium carbonate and starch.
The dosage form of composition pesticide of the present invention is suspending agent, aqueous emulsion, water dispersible granules, microemulsion or wettable powder.
The preparation method of the pesticide sterilizing Pesticidal combination containing MTI-446 and fluazinam as above, it is activity to be become
Divide and auxiliary agent mixes by weight, the most available by the conventional machining mode of its dosage form.
The purposes of the pesticide sterilizing Pesticidal combination containing MTI-446 and fluazinam as above, it is preventing and treating mandarin tree
Application on wood louse, red spider, blister mite, resin disease, anthrax.
The component of the present invention is commercially available prod.
Compared with prior art, the device have the advantages that into:
1. the MTI-446 of the present invention have tag, absorption height strong, quick-acting, long 3-4 lasting period, (reason week in stomach toxicity and root
Opinion lasting effect 43 days), the feature such as insecticidal spectrum is wide, and sucking insect is had excellent preventive effect, and i.e. shows at the lowest dosage
The highest insecticidal activity.The aphid that is mainly used in preventing and treating in the various crop such as Semen Tritici aestivi, Oryza sativa L., Cotton Gossypii, vegetable, fruit tree, Nicotiana tabacum L.,
Leafhopper, plant hopper, thrips, aleyrodid and resistant strain thereof, simultaneously to coleoptera, Diptera and Lepidoptera, Diptera, beetle mesh and total
Mesh insect has efficiently wing.Fluazinam effect is better than conventional protecting antibacterial.Non-resistant, the lasting period is long, reduces times for spraying, saves
Time, laborsaving, with other medicament no interactions resistances, resistance of rainwater washing against, to people, animal, natural enemy and Environmental security.Fluazinam itself defines
For antibacterial, diseases a lot of on fruit and vegetables all there is preferable prevention effect.But we are through overtesting, find red to Citrus
Aranea, blister mite also has preferable preventive effect.
2. the present composition is that the combination of parasite killing and antibacterial, MTI-446 and fluazinam are multiple with mass ratio 1:60～30:1
Join, higher potentiation can be produced, overcome and delayed pest resistance to insecticide, preventive effect to be better than single dose, resistance of rainwater washing against, quick-acting
Good, the lasting period is long, reduces access times, saves time, laborsaving, various pests and disease can be prevented and treated simultaneously, reduce drug cost.
The present invention, to insect agriculturally, especially goes up and has mandarin tree wood louse, red spider, blister mite, resin sick (rubber is sick), anthrax
Significantly potentiation, to other insect on the crop such as Oryza sativa L., vegetable, such as leafhopper, thrips, plant hopper, downy mildew, gray mold etc.
Disease also has preferable prevention effect.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited to
The scope that embodiment represents.
Embodiment 1:50% fluazinam MTI-446 suspending agent
Embodiment 2:2% fluazinam MTI-446 suspending agent
Embodiment 3:60% fluazinam MTI-446 suspending agent
Embodiment 4:40% fluazinam MTI-446 suspending agent
Embodiment 5:30% fluazinam MTI-446 suspending agent
The preparation method of embodiment 1-5 is: after weighing raw material according to the proportioning of each embodiment, raw material, solvent mixing is stirred
Mix dissolving, add the auxiliary agent such as emulsifying, dispersion and carry out high speed shear emulsifying, make corresponding MTI-446 fluazinam suspending agent.
Embodiment 6:40% fluazinam MTI-446 aqueous emulsion
Embodiment 7:2% fluazinam MTI-446 aqueous emulsion
Embodiment 8:60% fluazinam MTI-446 aqueous emulsion
Embodiment 9:40% fluazinam MTI-446 aqueous emulsion
Embodiment 10:30% fluazinam MTI-446 aqueous emulsion
The preparation method of embodiment 6-10 is: after weighing raw material according to the proportioning of each embodiment, raw material, solvent mixing is stirred
Mix dissolving, add emulsifying agent and carry out high speed shear emulsifying, make corresponding fluazinam MTI-446 aqueous emulsion.
Embodiment 11:25% fluazinam MTI-446 water dispersible granules
Embodiment 12:2% fluazinam MTI-446 water dispersible granules
Embodiment 13:55% fluazinam MTI-446 water dispersible granules
Embodiment 14:65% fluazinam MTI-446 water dispersible granules
Embodiment 15:40% fluazinam MTI-446 water dispersible granules
The manufacture method of embodiment 11-15 is: after weighing raw material according to the proportioning of each embodiment, by raw material co-grinding,
Through pelletize, it is dried and makes corresponding fluazinam MTI-446 water dispersible granules.
Embodiment 16:30% fluazinam MTI-446 wettable powder
Embodiment 17:2% fluazinam MTI-446 wettable powder
Embodiment 18:60% fluazinam MTI-446 wettable powder
Embodiment 19:65% fluazinam MTI-446 wettable powder
Embodiment 20:40% fluazinam MTI-446 wettable powder
The manufacture method of embodiment 16-20 is: after weighing raw material according to the proportioning of each embodiment, by raw material mixing superfine powder
Broken, make corresponding fluazinam MTI-446 wettable powder.
Embodiment 21:40% fluazinam dinotefuran micron-emulsion
Embodiment 22:10% fluazinam dinotefuran micron-emulsion
Embodiment 23:60% fluazinam dinotefuran micron-emulsion
Embodiment 24:40% fluazinam dinotefuran micron-emulsion
Embodiment 25:30% fluazinam dinotefuran micron-emulsion
The preparation method of embodiment 20-25 is: after weighing raw material according to the proportioning of each embodiment, by raw material, solvent mixing
Stirring and dissolving, addition emulsifying agent, water carry out high speed shear, make corresponding fluazinam dinotefuran micron-emulsion.
Application Example:
In order to detect the insecticidal effect of the compositions of the present invention, now enumerate following experimental data:
Table 1 below to table 10 medicament dilute after fountain height all by the conventional spray requirement of this area, i.e. leaf is just
The back side, fruit surface are sprayed to form drop-wise and flow down.
Application Example 5
The 30% fluazinam MTI-446 suspending agent that the embodiment of the present invention 5 is obtained and 500 grams per liter fluazinam suspending agents,
10% MTI-446 suspending agent carries out field control effectiveness test, and test site is mono-group of Citrus sinensis Osbeck fruit of land reclamation and cultivation Guilin, Guangxi, Guilin City Liang Feng
Garden, nebulization, use double dilution method during preparating liquid, uniformly spray in Citrus branch and leaf and fruit, at resin disease their early stage
Carrying out dispenser for the first time, execute altogether 4 times, within after last medicine 20 days, investigate, with community calculation, (every community is 2～3 strain Citrus chachiensiss Hort. to investigation area
Tangerine), 2 strain trees are investigated in every community, every strain by east, south, west, north, in the sampling of five points, two branches of every some investigation, Mei Gezhi
Bar investigation top down 4 leaves and all fruit, total leaf (really) leaf several, sick (really) number of record investigation and sick level, calculate the state of an illness
Index and preventive effect.
Application Example 5 result of the test such as table 1:
Table 130% fluazinam MTI-446 suspending agent preventing and treating Citrus resin sick (rubber is sick) test of pesticide effectiveness result
Table 1 result of the test shows, starts to execute medicine for the first time at Citrus resin sick (rubber is sick) early period of origination, is thanking to colored back seat
Really middle and late stage, young fruit period, fruit growth period are respectively executed once, and 30% fluazinam MTI-446 suspending agent preventing and treating Citrus resin is sick
(rubber is sick), by 1500 times of dilution sprayings, has preferable preventive effect.
Application Example 7
The 2% fluazinam MTI-446 aqueous emulsion that the embodiment of the present invention 7 is obtained and 500 grams per liter fluazinam suspending agents,
10% MTI-446 suspending agent carries out field control effectiveness test, and test site is mono-group of Citrus sinensis Osbeck fruit of land reclamation and cultivation Guilin, Guangxi, Guilin City Liang Feng
Garden, foliar spray method, it is watered dilution by process dosage and is made into medicinal liquid, uniformly spray in Citrus leaves tow sides, at Citrus
Aphid is contained and sends out phase dispenser 1 time, investigates insect population radix shortly before dispenser, after dispenser 1 day, 3 days, each investigation in 7 days once survives borer population, altogether
3 times.Investigation area with community calculate (every community is 2～3 strain mandarin trees), every community investigation 2 mandarin trees, every strain by east, south,
West, north, in 5 killed tips of 5 orientation investigation, the aphid number of every tip investigation top 5 leaves of the tip, calculate relative control effect.
Application Example 7 result of the test:
Table 22% fluazinam MTI-446 aqueous emulsion preventing and treating orange caterpillar test of pesticide effectiveness result
Table 2 result of the test shows, contains mandarin tree aphid and sends out a phase dispenser, more than 2% fluazinam MTI-446 aqueous emulsion is pressed
Usage amount spray medicine, has preferable preventive effect to preventing and treating orange caterpillar.
Application Example 15
The 40% fluazinam MTI-446 water dispersible granules embodiment of the present invention 15 obtained and 500 grams per liter fluazinams hang
Floating agent, 10% MTI-446 suspending agent carry out field control effectiveness test, and test site is land reclamation and cultivation Guilin, Guangxi, Guilin City mono-group of umbilicus of Liang Feng
Fructus Citri junoris garden, foliar spray method, it is watered dissolved dilution by process dosage and is made into medicinal liquid, strain whole to mandarin tree is sprayed, Citrus chachiensis Hort.
Fructus Citri tangerinae young sprout is taken out and is sent out phase dispenser 1 time, investigates insect population radix shortly before dispenser, after dispenser 5 days, 10 days, each investigation in 15 days once survives worm
Number, totally 3 times.Investigation area calculates (every community is 2～3 strain mandarin trees) with community, and investigation method employing is determined strain and determined tip investigation, the least
2 mandarin trees of district's investigation, every strain by east, south, west, north, in 5 different azimuth choose 2 and have the worm tip to be marked, investigation note
Record every tip borer population alive.Compare with blank district, calculate relative control effect.
Application Example 15 result of the test:
Table 340% fluazinam MTI-446 water dispersible granules prevents and treats diaphorina citri test of pesticide effectiveness result
Table 3 result of the test shows, endangers phase dispenser mandarin tree wood louse, and 40% fluazinam MTI-446 water dispersible granules exists
In the case of amount used above, there is preferable preventive effect to preventing and treating diaphorina citri.
The 40% fluazinam MTI-446 water dispersible granules embodiment of the present invention 15 obtained and 500 grams per liter fluazinams hang
Floating agent, 10% MTI-446 suspending agent carry out field control effectiveness test, and test site is land reclamation and cultivation Guilin, Guangxi, Guilin City mono-group of umbilicus of Liang Feng
Fructus Citri junoris garden, foliar spray method, it is watered dilution is made into medicinal liquid by processing dosage, uniformly spray in Citrus leaves tow sides,
Orange caterpillar is contained and is sent out phase dispenser 1 time, investigates insect population radix shortly before dispenser, after dispenser 1 day, 3 days, each investigation in 7 days once survives worm
Number, totally 3 times.Investigation area with community calculate (every community is 2～3 strain mandarin trees), every community investigation 2 mandarin trees, every strain by east,
South, west, north, in 5 killed tips of 5 orientation investigation, the aphid number of every tip investigation top 5 leaves of the tip, calculate relative control effect.
Table 440% fluazinam MTI-446 water dispersible granules preventing and treating orange caterpillar test of pesticide effectiveness result
Table 4 result of the test shows, contains mandarin tree aphid and sends out phase dispenser, and 40% fluazinam MTI-446 water dispersible granules exists
In the case of amount used above, preventing and treating orange caterpillar there is preferable preventive effect.
Application Example 16
The 30% fluazinam MTI-446 wettable powder embodiment of the present invention 16 obtained and 500 grams per liter fluazinams hang
Floating agent, 10% MTI-446 suspending agent carry out field control effectiveness test, and test site is land reclamation and cultivation Guilin, Guangxi, Guilin City mono-group of umbilicus of Liang Feng
Fructus Citri junoris garden, foliar spray method, it is watered dilution by process dosage and is made into medicinal liquid, uniformly spray in mandarin tree blade, branch top to the wettest
Profit, Citrus blister mite peak of occurrence early stage dispenser 1 time, shortly before dispenser investigation live demodicid mite quantity, after dispenser 1 day, 7 days, 14 days, 21
My god, the remaining of 28 days each investigation once fixed point leaves live demodicid mite number, totally 5 times.With community calculation, (every community is 2～3 strain Citrus to investigation area
Tree), investigation method be every community investigate 2 mandarin trees, every strain by east, south, west, north, in 5 azimuth mark side shoots, investigate 20
Open the demodicid mite quantity alive of new leaf back, directly observe the demodicid mite number in each visual field with 10 times of folding hand held megaloscopes.With blank
District compares, and calculates relative control effect.
Application Example 16 result of the test:
Table 530% fluazinam MTI-446 wettable powder preventing and treating Citrus blister mite test of pesticide effectiveness result
Table 5 result of the test shows, in mandarin tree blister mite peak of occurrence early stage dispenser, 30% fluazinam MTI-446 with
In the case of upper usage amount, wettable powder preventing and treating Citrus blister mite there is preferable preventive effect.
The 30% fluazinam MTI-446 wettable powder embodiment of the present invention 16 obtained and 500 grams per liter fluazinams hang
Floating agent, 10% MTI-446 suspending agent carry out field control effectiveness test, and test site is land reclamation and cultivation Guilin, Guangxi, Guilin City mono-group of umbilicus of Liang Feng
Fructus Citri junoris garden, foliar spray method, be watered dilution be made into medicinal liquid by processing dosage, uniformly spray in mandarin tree blade tow sides,
Branch, to moistening, contained citrus red mite and is sent out initial stage dispenser 1 time, and shortly before dispenser, investigation is lived demodicid mite quantity, after dispenser 15 days, 20 days,
Each investigation in 30 days once pinpoints the remaining red spider quantity of leaf, totally 3 times.With community calculation, (every community is 2～3 strain Citrus chachiensiss Hort. to investigation area
Tangerine), investigation method be every community investigate 2 mandarin trees, tree crown by east, south, west, north, in one tree of 5 each labellings in orientation
Tip branch, investigates 5 blades that every tip pushes up most, altogether remaining red spider quantity on 25 blades of investigation, with 10 times of folding hand held
The demodicid mite number in each visual field directly observed by megaloscope.Compare with blank district, calculate relative control effect.
Table 630% fluazinam MTI-446 wettable powder preventing and treating citrus red mite test of pesticide effectiveness result
Table 6 result of the test shows, contains citrus red mite and sends out initial stage dispenser, 30% fluazinam MTI-446 wettable powder
In the case of amount used above, preventing and treating citrus red mite there is preferable preventive effect.
Application Example 22
The 10% fluazinam dinotefuran micron-emulsion that the embodiment of the present invention 22 is obtained and 500 grams per liter fluazinam suspending agents,
10% MTI-446 suspending agent carries out field control effectiveness test, and test site is mono-group of Citrus sinensis Osbeck fruit of land reclamation and cultivation Guilin, Guangxi, Guilin City Liang Feng
Garden, foliar spray method, it is watered dissolved dilution by process dosage and is made into medicinal liquid, strain whole to mandarin tree is sprayed, new at Citrus
The tip is taken out and is sent out phase dispenser 1 time, investigates insect population radix shortly before dispenser, after dispenser 5 days, 10 days, each investigation in 15 days once survives borer population, altogether
3 times.Investigation area calculates (every community is 2～3 strain mandarin trees) with community, and investigation method employing is determined strain and determined tip investigation, and every community is adjusted
Look into 2 mandarin trees, every strain by east, south, west, north, in 5 different azimuth choose 2 and have the worm tip to be marked, investigation records is every
Tip borer population alive.Compare with blank district, calculate relative control effect.
Application Example 22 result of the test:
Table 710% fluazinam dinotefuran micron-emulsion prevents and treats diaphorina citri test of pesticide effectiveness result
Table 7 result of the test shows, causes harm phase dispenser mandarin tree wood louse, 10% fluazinam dinotefuran micron-emulsion more than
In the case of usage amount, there is preferable preventive effect to preventing and treating diaphorina citri.
Application Example 6
The 40% fluazinam MTI-446 aqueous emulsion that the embodiment of the present invention 6 is obtained and 500 grams per liter fluazinam suspending agents,
10% MTI-446 suspending agent carries out field control effectiveness test, and test site is mono-group of Citrus sinensis Osbeck fruit of land reclamation and cultivation Guilin, Guangxi, Guilin City Liang Feng
Garden, uses nebulization, uses double dilution method during preparating liquid, uniformly sprays in Citrus branch and leaf and fruit, falls ill in resin disease
Initial stage carries out dispenser for the first time, executes 4 times altogether.Within after last medicine 20 days, investigate.With community calculation, (every community is 2～3 to investigation area
Strain mandarin tree), 2 strain trees are investigated in every community, every strain by east, south, west, north, in the sampling of five points, two branches of every some investigation, often
Individual branch investigation top down 4 leaves and all fruit, total leaf (really) leaf several, sick (really) number of record investigation and sick level, calculate
Disease index and preventive effect.
Application Example 6 result of the test:
Table 840% fluazinam MTI-446 aqueous emulsion Citrus resin sick (rubber is sick) test of pesticide effectiveness result
Table 8 result of the test shows, starts to execute medicine for the first time at Citrus resin sick (rubber is sick) early period of origination, is thanking to colored back seat
Really middle and late stage, young fruit period, fruit growth period are respectively executed once, and 40% fluazinam MTI-446 aqueous emulsion is tested in amount used above
In the case of, sick to preventing and treating Citrus resin (rubber is sick) has preferable preventive effect.
The 40% fluazinam MTI-446 aqueous emulsion that the embodiment of the present invention 6 is obtained and 500 grams per liter fluazinam suspending agents,
10% MTI-446 suspending agent carries out field control effectiveness test, and test site is mono-group of Citrus sinensis Osbeck fruit of land reclamation and cultivation Guilin, Guangxi, Guilin City Liang Feng
Garden, uses nebulization, uses double dilution method, uniformly spray in Citrus branch and leaf and fruit, at citrus anthracnose during preparating liquid
Their early stage or premorbid carry out dispenser for the first time, execute altogether 3 times, and dispenser is spaced 10 days, within after last medicine 15 days, disposably adjusts
Looking into, investigation area calculates (every community is 2～3 strain mandarin trees) with community.
Blade disease survey method: 2 strain trees are investigated in every community, every strain by east, south, west, north, in five points sample, every point
Whole blades of two tips of investigation, total leaf tree of record investigation, sick leaf tree and sick level, calculate disease index and preventive effect.
Fruit disease investigation method: two strain mandarin trees, 100 fruits of every strain random searching, record investigation are investigated in every community
Total fruit tree and sick fruit number, calculate diseased fruit rate and preventive effect.
Application Example 6 result of the test:
Table 940% fluazinam MTI-446 aqueous emulsion citrus anthracnose test of pesticide effectiveness result
Table 9 result of the test shows, carries out for the first time dispenser at citrus anthracnose their early stage or premorbid, young fruit period, really
Growing directly from seeds and respectively execute once for a long time, 40% fluazinam MTI-446 aqueous emulsion is in the case of above dosage is tested, to preventing and treating Citrus chachiensis Hort.
Fructus Citri tangerinae anthrax has preferable preventive effect.
Application Example 11
The 25% fluazinam MTI-446 water dispersible granules embodiment of the present invention 11 obtained and 500 grams per liter fluazinams hang
Floating agent, 10% MTI-446 suspending agent carry out field control effectiveness test, and test site is land reclamation and cultivation Guilin, Guangxi, Guilin City mono-group of umbilicus of Liang Feng
Fructus Citri junoris garden, foliar spray method, it is watered dilution by process dosage and is made into medicinal liquid, uniformly spray in mandarin tree blade, branch top to the wettest
Profit, Citrus blister mite peak of occurrence early stage dispenser 1 time, shortly before dispenser investigation live demodicid mite quantity, after dispenser 1 day, 7 days, 14 days, 21
My god, the remaining of 28 days each investigation once fixed point leaves live demodicid mite number, totally 5 times.With community calculation, (every community is 2～3 strain Citrus to investigation area
Tree), investigation method be every community investigate 2 mandarin trees, every strain by east, south, west, north, in 5 azimuth mark side shoots, investigate 20
Open the demodicid mite quantity alive of new leaf back, directly observe the demodicid mite number in each visual field with 10 times of folding hand held megaloscopes.With blank
District compares, and calculates relative control effect.
Application Example 11 result of the test:
Table 1025% fluazinam MTI-446 water dispersible granules preventing and treating Citrus blister mite test of pesticide effectiveness result
Table 10 result of the test shows, at mandarin tree blister mite peak of occurrence early stage dispenser, 25% fluazinam MTI-446 water
Dispersible granule, in the case of amount used above is tested, has preferable preventive effect to preventing and treating Citrus blister mite.
The potentiation of following instance explanation compositions
The pesticide sterilizing Pesticidal combination Toxicity Determination to diaphorina citri
Subjects is diaphorina citri.
Test uses medicine embrane method.Take cylindrical transparent glass preserving jar (base diameter 6.8cm, bottleneck diameter 5.5cm, height
8.7cm), add 50ml and be diluted to the medicinal liquid of desired concn, cover tightly lid, shake up gently, be inverted 30s, make bottle inwall the most viscous
Full medicinal liquid, then pours out medicinal liquid, then allows bottle naturally dry.Citrus tender shoots is soaked 1min with identical medicinal liquid, naturally dries in the air
Put into after Gan in the bottle dried；Tender shoots base portion moisturizing is encased with the Cotton Gossypii of dipped identical medicinal liquid.Wood louse adult band plug glass
Test tube gathers from Folium Et Cacumen Murrayae tree.Each process is repeated 3 times, and repeats 10 adults every time.(18-20s) is anaesthetized with co2 during process
After put into each and process in bottle, blank clear water, each bottleneck is built with 40 mesh gauzes, in case adult flies out.20 minutes
The dead worm of rear check whether there is, borer population of living before record medicine.Vial after connecing worm is placed in the illumination box of temperature (25 ± 1) DEG C
In.After medicine, 24h estimates dead borer population, live worm worm, calculates mortality rate, and clear water comparison mortality rate is efficiency test less than 10%.
Concentration conversion first becomes natural logrithm value, and corrected mortality is converted into arcsine transformation value.Again with arcsine transformation
Value is dependent variable, with dosage natural logrithm value as independent variable, carries out linear regression analysis by DPS Biological Statistic Analysis Software, draws each
The toxicity regression linear equation of individual medicament.Toxicity index and the co-toxicity coefficient (CTC) of medicament is calculated according to the abundant method of Sun Yun.
Actual measurement toxicity index=standard agent EC50/ reagent agent EC50 × 100
Single dose theory toxicity index=single dose actual measurement toxicity index × single dose content in mixture
Mixture theory toxicity index=each single dose theory toxicity index sum
Toxicity index/mixture theory toxicity index × 100 of co-toxicity coefficient=mixture actual measurement
Evaluation criterion: CTC≤80 are antagonism, 80 ＜ CTC ＜ 120 are summation action, and CTC >=120 are potentiation.
Table 11: the toxicity index of each medicament and the co-toxicity coefficient of fluazinam MTI-446
| Reagent agent | Proportioning | EC50(mg/kg) | Co-toxicity coefficient |
| Fluazinam | -- | 5.68 | - |
| MTI-446 | -- | 4.17 | - |
| Fluazinam: MTI-446 | 60:1 | 3.63 | 155.55 |
| Fluazinam: MTI-446 | 50:1 | 3.54 | 159.30 |
| Fluazinam: MTI-446 | 40:1 | 3.42 | 164.63 |
| Fluazinam: MTI-446 | 30:1 | 3.31 | 169.78 |
| Fluazinam: MTI-446 | 15:1 | 3.09 | 179.76 |
| Fluazinam: MTI-446 | 1:1 | 2.78 | 172.99 |
| Fluazinam: MTI-446 | 1:5 | 2.61 | 167.17 |
| Fluazinam: MTI-446 | 1:10 | 2.74 | 155.96 |
| Fluazinam: MTI-446 | 1:15 | 2.81 | 150.91 |
| Fluazinam: MTI-446 | 1:20 | 2.87 | 147.17 |
| Fluazinam: MTI-446 | 1:30 | 2.93 | 143.55 |
Table 11 shows that fluazinam compounds with MTI-446 50:1～1:20 in mass ratio, all has potentiation to diaphorina citri,
When especially proportioning is between 1:5～40:1, potentiation is more notable, and co-toxicity coefficient is all higher than 160, is far longer than commenting of potentiation
Price card standard 120.
The compositions of the present invention Toxicity Determination to citrus red mite:
Test uses the microscope slide infusion process that FAO (Food and Agriculture Organization of the United Nation) (FAO) is recommended.Every piece of microscope slide 20 work of inoculation
Female one-tenth demodicid mite, sets series concentration value on the basis of 3 pilot studys, and clear water compares, and often processes 3 times and repeats (totally 60 female one-tenth
Demodicid mite).Leaching medicine blots with absorbent paper after 5 seconds immediately, is then placed in 24-26 DEG C of calorstat, within after medicine 48 hours, checks death
Rate, calculates corrected mortality.Concentration conversion becomes natural logrithm value, and corrected mortality is converted into arcsine transformation value, then with instead
Sinusoidal replacement value is dependent variable, with dosage natural logrithm value as independent variable, carries out rectilinear regression by DPS Biological Statistic Analysis Software and divides
Analysis, draws the toxicity regression linear equation of each medicament.Toxicity regression linear equation according to each medicament obtains correction death
Rate arcsine transformation value (y), draws EC50 value by looking into antilogarithm table, then according to the abundant method of Sun Yun calculate medicament toxicity index and
Co-toxicity coefficient (CTC).
Actual measurement toxicity index=standard agent EC50/ reagent agent EC50 × 100
Single dose theory toxicity index=single dose actual measurement toxicity index × single dose content in mixture
Mixture theory toxicity index=each single dose theory toxicity index sum
Toxicity index/mixture theory toxicity index × 100 of co-toxicity coefficient=mixture actual measurement
Evaluation criterion: CTC≤80 are antagonism, 80 ＜ CTC ＜ 120 are summation action, and CTC >=120 are potentiation,
Experimental result refer to table 12:
Table 12: the toxicity index of each medicament and the co-toxicity coefficient of fluazinam MTI-446
| Reagent agent | Proportioning | EC50(mg/kg) | Co-toxicity coefficient |
| MTI-446 | -- | 7.82 | - |
| Fluazinam | -- | 5.47 | - |
| MTI-446: fluazinam | 1:60 | 4.23 | 129.32 |
| MTI-446: fluazinam | 1:50 | 3.97 | 138.59 |
| MTI-446: fluazinam | 1:40 | 3.81 | 144.63 |
| MTI-446: fluazinam | 1:30 | 3.26 | 169.43 |
| MTI-446: fluazinam | 1:15 | 2.93 | 190.26 |
| MTI-446: fluazinam | 1:1 | 3.41 | 188.78 |
| MTI-446: fluazinam | 5:1 | 4.14 | 176.27 |
| MTI-446: fluazinam | 10:1 | 4.51 | 166.87 |
| MTI-446: fluazinam | 15:1 | 4.59 | 165.91 |
| MTI-446: fluazinam | 20:1 | 4.76 | 164.44 |
| MTI-446: fluazinam | 30:1 | 4.87 | 158.38 |
Table 12 test result indicate that MTI-446 and fluazinam 1:50～20:1 in mass ratio compound, equal to citrus red mite
Having potentiation, when especially proportioning is between 1:40～20:1, potentiation is more notable.
The Toxicity Determination of the compositions of the present invention sick to Citrus resin (broken skin is sick):
Test uses mycelial growth rate method, takes the experiment medicinal liquid that 5ml prepares and joins equipped with 45ml hot culture medium (PDA
Culture medium, 45-50 DEG C) conical flask in, after shaking up, pour rapidly diameter 90mm glass culture dish into, band poured into by each culture dish
Medicine culture medium 12ml, each process 4 repetition, horizontal rest, after cooling flat board.With diameter 5mm card punch from cultivating 4d
For examination bacterium edge cut bacterium cake, with hordeolum, the one side with mycelia is received in band poison culture medium, all operations is all ultra-clean
Workbench carries out sterile working.Decussation is used after flat board is placed on after process in the constant temperature aseptic culture case of 20 DEG C cultivation 4d
Method measures the colony diameter of each process respectively, calculates the mean net increment of the meansigma methods of each process colony diameter, colony diameter
And mycelial growth inhibition rate.
Bacterium colony net growth (mm)=colony diameter-5
Mycelial growth inhibition rate (%)=((comparison bacterium colony net growth-process bacterium colony net growth)/comparison bacterium colony is clean
Increment) × 100 concentration conversion become natural logrithm value, suppression ratio conversion arcsin function value, with arcsine letter replacement value be
Dependent variable, with dosage natural logrithm value as independent variable, carries out linear regression analysis by DPS Biological Statistic Analysis Software, draws recurrence side
Journey, then carry out anti-natural logrithm conversion draw EC50.Toxicity index and the co-toxicity coefficient (CTC) of medicament is calculated according to the abundant method of Sun Yun.
Actual measurement toxicity index=standard agent EC50/ reagent agent EC50 × 100
Single dose theory toxicity index=single dose actual measurement toxicity index × single dose content in mixture
Mixture theory toxicity index=each single dose theory toxicity index sum
Toxicity index/mixture theory toxicity index × 100 of co-toxicity coefficient=mixture actual measurement
Evaluation criterion: CTC≤80 are antagonism, 80 ＜ CTC ＜ 120 are summation action, and CTC >=120 are potentiation,
Experimental result refer to table 13；
Table 13: the toxicity index of each medicament and the co-toxicity coefficient of fluazinam MTI-446
| Reagent agent | Proportioning | EC50(mg/kg) | Co-toxicity coefficient |
| MTI-446 | - | 10.26 | - |
| Fluazinam | - | 6.43 | - |
| MTI-446: fluazinam | 1:60 | 5.14 | 125.87 |
| MTI-446: fluazinam | 1:50 | 4.68 | 138.41 |
| MTI-446: fluazinam | 1:40 | 4.23 | 153.41 |
| MTI-446: fluazinam | 1:30 | 3.72 | 174.96 |
| MTI-446: fluazinam | 1:15 | 3.31 | 198.90 |
| MTI-446: fluazinam | 1:1 | 3.62 | 218.39 |
| MTI-446: fluazinam | 5:1 | 4.31 | 216.55 |
| MTI-446: fluazinam | 10:1 | 4.75 | 204.90 |
| MTI-446: fluazinam | 15:1 | 5.03 | 196.66 |
| MTI-446: fluazinam | 20:1 | 5.94 | 167.96 |
| MTI-446: fluazinam | 30:1 | 6.58 | 152.99 |
Table 13 test result indicate that MTI-446 and fluazinam compositions 1:50～30:1 in mass ratio compound, to mandarin tree
Fat sick (broken skin is sick) all has potentiation, and when especially proportioning is between 1:40～20:1, potentiation is more notable.
Claims (5)
1. containing MTI-446 and a composition pesticide for fluazinam, including active component, it is characterised in that: described active component is
MTI-446 and fluazinam, be calculated by weight as:
MTI-446 1-30 part；
Fluazinam 1-60 part；
Described containing MTI-446 and the composition pesticide of fluazinam, it is at preventing and treating mandarin tree wood louse, citrus red mite, Citrus rust
Application on tick, Citrus resin disease, citrus anthracnose.
It is the most according to claim 1 a kind of containing MTI-446 with the composition pesticide of fluazinam, it is characterised in that: this pesticide group
Compound also includes that auxiliary agent, described auxiliary agent include dispersant, emulsifying agent, antifreezing agent, thickening agent, defoamer, solvent, wetting agent, collapse
Solve one or more in agent and filler.
It is the most according to claim 2 a kind of containing MTI-446 with the composition pesticide of fluazinam, it is characterised in that: described auxiliary agent
The parts by weight added are:
Dispersant 0.1-15 part；
Emulsifying agent 0.1-12 part；
Antifreezing agent 0.1-4 part；
Thickening agent 0.1-4 part；
Defoamer 0.1-2 part；
Solvent 25.9-95.8 part；
Wetting agent 0.1-15 part；
Disintegrating agent 0.1-6 part；
Filler 8-97.5 part.
4. according to a kind of described in Claims 2 or 3 containing MTI-446 with the composition pesticide of fluazinam, it is characterised in that: described
Emulsifying agent is calcium dodecyl benzene sulfonate, alkylpolyoxyethylene, styrylphenol polyoxyethylene ether, polyoxyethylene nonyl phenyl
Vinyl Ether, thermally coupled distillation columns, aliphatic acid polyethenoxy base ester, polyoxyethylene aliphatic alcohol ether, dodecyl are poly-
One or more in oxygen ethenesulfonic acid sodium salt and phenethyl phenol polyethenoxy ether；
Described solvent is dimethylbenzene, diesel oil, toluene, Hexalin, methanol, soybean oil, Oleum Terebinthinae, methyl oleate, solvent naphtha, diformazan
One or more in base Methanamide, ethanol, N-ketopyrrolidine, ethyl acetate and aqueous solvent；
Described wetting agent is sodium lauryl sulphate, calcium dodecyl benzene sulfonate, methyl naphthalene sulfonate formaldehyde condensate, pulls open
One or more in powder, Negel and spaonin powder；
Described dispersant is sodium lignin sulfonate, calcium lignosulfonate, alkylphenol polyoxyethylene formaldehyde condensation products sodium sulfate, alkane
Base benzenesulfonic acid calcium, alkylphenol polyoxyethylene, polycarboxylic acids sodium, aliphatic amine polyoxyethylene ether and glycerine fatty acid fat acid esters polyoxy second
One or more in alkene ether；
Described antifreezing agent is one or more in ethylene glycol, propylene glycol, glycerol and carbamide；
Described thickening agent is one or more in xanthan gum, Magnesiumaluminumsilicate, hydroxymethyl cellulose and polyvinyl alcohol；
Described defoamer is one or more in silicone oil, organic silicone and polypropylene glycerol aether；
Described disintegrating agent is one or more in bentonite, ammonium sulfate, sodium bicarbonate, aluminum chloride and succinic acid；
Described filler is one or more in white carbon, Kaolin, kieselguhr, precipitated calcium carbonate and starch.
It is the most according to claim 4 a kind of containing MTI-446 with the composition pesticide of fluazinam, it is characterised in that: pesticide combination
The dosage form of thing is suspending agent, aqueous emulsion, water dispersible granules, microemulsion or wettable powder.
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