CN103893570A - Method for preparing traditional Chinese medicine capsule for treating migraine - Google Patents
Method for preparing traditional Chinese medicine capsule for treating migraine Download PDFInfo
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- CN103893570A CN103893570A CN201210588320.4A CN201210588320A CN103893570A CN 103893570 A CN103893570 A CN 103893570A CN 201210588320 A CN201210588320 A CN 201210588320A CN 103893570 A CN103893570 A CN 103893570A
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Abstract
The invention provides a method for preparing a traditional Chinese medicine capsule for treating migraine. The content of the traditional Chinese medicine capsule comprises gastrodia elata powder, salvia miltiorrhiza dry extract, water extract and alcohol precipitate dry extract and essential oil, wherein the preparation method comprises pelletizing and drying. The method is characterized in that pelletizing and drying adopt pelletizing and drying in a boiling manner. The method is low in drying temperature, short in time, fewer in procedures, large in output, and high in yield, the medicine components are even, the effective components are high in content, and the dried material forms a powder shape, and is good in mobility, not easy to absorb moisture, and easy in capsule filling.
Description
Technical field
The present invention relates to a kind of preparation method of Chinese medicine capsules, be specifically related to treat the technology of preparing of migrainous Chinese medicine capsules.
Background technology
Chinese patent medicine sky chrysanthemum NAOAN JIAONANG, for being used for the treatment of migrainous Chinese medicine.In its prescription, contain Rhizoma Chuanxiong, Rhizoma Gastrodiae, Flos Chrysanthemi, Fructus Viticis, Rhizoma Ligustici, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Herba Ecliptae, Fructus Ligustri Lucidi, Radix Achyranthis Bidentatae totally 10 taste medical materials.Conventionally, Rhizoma Chuanxiong 150-450 part, Rhizoma Gastrodiae 100-300 part, Flos Chrysanthemi 125-375 part, Fructus Viticis 80-240 part, Rhizoma Ligustici 80-240 part, Radix Paeoniae Alba 100-300 part, Radix Salviae Miltiorrhizae 125-375 part, Herba Ecliptae 150-450 part, Fructus Ligustri Lucidi 80-240 part, Radix Achyranthis Bidentatae 80-240 part, in weight portion.
Existing preparation technology is: Rhizoma Gastrodiae powder is broken into fine powder; 85% alcohol reflux for Radix Salviae Miltiorrhizae, filters, and filtering residue adds 50% alcohol reflux secondary again, filters, and filtrate merges, and decompression recycling ethanol, obtains Radix Salviae Miltiorrhizae fluid extract, the dry dry extract (being Radix Salviae Miltiorrhizae dry extract) that to obtain; Rhizoma Chuanxiong, Fructus Viticis, Rhizoma Ligustici and Flos Chrysanthemi extract volatile oil, and the aqueous solution after distillation filters, and filtrate is concentrated in right amount, for subsequent use; Medicinal residues and the Radix Paeoniae Alba, Herba Ecliptae, Fructus Ligustri Lucidi, Radix Achyranthis Bidentatae decoct with water three times, collecting decoction, filters, and filtrate is concentrated in right amount, merge with the water drug-decocting concentrating liquid such as Rhizoma Chuanxiong, let cool, add ethanol to make to reach 65% containing alcohol amount, fully stir, leave standstill, get supernatant concentrating under reduced pressure, obtain water extract-alcohol precipitation fluid extract, be dried to obtain dry extract (being water extract-alcohol precipitation dry extract).Get Rhizoma Gastrodiae fine powder, Radix Salviae Miltiorrhizae extractum powder (being Radix Salviae Miltiorrhizae dry extract), water extract-alcohol precipitation extract powder (being water extract-alcohol precipitation dry extract) and appropriate amount of starch, mix, 60 DEG C are dried, spray into the volatile oil such as Rhizoma Chuanxiong, sealing, incapsulate.
In drying process, the fluid extract after concentrating adopts dry respectively method (constant pressure and dry or drying under reduced pressure), and rate of drying is slow, in production, often need 2～3 days, baking temperature is high, and temperature is at 70～95 DEG C, and power consumption is large, yield poorly, after dry, extractum needs to pulverize, because dried extractum is the bulk of porosity and looseness, very easily moisture absorption conglomeration of the extract powder after pulverizing, poor fluidity is difficult to mix homogeneously in extract powder, Rhizoma Gastrodiae powder and adjuvant mix up process.In filled capsules process, envionmental humidity is greater than 40% will the very fast moisture absorption, and medicated powder poor fluidity, cannot normally fill.This production technology time is long, yields poorly, and operation is many, and production cost is high, and the moisture absorption of product is large, and because need are heated for a long time, the effective ingredient in product can be degraded, and makes quality of products, is not suitable for large production.
Summary of the invention
The object of the present invention is to provide a kind of preparation method that is used for the treatment of migrainous Chinese medicine capsules, make its applicable suitability for industrialized production.
A kind of preparation method that is used for the treatment of migrainous Chinese medicine capsules, described Chinese medicine capsules content comprises Rhizoma Gastrodiae fine powder, Radix Salviae Miltiorrhizae dry extract, water extract-alcohol precipitation dry extract, volatile oil, described preparation method comprises that granulation is dry, it is characterized in that the dry boiling granulating that adopts of described granulation is dry.
Above-mentioned boiling granulating is dry, is by dry described Radix Salviae Miltiorrhizae fluid extract, water extract-alcohol precipitation fluid extract and Rhizoma Gastrodiae fine powder boiling granulating in the ebullated bed medicine coarse powder that obtains.Described boiling granulating, claims again fluidized bed granulation or one-step palletizing.Medicine coarse powder is made up of Rhizoma Gastrodiae fine powder, Radix Salviae Miltiorrhizae dry extract, water extract-alcohol precipitation dry extract.
Above-mentioned boiling granulating is dry comprises the steps: that (1) first sprays into water extract-alcohol precipitation fluid extract in ebullated bed and is dried with the common boiling granulating of Rhizoma Gastrodiae fine powder, then it is dry to spray into Radix Salviae Miltiorrhizae fluid extract boiling granulating; Or (2) mix homogeneously water extract-alcohol precipitation fluid extract with Radix Salviae Miltiorrhizae fluid extract, spray in ebullated bed dry with the common boiling granulating of Rhizoma Gastrodiae fine powder; Or (3) mix homogeneously water extract-alcohol precipitation fluid extract with the Radix Salviae Miltiorrhizae fluid extract of 1/2nd amounts, spray in ebullated bed dryly with the common boiling granulating of Rhizoma Gastrodiae fine powder, then it is dry to spray into remaining Radix Salviae Miltiorrhizae fluid extract boiling granulating; Or (4) first spray in ebullated bed Radix Salviae Miltiorrhizae fluid extract with the common boiling granulating of Rhizoma Gastrodiae fine powder dry, then it is dry to spray into water extract-alcohol precipitation fluid extract spray boiling granulating.
In order to reduce the moisture absorption of dry extract, increase the mobility of content in capsule, be beneficial to the filling of capsule; And reduce baking temperature and shortening time, reducing the loss of the effective ingredient in product, above-mentioned boiling granulating is dry to be preferably and first to spray into water extract-alcohol precipitation fluid extract to carry out boiling granulating dry, then it is dry to spray into Radix Salviae Miltiorrhizae fluid extract boiling granulating.
Test demonstration, it is dry that the inlet temperature of the dry ebullated bed adopting of above-mentioned boiling granulating all can be carried out preferably boiling granulating in the time of 50～99 DEG C, makes uniform medicine coarse powder, good fluidity.In test, record temperature of charge between 35～60 DEG C.In order to shorten drying time, do not make in dry run temperature of charge too high, preferably inlet temperature is 70～95 DEG C, more preferably 85～95 DEG C.
Further, above-mentioned fluid extract density is 1.10～1.33, fluid extract can be sprayed into vaporificly uniformly, and simultaneously water content is lower, is easy to be dried, and improves its humidity resistance, extends the shelf life.Avoid because water content is high, extended drying time, and affected the content of effective ingredient; And it is vaporific uniformly that fluid extract can be sprayed into, and prevents dough, is difficult to reach production requirement.
Further, above-mentioned fluid extract density is 1.25～1.33, before above-mentioned granulation drying steps, also comprise described fluid extract is heated to 40～80 DEG C, and to reduce the viscosity of fluid extract, can atomisation, complete boiling granulating dry.Otherwise fluid extract is difficult to be sprayed into vaporific uniformly, result is to produce more dough, is difficult to reach production requirement.
Preferably, Radix Salviae Miltiorrhizae fluid extract density for and water extract-alcohol precipitation fluid extract density be 1.15～1.25 for well.
Particularly; above-mentioned boiling granulating is that Rhizoma Gastrodiae powder and appropriate amount of auxiliary materials are placed in to fluid bed granulator; preheating; water extract-alcohol precipitation fluid extract is first sprayed in ebullated bed dry with Rhizoma Gastrodiae fine powder and the common boiling granulating of adjuvant; spray into again Radix Salviae Miltiorrhizae fluid extract boiling granulating dry; fluid extract density is controlled at 1.10～1.33, and ebullated bed inlet temperature is controlled at 50～99 DEG C.
The above-mentioned preparation method that is used for the treatment of migrainous Chinese medicine capsules, comprises following steps:
Rhizoma Gastrodiae powder is broken into fine powder; Radix Salviae Miltiorrhizae 85% alcohol reflux, filters, and filtering residue adds 50% alcohol reflux secondary again, filters, and filtrate merges, decompression recycling ethanol, being concentrated into relative density is 1.08～1.22(80 DEG C), obtain Radix Salviae Miltiorrhizae fluid extract, for subsequent use; Rhizoma Chuanxiong, Fructus Viticis, Rhizoma Ligustici and Flos Chrysanthemi extract volatile oil, and the aqueous solution after distillation filters, and filtrate is concentrated in right amount, for subsequent use; Medicinal residues and the Radix Paeoniae Alba, Herba Ecliptae, Fructus Ligustri Lucidi, Radix Achyranthis Bidentatae decoct with water two to three times, collecting decoction, filters, and filtrate is concentrated in right amount, merge with the water drug-decocting concentrating liquid of Rhizoma Chuanxiong, Fructus Viticis, Rhizoma Ligustici and Flos Chrysanthemi, let cool, add ethanol to make to reach 65% containing alcohol amount, fully stir, leave standstill, getting supernatant, to be evaporated to relative density be 1.08～1.22(80 DEG C), obtain water extract-alcohol precipitation fluid extract, for subsequent use.Rhizoma Gastrodiae fine powder and appropriate amount of auxiliary materials are placed in to ebullated bed, and temperature is controlled at 60～99 DEG C, first sprays into water extract-alcohol precipitation fluid extract boiling granulating dry, and continuing to spray into Radix Salviae Miltiorrhizae fluid extract, to carry out boiling granulating dry, adds volatile oil, mixes, and incapsulates.
The above-mentioned preparation method that is used for the treatment of migrainous Chinese medicine capsules, the density of fluid extract is 1.08～1.22(80 DEG C), referring to the extractum density of measuring at 80 DEG C, density is at normal temperatures 1.10～1.25.Other density not explaining is the density under room temperature.
beneficial effect
1. moisture absorption reduces, and good fluidity, is easy to the filling of capsule, to filling the less demanding of environment, makes it more easy to operate and controls;
2. baking temperature is low, and the time is short, effectively improves the effective ingredient in product, and reduces the consumption of the energy;
3. be applicable to suitability for industrialized production.
4. boiling granulating of the present invention is dry, and process optimization is that a step completes, and product yield is up to 95-97%, and in prior art because extractum need to be dried, pulverize, dry after several mixing of materials, product yield is 90-92%.
5. in granulation of the present invention, fluid extract can cover medicated powder surface equably, makes ingredient mix homogeneously.
6. result of the present invention shows, compared with technical scheme in background technology, method of the present invention has that baking temperature is low, the time is short, and operation is few, and output is large, and loss is low, and dried material is coarse powder shape, and good fluidity is difficult for the moisture absorption, is easy to the filling of capsule.This explained hereafter cost is low, is applicable to suitability for industrialized production.Its Contrast on effect is in table 1.
Table 1
| Project | Art methods | The present invention | Explanation |
| Technical process | Carry out respectively two kinds of extract dries, dried cream powder is broken, mixes, dry | Boiling granulating is dry once to be completed | New technology shortens into a step by former five operations and completes, and improves yield, and yield reaches 95-97%, and has saved a large amount of man-hours |
| Drying time | 2～3 days | 2～5 hours | New technology shortens the time more than 20 hours |
| Baking temperature | 80～95 DEG C of temperature of charge | 50～99 DEG C of inlet temperature, temperature of charge 35～60 | Temperature of charge is obviously low, and loss of effective components is little |
| Capsule-filling mealiness matter | Fine powder, the very easily moisture absorption, poor fluidity | Coarse powder, is difficult for the moisture absorption, and mobility is fine | |
| Capsule-filling situation | The easy moisture absorption in filling process, weight differential is unstable, requires envionmental humidity to fill below 30% | Filling process is nonhygroscopic, and weight differential is fine, requires envionmental humidity to fill below 50% | |
| Output | In the general 50Kg of separate unit drying baker | According to specification of equipment, separate unit is the highest can reach 300 Kg at every turn more than | |
| Product quality | Poor, easily moisture absorption conglomeration, active constituent content is low, and each component is difficult for mix homogeneously | Good, not conglomeration, active constituent content is high, and each component is mix homogeneously in the time granulating | |
| Production cost | Man-hour is many, and power consumption is large, and the time is long, and yield is low, and cost is high | Man-hour is few, consumes energy little, and the time is short, and yield is high, and cost is low |
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, but the present invention is not limited to this.
embodiment 1: drying means research
Prepare Rhizoma Gastrodiae fine powder and two kinds of fluid extracts by " Chinese Pharmacopoeia " 2010 editions prescriptions and method, the amount of gained extractum is the actual amount of preparing under this prescription.Get after Rhizoma Gastrodiae fine powder and adjuvant (starch) mixing, add in ebullated bed, preheating, adopts following 4 kinds of method boiling granulatings dry.
1, sample 1:
Prescription: Rhizoma Gastrodiae fine powder 800 g
Radix Salviae Miltiorrhizae fluid extract (density 1.19) 350 g
Water extract-alcohol precipitation fluid extract (density 1.24) 1506 g
Starch 20 g
First water extract-alcohol precipitation fluid extract is sprayed in ebullated bed dry with Rhizoma Gastrodiae fine powder and the common boiling granulating of starch, spraying into Radix Salviae Miltiorrhizae fluid extract, to carry out boiling granulating dry again, 70～90 DEG C of inlet temperature, record 37～55 DEG C of temperature of charge, dry 3 hours altogether, medicine coarse powder that must be dry, its good fluidity, is difficult for the moisture absorption.
2, sample 2:
Prescription: Rhizoma Gastrodiae fine powder 800 g
Radix Salviae Miltiorrhizae fluid extract (density 1.19) 350 g
Water extract-alcohol precipitation fluid extract (density 1.24) 1506 g
Starch 20 g
Water extract-alcohol precipitation fluid extract, Radix Salviae Miltiorrhizae fluid extract are closed evenly, spray in ebullated bed and be dried with Rhizoma Gastrodiae fine powder and the common boiling granulating of starch, 70～90 DEG C of baking temperatures, record 40～57 DEG C of temperature of charge, at 3.3 hours, obtain dry medicine coarse powder, good fluidity drying time.
3, sample 3:
Prescription: Rhizoma Gastrodiae fine powder 800 g
Radix Salviae Miltiorrhizae fluid extract (density 1.19) 350 g
Water extract-alcohol precipitation fluid extract (density 1.24) 1506 g
Starch 20 g
Water extract-alcohol precipitation fluid extract is mixed homogeneously with 175g Radix Salviae Miltiorrhizae fluid extract, spray in ebullated bed and be dried with Rhizoma Gastrodiae fine powder and the common boiling granulating of starch, then it is dry to spray into remaining Radix Salviae Miltiorrhizae fluid extract boiling granulating.70～90 DEG C of inlet temperature, record 37～59 DEG C of temperature of charge, 3.3 hours drying times, obtain the medicine coarse powder that dry, flowable is good.
4, sample 4:
Prescription: Rhizoma Gastrodiae fine powder 800 g
Radix Salviae Miltiorrhizae fluid extract (density 1.19) 350 g
Water extract-alcohol precipitation fluid extract (density 1.24) 1506 g
Starch 60 g
First Radix Salviae Miltiorrhizae fluid extract is sprayed into the common boiling granulating of ebullated bed and Rhizoma Gastrodiae fine powder and starch dry, then spray into water extract-alcohol precipitation fluid extract airpillow-dry.70～90 DEG C of inlet temperature, record 42～57 DEG C of temperature of charge, 3.7 hours drying times, obtain dry medicine coarse powder, the easier moisture absorption of gained medicated powder.
5, sample 5
In background technology, method is prepared medicine coarse powder
Prescription: Rhizoma Gastrodiae fine powder 800 g
Radix Salviae Miltiorrhizae fluid extract (density 1.19) 350 g
Water extract-alcohol precipitation fluid extract (density 1.24) 1506 g
Starch 20 g
Radix Salviae Miltiorrhizae fluid extract, water extract-alcohol precipitation fluid extract are carried out respectively to vacuum drying, and 85 DEG C of baking temperatures, pulverize, and mix with Rhizoma Gastrodiae fine powder, starch, and 60 DEG C dry, obtains dry fine drug powder, the very easily moisture absorption of gained medicated powder, poor fluidity.
embodiment 2
◆ the mensuration of different dry drying method medicine coarse powder moisture absorption: get 5 kinds of each 10g of sample in embodiment 1, accurately weighed, be put in relative humidity and be in 48.52% environment, weigh at times, the results are shown in Table 2:
Table 2
| Sample | 0 | 30 minutes | 1 hour | 2 hours | 4 hours | 6 hours |
| Sample 1 | 10.1012 | 10.1008 | 10.1005 | 10.0101 | 10.0995 | 10.0992 |
| Sample 2 | 10.3131 | 10.3542 | 10.3859 | 10.4264 | 10.4986 | 10.5192 |
| Sample 3 | 10.3123 | 10.3211 | 10.3221 | 10.3235 | 10.3248 | 10.3260 |
| Sample 4 | 10.2612 | 10.4046 | 10.5175 | 10.6714 | 10.7741 | 10.3225 |
| Sample 5 | 10.520 | 10.6042 | 10.6569 | 10.7409 | 10.8461 | 10.9197 |
Above result demonstration, it is dry that water extract-alcohol precipitation fluid extract boiling granulating is first sprayed in employing, then spray the dry gained medicine coarse powder moisture absorption minimum (sample 1) of Radix Salviae Miltiorrhizae fluid extract boiling granulating, is conducive to production and the protection against the tide of product.And it is dry first to spray Radix Salviae Miltiorrhizae fluid extract boiling granulating, rear spray water extract-alcohol precipitation fluid extract boiling granulating is dried the easier moisture absorption of gained medicine coarse powder (sample 4).This studies show that Radix Salviae Miltiorrhizae fluid extract has good moisture resistance, and by finally adding, to carry out boiling granulating dry, makes Radix Salviae Miltiorrhizae fluid extract be wrapped in medicated powder surface, played good moisture-proof role.Preferably dry first to spray water extract-alcohol precipitation fluid extract boiling granulating, then spray into Radix Salviae Miltiorrhizae fluid extract airpillow-dry.Fine drug powder (sample 5) moisture absorption of art methods gained is large.
◆ sample 1 is measured at the moisture absorption of different relative humiditys: 6 parts of the thing coarse powder of getting it filled, and every part of 10g, accurately weighed, be put in different relative humidity environment, weigh at times, calculate gained moisture absorption ratio and the results are shown in Table 3:
Table 3
| Time | Relative humidity (%) | Relative humidity (%) | Relative humidity (%) | Relative humidity (%) | Relative humidity (%) | Relative humidity (%) | Relative humidity (%) |
| 29.55 | 40.52 | 48.52 | 57.52 | 75.28 | 84.26 | 92.48 | |
| 2h | -0.41 | -0.34 | -0.12 | 0.94 | 2.80 | 2.80 | 2.80 |
| 4h | -0.63 | -0.40 | -0.17 | 1.60 | 4.00 | 5.21 | 5.90 |
| 8h | -0.83 | -0.53 | -0.22 | 2.60 | 7.00 | 8.13 | 9.00 |
| 10h | -0.86 | -0.58 | -0.24 | 3.00 | 7.90 | 9.06 | 10.00 |
| 12h | -0.93 | -0.62 | -0.26 | 3.40 | 8.70 | 9.50 | 10.90 |
| 24h | -1.09 | -0.72 | -0.31 | 5.40 | 13.00 | 14.23 | 16.30 |
Result show, sample 1 in the time that relative humidity is 75.28%, obviously moisture absorption in 4 hours; But relative humidity is below 48.52% time, and moisture gradually reduces.Depositing of prompting medicine coarse powder should be below 50%, to preserve or fill at relative humidity, and medicine coarse powder is nonhygroscopic.
◆ sample 1 and sample 5 are added to volatile oil and adjuvant, make capsule, use PVC blister package, then overlap with plastic bag sealing, carry out 6 months accelerated stability tests according to the method for " Chinese Pharmacopoeia " 2010 editions accelerated tests, measure water content, in table 4:
Table 4
| Water content | 0 month | January | February | March | June |
| Sample 1(wt%) | 1.85 | 1.87 | 1.80 | 1.87 | 1.87 |
| Sample 5(wt%) | 2.23 | 3.2 | 4.05 | 4.87 | 5.85 |
Test has shown after the dry finished product accelerated stability test of making of boiling granulating, water content is substantially unchanged, and method water content of the prior art has increased by 3.72%, show that sample prepared by boiling granulating drying means can keep good moisture resistance for a long time.
◆ sample 1 and sample 5 are added to volatile oil and adjuvant, make capsule, measure the effective ingredient (every capsules is equipped with content 0.40g) in capsule 's content, result is as table 5:
Table 5
| Gastrodin content/grain | Paeoniflorin content/grain | |
| Sample 1 | 0.65mg | 1.79mg |
| Sample 5 | 0.65mg | 1.08mg |
Employing boiling granulating is dry, and gastrodin content is suitable with existing method, but paeoniflorin content is apparently higher than existing method, proves to adopt the dry temperature of charge of boiling granulating low, and the time is short, and the loss of effective ingredient peoniflorin is little.
embodiment 3:
Prepare Rhizoma Gastrodiae fine powder according to " Chinese Pharmacopoeia " version sky chrysanthemum NAOAN JIAONANG method for making item in 2010, Radix Salviae Miltiorrhizae fluid extract, water extract-alcohol precipitation fluid extract, adjuvant carries out following experiment:
1, prescription: Rhizoma Gastrodiae fine powder 8 ㎏
Radix Salviae Miltiorrhizae fluid extract (density 1.19) 3.5 ㎏
Water extract-alcohol precipitation fluid extract (density 1.24) 15.06 ㎏
Starch 0.2 ㎏
Rhizoma Gastrodiae fine powder and starch are mixed, be placed in fluid bed granulator, preheating, spraying into water extract-alcohol precipitation fluid extract, to carry out boiling granulating dry, then spraying into Radix Salviae Miltiorrhizae fluid extract, to carry out boiling granulating dry, obtains the medicine coarse powder of good fluidity.Inlet temperature is controlled at 50～65 DEG C, 30～40 DEG C of temperature of charge, 5 hours drying times.
2, with writing out a prescription above, respectively inlet temperature is controlled to 65～80 DEG C, 85～99 DEG C, dry with above identical method boiling granulating, it records temperature of charge and is respectively 40～50 DEG C, 45～59 DEG C, is respectively drying time 3.8 hours and 2.2 hours.
By above dry drug coarse powder filled capsules, respectively, product yield is 95.3%, 96.2%, 97.3%; Gastrodin content is 0.65mg/ grain, 0.66mg/ grain, 0.64mg/ grain; Paeoniflorin content is 1.78mg/ grain, 1.82mg/ grain, 1.79mg/ grain.
embodiment 4:
Prepare Rhizoma Gastrodiae powder according to " Chinese Pharmacopoeia " version sky chrysanthemum NAOAN JIAONANG method for making item in 2010, volatile oil, Radix Salviae Miltiorrhizae fluid extract, water extract-alcohol precipitation fluid extract, carries out following experiment:
Prescription: Rhizoma Gastrodiae fine powder 80.0 ㎏
Radix Salviae Miltiorrhizae fluid extract (density 1.33) 26.3 ㎏
Water extract-alcohol precipitation fluid extract (density 1.32) 125.5 ㎏
Starch 2.0 ㎏
Rhizoma Gastrodiae powder and starch mixing are placed in to fluid bed granulator; spray into that to be heated to 75 DEG C of water extract-alcohol precipitation fluid extract boiling granulatings dry; spray into again and be heated to 75 DEG C of Radix Salviae Miltiorrhizae fluid extracts to carry out boiling granulating dry; temperature is controlled at 80～99 DEG C; recording temperature of charge is 45～59 DEG C, 2 hours drying times.
Medicine coarse powder is added with the volatile oil after ethanol dilution, mix, airtight placement, fills and obtains capsule.Gained medicine coarse powder is nonhygroscopic below 50% in humidity.
Product yield is 97.6%, and gastrodin content is 0.62mg/ grain, and paeoniflorin content is 1.79mg/ grain.
embodiment 5:
Rhizoma Gastrodiae fine powder 80 ㎏
Radix Salviae Miltiorrhizae fluid extract (density 1.106) 51.9 ㎏
Water extract-alcohol precipitation fluid extract (density 1.08) 264.4 ㎏
Rhizoma Gastrodiae powder is placed in to fluid bed granulator, and preheating, sprays into water extract-alcohol precipitation fluid extract and carries out airpillow-dry, then sprays into Radix Salviae Miltiorrhizae fluid extract and carry out airpillow-dry, 70～90 DEG C of temperature, and temperature of charge is respectively 35～50 DEG C, dry 5 hours, obtains dry medicine coarse powder.Gained medicine coarse powder good fluidity, is difficult for the moisture absorption.
Medicine coarse powder is added with the volatile oil after ethanol dilution, mix, add 0.5% magnesium stearate (lubricant) to mix, fill and obtain capsule.
Product yield is 95.3%, and gastrodin content is 0.56mg/ grain, and paeoniflorin content is 1.68mg/ grain.
Claims (8)
1. one kind is used for the treatment of the preparation method of migrainous Chinese medicine capsules, the content of described Chinese medicine capsules comprises Rhizoma Gastrodiae fine powder, Radix Salviae Miltiorrhizae dry extract, water extract-alcohol precipitation dry extract, volatile oil, described preparation method comprises that granulation is dry, it is characterized in that the dry boiling granulating that adopts of described granulation is dry.
2. the preparation method that is used for the treatment of migrainous Chinese medicine capsules as claimed in claim 1, described boiling granulating is dry, is to adopt ebullated bed by dry to Radix Salviae Miltiorrhizae fluid extract, water extract-alcohol precipitation fluid extract and the Rhizoma Gastrodiae fine powder boiling granulating medicine coarse powder that obtains.
3. the preparation method that is used for the treatment of migrainous Chinese medicine capsules as claimed in claim 2, described boiling granulating is dry comprises the steps: that (1) first sprays into water extract-alcohol precipitation fluid extract in ebullated bed and is dried with the common boiling granulating of Rhizoma Gastrodiae fine powder, then it is dry to spray into Radix Salviae Miltiorrhizae fluid extract boiling granulating; Or (2) mix homogeneously water extract-alcohol precipitation fluid extract with Radix Salviae Miltiorrhizae fluid extract, spray in ebullated bed dry with the common boiling granulating of Rhizoma Gastrodiae fine powder; Or (3) mix homogeneously water extract-alcohol precipitation fluid extract with the Radix Salviae Miltiorrhizae fluid extract of 1/2nd amounts, spray in ebullated bed dryly with the common boiling granulating of Rhizoma Gastrodiae fine powder, then it is dry to spray into remaining Radix Salviae Miltiorrhizae fluid extract boiling granulating; Or (4) first spray in ebullated bed Radix Salviae Miltiorrhizae runny plaste with the common boiling granulating of Rhizoma Gastrodiae fine powder dry, then it is dry to spray into water extract-alcohol precipitation fluid extract spray boiling granulating.
4. be used for the treatment of as claimed in claim 2 or claim 3 the preparation method of migrainous Chinese medicine capsules, the inlet temperature of described ebullated bed is 50～99 DEG C, and preferably inlet temperature is 70～95 DEG C, more preferably 85～95 DEG C.
5. the preparation method that is used for the treatment of migrainous Chinese medicine capsules as described in as arbitrary in claim 1～4, described fluid extract density is 1.10～1.33, is preferably 1.15～1.25.
6. the preparation method that is used for the treatment of migrainous Chinese medicine capsules as claimed in claim 5, described fluid extract density is 1.25～1.33, before above-mentioned boiling granulating drying steps, also comprises described fluid extract is heated to 40～80 DEG C.
7. the preparation method that is used for the treatment of migrainous Chinese medicine capsules as claimed in claim 1; described boiling granulating is dry is that Rhizoma Gastrodiae fine powder and appropriate amount of auxiliary materials are placed in to fluid bed granulator; preheating; water extract-alcohol precipitation fluid extract is first sprayed in ebullated bed dry with the common boiling granulating of Rhizoma Gastrodiae fine powder; spray into again Radix Salviae Miltiorrhizae fluid extract boiling granulating dry; fluid extract density is controlled at 1.10～1.33, and inlet temperature is controlled at 50～99 DEG C.
8. the preparation method that is used for the treatment of migrainous Chinese medicine capsules as claimed in claim 1, comprises following steps:
Rhizoma Gastrodiae powder is broken into fine powder; Radix Salviae Miltiorrhizae 85% alcohol reflux, filters, and filtering residue adds 50% alcohol reflux secondary again, filters, and filtrate merges, decompression recycling ethanol, being concentrated into relative density is 1.08～1.22(80 DEG C), obtain Radix Salviae Miltiorrhizae fluid extract, for subsequent use; Rhizoma Chuanxiong, Fructus Viticis, Rhizoma Ligustici and Flos Chrysanthemi extract volatile oil, and the aqueous solution after distillation filters, and filtrate is concentrated in right amount, for subsequent use; Medicinal residues and the Radix Paeoniae Alba, Herba Ecliptae, Fructus Ligustri Lucidi, Radix Achyranthis Bidentatae decoct with water two to three times, collecting decoction, filters, and filtrate is concentrated in right amount, merge with the water drug-decocting concentrating liquid of Rhizoma Chuanxiong, Fructus Viticis, Rhizoma Ligustici and Flos Chrysanthemi, let cool, add ethanol to make to reach 65% containing alcohol amount, fully stir, leave standstill, getting supernatant, to be evaporated to relative density be 1.08～1.22(80 DEG C), obtain water extract-alcohol precipitation fluid extract, for subsequent use; Rhizoma Gastrodiae fine powder and appropriate amount of auxiliary materials are placed in to ebullated bed, and temperature is controlled at 60～99 DEG C, first sprays into water extract-alcohol precipitation fluid extract boiling granulating dry, and continuing to spray into Radix Salviae Miltiorrhizae fluid extract, to carry out boiling granulating dry, adds volatile oil, mixes, and incapsulates.
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| CN1943724A (en) * | 2005-10-08 | 2007-04-11 | 周小明 | A Chinese traditional medicinal composition for treatment of migraine and its preparation method |
| CN101732585A (en) * | 2010-01-12 | 2010-06-16 | 四川梓橦宫药业有限公司 | Medicinal composition for treating migraine, preparation method and application thereof |
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| CN1943724A (en) * | 2005-10-08 | 2007-04-11 | 周小明 | A Chinese traditional medicinal composition for treatment of migraine and its preparation method |
| CN101732585A (en) * | 2010-01-12 | 2010-06-16 | 四川梓橦宫药业有限公司 | Medicinal composition for treating migraine, preparation method and application thereof |
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| CN106214757A (en) * | 2016-08-23 | 2016-12-14 | 李洪芳 | One treats migrainous medicine and preparation method thereof |
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