CN103893526A - Preparation method of traditional Chinese medicine composition for nourishing yin, clearing away lung-heat, clearing heat and relieving sore throat - Google Patents
Preparation method of traditional Chinese medicine composition for nourishing yin, clearing away lung-heat, clearing heat and relieving sore throat Download PDFInfo
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Abstract
The invention discloses a preparation method of a traditional Chinese medicine composition for nourishing yin, clearing away lung-heat, clearing heat and relieving sore throat, belonging to the field of modernization of traditional Chinese medicines. The traditional Chinese medicine composition for nourishing yin, clearing away lung-heat, clearing heat and relieving sore throat is prepared from the following raw materials in parts by weight: 250 parts of radix rehmanniae, 200 parts of figwort, 150 parts of ophiopogon root, 50 parts of licorice, 100 parts of moutan bark, 100 parts of fritillaria cirrhosa, 100 parts of white peony root and 0.3125 part of menthol. The Chinese medicine theory is utilized to analyze the prescription components, and the preparation method using reasonable and stable active components is obtained according to the research results of physicochemical properties and pharmacological actions of the components contained in the medicines. The pharmaceutical preparation prepared by adopting the technical scheme has the advantages of stable and controllable quality, obviously higher curative effect than the commercially available preparation formulation at present, smaller dosage for patients and higher bioavailability, and has obvious economic and social benefits.
Description
Technical field
The preparation method that the present invention relates to a kind of Chinese medicine composition of nourishing yin, clearing lung-heat, reducing fever sore-throat relieving, belongs to modern Chinese traditional medicine field.
Background technology
Throat is one of human body vitals, is the organ of swallowing food, breathe air, pronunciation, and the pharyngolaryngitis patient who suffers from various degree accounts for 40% in crowd.Chronic pharyngolaryngitis easily becomes antibacterial and viral multiple abscess joint and the internal organs such as streptococcus, streptomycete, staphylococcus, Diplococcus pneumoniae as obstinate, occur the obstinate diseases such as heart disease, pleuritis, rheumatoid arthritis, pulmonary tuberculosis, throat tumor, esophageal tumor, how to control wrong treatment relevant with the mistake of chronic pharyngolaryngitis.
Worldwide, because environmental pollution improvement is unfavorable and various bad life style, the mortality rate that respiratory system disease causes rises year by year, has become at present and has caused one of dead several large " killers ".
Along with the quickening of urbanization process, Urban Environmental Problem becomes increasingly conspicuous.Urban air pollution type is changed to fuel oil mixed type by coal smoke type, and primary pollutant transfers nitrogen oxide to by flue dust, and in addition, modern's various bad life style, as smoking has more increased the burden of respiratory system.Some emerging industries and occupation inevitably increase the chance of occupational lung damage.House fitting, kitchen cooking fume etc. also have the variation of subenvironment in room, as all can caused grave danger to human body.Along with air pollution and ecological deterioration, the sickness rate of respiratory system had corresponding rising relatively in the past.
Western medicine can only be controlled the state of an illness temporarily at present, takes too many antibiotic medicine, and antibiotic or sulfonamides can cause yin-Yang disequilibrium, immunologic hypofunction, and resistance goes down, and causes Relapse rate difficult.
Syrup for nourishing and clearing lung-heat is the Chinese medicine of current commercially available a kind of effective treatment laryngopharyngeal diseases, and it adopts Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae, Cortex Moutan, Bulbus Fritillariae Cirrhosae, the Radix Paeoniae Alba, Mentholum to make.The party is take Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis as principal agent, and with nourshing Yin and drynsessmoistening prescription, wherein Radix Ophiopogonis, Radix Scrophulariae can removing heat from blood, and Radix Scrophulariae also can resolving toxin and disinhibiting the throat.Radix Paeoniae Alba yin fluid astringing expels the heat-evil, the detumescence of Cortex Moutan removing heat from blood, and Bulbus Fritillariae Cirrhosae clearing away lung-heat and moistening for dryness is reduced phlegm, and is our accessory drugs altogether.Help less the loose evil sore-throat relieving of Mentholum, Radix Glycyrrhizae and medicine removing toxic substances.All medicine compatibilities, grow clearly and execute, and play altogether the merit of nourishing YIN and clearing away lung-heat, clearing throat.
This medicine has the function of nourishing yin, clearing lung-heat, reducing fever sore-throat relieving, for dry laryngopharynx pain, and dry cough, few expectorant or without expectorant.
The method for making of syrup for nourishing and clearing lung-heat is: by Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae decocting in water twice, merge decocting liquid, be concentrated in right amount, by Cortex Moutan, Bulbus Fritillariae Cirrhosae, the Radix Paeoniae Alba 60% ethanol extraction; Above-mentioned decocting in water concentrated solution and ethanol extract merging are mixed, leave standstill, draw supernatant for subsequent use, precipitation turns molten with appropriate 70% ethanol, fully mixes, and leaves standstill, draw supernatant, precipitation uses same method to dissolve once again, filtering precipitation, merge solution twice, reclaim ethanol, be concentrated into appropriate, above-mentioned reserve liquid and concentrated solution are merged, add 0.3% sodium benzoate to stir evenly, add simple syrup and Mentholum to stir evenly, standing, fill.This drug oral, a 20ml, 2 times on the one.
This medicine has good curative effect, leaves standstill but this preparation method relates to three times, and each time of repose is 72 hours, consuming time very long.If can improve preparation method, to this medicine important in inhibiting.
Summary of the invention
First technical problem that the present invention will solve is to provide a kind of Chinese medicine composition of nourishing yin, clearing lung-heat, reducing fever sore-throat relieving.
Another technical problem that the present invention will solve is to provide the preparation method of above-mentioned Chinese medicine composition.
For achieving the above object, the present invention is by the following technical solutions:
A Chinese medicine composition for nourishing yin, clearing lung-heat, reducing fever sore-throat relieving, is made up of the raw material of following parts by weight: 250 parts of Radix Rehmanniae, 200 parts of Radix Scrophulariaes, 150 parts of Radix Ophiopogonis, 50 parts, Radix Glycyrrhizae, 100 parts of Cortex Moutans, 100 parts of Bulbus Fritillariae Cirrhosaes, 100 parts of the Radix Paeoniae Albas, 0.3125 part of Mentholum.
Described Chinese medicine composition adopts following methods preparation:
A. proportioning raw material: 0.3125 part of 100 parts of Mentholum of 250 portions of Radix Scrophulariaes of Radix Rehmanniae, 100 portions of Radix Paeoniae Albas of 100 parts of Bulbus Fritillariae Cirrhosaes of 50 parts of Cortex Moutans of 150 portions of Radix Glycyrrhizaes, 200 parts of Radix Ophiopogonis;
B. take each raw material by proportioning raw materials, for subsequent use;
C. Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae boil twice with 8-10 times of water gaging, and each 1-2 hour, merges decocting liquid, and being evaporated to 70 ℃ of lower densities is 1.03-1.10, obtains concentrated solution A;
D. Cortex Moutan, Bulbus Fritillariae Cirrhosae, the Radix Paeoniae Alba doubly measure with 6-8 the ethanol extraction twice that concentration of volume percent is 30-90%, each 1-2 hour, and merge extractive liquid,, obtains extracting solution B;
E. concentrated solution A and extracting solution B merging are mixed, leave standstill 60-80 hour, centrifugal, divide and get supernatant, obtain supernatant C;
F. supernatant C being evaporated to 70 ℃ of lower densities is 1.03-1.10, obtains concentrated solution D;
G. by concentrated solution A and concentrated solution D mix homogeneously, obtain concentrated solution I;
I. Mentholum is added in concentrated solution I, to obtain final product.
Described Chinese medicine composition preferably adopts following methods preparation:
A. proportioning raw material: 0.3125 part of 100 parts of Mentholum of 250 portions of Radix Scrophulariaes of Radix Rehmanniae, 100 portions of Radix Paeoniae Albas of 100 parts of Bulbus Fritillariae Cirrhosaes of 50 parts of Cortex Moutans of 150 portions of Radix Glycyrrhizaes, 200 parts of Radix Ophiopogonis;
B. take each raw material by proportioning raw materials, for subsequent use;
C. Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae boil twice with 8-10 times of water gaging, and each 1.5-2 hour, merges decocting liquid, and being evaporated to 70 ℃ of lower densities is 1.05-1.08, obtains concentrated solution A;
D. Cortex Moutan, Bulbus Fritillariae Cirrhosae, the Radix Paeoniae Alba doubly measure with 6-8 the ethanol extraction twice that concentration of volume percent is 40-80%, each 1-1.5 hour, and merge extractive liquid,, obtains extracting solution B;
E. concentrated solution A and extracting solution B merging are mixed, leave standstill 70-80 hour, centrifugal, divide and get supernatant, obtain supernatant C;
F. supernatant C being evaporated to 70 ℃ of lower densities is 1.05-1.08, obtains concentrated solution D;
G. by concentrated solution A and concentrated solution D mix homogeneously, obtain concentrated solution I;
I. Mentholum is added in concentrated solution I, to obtain final product.
Described Chinese medicine composition most preferably adopts following methods preparation:
A. proportioning raw material: 0.3125 part of 100 parts of Mentholum of 250 portions of Radix Scrophulariaes of Radix Rehmanniae, 100 portions of Radix Paeoniae Albas of 100 parts of Bulbus Fritillariae Cirrhosaes of 50 parts of Cortex Moutans of 150 portions of Radix Glycyrrhizaes, 200 parts of Radix Ophiopogonis;
B. take each raw material by proportioning raw materials, for subsequent use;
C. Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae decocting in water twice, adds water 8 times at every turn and measures, and extracts 2 hours, merges decocting liquid, and concentrating under reduced pressure, obtains concentrated solution A, and concentrated solution density is 1.05;
D. Cortex Moutan, Bulbus Fritillariae Cirrhosae, the Radix Paeoniae Alba 70% ethanol extraction twice, adds for the first time 8 times of amounts of ethanol and extracts 1.5 hours, adds for the second time 6 times of amounts of ethanol and extracts 1 hour, and merge extractive liquid,, obtains extracting solution B;
E. concentrated solution A and extracting solution B merging are mixed, leave standstill 72 hours, centrifugal, divide and get supernatant, obtain supernatant C;
F. by supernatant C, being evaporated to 70 ℃ of lower densities is 1.05, obtains concentrated solution D;
G. by concentrated solution A and concentrated solution D mix homogeneously, obtain concentrated solution I;
I. Mentholum is added in concentrated solution I, to obtain final product.
Described pharmaceutical composition also contains the acceptable adjuvant of pharmaceutics.
The acceptable adjuvant of described pharmaceutics is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and sodium sulfite, xylitol, maltose, Polyethylene Glycol, simple syrup.
The dosage form of described Chinese medicine composition is pill, tablet, capsule, mixture, syrup or oral liquid.The selection of dosage form and the consumption of adjuvant all belong to prior art.
A preparation method for the Chinese medicine composition of nourishing yin, clearing lung-heat, reducing fever sore-throat relieving, step is as follows:
A. proportioning raw material: 0.3125 part of 100 parts of Mentholum of 250 portions of Radix Scrophulariaes of Radix Rehmanniae, 100 portions of Radix Paeoniae Albas of 100 parts of Bulbus Fritillariae Cirrhosaes of 50 parts of Cortex Moutans of 150 portions of Radix Glycyrrhizaes, 200 parts of Radix Ophiopogonis;
B. take each raw material by proportioning raw materials, for subsequent use;
C. Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae boil twice with 8-10 times of water gaging, and each 1-2 hour, merges decocting liquid, and being evaporated to 70 ℃ of lower densities is 1.03-1.10, obtains concentrated solution A;
D. Cortex Moutan, Bulbus Fritillariae Cirrhosae, the Radix Paeoniae Alba doubly measure with 6-8 the ethanol extraction twice that concentration of volume percent is 30-90%, each 1-2 hour, and merge extractive liquid,, obtains extracting solution B;
E. concentrated solution A and extracting solution B merging are mixed, leave standstill 60-80 hour, centrifugal, divide and get supernatant, obtain supernatant C;
F. supernatant C being evaporated to 70 ℃ of lower densities is 1.03-1.10, obtains concentrated solution D;
G. by concentrated solution A and concentrated solution D mix homogeneously, obtain concentrated solution I;
I. Mentholum is added in concentrated solution I, to obtain final product.
Described preparation method is preferably:
A. proportioning raw material: 0.3125 part of 100 parts of Mentholum of 250 portions of Radix Scrophulariaes of Radix Rehmanniae, 100 portions of Radix Paeoniae Albas of 100 parts of Bulbus Fritillariae Cirrhosaes of 50 parts of Cortex Moutans of 150 portions of Radix Glycyrrhizaes, 200 parts of Radix Ophiopogonis;
B. take each raw material by proportioning raw materials, for subsequent use;
C. Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae boil twice with 8-10 times of water gaging, and each 1.5-2 hour, merges decocting liquid, and being evaporated to 70 ℃ of lower densities is 1.05-1.08, obtains concentrated solution A;
D. Cortex Moutan, Bulbus Fritillariae Cirrhosae, the Radix Paeoniae Alba doubly measure with 6-8 the ethanol extraction twice that concentration of volume percent is 40-80%, each 1-1.5 hour, and merge extractive liquid,, obtains extracting solution B;
E. concentrated solution A and extracting solution B merging are mixed, leave standstill 70-80 hour, centrifugal, divide and get supernatant, obtain supernatant C;
F. supernatant C being evaporated to 70 ℃ of lower densities is 1.05-1.08, obtains concentrated solution D;
G. by concentrated solution A and concentrated solution D mix homogeneously, obtain concentrated solution I;
I. Mentholum is added in concentrated solution I, to obtain final product.
Described preparation method most preferably is:
A. proportioning raw material: 0.3125 part of 100 parts of Mentholum of 250 portions of Radix Scrophulariaes of Radix Rehmanniae, 100 portions of Radix Paeoniae Albas of 100 parts of Bulbus Fritillariae Cirrhosaes of 50 parts of Cortex Moutans of 150 portions of Radix Glycyrrhizaes, 200 parts of Radix Ophiopogonis;
B. take each raw material by proportioning raw materials, for subsequent use;
C. Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae decocting in water twice, adds water 8 times at every turn and measures, and extracts 2 hours, merges decocting liquid, and being evaporated to 70 ℃ of lower densities is 1.05, obtains concentrated solution A;
D. Cortex Moutan, Bulbus Fritillariae Cirrhosae, the Radix Paeoniae Alba, with 70% ethanol extraction twice, add for the first time 8 times of amounts of ethanol and extract 1.5 hours, add for the second time 6 times of amounts of ethanol and extract 1 hour, and merge extractive liquid,, obtains extracting solution B;
E. concentrated solution A and extracting solution B merging are mixed, leave standstill 72 hours, centrifugal, divide and get supernatant, obtain supernatant C;
F. by supernatant C, being evaporated to 70 ℃ of lower densities is 1.05, obtains concentrated solution D;
G. by concentrated solution A and concentrated solution D mix homogeneously, obtain concentrated solution I;
I. Mentholum is added in concentrated solution I, to obtain final product.
The Chinese medicine composition that technical solution of the present invention is protected and preparation thereof all have good nourishing YIN and clearing away lung-heat, relieving sore-throat by clearing away heat, eliminating phlegm and relieving cough effect, take safety.By zoopery, we unexpectedly find, pharmaceutical composition prepared by technique of the present invention compared with prior art, has more excellent antitussive effect.
Advantage of the present invention is: the present invention uses theory of Chinese medical science analysis prescription composition, and according to the result of study of the physicochemical property of each flavour of a drug ingredient and pharmacological action, research has obtained the preparation method of reasonable, stable active component.Adopt technical solution of the present invention, prepared pharmaceutical preparation stable and controllable for quality, that curative effect significantly improves compared with existing commercially available dosage form, patient's taking dose reduces, bioavailability improves.Technique of the present invention has greatly shortened medicine preparation time, has improved production capacity, has significant economic and social benefit.
Describe by the following examples technical solution of the present invention in detail, do not limit practical range of the present invention with this.
The specific embodiment
Embodiment 1: prepare Chinese medicine composition
One. prescription
Radix Rehmanniae 250g Radix Scrophulariae 200g 150g Radix Ophiopogonis Radix Glycyrrhizae 50g Cortex Moutan 100g Bulbus Fritillariae Cirrhosae 100g Radix Paeoniae Alba 100g Mentholum 0.3125g
Two. method for making
A. proportioning raw material: Radix Rehmanniae 250g Radix Scrophulariae 200g 150g Radix Ophiopogonis Radix Glycyrrhizae 50g Cortex Moutan 100g Bulbus Fritillariae Cirrhosae 100g Radix Paeoniae Alba 100g Mentholum 0.3125g
B. take each raw material by proportioning raw materials, for subsequent use;
C. Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae decocting in water twice, adds water 8 times at every turn and measures, and extracts 2 hours, merges decocting liquid, and being evaporated to 70 ℃ of lower densities is 1.05, obtains concentrated solution A;
D. Cortex Moutan, Bulbus Fritillariae Cirrhosae, the Radix Paeoniae Alba, with 70% ethanol extraction twice, add for the first time 8 times of amounts of ethanol and extract 1.5 hours, add for the second time 6 times of amounts of ethanol and extract 1 hour, and merge extractive liquid,, obtains extracting solution B;
E. concentrated solution A and extracting solution B merging are mixed, leave standstill 72 hours, centrifugal, divide and get supernatant, obtain supernatant C;
F. by supernatant C, being evaporated to 70 ℃ of lower densities is 1.05, obtains concentrated solution D;
G. by concentrated solution A and concentrated solution D mix homogeneously, obtain concentrated solution I;
I. Mentholum is added in concentrated solution I, obtain 390 grams of medicines of the present invention.
Embodiment 2: prepare Chinese medicine composition
One. prescription
Radix Rehmanniae 250g Radix Scrophulariae 200g 150g Radix Ophiopogonis Radix Glycyrrhizae 50g Cortex Moutan 100g Bulbus Fritillariae Cirrhosae 100g Radix Paeoniae Alba 100g Mentholum 0.3125g
Two. method for making
A. proportioning raw material: Radix Rehmanniae 250g Radix Scrophulariae 200g 150g Radix Ophiopogonis Radix Glycyrrhizae 50g Cortex Moutan 100g Bulbus Fritillariae Cirrhosae 100g Radix Paeoniae Alba 100g Mentholum 0.3125g;
B. take each raw material by proportioning raw materials, for subsequent use;
C. Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae boil twice with 8 times of water gagings, and each 1 hour, merge decocting liquid, being evaporated to 70 ℃ of lower densities is 1.03, obtains concentrated solution A;
D. the ethanol extraction that Cortex Moutan, Bulbus Fritillariae Cirrhosae, the Radix Paeoniae Alba are 30% with 6 times of amount concentration of volume percent 2 times, each 1 hour, merge extractive liquid,, obtained extracting solution B;
E. concentrated solution A and extracting solution B merging are mixed, leave standstill 60 hours, centrifugal, divide and get supernatant, obtain supernatant C;
F. supernatant C being evaporated to 70 ℃ of lower densities is 1.03, obtains concentrated solution D;
G. by concentrated solution A and concentrated solution D mix homogeneously, obtain concentrated solution I;
I. Mentholum is added in concentrated solution I, obtain 410 grams of medicines of the present invention.
Embodiment 3: prepare Chinese medicine composition
One. prescription
Radix Rehmanniae 250g Radix Scrophulariae 200g 150g Radix Ophiopogonis Radix Glycyrrhizae 50g Cortex Moutan 100g Bulbus Fritillariae Cirrhosae 100g Radix Paeoniae Alba 100g Mentholum 0.3125g
Two. method for making
A. proportioning raw material: Radix Rehmanniae 250g Radix Scrophulariae 200g 150g Radix Ophiopogonis Radix Glycyrrhizae 50g Cortex Moutan 100g Bulbus Fritillariae Cirrhosae 100g Radix Paeoniae Alba 100g Mentholum 0.3125g
B. take each raw material by proportioning raw materials, for subsequent use;
C. Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae boil twice with 10 times of water gagings, and each 2 hours, merge decocting liquid, being evaporated to 70 ℃ of lower densities is 1.10, obtains concentrated solution A;
D. the ethanol extraction twice that Cortex Moutan, Bulbus Fritillariae Cirrhosae, the Radix Paeoniae Alba are 90% with 8 times of amount concentration of volume percent, each 2 hours, merge extractive liquid,, obtained extracting solution B;
E. concentrated solution A and extracting solution B merging are mixed, leave standstill 80 hours, centrifugal, divide and get supernatant, obtain supernatant C;
F. supernatant C being evaporated to 70 ℃ of lower densities is 1.10, obtains concentrated solution D;
G. by concentrated solution A and concentrated solution D mix homogeneously, obtain concentrated solution I;
I. Mentholum is added in concentrated solution I, obtain 400 grams of medicines of the present invention.
Embodiment 4: prepare Chinese medicine composition
One. prescription
Radix Rehmanniae 250g Radix Scrophulariae 200g 150g Radix Ophiopogonis Radix Glycyrrhizae 50g Cortex Moutan 100g Bulbus Fritillariae Cirrhosae 100g Radix Paeoniae Alba 100g Mentholum 0.3125g
Two. method for making
A. proportioning raw material: Radix Rehmanniae 250g Radix Scrophulariae 200g 150g Radix Ophiopogonis Radix Glycyrrhizae 50g Cortex Moutan 100g Bulbus Fritillariae Cirrhosae 100g Radix Paeoniae Alba 100g Mentholum 0.3125g
B. take each raw material by proportioning raw materials, for subsequent use;
C. Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae boil twice with 9 times of water gagings, and each 1.5 hours, merge decocting liquid, being evaporated to 70 ℃ of lower densities is 1.05, obtains concentrated solution A;
D. the ethanol extraction twice that Cortex Moutan, Bulbus Fritillariae Cirrhosae, the Radix Paeoniae Alba are 40% with 7 times of amount concentration of volume percent, each 1.5 hours, merge extractive liquid,, obtained extracting solution B;
E. concentrated solution A and extracting solution B merging are mixed, leave standstill 70 hours, centrifugal, divide and get supernatant, obtain supernatant C;
F. supernatant C being evaporated to 70 ℃ of lower densities is 1.05, obtains concentrated solution D;
G. by concentrated solution A and concentrated solution D mix homogeneously, obtain concentrated solution I;
I. Mentholum is added in concentrated solution I, obtain 380 grams of medicines of the present invention.
Embodiment 5: prepare Chinese medicine composition
One. prescription
Radix Rehmanniae 250g Radix Scrophulariae 200g 150g Radix Ophiopogonis Radix Glycyrrhizae 50g Cortex Moutan 100g Bulbus Fritillariae Cirrhosae 100g Radix Paeoniae Alba 100g Mentholum 0.3125g
Two. method for making
A. proportioning raw material: Radix Rehmanniae 250g Radix Scrophulariae 200g 150g Radix Ophiopogonis Radix Glycyrrhizae 50g Cortex Moutan 100g Bulbus Fritillariae Cirrhosae 100g Radix Paeoniae Alba 100g Mentholum 0.3125g
B. take each raw material by proportioning raw materials, for subsequent use;
C. Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae boil twice with 8 times of water gagings, and each 1 hour, merge decocting liquid, being evaporated to 70 ℃ of lower densities is 1.08, obtains concentrated solution A;
D. the ethanol extraction twice that Cortex Moutan, Bulbus Fritillariae Cirrhosae, the Radix Paeoniae Alba are 80% with 8 times of amount concentration of volume percent, each 1 hour, merge extractive liquid,, obtained extracting solution B;
E. concentrated solution A and extracting solution B merging are mixed, leave standstill 72 hours, centrifugal, divide and get supernatant, obtain supernatant C;
F. supernatant C being evaporated to 70 ℃ of lower densities is 1.08, obtains concentrated solution D;
G. by concentrated solution A and concentrated solution D mix homogeneously, obtain concentrated solution I;
I. Mentholum is added in concentrated solution I, obtain 420 grams of medicines of the present invention.
Embodiment 6: prepare Chinese medicine composition
One. prescription
Radix Rehmanniae 250g Radix Scrophulariae 200g 150g Radix Ophiopogonis Radix Glycyrrhizae 50g Cortex Moutan 100g Bulbus Fritillariae Cirrhosae 100g Radix Paeoniae Alba 100g Mentholum 0.3125g
Two. method for making
A. proportioning raw material: Radix Rehmanniae 250g Radix Scrophulariae 200g 150g Radix Ophiopogonis Radix Glycyrrhizae 50g Cortex Moutan 100g Bulbus Fritillariae Cirrhosae 100g Radix Paeoniae Alba 100g Mentholum 0.3125g;
B. take each raw material by proportioning raw materials, for subsequent use;
C. Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae boil twice with 10 times of water gagings, and each 2 hours, merge decocting liquid, being evaporated to 70 ℃ of lower densities is 1.06, obtains concentrated solution A;
D. the ethanol extraction twice that Cortex Moutan, Bulbus Fritillariae Cirrhosae, the Radix Paeoniae Alba are 50% with 8 times of amount concentration of volume percent, each 2 hours, merge extractive liquid,, obtained extracting solution B;
E. concentrated solution A and extracting solution B merging are mixed, leave standstill 65 hours, centrifugal, divide and get supernatant, obtain supernatant C;
F. supernatant C being evaporated to 70 ℃ of lower densities is 1.06, obtains concentrated solution D;
G. by concentrated solution A and concentrated solution D mix homogeneously, obtain concentrated solution I;
I. Mentholum is added in concentrated solution I, obtain 387 grams of medicines of the present invention.
Embodiment 8: prepare Chinese medicine composition
One. prescription
Radix Rehmanniae 250g Radix Scrophulariae 200g 150g Radix Ophiopogonis Radix Glycyrrhizae 50g Cortex Moutan 100g Bulbus Fritillariae Cirrhosae 100g Radix Paeoniae Alba 100g Mentholum 0.3125g
Two. method for making
A. proportioning raw material: Radix Rehmanniae 250g Radix Scrophulariae 200g 150g Radix Ophiopogonis Radix Glycyrrhizae 50g Cortex Moutan 100g Bulbus Fritillariae Cirrhosae 100g Radix Paeoniae Alba 100g Mentholum 0.3125g;
B. take each raw material by proportioning raw materials, for subsequent use;
C. Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae boil twice with 8 times of water gagings, and each 1.5 hours, merge decocting liquid, being evaporated to 70 ℃ of lower densities is 1.07, obtains concentrated solution A;
D. the ethanol extraction twice that Cortex Moutan, Bulbus Fritillariae Cirrhosae, the Radix Paeoniae Alba are 60% with 6 times of amount concentration of volume percent, each 2 hours, merge extractive liquid,, obtained extracting solution B;
E. concentrated solution A and extracting solution B merging are mixed, leave standstill 75 hours, centrifugal, divide and get supernatant, obtain supernatant C;
F. supernatant C being evaporated to 70 ℃ of lower densities is 1.07, obtains concentrated solution D;
G. by concentrated solution A and concentrated solution D mix homogeneously, obtain concentrated solution I;
I. Mentholum is added in concentrated solution I, obtain 420 grams of medicines of the present invention.
Embodiment 9: prepare mixture
Get embodiment 1 medicine 100g of the present invention, add simple syrup 100g, stir evenly, obtain syrup, every bottled 100ml.
Embodiment 10: zoopery one: the impact of medicine of the present invention on mice phlegm-dispelling functions
One. materials and methods
Syrup for nourishing and clearing lung-heat (lot number: 20110625), Tianjin Zhong Xin Pharmaceutical limited company is grand along banyan pharmaceutical factory
Animal: ICR mice, is provided credit number by Beijing Vital River Experimental Animals Technology Co., Ltd.: SCXK(capital) 2002-0003.
Ammonium chloride (lot number: 20090127), Asia-Pacific, Tianjin Long Xing Chemical Co., Ltd.
Phenol red (lot number: 20081128), Tianjin Bo Di Chemical Co., Ltd.
UV7504 ultraviolet-uisible spectrophotometer: Shanghai precision instrument company limited
Get 72 of healthy ICR mices, body weight 18 ~ 22g, be divided at random 6 groups, be blank group, ammonium chloride positive controls (0.5g/kg), the basic, normal, high dosage group of nourishing YIN and clearing away lung-heat extract (press embodiment 1 method preparation) (1.68,3.36,6.72g crude drug/kg), syrup for nourishing and clearing lung-heat group (6.72g crude drug/kg), give isopyknic pure water except blank group, other administration groups are all by the continuous gastric infusion of above-mentioned dosage 5 days, and administration volume is 20ml/kg.Fasting 12h before last administration, 0.5 hour phenol red normal saline solution 10ml/kg of lumbar injection 5% after last administration, after 0.5 hour, disconnected neck is put to death mice, peel off trachea surrounding tissue, cut from thyroid cartilage to one section of trachea of trachea bifurcation, put into the test tube that fills alkaline normal saline (normal saline 2ml+1N sodium hydroxide 0.1ml) solution, place after 2 hours through room temperature, trachea eluent is surveyed to its absorbance with ultraviolet-uisible spectrophotometer in 546nm wavelength place, calculate every phenol red content of mice trachea by phenol red standard curve.Experimental data is added up with variance analysis.
Two. result: in table 1.
Table 1: impact on mice phlegm-dispelling functions of nourishing YIN and clearing away lung-heat extract administration five days (x ± s)
* P<0.05 compared with blank group, * * P<0.01
Result shows: the basic, normal, high dosage group of nourishing YIN and clearing away lung-heat extract and the comparison of blank group, all there is utmost point significant difference (P<0.01), point out this extract can obviously promote the phenol red excretion amount of mice trachea, and present certain dose-effect relationship, illustrate that this invention extract has good phlegm-dispelling functions.Under Isodose, nourishing YIN and clearing away lung-heat extract and former dosage form comparison, there was no significant difference (P<0.05).
Embodiment 11: zoopery two: medicine of the present invention causes the impact of mouse cough on ammonia
One. materials and methods:
Syrup for nourishing and clearing lung-heat (lot number: 20110625), Tianjin Zhong Xin Pharmaceutical limited company is grand along banyan pharmaceutical factory
FUFANG GANCAO PIAN (lot number 090119) Tianjin Lisheng Pharmaceutical Co., Ltd.
Strong aqua ammonia: Dongli District, Tianjin Tai Lande chemical reagent factory
Animal: ICR mice, is provided credit number by Beijing Vital River Experimental Animals Technology Co., Ltd.: SCXK(capital) 2002-0003.
Get 72 of healthy ICR mices, body weight 18 ~ 22g, be divided at random 6 groups, it is model control group, FUFANG GANCAO PIAN positive controls (0.5g/kg), the basic, normal, high dosage group of nourishing YIN and clearing away lung-heat extract (press embodiment 1 method preparation) (1.68,3.36,6.72g crude drug/kg), syrup for nourishing and clearing lung-heat group (6.72g crude drug/kg), except model control group gives isopyknic pure water, positive drug FUFANG GANCAO PIAN is in experiment administration on the same day 1 time, other administration groups are all by the continuous gastric infusion of above-mentioned dosage 5 days, and administration volume is 20ml/kg.Each group after last administration 1 hour, mice is placed in inverted 500ml beaker, draw after 0.3ml strong aqua ammonia injects 50mg cotton balls and put into beaker, observe and record the cough latent period of each group of mice and mouse cough number of times in 3 minutes (typical case's cough is that mice abdominal muscle shrinks, magnify mouth simultaneously, with coughing sound), experimental data is added up with variance analysis.
Two. result: in table 2.
Table 2 nourishing YIN and clearing away lung-heat extract successive administration five days causes the impact (x ± s) of mouse cough on ammonia
With model control group comparison, * P<0.05, * * P<0.01 compares #P<0.05 with syrup for nourishing and clearing lung-heat group
Result shows: the basic, normal, high dosage group of nourishing YIN and clearing away lung-heat extract and model control group comparison, all there is significant difference (P<0.05, P<0.01), the mouse cough incubation period of pointing out this extract can obviously can obviously extend ammonia induction, reduce cough number of times.Under the basic, normal, high dosage group of nourishing YIN and clearing away lung-heat extract dosage, can obviously reduce the cough number of times of ammonia inducing mouse, and the number of times that high dose group was coughed in 3 minutes has significant difference (P<0.05) with former dosage form ratio, illustrates that this extract has obvious antitussive effect and effect to be better than former dosage form.
Claims (10)
1. the Chinese medicine composition of a nourishing yin, clearing lung-heat, reducing fever sore-throat relieving, it is characterized in that, made by the raw material of following parts by weight: 250 parts of Radix Rehmanniae, 200 parts of Radix Scrophulariaes, 150 parts of Radix Ophiopogonis, 50 parts, Radix Glycyrrhizae, 100 parts of Cortex Moutans, 100 parts of Bulbus Fritillariae Cirrhosaes, 100 parts of the Radix Paeoniae Albas, 0.3125 part of Mentholum.
2. the Chinese medicine composition of a kind of nourishing yin, clearing lung-heat, reducing fever sore-throat relieving according to claim 1, is characterized in that, described Chinese medicine composition adopts following methods preparation:
A. proportioning raw material: 0.3125 part of 100 parts of Mentholum of 250 portions of Radix Scrophulariaes of Radix Rehmanniae, 100 portions of Radix Paeoniae Albas of 100 parts of Bulbus Fritillariae Cirrhosaes of 50 parts of Cortex Moutans of 150 portions of Radix Glycyrrhizaes, 200 parts of Radix Ophiopogonis;
B. take each raw material by proportioning raw materials, for subsequent use;
C. Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae boil twice with 8-10 times of water gaging, and each 1-2 hour, merges decocting liquid, and being evaporated to 70 ℃ of lower densities is 1.03-1.10, obtains concentrated solution A;
D. Cortex Moutan, Bulbus Fritillariae Cirrhosae, the Radix Paeoniae Alba doubly measure with 6-8 the ethanol extraction twice that concentration of volume percent is 30-90%, each 1-2 hour, and merge extractive liquid,, obtains extracting solution B;
E. concentrated solution A and extracting solution B merging are mixed, leave standstill 60-80 hour, centrifugal, divide and get supernatant, obtain supernatant C;
F. supernatant C being evaporated to 70 ℃ of lower densities is 1.03-1.10, obtains concentrated solution D;
G. by concentrated solution A and concentrated solution D mix homogeneously, obtain concentrated solution I;
I. Mentholum is added in concentrated solution I, to obtain final product.
3. the Chinese medicine composition of a kind of nourishing yin, clearing lung-heat, reducing fever sore-throat relieving according to claim 2, is characterized in that, described Chinese medicine composition adopts following methods preparation:
A. proportioning raw material: 0.3125 part of 100 parts of Mentholum of 250 portions of Radix Scrophulariaes of Radix Rehmanniae, 100 portions of Radix Paeoniae Albas of 100 parts of Bulbus Fritillariae Cirrhosaes of 50 parts of Cortex Moutans of 150 portions of Radix Glycyrrhizaes, 200 parts of Radix Ophiopogonis;
B. take each raw material by proportioning raw materials, for subsequent use;
C. Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae boil twice with 8-10 times of water gaging, and each 1.5-2 hour, merges decocting liquid, and being evaporated to 70 ℃ of lower densities is 1.05-1.08, obtains concentrated solution A;
D. Cortex Moutan, Bulbus Fritillariae Cirrhosae, the Radix Paeoniae Alba doubly measure with 6-8 the ethanol extraction twice that concentration of volume percent is 40-80%, each 1-1.5 hour, and merge extractive liquid,, obtains extracting solution B;
E. concentrated solution A and extracting solution B merging are mixed, leave standstill 70-80 hour, centrifugal, divide and get supernatant, obtain supernatant C;
F. supernatant C being evaporated to 70 ℃ of lower densities is 1.05-1.08, obtains concentrated solution D;
G. by concentrated solution A and concentrated solution D mix homogeneously, obtain concentrated solution I;
I. Mentholum is added in concentrated solution I, to obtain final product.
4. the Chinese medicine composition of a kind of nourishing yin, clearing lung-heat, reducing fever sore-throat relieving according to claim 2, is characterized in that, described Chinese medicine composition adopts following methods preparation:
A. proportioning raw material: 0.3125 part of 100 parts of Mentholum of 250 portions of Radix Scrophulariaes of Radix Rehmanniae, 100 portions of Radix Paeoniae Albas of 100 parts of Bulbus Fritillariae Cirrhosaes of 50 parts of Cortex Moutans of 150 portions of Radix Glycyrrhizaes, 200 parts of Radix Ophiopogonis;
B. take each raw material by proportioning raw materials, for subsequent use;
C. Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae decocting in water twice, adds water 8 times at every turn and measures, and extracts 2 hours, merges decocting liquid, and being evaporated to 70 ℃ of lower densities is 1.05, obtains concentrated solution A;
D. Cortex Moutan, Bulbus Fritillariae Cirrhosae, the Radix Paeoniae Alba, with 70% ethanol extraction twice, add for the first time 8 times of amounts of ethanol and extract 1.5 hours, add for the second time 6 times of amounts of ethanol and extract 1 hour, and merge extractive liquid,, obtains extracting solution B;
E. concentrated solution A and extracting solution B merging are mixed, leave standstill 72 hours, centrifugal, divide and get supernatant, obtain supernatant C;
F. by supernatant C, being evaporated to 70 ℃ of lower densities is 1.05, obtains concentrated solution D;
G. by concentrated solution A and concentrated solution D mix homogeneously, obtain concentrated solution I;
I. Mentholum is added in concentrated solution I, to obtain final product.
5. according to the Chinese medicine composition of a kind of nourishing yin, clearing lung-heat, reducing fever sore-throat relieving described in any one in claim 1-4, it is characterized in that: described Chinese medicine composition also contains the acceptable adjuvant of pharmaceutics.
6. a kind of Chinese medicine composition of nourishing yin, clearing lung-heat, reducing fever sore-throat relieving according to claim 5, is characterized in that: the acceptable adjuvant of described pharmaceutics is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and sodium sulfite, xylitol, maltose, Polyethylene Glycol, simple syrup.
7. the Chinese medicine composition of a kind of nourishing yin, clearing lung-heat, reducing fever sore-throat relieving according to claim 5, is characterized in that: the dosage form of described Chinese medicine composition is pill, tablet, capsule, mixture, syrup or oral liquid.
8. the preparation method of the Chinese medicine composition of a kind of nourishing yin, clearing lung-heat, reducing fever sore-throat relieving claimed in claim 1, is characterized in that step is as follows:
A. proportioning raw material: 0.3125 part of 100 parts of Mentholum of 250 portions of Radix Scrophulariaes of Radix Rehmanniae, 100 portions of Radix Paeoniae Albas of 100 parts of Bulbus Fritillariae Cirrhosaes of 50 parts of Cortex Moutans of 150 portions of Radix Glycyrrhizaes, 200 parts of Radix Ophiopogonis;
B. take each raw material by proportioning raw materials, for subsequent use;
C. Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae boil twice with 8-10 times of water gaging, and each 1-2 hour, merges decocting liquid, and being evaporated to 70 ℃ of lower densities is 1.03-1.10, obtains concentrated solution A;
D. Cortex Moutan, Bulbus Fritillariae Cirrhosae, the Radix Paeoniae Alba doubly measure with 6-8 the ethanol extraction twice that concentration of volume percent is 30-90%, each 1-2 hour, and merge extractive liquid,, obtains extracting solution B;
E. concentrated solution A and extracting solution B merging are mixed, leave standstill 60-80 hour, centrifugal, divide and get supernatant, obtain supernatant C;
F. supernatant C being evaporated to 70 ℃ of lower densities is 1.03-1.10, obtains concentrated solution D;
G. by concentrated solution A and concentrated solution D mix homogeneously, obtain concentrated solution I;
I. Mentholum is added in concentrated solution I, to obtain final product.
9. the preparation method of the Chinese medicine composition of a kind of nourishing yin, clearing lung-heat, reducing fever sore-throat relieving according to claim 8, is characterized in that step is as follows:
A. proportioning raw material: 0.3125 part of 100 parts of Mentholum of 250 portions of Radix Scrophulariaes of Radix Rehmanniae, 100 portions of Radix Paeoniae Albas of 100 parts of Bulbus Fritillariae Cirrhosaes of 50 parts of Cortex Moutans of 150 portions of Radix Glycyrrhizaes, 200 parts of Radix Ophiopogonis;
B. take each raw material by proportioning raw materials, for subsequent use;
C. Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae boil twice with 8-10 times of water gaging, and each 1.5-2 hour, merges decocting liquid, and being evaporated to 70 ℃ of lower densities is 1.05-1.08, obtains concentrated solution A;
D. Cortex Moutan, Bulbus Fritillariae Cirrhosae, the Radix Paeoniae Alba doubly measure with 6-8 the ethanol extraction twice that concentration of volume percent is 40-80%, each 1-1.5 hour, and merge extractive liquid,, obtains extracting solution B;
E. concentrated solution A and extracting solution B merging are mixed, leave standstill 70-80 hour, centrifugal, divide and get supernatant, obtain supernatant C;
F. supernatant C being evaporated to 70 ℃ of lower densities is 1.05-1.08, obtains concentrated solution D;
G. by concentrated solution A and concentrated solution D mix homogeneously, obtain concentrated solution I;
I. Mentholum is added in concentrated solution I, to obtain final product.
10. the preparation method of the Chinese medicine composition of a kind of nourishing yin, clearing lung-heat, reducing fever sore-throat relieving according to claim 8, is characterized in that step is as follows:
A. proportioning raw material: 0.3125 part of 100 parts of Mentholum of 250 portions of Radix Scrophulariaes of Radix Rehmanniae, 100 portions of Radix Paeoniae Albas of 100 parts of Bulbus Fritillariae Cirrhosaes of 50 parts of Cortex Moutans of 150 portions of Radix Glycyrrhizaes, 200 parts of Radix Ophiopogonis;
B. take each raw material by proportioning raw materials, for subsequent use;
C. Radix Rehmanniae, Radix Scrophulariae, Radix Ophiopogonis, Radix Glycyrrhizae decocting in water twice, adds water 8 times at every turn and measures, and extracts 2 hours, merges decocting liquid, and being evaporated to 70 ℃ of lower densities is 1.05, obtains concentrated solution A;
D. Cortex Moutan, Bulbus Fritillariae Cirrhosae, the Radix Paeoniae Alba, with 70% ethanol extraction twice, add for the first time 8 times of amounts of ethanol and extract 1.5 hours, add for the second time 6 times of amounts of ethanol and extract 1 hour, and merge extractive liquid,, obtains extracting solution B;
E. concentrated solution A and extracting solution B merging are mixed, leave standstill 72 hours, centrifugal, divide and get supernatant, obtain supernatant C;
F. by supernatant C, being evaporated to 70 ℃ of lower densities is 1.05, obtains concentrated solution D;
G. by concentrated solution A and concentrated solution D mix homogeneously, obtain concentrated solution I;
I. Mentholum is added in concentrated solution I, to obtain final product.
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| CN1879800A (en) * | 2006-05-14 | 2006-12-20 | 胡红芳 | A medicinal liquor for treating lung-heat yin-deficiency type laryngeal obstruction and method for preparing same |
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2012
- 2012-12-28 CN CN201210587146.1A patent/CN103893526A/en active Pending
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| CN1634452A (en) * | 2004-11-12 | 2005-07-06 | 北京正大绿洲医药科技有限公司 | Yin-nourishing lung-heat clearing drop pills |
| CN1660133A (en) * | 2004-12-27 | 2005-08-31 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Low alcohol type concentrated soloution for nourishing yin to clear away the lung-heat, preparation method and application |
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