CN103877376A - Pharmaceutical preparation for treating depression - Google Patents
Pharmaceutical preparation for treating depression Download PDFInfo
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- CN103877376A CN103877376A CN201410141164.6A CN201410141164A CN103877376A CN 103877376 A CN103877376 A CN 103877376A CN 201410141164 A CN201410141164 A CN 201410141164A CN 103877376 A CN103877376 A CN 103877376A
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Abstract
The invention discloses a pharmaceutical preparation for treating depression. The pharmaceutical preparation is prepared from the following crude drugs in parts by weight: 20-30 parts of herba portulacae, 10-20 parts of herba epimedii, 20-30 parts of polygala tenuifolia, 10-20 parts of pericarpium citri reticulatae, 20-30 parts of radix polygonati officinalis, 10-20 parts of ajowan, 20-30 parts of pseudo-ginseng, 20-30 parts of astragalus membranaceus, 5-15 parts of tinospora sinensis merr, 5-15 parts of rehmannia glutinosa, 5-15 parts of common cnidium fruits and 20-30 parts of corydalis sibirica. The preparation method comprises the following steps: mixing each crude drug; adding 8-10 times of water, and decocting for 2-3 hours; filtering to obtain filtrate; adding water to dregs, decocting for 1-2 hours, and filtering to obtain filtrate; merging the filtrate of twice, concentrating and drying into powder; enclosing into capsules to prepare the capsules. The pharmaceutical preparation for treating the depression disclosed by the invention is orally taken about 1g for three times a day in treatment, 15 days are taken as a course of treatment, and the depression can be cured by 2-3 courses of treatment in general.
Description
Technical field
The present invention relates to a kind of pharmaceutical preparation of Cure of depression.
Background technology
Depression is a kind of common affective disorders, is a kind of to continue mental state or depressed, interest blank, retardation of thinking the disease with somatizations such as loss of appetite, sexual hypofunction, sleep disorder.Can be caused by a variety of causes, low as main clinical characteristics take remarkable and lasting mental state, and mental state is low unbecoming with its situation, and can there is suicidal thought and behavior in severe patient.Majority of cases has the tendency of outbreak repeatedly, and the great majority that at every turn show effect can be alleviated, and part can have residual symptoms or transfer to chronic.The traditional Chinese medical science thinks that depression belongs to melancholia category, is because feelings will is not relaxed, the caused class disease of stagnation of QI stasis.Main manifestations for feeling depressed, irritable emotion, distending pain over the hypochondrium, or irritability, kind crying, the various complicated symptoms such as insomnia.
For the treatment of depression, at present doctor trained in Western medicine adopts 5-hydroxy tryptamine reuptake depressant, monoamine oxidase inhibitor, phenyl piperazines, 5-hydroxy tryptamine-norepinephrine reuptake inhibitor, aminoketones, tricyclic antidepressants, Fourth Ring sends the 7 class antidepressants such as piperazine azatropylidene class more, but synthetic antidepressants exist mostly that antidepressant spectrum is narrow, toxic and side effects greatly, the defect such as the high and easy recurrence of medicine valency.Therefore, aspect the domestic and international development at antidepressants and exploitation, more and more focus on traditional drugs (particularly having more than 2,000 year historical Chinese herbal medicine), the also main force's medicine as Cure of depression some true medicable traditional drugss of American-European countries being even good at using exploitation synthetic drug.
Depressed card belongs to the melancholia category of the traditional Chinese medical science, and disease is complicated and changeable, and the most common is stagnation of QI due to depression of the liver, syndrome of deficiency of both heart and spleen, how to cause because feelings will is upset, and its pathogenesis is mainly depression of liver-QI, the heart foster, the dysfunction of the spleen in transportation of becoming homeless.Medicine mainly with regulating the flow of vital energy, eliminate the phlegm, calm the nerves, have one's ideas straightened out, the class such as invigorating the heart and spleen is main.Chinese medicine compound has the advantages that composition is many, effect link is many, target spot is many, and multicomponent synergism, has made up the low feature of active constituent content, has reduced side effect.Therefore, development antidepressant good effect, side effect little, be applicable to long-term taking and safe and reliable Chinese medicine composition has become current study hotspot.
Summary of the invention
For above-mentioned prior art, the invention provides a kind of pharmaceutical preparation of Cure of depression.
The present invention is achieved by the following technical solutions:
A pharmaceutical preparation for Cure of depression is to be made up of the crude drug of following weight portion: 20～30 parts of Herba Portulacaes, 10～20 parts of Herba Epimedii, 20～30 parts of Radix Polygalaes, 10～20 parts of Pericarpium Citri Reticulataes, 20～30 parts of Rhizoma Polygonati Odorati, 10～20 parts of Cuminum celerys, 20～30 parts of Radix Notoginseng, 20～30 parts of the Radixs Astragali, 5～15 parts of Herba Lycopodii, 5～15 parts, Radix Rehmanniae Preparata, 5～15 parts of Fructus Cnidiis, 20～30 parts of northern Herba corydalis eduliss.
Preferably, be to be made by the crude drug of following weight portion: 25 parts of Herba Portulacaes, 15 parts of Herba Epimedii, 25 parts of Radix Polygalaes, 15 parts of Pericarpium Citri Reticulataes, 25 parts of Rhizoma Polygonati Odorati, 15 parts of Cuminum celerys, 25 parts of Radix Notoginseng, 25 parts of the Radixs Astragali, 10 parts of Herba Lycopodii, 10 parts, Radix Rehmanniae Preparata, 10 parts of Fructus Cnidiis, 25 parts of northern Herba corydalis eduliss.
The preparation method of the pharmaceutical preparation of described Cure of depression is: get each crude drug, mix, add 8～10 times of amounts (weight multiple) water, decoct 2～3 hours, filter to get filtrate, to the water that adds again 4～6 times of amounts (weight multiple) in medicinal residues, decoct 1～2 hour, filter to get filtrate, merge filtrate twice, routine concentrating under reduced pressure, the dry medicated powder that to obtain, incapsulate and make capsule, to obtain final product.
The pharmaceutical preparation of Cure of depression of the present invention, has soothing liver-QI for relieving depression, conciliates circulation of qi promoting, tranquillizing and allaying excitement, and the feature of lasting medicine, is mainly used in light, moderate depressive patients and belongs to stagnation of QI due to depression of the liver, deficiency of both the heart and spleen person.When treatment, oral, every day three times, each 1 gram of left and right (by medicated powder quality), every day three times, 15 days courses for the treatment of, can cure general 2～3 courses for the treatment of.
The specific embodiment
Below in conjunction with embodiment, the present invention is further illustrated.
Embodiment 1 prepares the pharmaceutical preparation of Cure of depression
Formula is: 25 grams of Herba Portulacaes, 15 grams of Herba Epimedii, 25 grams of Radix Polygalaes, 15 grams of Pericarpium Citri Reticulataes, 25 grams of Rhizoma Polygonati Odorati, 15 grams of Cuminum celerys, 25 grams of Radix Notoginseng, 25 grams of the Radixs Astragali, 10 grams of Herba Lycopodii, 10 grams, Radix Rehmanniae Preparata, 10 grams of Fructus Cnidiis, 25 grams of northern Herba corydalis eduliss.
Preparation method is: get each crude drug, mix, add 10 times of amounts (weight multiple) water, decoct 3 hours, filter to get filtrate, to the water that adds again 5 times of amounts (weight multiple) in medicinal residues, decoct 2 hours, filter to get filtrate, merge filtrate twice, routine concentrating under reduced pressure, the dry medicated powder that to obtain, incapsulate and make capsule (0.3 gram of every capsules explosive payload), to obtain final product.
Embodiment 2 prepares the pharmaceutical preparation of Cure of depression
Formula is: 20 grams of Herba Portulacaes, 20 grams of Herba Epimedii, 20 grams of Radix Polygalaes, 20 grams of Pericarpium Citri Reticulataes, 20 grams of Rhizoma Polygonati Odorati, 20 grams of Cuminum celerys, 20 grams of Radix Notoginseng, 30 grams of the Radixs Astragali, 5 grams of Herba Lycopodii, 15 grams, Radix Rehmanniae Preparata, 5 grams of Fructus Cnidiis, 30 grams of northern Herba corydalis eduliss.
Preparation method is: get each crude drug, mix, add 8 times of amounts (weight multiple) water, decoct 2 hours, filter to get filtrate, to the water that adds again 6 times of amounts (weight multiple) in medicinal residues, decoct 2 hours, filter to get filtrate, merge filtrate twice, routine concentrating under reduced pressure, the dry medicated powder that to obtain, incapsulate and make capsule, to obtain final product.
Embodiment 3 prepares the pharmaceutical preparation of Cure of depression
Formula is: 30 grams of Herba Portulacaes, 10 grams of Herba Epimedii, 30 grams of Radix Polygalaes, 10 grams of Pericarpium Citri Reticulataes, 30 grams of Rhizoma Polygonati Odorati, 10 grams of Cuminum celerys, 30 grams of Radix Notoginseng, 20 grams of the Radixs Astragali, 15 grams of Herba Lycopodii, 5 grams, Radix Rehmanniae Preparata, 15 grams of Fructus Cnidiis, 20 grams of northern Herba corydalis eduliss.
Preparation method is: get each crude drug, mix, add 9 times of amounts (weight multiple) water, decoct 2.5 hours, filter to get filtrate, to the water that adds again 4 times of amounts (weight multiple) in medicinal residues, decoct 1 hour, filter to get filtrate, merge filtrate twice, routine concentrating under reduced pressure, the dry medicated powder that to obtain, incapsulate and make capsule, to obtain final product.
Embodiment 4 prepares the pharmaceutical preparation of Cure of depression
Formula is: 22 grams of Herba Portulacaes, 12 grams of Herba Epimedii, 28 grams of Radix Polygalaes, 18 grams of Pericarpium Citri Reticulataes, 22 grams of Rhizoma Polygonati Odorati, 12 grams of Cuminum celerys, 28 grams of Radix Notoginseng, 28 grams of the Radixs Astragali, 8 grams of Herba Lycopodii, 8 grams, Radix Rehmanniae Preparata, 12 grams of Fructus Cnidiis, 28 grams of northern Herba corydalis eduliss.
Preparation method is: get each crude drug, mix, add 8 times of amounts (weight multiple) water, decoct 2 hours, filter to get filtrate, to the water that adds again 4 times of amounts (weight multiple) in medicinal residues, decoct 1 hour, filter to get filtrate, merge filtrate twice, routine concentrating under reduced pressure, the dry medicated powder that to obtain, incapsulate and make capsule, to obtain final product.
Embodiment 5 prepares the pharmaceutical preparation of Cure of depression
Formula is: 28 grams of Herba Portulacaes, 18 grams of Herba Epimedii, 22 grams of Radix Polygalaes, 12 grams of Pericarpium Citri Reticulataes, 28 grams of Rhizoma Polygonati Odorati, 18 grams of Cuminum celerys, 22 grams of Radix Notoginseng, 22 grams of the Radixs Astragali, 12 grams of Herba Lycopodii, 13 grams, Radix Rehmanniae Preparata, 8 grams of Fructus Cnidiis, 22 grams of northern Herba corydalis eduliss.
Preparation method is: get each crude drug, mix, add 10 times of amounts (weight multiple) water, decoct 2.5 hours, filter to get filtrate, to the water that adds again 6 times of amounts (weight multiple) in medicinal residues, decoct 1.5 hours, filter to get filtrate, merge filtrate twice, routine concentrating under reduced pressure, the dry medicated powder that to obtain, incapsulate and make capsule, to obtain final product.
Clinical data:
Western medicine diagnose standard: meet the 3rd edition (CCMD-3) criteria for depression were of Chinese Spirit Obstacles classification and diagnostic criteria, 17 Hamilton depressive scales (HAMD) total score >=18 point.
TCM syndrome diagnostic criteria: diagnostic criteria is with reference to State Administration of Traditional Chinese Medicine's nineteen ninety-five version " traditional Chinese medical science disease Standardization of diagnosis and curative effect "; Stagnation of liver-QI with deficiency of the spleen, the diagnostic criteria of malaise card are with reference to " new Chinese medicine guideline of clinical investigations ".Primary symptom: spirit depressing, fatigue and weakness, sleeps less; Inferior disease: gastral cavity abdominal distention is vexed, sighing frequently uncomfortable in chest, constipation, poor appetite; Light red tongue or fat, white and thin fur or greasy; Stringy and rolling pulse, or thready and weak pulse without strength.Possess 3 of above primary symptoms, 2 of inferior diseases, meet stagnation of liver-QI with deficiency of the spleen, the picture of the tongue of malaise card, pulse condition, can be diagnosed as stagnation of liver-QI with deficiency of the spleen, malaise card.
Case inclusive criteria: meet criteria for depression were, and belong to light, moderate paralepsy person; Chinese medical discrimination is stagnation of liver-QI with deficiency of the spleen, malaise card person; 18～70 years old age; The course of disease is more than 6 months, HAMD24 item total score >=18 point, and≤35 points of persons; Be ready to accept clinical trial and the better person of prediction compliance; Treat in first 1 week and do not use other antidepressant, in 2 weeks, do not use oxidase inhibitor, in treatment, nonjoinder is used other antidepressant and psychosis person.
Case exclusion standard: spiritedness medical history and psychosis family history person; In nearly half a year, took psychoactive drug, contraceptive, hormone medicine, or alcoholic; Trimester of pregnancy, age of sucking patient; Check noncooperationist; Age <18 year or >70 year person; HAMD24 item <18 divides or the >35 person of dividing; Severe depression outbreak and the person that has suicidal tendency.
Case grouping:
Treatment group: 54 examples, male 24 examples, female's 30 examples, 34 years old mean age, minimum 27 years old, maximum 49 years old; Average course of disease 8 months.
Matched group: 52 examples, male 23 examples, female's 29 examples, 32 years old mean age, 34 years old mean age, minimum 28 years old, maximum 48 years old; Average course of disease 8 months.
Between two groups, physical data is learned by statistics (X 2 test and t check) and is processed no significant difference (P > 0.05), has comparability.
Therapeutic Method: capsule prepared by the oral embodiment 1 for the treatment of group, every day three times, each 3.Matched group is taken fluoxetine, every day 20mg, once take the morning.Treat after 1 first quarter moon (3 courses for the treatment of) statistics curative effect.
Observation index and method: before and after treatment, fill in HAMD (HAMD), record tcm syndrome integration.Tcm syndrome point system: primary symptom by without, light, in, heavy degree counts respectively 0 point, 2 points, 4 points, 6 points, inferior disease by without, light, in, heavy degree counts respectively and is divided into 0 point, 1 point, 2 points, 3 points, the picture of the tongue, the pulse condition that meet stagnation of liver-QI with deficiency of the spleen, malaise card are respectively counted 1 point, otherwise count 0 point.
Tcm syndrome curative effect judging standard:
Cure: clinical symptom disappearance or substantially disappearance, syndrome total mark is treated front minimizing >=95%;
Effective: clinical symptoms is clearly better, syndrome total mark is treated front minimizing >=70%; Have
Effective: clinical symptom relief, syndrome total mark is treated front minimizing >=30%;
Invalid: clinical symptoms is without being clearly better or increasing the weight of, and syndrome total mark is treated front minimizing < 30%.
Therapeutic outcome:
Matched group: 54 routine patients, cure 27 examples (50.0%), effective 15 examples (27.8%), effective 8 examples (14.8%), invalid 4 examples (7.4%), total effective rate 92.6%.
Treatment group: 52 routine patients, cure 22 examples (42.3%), effective 14 examples (26.9%), effective 10 examples (19.2%), invalid 6 examples (11.5%), total effective rate 88.5%.
Untoward reaction comparison:
Treatment group: sleepy 2 examples, drowsy 4 examples, body weight increases by 3 examples.
Matched group: xerostomia 4 examples, constipation 4 examples, headache 2, anorexia 2 examples, blurred vision 3 examples, body weight increases by 5 examples, 2 examples of trembling, 3 examples of cathisophobiaing, nasal obstruction 1 example, tachycardia 3 examples.
From the main clinical manifestation of untoward reaction, fluoxetine is mainly cholinolytic side reaction: xerostomia, blurred vision, headache, insomnia etc., and patient's multipotency tolerance, need not special handling, and major part is died away.Medicine of the present invention is without anticholinergic side reaction, and two groups all without serious adverse reaction.
Claims (7)
1. a pharmaceutical preparation for Cure of depression, is characterized in that: be to be made up of the crude drug of following weight portion: 20～30 parts of Herba Portulacaes, 10～20 parts of Herba Epimedii, 20～30 parts of Radix Polygalaes, 10～20 parts of Pericarpium Citri Reticulataes, 20～30 parts of Rhizoma Polygonati Odorati, 10～20 parts of Cuminum celerys, 20～30 parts of Radix Notoginseng, 20～30 parts of the Radixs Astragali, 5～15 parts of Herba Lycopodii, 5～15 parts, Radix Rehmanniae Preparata, 5～15 parts of Fructus Cnidiis, 20～30 parts of northern Herba corydalis eduliss.
2. the pharmaceutical preparation of Cure of depression according to claim 1, is characterized in that: be to be made up of the crude drug of following weight portion: 25 parts of Herba Portulacaes, 15 parts of Herba Epimedii, 25 parts of Radix Polygalaes, 15 parts of Pericarpium Citri Reticulataes, 25 parts of Rhizoma Polygonati Odorati, 15 parts of Cuminum celerys, 25 parts of Radix Notoginseng, 25 parts of the Radixs Astragali, 10 parts of Herba Lycopodii, 10 parts, Radix Rehmanniae Preparata, 10 parts of Fructus Cnidiis, 25 parts of northern Herba corydalis eduliss.
3. the pharmaceutical preparation of Cure of depression according to claim 1, is characterized in that: be to be made up of the crude drug of following weight portion: 20 grams of Herba Portulacaes, 20 grams of Herba Epimedii, 20 grams of Radix Polygalaes, 20 grams of Pericarpium Citri Reticulataes, 20 grams of Rhizoma Polygonati Odorati, 20 grams of Cuminum celerys, 20 grams of Radix Notoginseng, 30 grams of the Radixs Astragali, 5 grams of Herba Lycopodii, 15 grams, Radix Rehmanniae Preparata, 5 grams of Fructus Cnidiis, 30 grams of northern Herba corydalis eduliss.
4. the pharmaceutical preparation of Cure of depression according to claim 1, is characterized in that: be to be made up of the crude drug of following weight portion: 30 grams of Herba Portulacaes, 10 grams of Herba Epimedii, 30 grams of Radix Polygalaes, 10 grams of Pericarpium Citri Reticulataes, 30 grams of Rhizoma Polygonati Odorati, 10 grams of Cuminum celerys, 30 grams of Radix Notoginseng, 20 grams of the Radixs Astragali, 15 grams of Herba Lycopodii, 5 grams, Radix Rehmanniae Preparata, 15 grams of Fructus Cnidiis, 20 grams of northern Herba corydalis eduliss.
5. the medicine of Cure of depression according to claim 1, is characterized in that: be to be made up of the crude drug of following weight portion: 22 grams of Herba Portulacaes, 12 grams of Herba Epimedii, 28 grams of Radix Polygalaes, 18 grams of Pericarpium Citri Reticulataes, 22 grams of Rhizoma Polygonati Odorati, 12 grams of Cuminum celerys, 8 grams of Radix Notoginseng, 28 grams of the Radixs Astragali, 8 grams of Herba Lycopodii, 8 grams, Radix Rehmanniae Preparata, 12 grams of Fructus Cnidiis, 28 grams of northern Herba corydalis eduliss.
6. the medicine of Cure of depression according to claim 1, is characterized in that: be to be made up of the crude drug of following weight portion: 28 grams of Herba Portulacaes, 18 grams of Herba Epimedii, 22 grams of Radix Polygalaes, 12 grams of Pericarpium Citri Reticulataes, 28 grams of Rhizoma Polygonati Odorati, 18 grams of Cuminum celerys, 2 grams of Radix Notoginseng, 22 grams of the Radixs Astragali, 12 grams of Herba Lycopodii, 13 grams, Radix Rehmanniae Preparata, 8 grams of Fructus Cnidiis, 22 grams of northern Herba corydalis eduliss.
7. the preparation method of the pharmaceutical preparation of the Cure of depression described in claim 1～6, is characterized in that: get each crude drug, mix, add 8～10 times of amounts (weight multiple) water, decoct 2～3 hours, filter to get filtrate, to the water that adds again 4～6 times of amounts (weight multiple) in medicinal residues, decoct 1～2 hour, filter to get filtrate, merge twice filtrate, conventional concentrating under reduced pressure, the dry medicated powder that to obtain, incapsulate and make capsule, to obtain final product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410141164.6A CN103877376B (en) | 2014-04-09 | 2014-04-09 | A kind of pharmaceutical preparation treating depression |
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| CN201410141164.6A CN103877376B (en) | 2014-04-09 | 2014-04-09 | A kind of pharmaceutical preparation treating depression |
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| CN103877376A true CN103877376A (en) | 2014-06-25 |
| CN103877376B CN103877376B (en) | 2016-09-14 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107261057A (en) * | 2017-06-07 | 2017-10-20 | 杜彪 | Chinese medicine composition for treating depression and preparation method thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11554154B2 (en) * | 2020-07-22 | 2023-01-17 | Biolite, Inc. | Polygala extract for the treatment of major depressive disorder |
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| CN101015654A (en) * | 2007-03-07 | 2007-08-15 | 中国人民解放军第三医院 | Oral traditional Chinese medicine preparation for treating depression and dysphoria |
| CN102526645A (en) * | 2012-03-23 | 2012-07-04 | 吴玉秋 | Medicament for treating dysthymic disorder |
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2014
- 2014-04-09 CN CN201410141164.6A patent/CN103877376B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101015654A (en) * | 2007-03-07 | 2007-08-15 | 中国人民解放军第三医院 | Oral traditional Chinese medicine preparation for treating depression and dysphoria |
| CN102526645A (en) * | 2012-03-23 | 2012-07-04 | 吴玉秋 | Medicament for treating dysthymic disorder |
Non-Patent Citations (2)
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| 王鹏: "从肝论治脑卒中后抑郁症42例临床观察", 《实用中医内科杂志》 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107261057A (en) * | 2017-06-07 | 2017-10-20 | 杜彪 | Chinese medicine composition for treating depression and preparation method thereof |
| CN107261057B (en) * | 2017-06-07 | 2020-09-29 | 杜彪 | Traditional Chinese medicine composition for treating depression and preparation method thereof |
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| CN103877376B (en) | 2016-09-14 |
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