CN103877376B - A kind of pharmaceutical preparation treating depression - Google Patents
A kind of pharmaceutical preparation treating depression Download PDFInfo
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- CN103877376B CN103877376B CN201410141164.6A CN201410141164A CN103877376B CN 103877376 B CN103877376 B CN 103877376B CN 201410141164 A CN201410141164 A CN 201410141164A CN 103877376 B CN103877376 B CN 103877376B
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Abstract
The invention discloses a kind of pharmaceutical preparation treating depression, be made up of the crude drug of following weight portion: Herba Portulacae 20～30 parts, Herba Epimedii 10～20 parts, Radix Polygalae 20～30 parts, Pericarpium Citri Reticulatae 10～20 parts, Rhizoma Polygonati Odorati 20～30 parts, Cuminum celery 10～20 parts, Radix Notoginseng 20～30 parts, the Radix Astragali 20～30 parts, Herba Lycopodii 5～15 parts, Radix Rehmanniae Preparata 5～15 parts, Fructus Cnidii 5～15 parts, north Herba corydalis edulis 20～30 parts.Preparation method is: take each crude drug, mixing, adds 8～10 times amount water, decocts 2～3 hours, filter to get filtrate, add water in medicinal residues, decocts 1～2 hour, filter to get filtrate, merge twice filtrate, concentrates, is dried to obtain medicated powder, loads capsule and makes capsule, to obtain final product.The pharmaceutical preparation of the treatment depression of the present invention, during treatment, oral, three times a day, each about 1 gram, three times a day, 15 days courses for the treatment of, general 2～3 courses for the treatment of can cure.
Description
Technical field
The present invention relates to a kind of pharmaceutical preparation treating depression.
Background technology
Depression is a kind of common affective disorders, is a kind of with lasting mental state or depressed, interest blank, thinking
Slow and disease with somatizations such as loss of appetite, sexual hypofunction, sleep disorder.Can be caused by a variety of causes, with aobvious
Writing and lasting mental state is low for main clinical characteristics, and mental state is low unbecoming with its situation, severe patient may occur in which suicidal thought
And behavior.Majority of cases has the tendency of recurrent exerbation, and outbreak great majority can be alleviated every time, and part can have residual symptoms or transfer to
Chronic.The traditional Chinese medical science thinks that depression belongs to melancholia category, be due to feelings will do not relax, a class disease caused by stagnation of QI stasis.Main table
Now for feeling depressed, irritable emotion, distending pain over the hypochondrium, or irritability, kind cry, the various complicated symptoms such as insomnia.
For the treatment of depression, current doctor trained in Western medicine many employings 5-hydroxy tryptamine reuptake depressant, monoamine oxidase inhibitor, phenyl
Piperazine azatropylidene class is sent at piperazines, 5-hydroxy tryptamine-norepinephrine reuptake inhibitor, aminoketones, tricyclic antidepressants, Fourth Ring
Deng 7 class antidepressants, but synthesis antidepressants exist that antidepressant narrow, the toxic and side effects of spectrum is big, medicine valency is high mostly and easily recurrence etc. lacks
Fall into.Therefore, in terms of the development and exploitation of antidepressants, increasingly focus on traditional drugs both at home and abroad and (particularly have more than 2,000 year history
Chinese herbal medicine), even using the American-European countries be good at of exploitation synthetic drug also some true medicable traditional drugss as treatment depression
Main force's medicine.
Depressed card belongs to the melancholia category of the traditional Chinese medical science, and disease is complicated and changeable, most commonly stagnation of QI due to depression of the liver, syndrome of deficiency of both heart and spleen, how due to
Feelings will is upset and causes, and its pathogenesis predominantly depression of liver-QI, the heart are become homeless foster, dysfunction of the spleen in transportation.Medicine many to regulate the flow of vital energy, to eliminate the phlegm,
Calm the nerves, have one's ideas straightened out, the class such as invigorating the heart and spleen is main.Chinese medicine compound has that composition is many, effect link is many, target spot is many feature, and many
The synergism of composition, compensate for the feature that active constituent content is low, reduces side effect.Therefore, develop antidepressant good effect,
Side effect is little, be suitable for long-term taking and safe and reliable Chinese medicine composition has become current study hotspot.
Summary of the invention
For above-mentioned prior art, the invention provides a kind of pharmaceutical preparation treating depression.
The present invention is achieved by the following technical solutions:
A kind of pharmaceutical preparation treating depression, is made up of the crude drug of following weight portion: Herba Portulacae 20～30 parts, excessive sheep
The leaves of pulse plants 10～20 parts, Radix Polygalae 20～30 parts, Pericarpium Citri Reticulatae 10～20 parts, Rhizoma Polygonati Odorati 20～30 parts, Cuminum celery 10～20 parts, Radix Notoginseng
20～30 parts, the Radix Astragali 20～30 parts, Herba Lycopodii 5～15 parts, Radix Rehmanniae Preparata 5～15 parts, Fructus Cnidii 5～15 parts, north Herba corydalis edulis 20～
30 parts.
Preferably, it is made up of the crude drug of following weight portion: Herba Portulacae 25 parts, Herba Epimedii 15 parts, Radix Polygalae 25 parts, old
Skin 15 parts, Rhizoma Polygonati Odorati 25 parts, Cuminum celery 15 parts, Radix Notoginseng 25 parts, the Radix Astragali 25 parts, Herba Lycopodii 10 parts, 10 parts of Radix Rehmanniae Preparata, Serpentis
Machine tool 10 parts, north Herba corydalis edulis 25 parts.
The preparation method of the pharmaceutical preparation of described treatment depression is: take each crude drug, mixing, adds 8～10 times amount (times of weight
Number) water, decocts 2～3 hours, filters to get filtrate, in medicinal residues, add 4 again～the water of 6 times amount (weight multiple), decoction 1～
2 hours, filtering to get filtrate, merge twice filtrate, conventional vacuum concentrates, is dried to obtain medicated powder, loads capsule and makes capsule,
Obtain.
The pharmaceutical preparation of the treatment depression of the present invention, has soothing liver-QI for relieving depression, conciliates circulation of qi promoting, tranquillizing and allaying excitement, the spy of lasting medicine
Point, is mainly used in light, moderate depressive patients and belongs to stagnation of QI due to depression of the liver, deficiency of both the heart and spleen person.During treatment, oral, three times a day, every time
About 1 gram (based on medicated powder quality), three times a day, 15 days courses for the treatment of, general 2～3 courses for the treatment of can cure.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated.
The pharmaceutical preparation of embodiment 1 preparation treatment depression
Formula is: Herba Portulacae 25 grams, Herba Epimedii 15 grams, Radix Polygalae 25 grams, Pericarpium Citri Reticulatae 15 grams, Rhizoma Polygonati Odorati 25 grams, Cuminum celery 15
Gram, Radix Notoginseng 25 grams, the Radix Astragali 25 grams, Herba Lycopodii 10 grams, 10 grams of Radix Rehmanniae Preparata, Fructus Cnidii 10 grams, north Herba corydalis edulis 25 grams.
Preparation method is: take each crude drug, mixing, adds 10 times amount (weight multiple) water, decocts 3 hours, filter to get filtrate,
Adding the water of 5 times amount (weight multiple) in medicinal residues again, decoct 2 hours, filter to get filtrate, merge twice filtrate, routine subtracts
Pressure concentrates, is dried to obtain medicated powder, loads capsule and makes capsule (every seed lac capsule explosive payload 0.3 gram), to obtain final product.
The pharmaceutical preparation of embodiment 2 preparation treatment depression
Formula is: Herba Portulacae 20 grams, Herba Epimedii 20 grams, Radix Polygalae 20 grams, Pericarpium Citri Reticulatae 20 grams, Rhizoma Polygonati Odorati 20 grams, Cuminum celery 20
Gram, Radix Notoginseng 20 grams, the Radix Astragali 30 grams, Herba Lycopodii 5 grams, 15 grams of Radix Rehmanniae Preparata, Fructus Cnidii 5 grams, north Herba corydalis edulis 30 grams.
Preparation method is: take each crude drug, mixing, adds 8 times amount (weight multiple) water, decocts 2 hours, filter to get filtrate,
Adding the water of 6 times amount (weight multiple) in medicinal residues again, decoct 2 hours, filter to get filtrate, merge twice filtrate, routine subtracts
Pressure concentrates, is dried to obtain medicated powder, loads capsule and makes capsule, to obtain final product.
The pharmaceutical preparation of embodiment 3 preparation treatment depression
Formula is: Herba Portulacae 30 grams, Herba Epimedii 10 grams, Radix Polygalae 30 grams, Pericarpium Citri Reticulatae 10 grams, Rhizoma Polygonati Odorati 30 grams, Cuminum celery 10
Gram, Radix Notoginseng 30 grams, the Radix Astragali 20 grams, Herba Lycopodii 15 grams, 5 grams of Radix Rehmanniae Preparata, Fructus Cnidii 15 grams, north Herba corydalis edulis 20 grams.
Preparation method is: take each crude drug, mixing, adds 9 times amount (weight multiple) water, decocts 2.5 hours, filters to obtain filter
Liquid, adds the water of 4 times amount (weight multiple) in medicinal residues again, decocts 1 hour, filters to get filtrate, merges twice filtrate, often
Rule concentrating under reduced pressure, the dry medicated powder that to obtain, loading capsule is made capsule, to be obtained final product.
The pharmaceutical preparation of embodiment 4 preparation treatment depression
Formula is: Herba Portulacae 22 grams, Herba Epimedii 12 grams, Radix Polygalae 28 grams, Pericarpium Citri Reticulatae 18 grams, Rhizoma Polygonati Odorati 22 grams, Cuminum celery 12
Gram, Radix Notoginseng 28 grams, the Radix Astragali 28 grams, Herba Lycopodii 8 grams, 8 grams of Radix Rehmanniae Preparata, Fructus Cnidii 12 grams, north Herba corydalis edulis 28 grams.
Preparation method is: take each crude drug, mixing, adds 8 times amount (weight multiple) water, decocts 2 hours, filter to get filtrate,
Adding the water of 4 times amount (weight multiple) in medicinal residues again, decoct 1 hour, filter to get filtrate, merge twice filtrate, routine subtracts
Pressure concentrates, is dried to obtain medicated powder, loads capsule and makes capsule, to obtain final product.
The pharmaceutical preparation of embodiment 5 preparation treatment depression
Formula is: Herba Portulacae 28 grams, Herba Epimedii 18 grams, Radix Polygalae 22 grams, Pericarpium Citri Reticulatae 12 grams, Rhizoma Polygonati Odorati 28 grams, Cuminum celery 18
Gram, Radix Notoginseng 22 grams, the Radix Astragali 22 grams, Herba Lycopodii 12 grams, 13 grams of Radix Rehmanniae Preparata, Fructus Cnidii 8 grams, north Herba corydalis edulis 22 grams.
Preparation method is: take each crude drug, mixing, adds 10 times amount (weight multiple) water, decocts 2.5 hours, filters to obtain filter
Liquid, adds the water of 6 times amount (weight multiple) in medicinal residues again, decocts 1.5 hours, filters to get filtrate, merge twice filtrate,
Conventional vacuum concentrates, is dried to obtain medicated powder, loads capsule and makes capsule, to obtain final product.
Clinical data:
Western medicine diagnose standard: meet Chinese Spirit Obstacles classification and the 3rd edition (CCMD-3) criteria for depression of diagnostic criteria, 17
Item Hamilton depressive scale (HAMD) total score >=18 point.
TCM syndrome diagnostic criteria: diagnostic criteria is with reference to State Administration of Traditional Chinese Medicine's nineteen ninety-five version " Chinese medical disease diagnosis curative effect mark
Accurate "；The card diagnostic criteria of stagnation of liver-QI with deficiency of the spleen, malaise is with reference to " new Chinese medicine guideline of clinical investigations ".Primary symptom: spirit presses down
Strongly fragrant, fatigue and weakness, sleep less；Secondary disease: gastral cavity abdominal distention is vexed, sighing frequently uncomfortable in chest, constipation, poor appetite；Light red tongue or fat, white and thin fur or greasy；
Stringy and rolling pulse, or thready and weak pulse without strength.Possess above primary symptom 3, secondary disease 2, meet stagnation of liver-QI with deficiency of the spleen, the picture of the tongue of malaise card,
Pulse condition, can be diagnosed as stagnation of liver-QI with deficiency of the spleen, malaise card.
Case inclusive criteria: meet criteria for depression, and genus is light, modest depression sends out author；Chinese medical discrimination is stagnation of liver-QI with deficiency of the spleen,
Malaise card person；Age 18～70 years old；The course of disease more than 6 months, HAMD24 item total score >=18 point, and≤35 points of persons；
It is ready to accept clinical trial and the prediction preferable person of compliance；Do not use other antidepressant in treating first 1 week, do not use in 2 weeks
Oxidase inhibitor, in treatment, nonjoinder uses other antidepressant and psychosis person.
Case exclusion standard: spiritedness medical history and psychosis family history person；Took in nearly half a year psychoactive drug, contraceptive,
Hormone medicine, or alcoholic；Trimester of pregnancy, age of sucking patient；Check noncooperationist；Age<18 years old or>70 years old person；HAMD24
<18 points or>35 points of persons；Major depressive episodes and the person that has suicidal tendency.
Case is grouped:
Treatment group: 54 examples, male 24 examples, female 30 example, 34 years old mean age, minimum 27 years old, maximum 49 years old；Average sick
Journey 8 months.
Matched group: 52 examples, male 23 examples, female 29 example, 32 years old mean age, 34 years old mean age, minimum 28 years old,
Big 48 years old；Average course of disease 8 months.
Between two groups, physical data processes no significant difference (P ＞ 0.05) through statistics (X 2 test and t inspection), has comparable
Property.
Therapeutic Method: treatment group is administered orally the capsule of embodiment 1 preparation, three times a day, each 3.Matched group takes fluorine west
Spit of fland, every day, 20mg, once took the morning.After treating 1 first quarter moon (3 courses for the treatment of), add up curative effect.
Observation index and method: before and after treatment, fill in HAMD (HAMD), record Chinese medicine syndrome integral.Tcm syndrome
Point system: primary symptom by without, light, in, weight degree be calculated as 0 point, 2 points, 4 points, 6 points respectively, secondary disease by without, light, in,
Weight degree is calculated as being divided into 0 point, 1 point, 2 points, 3 points respectively, meets stagnation of liver-QI with deficiency of the spleen, the picture of the tongue of malaise card, pulse condition respectively counts
It is 1 point, otherwise meter 0 point.
Tcm syndrome curative effect judging standard:
Curing: clinical symptom disappearance or substantially disappear, syndrome total mark relatively treats front minimizing >=95%；
Effective: clinical symptoms is clearly better, syndrome total mark relatively treats front minimizing >=70%；Have
Effective: clinical symptom relief, syndrome total mark relatively treats front minimizing >=30%；
Invalid: clinical symptoms is without being clearly better or increasing the weight of, and syndrome total mark reduces ＜ 30% before relatively treating.
Therapeutic outcome:
Matched group: 54 example patients, cures 27 examples (50.0%), effective 15 examples (27.8%), effective 8 examples (14.8%), nothing
Imitate 4 examples (7.4%), total effective rate 92.6%.
Treatment group: 52 example patients, cures 22 examples (42.3%), effective 14 examples (26.9%), effective 10 examples (19.2%),
Invalid 6 examples (11.5%), total effective rate 88.5%.
Untoward reaction is compared:
Treatment group: sleepy 2 examples, drowsy 4 examples, body weight increases by 3 examples.
Matched group: xerostomia 4 example, constipation 4 example, headache 2, anorexia 2 example, blurred vision 3 example, body weight increases by 5 examples, shake
Quiver 2 examples, 3 examples of cathisophobiaing, 1 example of having a stuffy nose, tachycardia 3 example.
In terms of the main clinical manifestation of untoward reaction, fluoxetine is mainly cholinolytic side reaction: xerostomia, blurred vision, headache,
Insomnias etc., patient is resistant to more, and without special handling, major part is died away.The medicine of the present invention is then secondary anti-without anticholinergic
Should, two groups all without serious adverse reaction.
Claims (7)
1. the pharmaceutical preparation treating depression, it is characterised in that: it is made up of the crude drug of following weight portion: Herba Portulacae
20～30 parts, Herba Epimedii 10～20 parts, Radix Polygalae 20～30 parts, Pericarpium Citri Reticulatae 10～20 parts, Rhizoma Polygonati Odorati 20～30 parts, Cuminum celery
10～20 parts, Radix Notoginseng 20～30 parts, the Radix Astragali 20～30 parts, Herba Lycopodii 5～15 parts, Radix Rehmanniae Preparata 5～15 parts, Fructus Cnidii 5～
15 parts, north Herba corydalis edulis 20～30 parts.
The pharmaceutical preparation for the treatment of depression the most according to claim 1, it is characterised in that: it is by the raw material of following weight portion
Medicine is made: Herba Portulacae 25 parts, Herba Epimedii 15 parts, Radix Polygalae 25 parts, Pericarpium Citri Reticulatae 15 parts, Rhizoma Polygonati Odorati 25 parts, Cuminum celery 15 parts,
Radix Notoginseng 25 parts, the Radix Astragali 25 parts, Herba Lycopodii 10 parts, 10 parts of Radix Rehmanniae Preparata, Fructus Cnidii 10 parts, north Herba corydalis edulis 25 parts.
The pharmaceutical preparation for the treatment of depression the most according to claim 1, it is characterised in that: it is by the crude drug of following weight
Make: Herba Portulacae 20 grams, Herba Epimedii 20 grams, Radix Polygalae 20 grams, Pericarpium Citri Reticulatae 20 grams, Rhizoma Polygonati Odorati 20 grams, Cuminum celery 20 grams,
Radix Notoginseng 20 grams, the Radix Astragali 30 grams, Herba Lycopodii 5 grams, 15 grams of Radix Rehmanniae Preparata, Fructus Cnidii 5 grams, north Herba corydalis edulis 30 grams.
The pharmaceutical preparation for the treatment of depression the most according to claim 1, it is characterised in that: it is by the crude drug of following weight
Make: Herba Portulacae 30 grams, Herba Epimedii 10 grams, Radix Polygalae 30 grams, Pericarpium Citri Reticulatae 10 grams, Rhizoma Polygonati Odorati 30 grams, Cuminum celery 10 grams,
Radix Notoginseng 30 grams, the Radix Astragali 20 grams, Herba Lycopodii 15 grams, 5 grams of Radix Rehmanniae Preparata, Fructus Cnidii 15 grams, north Herba corydalis edulis 20 grams.
The pharmaceutical preparation for the treatment of depression the most according to claim 1, it is characterised in that: it is by the crude drug of following weight
Make: Herba Portulacae 22 grams, Herba Epimedii 12 grams, Radix Polygalae 28 grams, Pericarpium Citri Reticulatae 18 grams, Rhizoma Polygonati Odorati 22 grams, Cuminum celery 12 grams,
Radix Notoginseng 28 grams, the Radix Astragali 28 grams, Herba Lycopodii 8 grams, 8 grams of Radix Rehmanniae Preparata, Fructus Cnidii 12 grams, north Herba corydalis edulis 28 grams.
The pharmaceutical preparation for the treatment of depression the most according to claim 1, it is characterised in that: it is by the crude drug of following weight
Make: Herba Portulacae 28 grams, Herba Epimedii 18 grams, Radix Polygalae 22 grams, Pericarpium Citri Reticulatae 12 grams, Rhizoma Polygonati Odorati 28 grams, Cuminum celery 18 grams,
Radix Notoginseng 22 grams, the Radix Astragali 22 grams, Herba Lycopodii 12 grams, 13 grams of Radix Rehmanniae Preparata, Fructus Cnidii 8 grams, north Herba corydalis edulis 22 grams.
7. the preparation method of the pharmaceutical preparation of the treatment depression described in claim 1～6 any one, it is characterised in that: take
Each crude drug, mixing, add 8～the water of 10 times of dose weight multiples, decoct 2～3 hours, filter to get filtrate, in medicinal residues
Adding 4 again～the water of 6 times of dose weight multiples, decoct 1～2 hour, filter to get filtrate, merge twice filtrate, conventional vacuum is dense
Contracting, the dry medicated powder that to obtain, loading capsule is made capsule, to be obtained final product.
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| CN201410141164.6A CN103877376B (en) | 2014-04-09 | 2014-04-09 | A kind of pharmaceutical preparation treating depression |
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| CN201410141164.6A CN103877376B (en) | 2014-04-09 | 2014-04-09 | A kind of pharmaceutical preparation treating depression |
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| CN103877376B true CN103877376B (en) | 2016-09-14 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022019967A1 (en) * | 2020-07-22 | 2022-01-27 | Biolite, Inc. | Polygala extract for the treatment of major depressive disorder |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107261057B (en) * | 2017-06-07 | 2020-09-29 | 杜彪 | Traditional Chinese medicine composition for treating depression and preparation method thereof |
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| CN101015654A (en) * | 2007-03-07 | 2007-08-15 | 中国人民解放军第三医院 | Oral traditional Chinese medicine preparation for treating depression and dysphoria |
| CN102526645A (en) * | 2012-03-23 | 2012-07-04 | 吴玉秋 | Medicament for treating dysthymic disorder |
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2014
- 2014-04-09 CN CN201410141164.6A patent/CN103877376B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101015654A (en) * | 2007-03-07 | 2007-08-15 | 中国人民解放军第三医院 | Oral traditional Chinese medicine preparation for treating depression and dysphoria |
| CN102526645A (en) * | 2012-03-23 | 2012-07-04 | 吴玉秋 | Medicament for treating dysthymic disorder |
Non-Patent Citations (2)
| Title |
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| 从肝论治脑卒中后抑郁症42例临床观察;王鹏;《实用中医内科杂志》;20060831;第20卷(第4期);第381-382页 * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022019967A1 (en) * | 2020-07-22 | 2022-01-27 | Biolite, Inc. | Polygala extract for the treatment of major depressive disorder |
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