CN103877132A - Sunset abelmoschus flower general flavone gel for treating dental ulcer and preparation method of gel - Google Patents
Sunset abelmoschus flower general flavone gel for treating dental ulcer and preparation method of gel Download PDFInfo
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- CN103877132A CN103877132A CN201410063163.4A CN201410063163A CN103877132A CN 103877132 A CN103877132 A CN 103877132A CN 201410063163 A CN201410063163 A CN 201410063163A CN 103877132 A CN103877132 A CN 103877132A
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Abstract
The invention discloses sunset abelmoschus flower general flavone gel for treating dental ulcer. The gel is prepared from sunset abelmoschus flower general flavone (the content of general flavone is 50-90%), an adhesive, a moistening agent and a transdermal enhancer. The invention further discloses a preparation method of the gel. Experiments show that the gel disclosed by the invention is strong in pharmacologic action, free from irritation and few in adverse effect, and has good effects of relieving pain, preventing inflammation and promoting anabrosis to be healed.
Description
Technical field
The invention belongs to technical field of Chinese medicines, specifically, relate to a kind of Flos abelmoschi manihot total flavones gel for the treatment of oral ulcer and preparation method thereof.
Background technology
Flos abelmoschi manihot is the dry corolla of Malvaceae plant Abelmoschus manihot （L.） Medic Abelmoschus manihot (L.) Medi c., records in " Jiangsu Province's Chinese crude drug standard " (version in 1989) enlarged edition, " Shandong Province's Chinese crude drug standard " version in 2002.Have eliminating damp-heat, effect of eliminating inflammation and expelling toxin, is the traditional medicinal plants of China, and the history of being used as medicine can trace back to " Handbook of Prescriptions for Emergencies " that before 1500, Jin Chaoge flood is shown, and " treating stranguria, detumescence, detoxifies to record it.Control gonorrhea, swollen ulcer drug, the burning hot wound of soup." there is a more application among the people, treat skin ulcer, parotitis, urinary tract infection, cough due to lung-heat and burn and scald etc. in order to treatment.Modern chemistry composition Study data shows; the main component of Flos abelmoschi manihot is flavone compound; aspect pharmacological experiment study; there is the flavones ingredient of bibliographical information Flos abelmoschi manihot to there is antiinflammatory antipyretic; anti-herpesvirus, the pharmacological actions such as treatment stomatocace, Ischemic myocardium, heart and brain hypoxic damage, treatment nephrotic syndrome.
Existing listing kind has Jiangsu Su Zhong pharmaceutical Co. Ltd Radix seu folium abelmoschi moschati capsule, is mainly treatment nephropathy; State Bureau in 2004 approval: the Flos abelmoschi manihot total flavones clinical official written reply (the coastal pharmaceutcal corporation, Ltd in Jiangxi declares) that fall apart is mainly to treat oral ulcer.This Flos abelmoschi manihot total flavones loose (spray) has many weak points: dosage is large, waste is large, after medication (spray), and ulcer surface medicine is inhomogeneous, and patient often occurs it being profusely medicine, and zest is large, and patient tolerability is poor; Disperse patient for ulcer spot, be difficult to especially accept, cause clinical position to be had difficulty in taking a step, be difficult to continue, manufacturer has abandoned exploitation now.
Therefore, our scientific research personnel, through scientific research repeatedly, makes gel, makes its better performance clinical efficacy, and it is necessary significantly reducing its untoward reaction.
In patent retrieval, find no any report that closes Flos abelmoschi manihot total flavones gel.
Gel can carry out lasting administration in the part of patient body, and the drug level in maintenance local blood is in effective therapeutic domain; Medicine in gel constantly absorbs through skin diffusion, makes the blood drug level held stationary of medicine, has avoided the fluctuation of blood drug level and the damage to liver, kidney after oral administration, has guaranteed the safety of medication; Gel can reduce the frequency of administration, reduces the individual variation of Absorption And Metabolism, thereby can the short period, high efficiency treatment disease.
Summary of the invention
There are many weak points in order to solve Flos abelmoschi manihot total flavones loose (spray), the a large amount of test of our research worker processes, researched and developed Flos abelmoschi manihot total flavones gel, not only obtained good therapeutic effect, and untoward reaction also reduces greatly.
The object of the invention is open a kind of curative effect better, the Flos abelmoschi manihot total flavones gel that side effect easy to use is little.
Another object of the present invention is the open preparation method of above-mentioned Flos abelmoschi manihot total flavones gel.
The present invention is achieved through the following technical solutions:
One, preparation method
The dosage of Flos abelmoschi manihot total flavones gel Raw medicine of the present invention is little, so carrying capacity is also little in the Flos abelmoschi manihot total flavones gel of making.For easy to use and easy to patients, the present invention is aqueous gel.
Flos abelmoschi manihot total flavones gel of the present invention contains following component:
Flos abelmoschi manihot total flavones 5-50 weight portion, adhesive 10-50 weight portion, wetting agent 10-80 weight portion and transdermal enhancer 10-50 weight portion.
Research worker of the present invention confirms through a large amount of tests, contained medicine in Flos abelmoschi manihot total flavones gel is very low for the selectivity of adhesive (carbomer, hydroxypropyl emthylcellulose, Carboxymethyl cellulose sodium, tragacanth, pectin, gelatin, xanthan gum), wetting agent (glycerol, Polyethylene Glycol, sorbitol, glycerol).In above-mentioned amount ranges, made Flos abelmoschi manihot total flavones gel is not all having the difference of significance qualitatively with in drug absorption.
The present invention is prepared from by the following method:
(1) Flos abelmoschi manihot total flavones of above-mentioned weight portion is ground into fine powder, for subsequent use;
(2) swelling to adding water soaking to make in the adhesive of above-mentioned weight portion; The wetting agent and the transdermal enhancer that add above-mentioned weight portion, stir, and obtains gel substrate;
(3) above-mentioned fine powder and gel substrate are mixed, add water to a certain amount ofly, stir and make evenly, to obtain a kind of Flos abelmoschi manihot total flavones gel for the treatment of oral ulcer of the present invention.
Two, the selection of transdermal enhancer
Gel in clinical practice, the number of transdermal dose, the height that enters blood Chinese medicine directly affects its therapeutical effect.Therefore,, in the preparation of gel, the selection of transdermal enhancer has just become a critical factor of gel clinical therapeutic efficacy quality.It is good that transdermal enhancer is selected, and medicine not only transdermal speed is fast, and the time that reaches blood drug level is short, and therapeutic effect is good, but also can keep between medicine and skin that drug level is poor for a long time, makes the action time of gel more lasting.The drug loading that this can reduce gel Chinese medicine virtually, can also increase the life cycle of a slice gel, reduces patient and use the frequency of gel, patient is used convenient, reduces patient's expense burden.The transdermal enhancer that our research worker is used Flos abelmoschi manihot total flavones gel is for this reason selected.
Conventional transdermal enhancer has dimethyl sulfoxide, dimethyl formamide, azone, Oleum menthae, Borneolum Syntheticum, Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods at present.But transdermal formulation multiselect azone both domestic and external is transdermal enhancer.Azone is a kind of nonpolar penetration enhancer, and its feature is no color or smell, and mucosa is produced to bottom line to stimulate, and effect extensively, hydrophilic and oleophilic type medicine is all had to short saturating effect, and there is no concentration dependent; Low, short effective, nontoxic nonirritant thoroughly of concentration when so azone uses with transdermal enhancer.1% azone can promote the Transdermal absorption of most hydrophobic and hydrophilic compounds, thereby is more suitable for the Chinese medicine preparation of effective site high (effective site content is higher than 50%).So this test, take the skin permeation rate of the effective ingredient hyperin of Flos abelmoschi manihot total flavones as index, using azone as transdermal enhancer, is investigated its proportioning.
Test apparatus and reagent: Japanese Shimadzu company high performance liquid chromatograph system; Improved Franz diffusing cells method is purchased from Shanghai Yu Yan scientific instrument company limited; 79HW-1 type constant temperature blender with magnetic force is purchased Changzhou Pu Tian instrument manufacturing company limited; Azone and other reagent are analytical pure.
Test method: get healthy rabbits, electricity consumption scraper scrapes off belly wool, strips skin of abdomen after 24 hours, separates subcutaneous fat and tissue, selects not damaged skin, is soaked in normal saline.By skin be fixed on improved Franz diffusing cells method between coyote hole and acceptance pool, corium one side contacts with acceptable solution, emptying bubble.Get certain area and be attached on the skin to coyote hole containing the Flos abelmoschi manihot total flavones gel sample of identical adhesive, wetting agent, different transdermal enhancers, make it and skin close contact.Fluid Contacting is the phosphate buffer of about 1OmlpH7.4, and magnetic agitation speed is about 100r/min, and bath temperature is (37 ± 0.5) ℃.In 24 hours, incline and get whole acceptable solutions every certain hour, then supplement immediately equal-volume acceptable solution.The acceptable solution taking out is placed in dry evaporating dish, adds methanol and be surely dissolved in 1ml measuring bottle after water bath method, and the high performance liquid chromatograph of measuring under item according to 287 pages of Flos abelmoschi manihot standard content of " Chinese Pharmacopoeia " version in 2010 is measured.For the ease of test, the content of transdermal enhancer is weight percentage.The results are shown in Table 1.
Table 1 transdermal enhancer is selected test
Note: A table is not azone.
Can be found out by above test data, the weight percentage of azone is 2%-4%, and transdermal facilitation effect is better, and when content is 3%, transdermal facilitation effect is best; Illustrate, Flos abelmoschi manihot total flavones gel of the present invention has selectivity to transdermal enhancer, in the scope that the weight percentage of azone is 2%-4%, all has good transdermal facilitation, best as 3% time take the weight percentage of azone.
Three, pharmacology and toxicological effect
1, the therapeutical effect of total Flavone of A gel to rabbit oral ulcer.
Get 30 of rabbit, be divided at random 3 groups, be i.e. model group, positive drug (BINGPENG SAN) group, total Flavone of A gel group (HSKNJ).By internal diameter 6mm, the glass tubing of long 30mm is vertically positioned over rabbit oral mucosa surface, in tube chamber, add 30% glacial acetic acid O.2ml, after 30 seconds, dip in out glacial acetic acid with cotton swab, (grade scale is: 3 grades: ulcer is blush around, and edema is obvious after 24 hours, to measure mucosal ulcer's area and observation inflammatory congestion situation reference literature standard grading; 2 grades: ulcer has blush around, without edema; 1 grade: ulcer blush slightly around, without edema; 0 grade: ulcer is around without blush, without edema), then positive drug group and HSKNJ group give respectively BINGPENG SAN 60mg, HSKNJ group 20mg and are coated in rabbit stomatocace place, a twice-daily, totally 3 days.The inflammatory congestion situation of the sticky ulcer in each group of rabbit oral cavity had been carried out to observation and classification in the 4th day, and measured ulcer area, then put to death rabbit, got ulcer place mucosal tissue, 10% formaldehyde is fixed, and send histopathological examination.
The impact of 1.1HSKNJ on rabbit stomatocace
1.1.1HSKNJ the impact on rabbit stomatocace inflammatory congestion
Result is as shown in table 1, and 30% glacial acetic acid 0.2ml can cause rabbit stomatocace, produces the reactions such as inflammation, hyperemia.The HSKNJ of 20mg can obviously alleviate the reaction such as inflammation, hyperemia of the rabbit stomatocace that glacial acetic acid brings out, and effect is obviously better than BINGPENG SAN.
The impact (n=1O) of table 1 total Flavone of A gel on rabbit stomatocace inflammatory congestion
With model group comparison, * P<O.05, * * P<O.01.
1.1.2HSKNJ the impact on rabbit stomatocace area
The impact of table 2HSKNJ on rabbit stomatocace area (
n=1O)
With model group comparison, * P<O.05, * * P<0.01.
1.1.3HSKNJ impact rabbit stomatocace histopathology being changed:
Result is as shown in photo, and model group perusal mucosal surface is almost all shown in that to have pitting damaged, diameter 0.2～0.3cm, and there is more greyish white lark inflammatory necrosis sample thing on surface; Under microscope, see and have obvious ulcer, scope is larger, ulcer surface squamous epithelial cancer destroys, come off and cover more amount slough and inflammatory exudate, under ulcer, connective tissue is also shown in obvious destruction, the inflammatory cell infiltrations such as a large amount of neutrophilic granulocytes, eosinophilic granulocyte, mononuclear cell and lymphocyte, reach tela submucosa deeply; The HSKNJ of 20mg is the same with 60mg BINGPENG SAN, and naked eyes are showed no obvious ulcer, only the visible about needle point size of indivedual mucosal surfaces depressed area; Under mirror, see the light or nothing of former ulcer place's slough and inflammatory exudate, the surface-coated lid thin layer of ulcer squama is strengthened epithelium, and upper subcutaneous connective tissue only has a small amount of inflammatory cell infiltration, and sees granulation tissue and proliferation of fibrous tissue.
Result shows that the HSKNJ of 20mg can obviously improve rabbit stomatocace histopathology and change, and is better than BINGPENG SAN.
2, the research of Flos abelmoschi manihot total flavones (TFA) anti-inflammatory and analgesic effect
This research shows that, on mouse writhing model, ig TFA is at 70～280mg.kg
-1in scope, can be dose-dependent inhibition AA and cause the writhing response of mice, ip TFA5,1O, 20mg.kg
-1can significantly suppress mouse writhing reaction, the above results prompting TFA has certain analgesic activity; In formalin model, systemic administration (ig) TFA140,280mg.kg
-1can significantly suppress I, II phase reaction that formalin causes mice pain, further show that TFA truly has obvious analgesic activity.This research also finds that I, the II reaction that ipl TFA causes pain model in mice to homonymy ipl formalin has remarkable inhibitory action, but offside ipl formalin is caused to mice pain to be had no significant effect, this presentation of results TFA local application causes mice pain reaction to formalin also obvious inhibitory action, and prompting TFA has obvious topical pain relief effect; Bring out in rabbit local pain model tremulous pulse local injection TFA200mg.kg at KCl
-1can obviously suppress KCl and bring out the pain reaction of rabbit, further show that TFA has topical pain relief effect.
This research also finds that local coating TFA not only can significantly suppress the swelling of mice caused by dimethylbenzene xylene auricle, also can significantly reduce the granulomatous weight of rat, and result shows that TFA topical has certain antiinflammatory action, all has certain inhibitory action to Acute and chronic inflammation.
In sum, TFA has obvious analgesia and antiinflammatory action, and topical is effective.
3, the research of Flos abelmoschi manihot total flavones (TFA) refrigeration function
The model that this experiment adopts two kinds of sc. Oleum Terebinthinae or iv escherichia coli liquid to bring out fever in rabbits is observed the refrigeration function of TFA.Research is found on sc. Oleum Terebinthinae pyrogenicity model, TFA140,280mg.kg
-1after administration, can produce significant refrigeration function when 150min; On iv escherichia coli liquid pyrogenicity model, TFA280mg.kg
-1after administration, can there is obvious refrigeration function when 90min, 150min.Result has certain refrigeration function while showing TFA larger dose, but onset is slower.
4, Flos abelmoschi manihot total flavones (TFA) addiction research
The mode of this product employing successive administration is observed TFA and is had or not addiction.Find that after deliberation subcutaneous injection (sc) is subject to reagent TFA after continuous 8 days, mice is without the generation of addiction phenomenon.Result shows to have the TFA of necessarily antipyretic, analgesia, antiinflammatory action, and continuous application is without addiction.
5, the research of Flos abelmoschi manihot total flavones (TFA) acute toxicity test
This experimental study Flos abelmoschi manihot total flavones is to chmice acute toxic action.Result of the test shows mouse stomach administration Flos abelmoschi manihot total flavones 20000mg.kg
-1, in 2W, have no mice and occur obvious toxic reaction, also have no dead, show Flos abelmoschi manihot total flavones mouse stomach administration LD
50be greater than 20000mg.kg
-1; After Flos abelmoschi manihot total flavones mouse peritoneal injection 1h, start to occur toxic reaction, dead animal mainly occurs in after medication in 1-2d, and after dead animal obduction, perusal has no the heart, liver, kidney, brain, lung and gastrointestinal obvious pathological changes; Mouse peritoneal injection Flos abelmoschi manihot total flavones LD
50be 2420.3 ± 199.8mg.kg
-1, 95% confidence region is limited to 2229.1-2627.9mg.kg
-1.
6, the research of Flos abelmoschi manihot total flavones (TFA) long term toxicity test
The gavage Flos abelmoschi manihot total flavones 150,300 of rat continuous 15 weeks (W), 600mg.kg
-1.During experiment administration and drug withdrawal recover viewing duration and be showed no animal and have obvious poisoning symptom to occur, it is ingested, body weight gain and relatively no significant difference of matched group, the organ coefficient of main organs and histopathological examination and matched group compare no significant difference; In when hematological examination and blood biochemical only have medication 15W in learning and checking, HGB and the large and small dosage group GLU of dosage group have obvious reduction, and other index is without obvious disadvantageous change; Drug withdrawal convalescent period is observed the ALT of the heavy dose of group of the rarely seen TFA of having and TCH to be had significantly and increases, and has no the generation of other new toxic reaction.
Than the gavage Flos abelmoschi manihot total flavones of lattice Canis familiaris L. continuous 15 weeks (W) 50,122.5,300mg.kg
-1.High dose group Some Animals has one to cross the feeling sick of property, vomiting reaction during experiment administration and when drug withdrawal recovers viewing duration rarely seen administration 2-3W, and other animal occurs without obvious poisoning symptom; Flos abelmoschi manihot total flavones 50,122.5,300mg.kg
-1the ingesting of animal, body weight gain, ECG, hematological examination, blood biochemical are learned and checked and the index such as the organ coefficient of main organs and impact without significant adverse; In the time of 15W, there is adverse effect to reproductive system in heavy dose of group, but between histopathologic examination's result and matched group without significant difference.Result of study shows than the gavage Flos abelmoschi manihot total flavones of lattice Canis familiaris L. continuous 15 weeks (W) 50,122.5,300mg.kg
-1except on reproductive system impact, without other obvious toxic action, drug withdrawal is observed the toxic action that also has no new for 15 days and is occurred.
More than experiment showed, that Flos abelmoschi manihot total flavones gel of the present invention has similar therapeutic effect with BINGPENG SAN, and curative effect is better than commercially available like product, acute, long term toxicity reaction and display, this product application is safer.The exploitation that Flos abelmoschi manihot total flavones gel of the present invention is described is successfully, has practicality.
The specific embodiment
Embodiment 1
Get 10g Flos abelmoschi manihot total flavones medicated powder porphyrize, for subsequent use; Adhesive carbomer 20g is added water and is made into 2% solution, and immersion makes swelling, and adding triethanolamine to regulate pH value is 7, then adds wetting agent glycerol 30g, transdermal enhancer azone 20g, stirs, and obtains gel substrate; Substrate is mixed with fine powder, add water to 1000g, stir and make evenly, to obtain Flos abelmoschi manihot total flavones gel of the present invention.
Embodiment 2
Get 25g Flos abelmoschi manihot total flavones medicated powder porphyrize, for subsequent use; Adhesive hydroxypropyl emthylcellulose 40g is added water and is made into 7% solution, and immersion makes swelling, then adds wetting agent Polyethylene Glycol 100g, transdermal enhancer azone 40g, stirs, and obtains gel substrate; Substrate is mixed with fine powder, add water to 1000g, stir and make evenly, to obtain Flos abelmoschi manihot total flavones gel of the present invention.
Embodiment 3
Get 20g Flos abelmoschi manihot total flavones medicated powder porphyrize, for subsequent use; Adhesive Carboxymethyl cellulose sodium 32g is added water and is made into 4% solution, and immersion makes swelling, then adds wetting agent sorbitol 60g, transdermal enhancer azone 31g, stirs, and obtains gel substrate; Substrate is mixed with fine powder, add water to 1000g, stir and make evenly, to obtain Flos abelmoschi manihot total flavones gel of the present invention.
Embodiment 4
Get 18g Flos abelmoschi manihot total flavones medicated powder porphyrize, for subsequent use; Adhesive tragacanth 28g is added water and is made into 6% solution, and immersion makes swelling, then adds wetting agent glycerol 75g, transdermal enhancer azone 28g, stirs, and obtains gel substrate; Substrate is mixed with fine powder, add water to 1000g, stir and make evenly, to obtain Flos abelmoschi manihot total flavones gel of the present invention.
Embodiment 5
Get 15g Flos abelmoschi manihot total flavones medicated powder porphyrize, for subsequent use; Adhesive pectin 38g is added water and is made into 5% solution, and immersion makes swelling, then adds wetting agent glycerol and sorbitol 35g, transdermal enhancer azone 22g altogether, stirs, and obtains gel substrate; Substrate is mixed with fine powder, add water to 1000g, stir and make evenly, to obtain Flos abelmoschi manihot total flavones gel of the present invention.
Embodiment 6
Get 16g Flos abelmoschi manihot total flavones medicated powder porphyrize, for subsequent use; Adhesive gelatin 25g is added water and is made into 3% solution, and immersion makes swelling, then adds wetting agent Polyethylene Glycol and glycerol 80g, transdermal enhancer azone 36g, stirs, and obtains gel substrate; Substrate is mixed with fine powder, add water to 1000g, stir and make evenly, to obtain Flos abelmoschi manihot total flavones gel of the present invention.
Embodiment 7
Get 30g Flos abelmoschi manihot total flavones medicated powder porphyrize, for subsequent use; Adhesive xanthan gum 50g is added water and is made into 5% solution, and immersion makes swelling, then adds wetting agent glycerol and glycerol 75g, transdermal enhancer azone 39g, stirs, and obtains gel substrate; Substrate is mixed with fine powder, add water to 1000g, stir and make evenly, to obtain Flos abelmoschi manihot total flavones gel of the present invention.
Embodiment 8
Get 19g Flos abelmoschi manihot total flavones medicated powder porphyrize, for subsequent use; Adhesive hydroxypropyl emthylcellulose 35g is added water and is made into 3% solution, and immersion makes swelling, then adds wetting agent Polyethylene Glycol and sorbitol 55g, transdermal enhancer azone 35g, stirs, and obtains gel substrate; Substrate is mixed with fine powder, add water to 1000g, stir and make evenly, to obtain Flos abelmoschi manihot total flavones gel of the present invention.
Although, above with a general description of the specific embodiments the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (7)
1. treat a Flos abelmoschi manihot total flavones gel for oral ulcer, it is characterized in that Flos abelmoschi manihot total flavones (general flavone content is 50-90%) 5-50 weight portion and make with adhesive 10-50 weight portion, wetting agent 1O-80 weight portion and transdermal enhancer 10-50 weight portion.
2. a kind of Flos abelmoschi manihot total flavones gel for the treatment of oral ulcer according to claim 1, is characterized in that, its preparation method comprises the following steps:
(1) Flos abelmoschi manihot total flavones of above-mentioned weight portion is ground into fine powder, for subsequent use;
(2) swelling to adding water soaking to make in the adhesive of above-mentioned weight portion; The wetting agent and the transdermal enhancer that add above-mentioned weight portion, stir, and obtains gel substrate;
(3) above-mentioned fine powder and gel substrate are mixed, add water to a certain amount ofly, stir and make evenly, to obtain a kind of Flos abelmoschi manihot total flavones gel for the treatment of oral ulcer of the present invention.
3. a kind of Flos abelmoschi manihot total flavones gel for the treatment of oral ulcer according to claim 1 and 2, it is characterized in that, gel is wherein one or more in carbomer, hydroxypropyl emthylcellulose, Carboxymethyl cellulose sodium, tragacanth, pectin, gelatin, xanthan gum.
4. a kind of Flos abelmoschi manihot total flavones gel for the treatment of oral ulcer according to claim 1 and 2, is characterized in that, wetting agent is wherein one or more in glycerol, Polyethylene Glycol, sorbitol, glycerol.
5. a kind of Flos abelmoschi manihot total flavones gel for the treatment of oral ulcer according to claim 1 and 2, is characterized in that, transdermal enhancer is wherein azone.
6. according to a kind of Flos abelmoschi manihot total flavones gel for the treatment of oral ulcer described in claim 1 or 2 or 5, it is characterized in that, azone weight percentage is wherein 2-4%.
7. according to a kind of Flos abelmoschi manihot total flavones gel for the treatment of oral ulcer described in claim 1 or 2 or 5 or 6, it is characterized in that, azone weight percentage is wherein 3%.
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| CN107049874A (en) * | 2017-05-23 | 2017-08-18 | 许备占 | Sunset abelmoschus flower mouthwash |
| CN107126484A (en) * | 2017-04-26 | 2017-09-05 | 合肥海大生物医药科技有限公司 | It is a kind of to treat callicarpa nudiflora gel of gynaecological imflammation and preparation method thereof |
| CN109953930A (en) * | 2017-12-14 | 2019-07-02 | 江苏苏中药业集团股份有限公司 | A kind of Chinese herbal toothpaste and preparation method thereof with canker sore repair |
| CN110302140A (en) * | 2019-06-04 | 2019-10-08 | 佛山科学技术学院 | A kind of picria fel tarrae gel and preparation method thereof |
| CN112353825A (en) * | 2020-11-09 | 2021-02-12 | 山东省药学科学院 | Traditional Chinese medicine double-layer patch for treating oral ulcer and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107126484A (en) * | 2017-04-26 | 2017-09-05 | 合肥海大生物医药科技有限公司 | It is a kind of to treat callicarpa nudiflora gel of gynaecological imflammation and preparation method thereof |
| CN107049874A (en) * | 2017-05-23 | 2017-08-18 | 许备占 | Sunset abelmoschus flower mouthwash |
| CN109953930A (en) * | 2017-12-14 | 2019-07-02 | 江苏苏中药业集团股份有限公司 | A kind of Chinese herbal toothpaste and preparation method thereof with canker sore repair |
| CN109953930B (en) * | 2017-12-14 | 2022-04-12 | 苏中药业集团股份有限公司 | Chinese herbal medicine toothpaste with dental ulcer repairing effect and preparation method thereof |
| CN110302140A (en) * | 2019-06-04 | 2019-10-08 | 佛山科学技术学院 | A kind of picria fel tarrae gel and preparation method thereof |
| CN112353825A (en) * | 2020-11-09 | 2021-02-12 | 山东省药学科学院 | Traditional Chinese medicine double-layer patch for treating oral ulcer and preparation method thereof |
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