CN103875685A - Ametoctradin-containing bactericidal composition - Google Patents
Ametoctradin-containing bactericidal composition Download PDFInfo
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- CN103875685A CN103875685A CN201210563613.7A CN201210563613A CN103875685A CN 103875685 A CN103875685 A CN 103875685A CN 201210563613 A CN201210563613 A CN 201210563613A CN 103875685 A CN103875685 A CN 103875685A
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- azoles mepanipyrim
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- mepanipyrim
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- 239000000203 mixture Substances 0.000 title claims abstract description 48
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 17
- 239000005726 Ametoctradin Substances 0.000 title abstract description 4
- GGKQIOFASHYUJZ-UHFFFAOYSA-N ametoctradin Chemical compound NC1=C(CCCCCCCC)C(CC)=NC2=NC=NN21 GGKQIOFASHYUJZ-UHFFFAOYSA-N 0.000 title abstract description 4
- 201000010099 disease Diseases 0.000 claims abstract description 25
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 25
- 239000005780 Fluazinam Substances 0.000 claims abstract description 18
- 239000005782 Fluopicolide Substances 0.000 claims abstract description 18
- UZCGKGPEKUCDTF-UHFFFAOYSA-N fluazinam Chemical compound [O-][N+](=O)C1=CC(C(F)(F)F)=C(Cl)C([N+]([O-])=O)=C1NC1=NC=C(C(F)(F)F)C=C1Cl UZCGKGPEKUCDTF-UHFFFAOYSA-N 0.000 claims abstract description 18
- GBOYJIHYACSLGN-UHFFFAOYSA-N fluopicolide Chemical compound ClC1=CC(C(F)(F)F)=CN=C1CNC(=O)C1=C(Cl)C=CC=C1Cl GBOYJIHYACSLGN-UHFFFAOYSA-N 0.000 claims abstract description 18
- 150000003851 azoles Chemical class 0.000 claims description 83
- 239000005805 Mepanipyrim Substances 0.000 claims description 77
- CIFWZNRJIBNXRE-UHFFFAOYSA-N mepanipyrim Chemical compound CC#CC1=CC(C)=NC(NC=2C=CC=CC=2)=N1 CIFWZNRJIBNXRE-UHFFFAOYSA-N 0.000 claims description 77
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 34
- 239000000375 suspending agent Substances 0.000 claims description 27
- 241000894006 Bacteria Species 0.000 claims description 17
- 241000233679 Peronosporaceae Species 0.000 claims description 17
- 150000001412 amines Chemical class 0.000 claims description 17
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 17
- 239000003094 microcapsule Substances 0.000 claims description 14
- 239000000839 emulsion Substances 0.000 claims description 12
- 235000007164 Oryza sativa Nutrition 0.000 claims description 10
- 235000009566 rice Nutrition 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 7
- 239000000725 suspension Substances 0.000 claims description 7
- 238000009736 wetting Methods 0.000 claims description 7
- 241000221785 Erysiphales Species 0.000 claims description 6
- 239000004530 micro-emulsion Substances 0.000 claims description 6
- 239000004562 water dispersible granule Substances 0.000 claims description 6
- 241000582441 Peronospora tabacina Species 0.000 claims description 5
- 241000607479 Yersinia pestis Species 0.000 claims description 2
- 240000007594 Oryza sativa Species 0.000 claims 1
- 241000918585 Pythium aphanidermatum Species 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 abstract description 23
- 230000000694 effects Effects 0.000 abstract description 5
- 150000001875 compounds Chemical class 0.000 abstract description 3
- 238000001228 spectrum Methods 0.000 abstract description 2
- 239000005740 Boscalid Substances 0.000 abstract 1
- NQRFDNJEBWAUBL-UHFFFAOYSA-N N-[cyano(2-thienyl)methyl]-4-ethyl-2-(ethylamino)-1,3-thiazole-5-carboxamide Chemical compound S1C(NCC)=NC(CC)=C1C(=O)NC(C#N)C1=CC=CS1 NQRFDNJEBWAUBL-UHFFFAOYSA-N 0.000 abstract 1
- WYEMLYFITZORAB-UHFFFAOYSA-N boscalid Chemical compound C1=CC(Cl)=CC=C1C1=CC=CC=C1NC(=O)C1=CC=CN=C1Cl WYEMLYFITZORAB-UHFFFAOYSA-N 0.000 abstract 1
- 229940118790 boscalid Drugs 0.000 abstract 1
- 239000002131 composite material Substances 0.000 description 37
- 238000012360 testing method Methods 0.000 description 35
- 239000003814 drug Substances 0.000 description 27
- 230000003449 preventive effect Effects 0.000 description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- 239000013530 defoamer Substances 0.000 description 13
- 239000002270 dispersing agent Substances 0.000 description 13
- 239000000575 pesticide Substances 0.000 description 13
- 239000012071 phase Substances 0.000 description 12
- 239000008367 deionised water Substances 0.000 description 11
- 229910021641 deionized water Inorganic materials 0.000 description 11
- 239000003995 emulsifying agent Substances 0.000 description 10
- 239000002904 solvent Substances 0.000 description 10
- 240000008067 Cucumis sativus Species 0.000 description 9
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 9
- 241000209094 Oryza Species 0.000 description 9
- 230000002528 anti-freeze Effects 0.000 description 9
- 239000000080 wetting agent Substances 0.000 description 9
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 8
- 240000003768 Solanum lycopersicum Species 0.000 description 8
- 239000002562 thickening agent Substances 0.000 description 8
- 231100000820 toxicity test Toxicity 0.000 description 8
- 241000233622 Phytophthora infestans Species 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 206010067482 No adverse event Diseases 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 206010011732 Cyst Diseases 0.000 description 5
- 235000009754 Vitis X bourquina Nutrition 0.000 description 5
- 235000012333 Vitis X labruscana Nutrition 0.000 description 5
- 240000006365 Vitis vinifera Species 0.000 description 5
- 235000014787 Vitis vinifera Nutrition 0.000 description 5
- 208000031513 cyst Diseases 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 5
- 229920002521 macromolecule Polymers 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 244000183278 Nephelium litchi Species 0.000 description 4
- 241000233614 Phytophthora Species 0.000 description 4
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- 238000004458 analytical method Methods 0.000 description 4
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- 239000003905 agrochemical Substances 0.000 description 3
- 230000008485 antagonism Effects 0.000 description 3
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- 230000010165 autogamy Effects 0.000 description 3
- 238000000498 ball milling Methods 0.000 description 3
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- 239000007787 solid Substances 0.000 description 3
- 239000013543 active substance Substances 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
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- 231100000419 toxicity Toxicity 0.000 description 2
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- 241000219112 Cucumis Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000510928 Erysiphe necator Species 0.000 description 1
- 241001361634 Rhizoctonia Species 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000012271 agricultural production Methods 0.000 description 1
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- 210000003608 fece Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
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- 230000000855 fungicidal effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 239000010871 livestock manure Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
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- YWBFPKPWMSWWEA-UHFFFAOYSA-O triazolopyrimidine Chemical class BrC1=CC=CC(C=2N=C3N=CN[N+]3=C(NCC=3C=CN=CC=3)C=2)=C1 YWBFPKPWMSWWEA-UHFFFAOYSA-O 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses an ametoctradin-containing bactericidal composition whose effective active components are active component A and active component B, wherein the active component A is selected from ametoctradin, the active component B is selected from any one of the following compounds: fluazinam, boscalid, fluopicolide, and ethaboxam, and the weight ratio of the active component A to the active component B is 1:70-70:1. The composition of the invention has high activity on various diseases of various crops, has significant synergistic effect, and has an extended bacteriocidal spectrum. The composition of the invention also has the characteristics of small dosage, rain wash resistance, and significant synergistic effect.
Description
Technical field
The invention belongs to technical field of pesticide, relate to the application of a kind of bactericidal composition containing azoles mepanipyrim in crop pest.
Technical background
Azoles mepanipyrim (ametoctradin) is obtained interim registration in China, and azoles mepanipyrim is brand-new triazolo pyrimidine series bactericidal agent, for the downy mildew of prevention and control cucumber and grape crop.
In the real process of agricultural production, preventing and treating the problem that disease the most easily produces is the generation of disease drug resistance.Different cultivars composition carries out composite, is to prevent and treat the very common method of resistance disease.Heterogeneity is carried out composite, according to practical application effect, judge certain composite be synergy, add and or antagonism.In most cases, the composite effect of agricultural chemicals is all additive effect, really have a synergistic effect composite seldom, especially synergistic effect very obviously, synergy ratio very high composite just still less.Through inventor's research, find mutually composite to azoles mepanipyrim and fluazinam, pyridine bacterium amine, fluopicolide, Guardian, there is within the specific limits good synergistic effect, and relevant composite about azoles mepanipyrim and fluazinam, pyridine bacterium amine, fluopicolide, Guardian, there is not yet at present relevant report at home and abroad.
Summary of the invention
The object of the invention is to propose a kind of have synergistic function, use cost is low, preventive effect the is good bactericidal composition containing azoles mepanipyrim.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition containing azoles mepanipyrim, contain active components A and active component B, active components A and active component B weight ratio are 1: 70～70: 1, described active components A is selected from azoles mepanipyrim, and active component B is selected from the one in fluazinam, pyridine bacterium amine, fluopicolide, Guardian; The weight ratio that is preferably active components A and active component B is 1 ︰ 50～50 ︰ 1; More preferably the weight ratio of azoles mepanipyrim and fluazinam is 1: 20～20: 1, the weight ratio of azoles mepanipyrim and pyridine bacterium amine is 1: 10～30: 1, the weight ratio of azoles mepanipyrim and fluopicolide is 1: 20～20: 1, and the weight ratio of azoles mepanipyrim and Guardian is 1: 20～20: 1; More preferably the weight ratio of azoles mepanipyrim and fluazinam is 1: 9～9: 1, the weight ratio of azoles mepanipyrim and pyridine bacterium amine is 1: 4～19: 1, the weight ratio of azoles mepanipyrim and fluopicolide is 1: 9～9: 1, and the weight ratio of azoles mepanipyrim and Guardian is 1: 9～9: 1.
Bactericidal composition of the present invention, can be processed on demand acceptable formulation in any sterilization, wherein more preferably formulation is wetting powder, water dispersible granules, suspending agent, aqueous emulsion, microemulsion, suspension emulsion, microcapsule suspending agent, microcapsule suspension-suspending agent.
The disease of the described bactericidal composition containing azoles mepanipyrim for preventing and treating crop; Described crop is cereal crops, legume crop, fiber crop, sugar [yielding, melon crop, fruits crop, dry fruit crop, hobby crop, root crop, oil crop, flowers crop, medicinal crop, raw material crop, green manure pasture crop; Described disease is downy mildew, epidemic disease, peronospora tabacina, gray mold, powdery mildew, rice blast, damping off.
The amount of application when content of active component depends on independent use in bactericidal composition of the present invention, also depends on mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, and the while is also relevant with target disease.Conventionally in composition, the weight percentage of active component is gross weight 1%～90%, is preferably 5%～80%.According to different preparation types, active component content scope is different.Liquids in general preparation contains 1%～60% active substance by weight, is preferably 5%～50%; Solid pharmaceutical preparation contains 5%～80% active substance by weight, is preferably 10%～80%.
In bactericidal composition of the present invention, at least contain a kind of surfactant, the dispersion of active component in water while being beneficial to use.Surface-active contents is 2%～30% of total formulation weight amount, and surplus is solid or liquid diluent.
Bactericidal composition of the present invention can be by user before use through dilution or directly use.Its preparation can be prepared by processing method known in those skilled in the art, after mixing with liquid flux or solid carrier by active component, then add surfactant as one or more in dispersant, stabilizing agent, wetting agent, binding agent, disintegrant, defoamer etc.According to different dosage form, in preparation, can also contain antifreeze known in those skilled in the art etc.
When making wetting powder, composition comprises following component and content: active components A 0.5% ~ 70%, active component B0.5% ~ 70%, dispersant 1% ~ 12%, wetting agent 1% ~ 8%, filler surplus.
When making water dispersible granules, composition comprises following component and content: active components A 0.5% ~ 70%, active component B0.5% ~ 70%, dispersant 1% ~ 12%, wetting agent 1% ~ 8%, disintegrant 1% ~ 10%, binding agent 0 ~ 8%, filler surplus.
When making suspending agent, composition comprises following component and content: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, dispersant 1% ~ 10%, wetting agent 1% ~ 10%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, antifreeze 0 ~ 8%, deionized water add to 100%.
When making aqueous emulsion, composition comprises following component and content: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, solvent 1% ~ 20%, emulsifier 1% ~ 12%, antifreeze 0 ~ 8%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, deionized water add to 100%.
When making microemulsion, composition comprises following component and content: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, emulsifier 3% ~ 25%, solvent 1% ~ 10%, antifreeze 0 ~ 8%, defoamer 0.01% ~ 2%, deionized water add to 100%.
When making suspension emulsion, composition comprises following component and content: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, emulsifier 1% ~ 10%, dispersant 1% ~ 10%, solvent 1% ~ 20%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, antifreeze 0 ~ 8%, deionized water add to 100%.
When making microcapsule suspending agent, composition comprises following component and content: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, macromolecule cyst material 1% ~ 10%, dispersant 2% ~ 10%, solvent 1% ~ 10%, emulsifier 1% ~ 7%, pH adjusting agent 0.01% ~ 5%, defoamer 0.01% ~ 2%, deionized water add to 100%.
When making microcapsule suspension-suspending agent, composition comprises following component and content: active components A 0.5% ~ 50%, active component B0.5% ~ 50%, macromolecule cyst material 1% ~ 12%, dispersant 1% ~ 12%, wetting agent 1% ~ 8%, solvent 1% ~ 15%, emulsifier 1% ~ 8%, defoamer 0.01% ~ 2%, thickener 0 ~ 2%, pH adjusting agent 0.01% ~ 5%, deionized water add to 100%.
Wetting powder the key technical indexes of the present invention:
Water dispersible granules the key technical indexes of the present invention:
Suspending agent the key technical indexes of the present invention:
Aqueous emulsion the key technical indexes of the present invention:
Microemulsion the key technical indexes of the present invention:
Suspension emulsion the key technical indexes of the present invention:
Microcapsule suspending agent the key technical indexes of the present invention:
Microcapsule suspension-suspending agent the key technical indexes of the present invention:
The invention has the advantages that:
(1) present composition has good synergy and lasting effect within the specific limits, and preventive effect is higher than single dose; (2) agricultural chemicals dosage reduces, and reduces the residual quantity of agricultural chemicals on crop, alleviates environmental pollution; (3) expanded fungicidal spectrum, multiple diseases has been had to greater activity as downy mildew, epidemic disease, peronospora tabacina, gray mold, powdery mildew, rice blast, damping off etc.
Embodiment
Below in conjunction with embodiment, to further instruction of the present invention, the percentage in embodiment is all weight percentage, but the present invention is not limited thereto.
Application Example one
Embodiment 1～13 wetting powder
Azoles mepanipyrim, active component B, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, can be made into wetting powder product of the present invention.Specifically in table 1.
The each component of table 1 embodiment 1～13 and content
Embodiment 14～26 water dispersible granules
Azoles mepanipyrim, active component B, dispersant, wetting agent, disintegrant, filler etc. are obtained to the particle diameter needing through air-flow crushing together, then add other auxiliary agents such as binding agent (can add and can not add), obtain the materials of granulating.By item quantitatively send in fluidized bed granulation dryer through granulation and dry after, can make water dispersible granules product of the present invention, specifically in table 2.
The each component of table 2 embodiment 14～26 and content
Embodiment 27～39 suspending agents
By dispersant, wetting agent, defoamer, thickener (can add and can not add), antifreeze (can add and can not add), mix through high speed shear, add azoles mepanipyrim, active component B, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μ m, surplus is supplied by deionized water, can make suspending agent product of the present invention, specifically in table 3.
The each component of table 3 embodiment 27～39 and content
Embodiment 40～48 aqueous emulsions
Azoles mepanipyrim, active component B, solvent, emulsifier are added together, make to be dissolved into even oil phase; Deionized water, antifreeze (can add and can not add), thickener (can add and can not add), defoamer are mixed, become homogeneous water.Under high-speed stirred, water is added to oil phase, make aqueous emulsion product of the present invention.Specifically in table 4.
The each component of table 4 embodiment 40～48 and content
Embodiment 49～57 microemulsions
Azoles mepanipyrim, active component B are dissolved in the homogenizer that solvent is housed, by emulsifier, antifreeze (can add and can not add), defoamer, join in the homogenizer that above-mentioned solution is housed, surplus gives strong mixing and homogenize after supplying by deionized water, finally obtain the as clear as crystal microemulsion product of the present invention of outward appearance.Specifically in table 5.
The each component of table 5 embodiment 49～57 and content
Fluazinam, pyridine bacterium amine, fluopicolide, Guardian in table 1 ~ 5 are exchanged, can make novel formulation.
Embodiment 58～60 suspension emulsions
Dispersant, defoamer, thickener (can add and can not add), antifreeze (can add and can not add) are mixed through high speed shear, add azoles mepanipyrim, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μ m, make azoles mepanipyrim suspending agent, then by active component B, emulsifier, solvent and various auxiliary agent with the direct emulsification of high speed agitator in suspending agent, make suspension emulsion product of the present invention.Specifically in table 6.
The each component of table 6 embodiment 58～60 and content
Embodiment 61～63 microcapsule suspending agents
By azoles mepanipyrim, active component B, macromolecule cyst material, solvent, make to be dissolved into even oil phase, under shearing condition, oil phase is joined in the aqueous phase solution that contains emulsifier, pH adjusting agent, dispersant, defoamer, surplus is supplied by deionized water, bi-material reacts at oil-water interfaces, forms macromolecule cyst wall, makes the finely disseminated microcapsule suspending agent product of the present composition.Specifically in table 7.
The each component of table 7 embodiment 61～63 and content
Embodiment 64～66 microcapsule suspensions-suspending agent
By active component B, macromolecule cyst material, solvent, make to be dissolved into even oil phase, oil phase is joined in the aqueous phase solution that contains emulsifier, pH adjusting agent under shearing condition, make finely disseminated microcapsule suspending agent.Dispersant, wetting agent, defoamer, thickener (can add and can not add) are mixed through high speed shear, add azoles mepanipyrim, ball milling 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μ m, make suspending agent, then suspending agent is joined in the aqueous phase solution of micro-capsule suspension, deionized water is supplied surplus, makes the finely disseminated microcapsule suspension-suspending agent of present composition product.Specifically in table 8.
The each component of table 8 embodiment 64～66 and content
The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.First by Toxicity Determination, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR < 0.5 is antagonism, 0.5≤SR≤1.5 are summation action, SR > 1.5 is synergistic effect, on this basis, then carries out field trial.
Test method: after the effective inhibition concentration scope of each medicament is determined in prerun, medicament is established respectively 5 dosage processing by active constituent content, establishes clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt mycelial growth rate method to measure the virulence of medicament to crop germ.After 72h, measure colony diameter by right-angled intersection method, calculate each processing net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value to (x), tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates thus the EC50 value of every kind of medicament.Calculate the different proportioning synergy ratios of two medicaments (SR) according to Wadley method, SR < 0.5 is antagonism simultaneously, and 0.5≤SR≤1.5 are summation action, and SR > 1.5 is synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active components A and active component B shared ratio in combination;
A is azoles mepanipyrim;
B is selected from the one in fluazinam, pyridine bacterium amine, fluopicolide or Guardian.
Application Example two:
For trying disease: potato late blight, test medicine provides by Shanxi Thompson Biological Technology Co., Ltd., experimental scheme: effective inhibition concentration scope of determining the two different proportioning mixture of azoles mepanipyrim and fluazinam through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to potato late blight of table 9 azoles mepanipyrim and fluazinam
As shown in Table 9, the proportioning of the composite control potato late blight of azoles mepanipyrim and fluazinam is in the time of 1 ︰ 70 ~ 70 ︰ 1, synergy ratio SR is all greater than 1.5, illustrate that both all show synergistic effect at mixture in 1 ︰ 70 ~ 70 ︰ 1 scopes, the proportioning of azoles mepanipyrim and fluazinam was at 1: 20～20: 1, synergistic effect is more outstanding, and synergy ratio is all more than 2.20.Test and find that the proportioning of azoles mepanipyrim and fluazinam is 20 ︰ 1,15 ︰ 1,10 ︰ 1,9 ︰ 1,8 ︰ 1,7 ︰ 1,6 ︰ 1,5 ︰ 1,4 ︰ 1,3 ︰ 1,2 ︰ 1,1 ︰ 1,1 ︰ 2,1 ︰ 3,1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 15,1 ︰ 20 through applicant, synergy ratio maximum when wherein azoles mepanipyrim and fluazinam weight ratio are 1:1, synergistic effect is the most obvious.
Application Example three:
For examination disease: graw mold of tomato, test medicine provides by Shanxi Thompson Biological Technology Co., Ltd., experimental scheme: effective inhibition concentration scope of determining azoles mepanipyrim and the former medicine of pyridine bacterium amine and the two different proportioning mixture through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to graw mold of tomato of table 10 azoles mepanipyrim and pyridine bacterium amine
As shown in Table 10, the proportioning of azoles mepanipyrim and the composite control graw mold of tomato of pyridine bacterium amine is in the time of 1 ︰ 70 ~ 70 ︰ 1, synergy ratio SR is all greater than 1.5, illustrate that both all show synergistic effect at mixture in 1 ︰ 70 ~ 70 ︰ 1 scopes, the proportioning of azoles mepanipyrim and pyridine bacterium amine was at 1: 10～30: 1, synergistic effect is more outstanding, and synergy ratio is all more than 2.25.Test and find that the proportioning of azoles mepanipyrim and pyridine bacterium amine is 30 ︰ 1,25 ︰ 1,20 ︰ 1,19 ︰ 1,18 ︰ 1,17 ︰ 1,16 ︰ 1,15 ︰ 1,14 ︰ 1,13 ︰ 1,12 ︰ 1,11 ︰ 1,10 ︰ 1,9 ︰ 1,8 ︰ 1,7 ︰ 1,6 ︰ 1,5 ︰ 1,4 ︰ 1,3 ︰ 1,2 ︰ 1,1 ︰ 1,1 ︰ 5,1 ︰ 10 through applicant, synergy ratio maximum when wherein azoles mepanipyrim and pyridine bacterium amine weight ratio are 9:1, synergistic effect is the most obvious.
Application Example four:
For trying disease: downy mildew of garpe, test medicine provides by Shanxi Thompson Biological Technology Co., Ltd., experimental scheme: effective inhibition concentration scope of determining the former medicine of azoles mepanipyrim and fluopicolide and the two different proportioning mixture through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to downy mildew of garpe of table 11 azoles mepanipyrim and fluopicolide
As shown in Table 11, the composite proportioning of preventing and treating downy mildew of garpe of azoles mepanipyrim and fluopicolide is in the time of 1 ︰ 70 ~ 70 ︰ 1, synergy ratio SR is all greater than 1.5, illustrate that both all show synergistic effect at mixture in 1 ︰ 70 ~ 70 ︰ 1 scopes, the proportioning of azoles mepanipyrim and fluopicolide was at 1: 20～20: 1, synergistic effect is more outstanding, and synergy ratio is all more than 2.20.Test and find that the proportioning of azoles mepanipyrim and fluopicolide is 20 ︰ 1,15 ︰ 1,10 ︰ 1,9 ︰ 1,8 ︰ 1,7 ︰ 1,6 ︰ 1,5 ︰ 1,4 ︰ 1,3 ︰ 1,2 ︰ 1,1 ︰ 1,1 ︰ 2,1 ︰ 3,1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 15,1 ︰ 20 through applicant, synergy ratio maximum when wherein azoles mepanipyrim and fluopicolide weight ratio are 1:1, synergistic effect is the most obvious.
Application Example five:
For trying disease: cucumber downy mildew, test medicine provides by Shanxi Thompson Biological Technology Co., Ltd., experimental scheme: effective inhibition concentration scope of determining the former medicine of azoles mepanipyrim and Guardian and the two different proportioning mixture through preliminary experiment.
Toxicity test result
The composite toxicity test analysis of results table to cucumber downy mildew of table 12 azoles mepanipyrim and Guardian
As shown in Table 12, the proportioning of the composite control cucumber downy mildew of azoles mepanipyrim and Guardian is in the time of 1 ︰ 70 ~ 70 ︰ 1, synergy ratio SR is all greater than 1.5, illustrate that both all show synergistic effect at mixture in 1 ︰ 70 ~ 70 ︰ 1 scopes, the proportioning of azoles mepanipyrim and Guardian was at 1: 20～20: 1, synergistic effect is more outstanding, and synergy ratio is all more than 2.20.Test and find that the proportioning of azoles mepanipyrim and Guardian is 20 ︰ 1,15 ︰ 1,10 ︰ 1,9 ︰ 1,8 ︰ 1,7 ︰ 1,6 ︰ 1,5 ︰ 1,4 ︰ 1,3 ︰ 1,2 ︰ 1,1 ︰ 1,1 ︰ 2,1 ︰ 3,1 ︰ 4,1 ︰ 5,1 ︰ 6,1 ︰ 7,1 ︰ 8,1 ︰ 9,1 ︰ 10,1 ︰ 15,1 ︰ 20 through applicant, synergy ratio maximum when wherein azoles mepanipyrim and Guardian weight ratio are 3:2, synergistic effect is the most obvious.
Find through test: after azoles mepanipyrim and active component B are composite, the control of the downy mildew in various crop, epidemic disease, peronospora tabacina, gray mold, powdery mildew, rice blast, damping off is had to obvious synergistic effect, synergy ratio is all more than 1.5.
Effect experiment part: test medicine is researched and developed, provided by Shanxi Thompson Biological Technology Co., Ltd., contrast medicament 20% azoles mepanipyrim suspending agent (autogamy), 500gL fluazinam suspending agent (commercial), 5% pyridine bacterium amine suspending agent (autogamy), 20% fluopicolide suspending agent (autogamy), 12.5% Guardian wetting powder (commercial).
Application Example six azoles mepanipyrims and active component B and the composite control potato late blight test of pesticide effectiveness thereof
This experimental establishment, at Shaanxi Province's Weinan City, is investigated the potato late blight state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 13 azoles mepanipyrim and active component B and the composite control potato late blight test of pesticide effectiveness thereof
As can be seen from Table 13, azoles mepanipyrim and active component B and composite after can effectively prevent and treat potato late blight, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
Application Example seven azoles mepanipyrims and active component B and the composite control cucumber downy mildew test of pesticide effectiveness thereof
This test arrangement, in Jingyang County, Shaanxi Province, is investigated the cucumber downy mildew state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 3 days, 7 days, 15 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 14 azoles mepanipyrim and active component B and the composite control cucumber downy mildew test of pesticide effectiveness thereof
As can be seen from Table 14, azoles mepanipyrim and active component B and composite after can effectively prevent and treat cucumber downy mildew, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long, target crop is had no adverse effects in scope of medication in test.Cucumber rhizoctonia rot, gray mold, powdery mildew are also had to good preventive effect, drug effect is up to more than 96% simultaneously.
Application Example eight azoles mepanipyrims and active component B and the composite control rice blast test of pesticide effectiveness thereof
This test arrangement, at Shaanxi Province's Hanzhong City, is investigated the rice blast state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 15 azoles mepanipyrim and active component B and the composite control rice blast test of pesticide effectiveness thereof
As can be seen from Table 15, azoles mepanipyrim and active component B and composite rear efficiency control rice blast thereof, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.Rice seedling blight is also had to good preventive effect, drug effect is up to more than 96% simultaneously.
Application Example nine azoles mepanipyrims and active component B and the composite control grape grey mould test of pesticide effectiveness thereof
This test arrangement, at Shaanxi Province's Weinan City, is investigated the grape grey mould state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 16 azoles mepanipyrim and active component B and the composite control grape grey mould test of pesticide effectiveness thereof
As can be seen from Table 16, azoles mepanipyrim and active component B and composite after can effectively prevent and treat grape grey mould, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.Grape powdery mildew, downy mildew are also had to good preventive effect, drug effect is up to more than 96% simultaneously.
Application Example ten azoles mepanipyrims and active component B and the composite control tomato blight test of pesticide effectiveness thereof
This test arrangement, in Xi'an City, Shanxi Province, is investigated the tomato blight state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 17 azoles mepanipyrim and active component B and the composite control tomato blight test of pesticide effectiveness thereof
As can be seen from Table 17, azoles mepanipyrim and active component B and composite after can effectively prevent and treat tomato blight, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.Graw mold of tomato is also had to good preventive effect, drug effect is up to more than 96% simultaneously.
Application Example 11 azoles mepanipyrims and active component B and the composite control peronophythora litchi test of pesticide effectiveness thereof
This test arrangement, in Zengcheng City of Guangdong Province, is investigated the peronophythora litchi state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once, is total to dispenser 2 times.Within after dispenser 7 days, 14 days, 30 days for the second time, investigate respectively disease index and calculate preventive effect.Experimental result is as follows:
Table 18 azoles mepanipyrim and active component B and the composite control peronophythora litchi test of pesticide effectiveness thereof
As can be seen from Table 18, azoles mepanipyrim and active component B and composite after can effectively prevent and treat peronophythora litchi, control efficiency is all better than the preventive effect of single dose, and the preventive effect phase is long.In test scope of medication, target crop is had no adverse effects.
After draw through different local throughout the country tests, azoles mepanipyrim and fluazinam, pyridine bacterium amine, fluopicolide, Guardian composite rear to the preventive effect of the Common Diseases such as the downy mildew in various crop, epidemic disease, peronospora tabacina, gray mold, powdery mildew, rice blast, damping off all more than 95%, be better than single dose preventive effect, synergistic effect is obvious.
Claims (6)
1. the bactericidal composition containing azoles mepanipyrim, effective active composition is active components A and active component B, it is characterized in that: the weight ratio of active components A and active component B is 1: 70～70: 1, described active components A is selected from azoles mepanipyrim, and active component B is selected from the one in fluazinam, pyridine bacterium amine, fluopicolide or Guardian.
2. the bactericidal composition containing azoles mepanipyrim according to claim 1, is characterized in that: the weight ratio of active components A and active component B is 1: 50～50: 1.
3. the bactericidal composition containing azoles mepanipyrim according to claim 2, is characterized in that:
The weight ratio of azoles mepanipyrim and fluazinam is 1: 20～20: 1;
The weight ratio of azoles mepanipyrim and pyridine bacterium amine is 1: 10～30: 1;
The weight ratio of azoles mepanipyrim and fluopicolide is 1: 20～20: 1;
The weight ratio of azoles mepanipyrim and Guardian is 1: 20～20: 1.
4. according to the bactericidal composition containing azoles mepanipyrim described in any one in claim 1～3, it is characterized in that: composition is made wetting powder, water dispersible granules, suspending agent, aqueous emulsion, microemulsion, suspension emulsion, microcapsule suspending agent or microcapsule suspension-suspending agent.
5. the bactericidal composition containing azoles mepanipyrim according to claim 4 is for preventing and treating the purposes of crop pest.
6. purposes according to claim 5, is characterized in that: described disease is downy mildew, epidemic disease, peronospora tabacina, gray mold, powdery mildew, rice blast or damping off.
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| WO2011108759A2 (en) * | 2010-03-03 | 2011-09-09 | Sumitomo Chemical Company, Limited | Plant disease controlling composition and method for controlling plant disease |
| WO2011131602A2 (en) * | 2010-04-20 | 2011-10-27 | Basf Se | Fungicidal mixtures based on azolopyrimmidinylamines |
| CN102318622A (en) * | 2005-07-27 | 2012-01-18 | 巴斯夫欧洲公司 | Fungicidal mixture based on azoles and pyrimidine radicals amine |
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|---|---|---|---|---|
| CN102318622A (en) * | 2005-07-27 | 2012-01-18 | 巴斯夫欧洲公司 | Fungicidal mixture based on azoles and pyrimidine radicals amine |
| WO2011108759A2 (en) * | 2010-03-03 | 2011-09-09 | Sumitomo Chemical Company, Limited | Plant disease controlling composition and method for controlling plant disease |
| WO2011131602A2 (en) * | 2010-04-20 | 2011-10-27 | Basf Se | Fungicidal mixtures based on azolopyrimmidinylamines |
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