CN103860774A - Traditional Chinese medicine composition for treating dysentery and haemorrhoids and preparation method - Google Patents
Traditional Chinese medicine composition for treating dysentery and haemorrhoids and preparation method Download PDFInfo
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- CN103860774A CN103860774A CN201410106095.5A CN201410106095A CN103860774A CN 103860774 A CN103860774 A CN 103860774A CN 201410106095 A CN201410106095 A CN 201410106095A CN 103860774 A CN103860774 A CN 103860774A
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Abstract
The invention relates to a traditional Chinese medicine composition for treating dysentery and haemorrhoids and a preparation method. The composition is characterized by having the functions of clearing away heat and toxic materials, stopping bleeding and preventing inflammations, stopping dysentery and relieving pains, purging gut and relaxing the bowels, inducing diuresis and reducing edema, dispelling wind and removing obstruction in the meridians and the like. The matrix is prepared from the traditional Chinese medicine compositions according to weight part and an excipient in the pharmaceutical sense: scutellaria baicalensis, amaranthus spinosus, angelica sinensis, verbena, long stephania herb, eclipta alba, divaricate saposhnikovia roots, immature bitter oranges and the like. The traditional Chinese medicine composition provided by the invention can relax the bowels and stop dysentery with two-ways regulation. The traditional Chinese medicine composition has the effect of safe, wide and convenient general treatment on intestinal disease such as dysentery and haemorrhoids. At present, in the 6 cases of patients with haemorrhoids are treated by the composition, the youngest patient is 12 years old, the oldest is 55 years old, and the longest course of disease is 13 years. All the patients are cured. In 22 cases of patients with dysentery, the patients are cured in half a day in the fastest manner, and the patients are cured in the lowest manner in three days. In 7 cases of patients with constipation, defecation is completed by delivering the composition once.
Description
[technical field]
A kind of Chinese medicine composition and method for making for the treatment of the disease such as dysentery and hemorrhoid of this disclosure of the invention, is characterized in that having heat-clearing and toxic substances removing, the effect such as hemostasis antiinflammatory, dysentery relieving pain relieving, bowel relieving relieving constipation, inducing diuresis and reducing edema, dispelling wind and removing obstruction in the collateral.
[background technology]
Hemorrhoid are a kind of common diseases that are positioned at anus position, and any age all can fall ill, but with age, sickness rate increases gradually.In China, hemorrhoid are modal anal and intestinal diseases, have the saying of " ten male nine hemorrhoid ", " ten female's ten hemorrhoid ".Mainly contain two kinds of theories about the cause of disease of hemorrhoid.First be varicosis theory, think hemorrhoid be under distal rectal mucosa and anal canal skin under the vein group that forms of venous plexus congestion, expansion and flexing.But the anus pad that current well accepted theory is Thomson moves down theory, think that hemorrhoid are the normal anatomical structures in anal canal position originally, i.e. blood vessel pad, is the ring-type cavernous transformation taeniae telarum of pectinate line and above 1.5cm.While only having anus pad tissue occur extremely and be associated with symptom, just can be called hemorrhoid, just need treatment, therapeutic purposes are to remove symptom, and non-elimination hemorrhoid body.
Clinical main manifestations: have blood in stool, that the character of having blood in stool can be is painless, intermittent, blood after an action of the bowels, just time, bleed or toilet paper on be with blood, constipation, drink or take food irritable food postemphasis.Pure internal hemorrhoid, can be hemorrhage without only falling inflation sense of pain, is developed to prolapsus, just occurs pain while merging thrombosis, incarceration, infection.. internal hemorrhoid is divided into 4 degree: 1. hemorrhage when I degree defecation, and hemorrhage can stopping voluntarily after an action of the bowels, hemorrhoid are not deviate from anus; 2. II degree is often had blood in stool; When defecation, deviate from anus, after defecation, automatically also receive; 3. III degree hemorrhoid need after deviating from that hands is auxiliary also to be received; IV degree hemorrhoid outside anus, can not also be received for a long time: wherein, internal hemorrhoid multiform more than II degree becomes mixed hemorrhoid, and the symptom that shows as internal hemorrhoid and external hemorrhoid exists simultaneously, can occur pain discomfort, pruritus, and when wherein pruritus is often deviate from due to hemorrhoid, toughness secretions flows out.The many one-tenth of rear three degree mixed hemorrhoid.External hemorrhoid, at ordinary times without characteristic symptom, can have swelling, pain while there is thrombosis and inflammation.
Cause the etiology and pathogenesis multiterminal of hemorrhoid.As improper diet, raw food is rich, moxibustion, and the sitting walking for a long time of standing for a long time, so that internal organs imbalance of YIN and YANG, the corruption of intestinal mansion is not normal, accumulates wet accumulated heat, defecate not smooth, because of damp invasion of lower energizer anorectal, thermal burn yin collaterals, the mad row of heat in blood, so the hematochezia of defecating.Not smooth because of local QI-blood circulation, swell and ache and cause rectum.Damp and hot inner product, taste abnormal ascending-descending of QI, heat smokes in upper dry mouth with bitter taste stomach not each, therefore appetite owes to shake.Intestinal internal organs is damp and hot does not dispel, and internal organs gas is not smooth, and large dry stool is long-pending to be difficult to resolve, hematochezia often just time.The etiology and pathogenesis of hemorrhoid is except above-mentioned, also relevant with wind, the exopathogen such as dry, wet, hot.Chamber is excessive in addition, or because of chronic diarrhea chronic dysentery, prolonged constipation, gestation is produced, abdominal tumor compressing etc.
The harm of hemorrhoid: one, have blood in stool, bleed and serious spray blood all will cause iron deficiency anemia, even infect.Two,, because secretions increase overflows outside anus, not only pollution clothes, also easily causes pain eczema, for female patient, also will cause the outbreak of some gynaecopathias etc.Three, constipation, constipation due to dry stool, be easy to squeeze and hinder blood stasis so that have blood in stool, very painful when patient Chang Yin defecation, so bear by force inconvenience, makes stool drier, so repeatedly, forms vicious cycle.Four, have blood in stool, this vicious cycle of pain and constipation, make people's anorexia, cause the not normal and malnutrition of the not normal and whole human body balance of spleen and stomach function, easily cause the generations such as hepatorenal disease, chronic colitis, anal fistula, intestinal cancer.
Asymptomatic hemorrhoid do not need treatment; Symptomatic hemorrhoid are without radical cure; Take non-operative treatment as main.Expectant treatment is invalid, and hemorrhoid are deviate from seriously, and the treatment such as larger fibrosis internal hemorrhoid, injection is not good, merges anal fissure, anal fistula etc. and needs operative treatment.Develop into and need operative treatment from the hemorrhoid of lighter symptom, because do not take treatment, do not note adjusting daily life often, cause due to hemorrhoid show effect repeatedly.
Dysentery, ancient title intestinal is warded off, dysentery.For one of acute infectious intestinal disease.Clinical take heating, stomachache, tenesmus, stool containing pus and blood as cardinal symptom.If infect epidemic disease poison, sharply, companion is high heat suddenly in morbidity, and coma, convulsions person, be fulminant dysentery.Dysentery is from the beginning of, foreknowledge stomachache, dysentery then, day and night for several times to tens of times not etc.Be mainly in summer and autumn, by damp and hot heresy, disorder of the spleen and stomach caused by internal damage, causes dysfunction of the spleen in transportation, and stomach loses food stagnation removing, more holds under the arm stagnantly, ferments intestinal and forms.The dysentery that the traditional Chinese medical science is said, had both been equal to the dysentery of modern medicine, also comprised amebic dysentery, ulcerative colitis, allergic colitis and some other intestinal infection, the intestinal development of evil in febrile disease causing such as poisoning, the disease of absorption function imbalance.
Modern medicine thinks that the pathogeny of dysentery is mainly that antibacterial, virus, fungus and parasite etc. cause, take colon or terminal ileum suppurative inflammation as major lesions.Make intestinal mucosa impaired because produce inside and outside toxin after dysentery bacterium invasion and attack, diseased region has apocyte to infiltrate, and forms abscess or ulcer.The congested enlargement of the local mesenteric lymph node of pathological changes.The main pathological change of toxic dysentery is that whole body small artery vessel wall permeability increases, and makes the serious edema of blood vessel wall surrounding tissue, and edema appears in internal organs (as brain, liver, kidney and adrenal gland etc.).In the time that people's resistance reduces, dysentery bacterium enters small intestinal amount reproduction through stomach, some death antibacterial discharge endotoxin, stimulate intestinal wall that its permeability is increased.Be absorbed into the toxin of blood flow, finally can discharge from mucous membrane of colon, make adaptive colitis and cause mucosal injury, on this basis, other antibacterials of dysentery bacterium and intestinal breed under mucomembranous surface and mucosa, further produce destruction, and reaction causes inflammation.The initial stage of morbidity, endotoxin and the inflammatory stimulus intestinal wall teleneuron of dysentery bacterium secretion, and cause that intestinal tube spasm, enterokinesia increase, intestinal wall absorb moisture minimizing and intestinal wall blood vessel serosity oozes out, and there is diarrhoea; After this, intestinal mucosa diffusivity congestion and edema, a large amount of neutrophil infiltration, ooze out with a large amount of mucus and cellulose, finally form ulcer, hemorrhage, just occur mucopurulent bloody stool.
Hemorrhoid and dysentery are both intestinal tract disease, most dysentery (except deficiency and coldness dysentery) and hemorrhoid be because of wind, the exopathogen such as dry, wet, hot relevant, can " logical because of extensively treating ", but it is little to treat at present the medicine of hemorrhoid and dysentery simultaneously, under the Chinese medicine of most treatment hemorrhoid is taken and can be caused and rush down.The Chinese medicine composition energy relieving constipation of this invention also can dysentery relieving, two-ways regulation, " logical because of extensively treating ", and for dysentery, enteritis, Stomach duodenum ulcerative hemorrhage, swelling and pain of hemorrhoid, hemorrhoidal hemorrhage, constipation, the general wide convenience of safety.
[summary of the invention]
A kind of Chinese medicine composition and method for making for the treatment of the disease such as dysentery and hemorrhoid of this disclosure of the invention.
The object of this invention is openly a kind of Chinese medicine composition and method for making for the treatment of the disease such as dysentery and hemorrhoid, it is characterized in that thering is heat-clearing and toxic substances removing, the effect such as hemostasis antiinflammatory, dysentery relieving pain relieving, bowel relieving relieving constipation, inducing diuresis and reducing edema, dispelling wind and removing obstruction in the collateral, for dysentery, enteritis, Stomach duodenum ulcerative hemorrhage, swelling and pain of hemorrhoid, hemorrhoidal hemorrhage, constipation, substrate is prepared from by excipient in following Chinese medicine composition and pharmacy meaning:
Radix Scutellariae Amaranthusspinosus L. Radix Angelicae Sinensis Herba Verbenae Herba Stephaniae Longae Herba Ecliptae Radix Saposhnikoviae Fructus Aurantii Immaturus.
Present composition pharmacology is:
Radix Scutellariae: bitter in the mouth is cold in nature, enters lung, the heart, gallbladder, large intestine channel, has heat clearing and damp drying, eliminating fire and detoxication, antiabortive function, and fever disease in summer vomiting uncomfortable in chest, cough due to lung-heat, bleeding due to blood-heat, high hot excessive thirst, damp-heat diarrhea etc. are had to good efficacy." Bencao Jingshu ": Radix Scutellariae, its property is respectful clearly, so evil removing: so bitter in the mouth dampness; So YIN-cold victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, the disease of all damp and hot victory also, is analysed it, the white recover of all diseases.Bitter cold can be except damp and hot, thus small intestinal profit and water from by, source is clearly flowed also clean.Modern study test Radix Scutellariae has inhibitory action to dysentery bacterium, Bacillus typhi, Salmonella paratyphi, vibrio cholera, escherichia coli, Bacillus proteus, bacillus pyocyaneus, staphylococcus, hemolytic vessel used to hold grain at the imperial sacrifice coccus (a, B), Diplococcus pneumoniae, diphtheria corynebacterium etc.
Amaranthusspinosus L.: slightly sweet flavor, micro-bitterness, cool in nature.Enter lung, liver, large intestine channel, clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, cooling blood for hemostasis.For dysentery, enteritis, Stomach duodenum ulcerative hemorrhage, swelling and pain of hemorrhoid, hemorrhoidal hemorrhage, thyromegaly, cholecystitis, calculus, constipation, infantile carbuncle; Venom is controlled in external, skin eczema, furuncle and phyma pus infections.
Radix Angelicae Sinensis: sweet in the mouth, pungent, bitter; Warm in nature.Return liver, the heart, spleen channel.Enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.Cure mainly all cards of blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.Modern study shows that Radix Angelicae Sinensis all has antibacterial action to external dysentery, typhoid fever, paratyphoid fever, escherichia coli, diphtheria corynebacterium, vibrio cholera and a, B Hemolytic streptococcus etc.Can reduce mice capillary permeability.External can be accelerated rabbit ear wound healing, and contrafluxion, leukocyte and fiber are infiltrated, and newborn epithelium regeneration has hemostasis and strengthens peripheral circulation effect local organization.Illustrate that Radix Angelicae Sinensis has antibacterial, antiinflammation.
Herba Verbenae: bitter in the mouth, cool in nature.Return liver, spleen channel.Heat-clearing and toxic substances removing; Promoting blood circulation to restore menstrual flow; Inducing diuresis to remove edema; Preventing the attack (or recurrence) of malaria; For lump in the abdomen, amenorrhea dysmenorrhea, acute gastroenteritis, bacillary dysentery, hepatitis, nephritis, edema, urinary tract infection, hemorrhoid etc.
Herba Stephaniae Longae: puckery, hardship, cold in nature, enter spleen kidney channel.There is heat-clearing and toxic substances removing, dampness removing, detumescence, relieving constipation, dispelling wind and removing obstruction in the collateral, go to amass effect of pain relieving.Cure mainly: diarrhoea, acute nephritis, bacillary dysentery, mastitis, carbuncle skin ulcer redness, rheumatic arthritis, sciatica, hernia, dysuria, finger skin ulcer, traumatic injury, control calentura and go mad, jaundice, gastroenteritis, dysentery, constipation, hematuria, nebulousurine, sore and toxic, can promoting regeneration of the tissue and arresting bleeding.
Herba Ecliptae: sweet in the mouth, acid, cold in nature.Return liver, kidney channel.Nourishing the liver and kidney, cooling blood for hemostasis.Modern study this product has the body of raising non-specific immunity; eliminate oxygen-derived free radicals to suppress 5-lipoxygenase; protection chromosome; protect the liver; promote hepatocellular regeneration, increase coronary flow, extend the life of mice under normobaric hypoxia; improve the survival rate of mice in hypobaric hypoxia situation, and have calmness, analgesia, promotion hair growth, make hair blackening, hemostasis, antibacterial, anti-ameba, the effect such as anticancer.
Radix Saposhnikoviae: acrid in the mouth; Sweet; Slightly warm in nature.Return urinary bladder channel; Lung meridian; Spleen channel; Liver Channel.Energy expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.Cure mainly: affection of exogenous wind-cold; Headache general pain; Rheumatic arthralgia; Joint is ached; Stomachache is had loose bowels; Discharging fresh blood stool; Tetanus; Rubella pruritus; Skin infection from the beginning of.
Fructus Aurantii Immaturus: bitter in the mouth is pungent; Cold in nature.Return spleen; Stomach; Liver; The heart; Large intestine channel.Cure mainly: in stagnant, stop; Feeling of fullness distending pain; Constipation; Heavy after dysentery; Blocked-up chest; Gastroptosis; Uterine prolapse; Proctoptosis.
Treat hemorrhoid 6 examples with the present invention, 12 years old of age minimum, maximum 55 years old, what wherein the course of disease was the longest had 13 years, all recovery from illness; Treatment dysentery 22 examples, the fastest recovery from illness half a day, recovery from illness in the longest 3 days; Treatment constipation 7 examples, all take once and discharge.
The preparation method of the present composition and step are:
Method for making one:
Each composition weight ratio is:
Radix Scutellariae: Amaranthusspinosus L.: Radix Angelicae Sinensis: Herba Verbenae: Herba Stephaniae Longae: Herba Ecliptae: Radix Saposhnikoviae: Fructus Aurantii Immaturus=(1-2): (2-4): (1-2): (1-3): (1-3): (2-4): (1-2): (1-2).By above-mentioned raw materials rinsing airing, vacuum drying, is crushed and screened into fine powder, mixes with appropriate auxiliary material, makes various shape agent in pharmacy meaning.
Method for making two:
Each composition weight ratio is:
Radix Scutellariae (50-200) part, Amaranthusspinosus L. (150-800) part, Radix Angelicae Sinensis (60-300) part, Herba Verbenae (150-500) part, Herba Stephaniae Longae (150-600) part, Herba Ecliptae (100-800) part, Radix Saposhnikoviae (50-200) part, Fructus Aurantii Immaturus (50-200) part.
(1) adopt the method for water distillation to extract after volatile oil Radix Angelicae Sinensis, Radix Saposhnikoviae, Fructus Aurantii Immaturus, with Radix Scutellariae, Amaranthusspinosus L., Herba Verbenae, Herba Stephaniae Longae, Herba Ecliptae etc., adopt water to decoct or with alcohol reflux, extracting solution is condensed into after fluid extract, add volatile oil, mix with appropriate auxiliary material, make various shape agent in pharmacy meaning;
(2) first adopt water to decoct Radix Scutellariae, Amaranthusspinosus L., Radix Angelicae Sinensis, Herba Verbenae, Herba Stephaniae Longae, Herba Ecliptae, Radix Saposhnikoviae, Fructus Aurantii Immaturus eight taste medical materials, collect volatile oil simultaneously, then filter, by eight taste medical material alcohol reflux, extracting solution is merged and is condensed into after fluid extract, add volatile oil, mix with appropriate auxiliary material, make various shape agent in pharmacy meaning;
(3) the part pulverizing medicinal materials in Radix Scutellariae, Amaranthusspinosus L., Radix Angelicae Sinensis, Herba Verbenae, Herba Stephaniae Longae, Herba Ecliptae, Radix Saposhnikoviae, Fructus Aurantii Immaturus eight taste medical materials is become to fine powder, remaining medical material adopts water to decoct or with alcohol reflux, extracting solution is condensed into after fluid extract, mix with fine powder and appropriate auxiliary material, make various shape agent in pharmacy meaning;
(4) the part pulverizing medicinal materials in Radix Scutellariae, Amaranthusspinosus L., Radix Angelicae Sinensis, Herba Verbenae, Herba Stephaniae Longae, Herba Ecliptae, Radix Saposhnikoviae, Fructus Aurantii Immaturus eight taste medical materials is become to fine powder, remaining Radix Angelicae Sinensis, Radix Saposhnikoviae, Fructus Aurantii Immaturus adopts the method for water distillation to extract after volatile oil, adopt water to decoct with the medical material such as remaining Radix Scutellariae, Amaranthusspinosus L., Herba Verbenae, Herba Stephaniae Longae, Herba Ecliptae or with alcohol reflux, extracting solution is condensed into after fluid extract, add volatile oil, mix with fine powder and appropriate auxiliary material, make various shape agent in pharmacy meaning.
In above-mentioned preparation method, if water decocts, add the water of 4～10 times of weight, decoct 0.5 hour～3 hours, decoct 1～4 time, preferably add the water of 8 times of amounts, decoct 1 hour, decoct 3 times; If with alcohol reflux, add the ethanol of 4～12 times of amounts, reflux, extract, 0.5～3 hour, extracts 1～4 time, preferably adds the ethanol (concentration 50%～70%) of 10 times of amounts to extract 3 times, each 1 hour; If first water decocts, rear with alcohol reflux, preferably add the water of 8 times of amounts, decoct 1 hour, decoct 2 times, then add the ethanol (concentration 50%～70%) of 10 times of amounts to extract 2 times, each 1 hour.Radix Angelicae Sinensis, Radix Saposhnikoviae, Fructus Aurantii Immaturus adopt the method for water distillation and extraction volatile oil to be: medical material is placed in to the container of sealing, adds the water of 4～10 times of weight, connect reflux, decoct or distill 2～4 hours, collect volatile oil simultaneously.Also the volatile oil of collecting can be carried out to beta-cyclodextrin inclusion compound, make it more stable, be convenient to join in powder or granule.
In above-mentioned preparation method, part pulverizing medicinal materials being become to fine powder, is the application in order to reduce adjuvant, is also for drug effect, and the medical material of pulverizing can be all or part of of single medical material, can be also a part for a few taste medicines.
In above-mentioned preparation method, the excipient substance adding can be one or more the combination in starch, Mel, sucrose, magnesium stearate, sorbitol, microcrystalline cellulose, micropowder silica gel, carboxymethyl starch sodium, lactose.In the situation that not violating the design's spirit, the medicine that can also add has: Flos Lonicerae, Fructus Forsythiae, Radix Isatidis, Herba Houttuyniae, Herba Portulacae, the Radix Pulsatillae, native Lignum Dalbergiae Odoriferae, Radix Notoginseng, Radix Rehmanniae, Radix Et Rhizoma Rhei, Flos Sophorae, Fructus Cannabis, Poria, Rhizoma Coptidis, Rhizoma Imperatae, Herba Plantaginis, Cacumen Platycladi, Radix Sanguisorbae, the Fructus Sophorae, Radix Cirsii Japonici, Herba Cirsii, Pollen Typhae, Herba Agrimoniae, Folium Callicarpae Macrophyllae, the Radix Aucklandiae, Herba Acalyphae, Herba Schizonepetae, Radix Stephaniae Japonicae, Colla Corii Asini, Herba Taraxaci, Herba Violae, Cortex Magnoliae Officinalis, Herba Menthae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Alismatis, Semen Coicis, Herba Pogostemonis etc., the combination of wherein one or more.
Medicine of the present invention is prepared preferably capsule, tablet, granule, oral solutions, also can make any dosage form, as: powder, pill, unguentum, mixture, syrup, injection, note agent, liniment, suppository etc.In the time that said medicine combination is prepared into medicament, as required, can add other excipient, as: flavoring agent, solubilizing agent, suspensoid, dilution, disintegrating agent, lubricant etc.Coating can be sugar-coat, film-coat, enteric coating etc.
The test of pesticide effectiveness of the present invention shows:
Anastalsis of the present invention: experiment shows that anastalsis is obvious, can obviously shorten bleeding time and the amount of bleeding of rat.With negative control group ratio, the bleeding time shortens 1.2 times, and amount of bleeding is fewer more than 1 times than negative control group; With " formulary of peaceful benevolent dispensary " " Pilulae Fructus Sophorae " side, (Isodose, same dosage form, same processing method) in contrast test, the present composition is better than " Pilulae Fructus Sophorae " side, and the bleeding time obviously shortens, amount of bleeding is obviously few, wherein, in median dose contrast, the bleeding time is short by 40%.
Anti-infectious function of the present invention: experiment shows that anti-infectious function is obvious.On rat traumatic infection model, rat bacillary dysentery model, big or middle dosage is obviously better than " formulary of peaceful benevolent dispensary " " Pilulae Fructus Sophorae " side (Isodose, same dosage form, same processing method), and speed of wound healing is obviously fast.
Analgesic effect of the present invention: experiment shows there is certain analgesic effect.On the trauma model of rat tail, be obviously better than negative control group.
Antiinflammatory action of the present invention: experiment shows that the present invention has antiinflammatory action.Can suppress the mice ear degree that dimethylbenzene causes, can reduce mice acetic acid and cause scorching capillary permeability.
Bowel relieving defecating feces excretion of the present invention: normal person takes this product, defecation frequency increases, and feces is shaped normal, and feces surface is glossy glossy.Constipation person takes this product, and after clothes, be defecation half an hour.
[specific embodiment]
Following specific embodiment is detailed description of the invention, should not be understood as limitation of the present invention.
Embodiment 1:
100 grams of Radix Scutellariaes, 200 grams of Amaranthusspinosus L., 100 grams of Radix Angelicae Sinensis, 100 grams of Herba Verbenae, 100 grams of Herba Stephaniae Longaes, 200 grams of Herba Ecliptaes, 100 grams of Radix Saposhnikoviaes, 100 grams of Fructus Aurantii Immaturuss, by above-mentioned raw materials rinsing airing, vacuum drying, pulverized 60 mesh sieves, became fine powder, mixed, every 100 grams of powder add refined honey 120-150 and restrain into honeyed pill, 10 grams, every ball.
Embodiment 2:
200 grams of Radix Scutellariaes, 500 grams of Amaranthusspinosus L., 200 grams of Radix Angelicae Sinensis, 200 grams of Herba Verbenae, 200 grams of Herba Stephaniae Longaes, 500 grams of Herba Ecliptaes, 200 grams of Radix Saposhnikoviaes, 200 grams of Fructus Aurantii Immaturuss, adopt the method for water distillation to extract after volatile oil Radix Angelicae Sinensis, Radix Saposhnikoviae, Fructus Aurantii Immaturus, mix with Radix Scutellariae, Amaranthusspinosus L., Herba Verbenae, Herba Stephaniae Longae, Herba Ecliptae etc., add 22 premium on currency, decoct 1 hour, decoct 3 times, extracting solution is condensed into after fluid extract, mixes with appropriate Icing Sugar, granulate, be dried, spray into volatile oil, seal 12 hours, make drug particles.
Embodiment 3:
250 grams of Radix Scutellariaes, 500 grams of Amaranthusspinosus L., 250 grams of Radix Angelicae Sinensis, 300 grams of Herba Verbenae, 300 grams of Herba Stephaniae Longaes, 500 grams of Herba Ecliptaes, 250 grams of Radix Saposhnikoviaes, 250 grams of Fructus Aurantii Immaturuss, 20 premium on currency, the container that adds together sealing, connects reflux, decocts, extract volatile oil 2 hours, leach extracting solution, then adding concentration is 22 liters of 60% ethanol, reflux, extract, 1 hour, extract 2 times, by after extracting solution recovered alcohol, extracting solution is condensed into fluid extract, mixes with appropriate starch, dry, spray into volatile oil, seal 12 hours, be distributed into capsule.
Embodiment 4:
200 grams of Radix Scutellariaes, 300 grams of Amaranthusspinosus L., 300 grams of Radix Angelicae Sinensis, 300 grams of Herba Verbenae, 300 grams of Herba Stephaniae Longaes, 300 grams of Herba Ecliptaes, 200 grams of Radix Saposhnikoviaes, 200 grams of Fructus Aurantii Immaturuss, each 100 grams of Amaranthusspinosus L. wherein, Radix Angelicae Sinensis is ground into fine powder, and remaining medical material is put into the container of sealing, adds 20 liters of the ethanol of 50% concentration, extracts 1 hour, extract 3 times, merge extractive liquid,, reclaims ethanol, extracting solution is condensed into fluid extract, mixes with fine powder, dry, dividing potential drop is in blocks, carries out coating, every 0.5 gram.
Embodiment 5:
250 grams of Radix Scutellariaes, 250 grams of Amaranthusspinosus L., 250 grams of Radix Angelicae Sinensis, 250 grams of Herba Verbenae, 250 grams of Herba Stephaniae Longaes, 250 grams of Herba Ecliptaes, 250 grams of Radix Saposhnikoviaes, 250 grams of Fructus Aurantii Immaturuss, by Amaranthusspinosus L. wherein, Herba Ecliptae, Radix Angelicae Sinensis, each 50 grams of Fructus Aurantii Immaturus is ground into fine powder, remaining Radix Angelicae Sinensis, Radix Saposhnikoviae, Fructus Aurantii Immaturus adopts the method for vapor distillation to extract after volatile oil, be incorporated to remaining Radix Scutellariae, Amaranthusspinosus L., Herba Verbenae, Herba Stephaniae Longae, the medical materials such as Herba Ecliptae, be placed in the container of sealing, adding concentration is 20 liters of 70% ethanol, reflux, extract, 1 hour, extract 2 times, then decoct with 20 premium on currency, each 1 hour, decoct 2 times, extracting solution is reclaimed after ethanol, be condensed into together fluid extract, fluid extract and fine powder mix, dry, spray into volatile oil, seal 12 hours, be distributed into capsule.
Model case:
Treatment constipation case:
Land, female, 80 years old, readme suffered from habitual constipation 3 years, and often 3～4 talentes defecate once, and just time, constipation due to dry stool, can not make great efforts, and haves no alternative but, and oneself removes to pluck out stercoroma with hands, is very worried, within 4 days now, does not defecate, and has awareness of defecation, for a long time also can not pull but squatted.Take water decoction of the present invention, after half an hour, awareness of defecation is strong, at once discharges stercoroma, feels light immediately.
Treatment hemorrhoid case:
Thunder, man, 55 years old, peasant, readme is suffered from hemorrhoid for many years, and intermittent attack, drips a small amount of blood when stool, and with anus distending pain, the past all can take a turn for the better voluntarily, so do not treat, has blood in stool within the next few days more, and just time, anus intumescence is deviate from and distending pain, and abdominal part has a little pain.Take this product, stomachache disappears, and second day, stool bled and stops, and there is a small amount of bloodstain on stool surface, and anus stomachache is not obvious, continues to take this product 5 days, within 1 year, does not reaccess.
Lee, female, 46 years old, peasant, readme is suffered from hemorrhoid for many years, intermittent attack, nearly outbreak increases the weight of.While now stool, penetrate blood, bleed, color is scarlet, and with not freely sense not to the utmost of stool, just time, in anus, intumescence is deviate from, and need return in anus with hand rest.Take this product one day 3～5 times, smoke and wash anus with the warm water preparation demibain of this product simultaneously, one day 2～3 times.Take this product second day, the amount of having blood in stool obviously reduces.Demibain smokes washed anus after three days, and intumescence is no longer deviate from.Take continuously this product after 15 days, recovery from illness.
Treatment dysentery case:
Huang, man, 25 years old, diarrhoea.Readme these two days is celebrating, consumes oil greasy, and raw food is assorted.This morning diarrhoea, tenesmus, feces stench, just sense not to the utmost, had loose bowels once every half an hour.With abdominal distention, without appetite.Take this product water decoction noon, go to side institute at once, feel emptying immediately, abdominal distention sense has also disappeared.Take this product afternoon, evening, defecation was normally accused more again.
Wang, man, 6 years old, body temperature 38 was spent, and early top faintishness, thirsty, watery diarrhea, tenesmus, draws about each hour once, draws the light violet pus and blood of a small amount of Ovum Gallus domesticus album sample noon.Take this product noon, afternoon, temperature recovery was normal, and stool colour is normal, and the obvious and rear reinfection of defecation frequency reduces, but feces or bulk and water sample are assorted.Take this product, one day three times, the next afternoon accuses more, continues to take one day.
Design under the prerequisite of spirit not departing from the present invention, various change row and improvement that this area ordinary person carries out technical solution of the present invention, all should fall in the definite protection domain of claim of the present invention.
Claims (9)
1. treat Chinese medicine composition and the method for making of dysentery and hemorrhoid for one kind, it is characterized in that thering is heat-clearing and toxic substances removing, the effect such as hemostasis antiinflammatory, dysentery relieving pain relieving, bowel relieving relieving constipation, inducing diuresis and reducing edema, dispelling wind and removing obstruction in the collateral, for dysentery, enteritis, Stomach duodenum ulcerative hemorrhage, swelling and pain of hemorrhoid, hemorrhoidal hemorrhage, constipation, substrate is prepared from by excipient in following Chinese medicine composition and pharmacy meaning: Radix Scutellariae, Amaranthusspinosus L., Radix Angelicae Sinensis, Herba Verbenae, Herba Stephaniae Longae, Herba Ecliptae, Radix Saposhnikoviae, Fructus Aurantii Immaturus.
2. according to claim 1, the method for making of Chinese medicine composition of the present invention is:
(1) adopt the method for water distillation to extract after volatile oil Radix Angelicae Sinensis, Radix Saposhnikoviae, Fructus Aurantii Immaturus, with Radix Scutellariae, Amaranthusspinosus L., Herba Verbenae, Herba Stephaniae Longae, Herba Ecliptae etc., adopt water to decoct or with alcohol reflux, extracting solution is condensed into after fluid extract, add volatile oil, mix with appropriate auxiliary material, make various shape agent in pharmacy meaning;
(2) first adopt water to decoct Radix Scutellariae, Amaranthusspinosus L., Radix Angelicae Sinensis, Herba Verbenae, Herba Stephaniae Longae, Herba Ecliptae, Radix Saposhnikoviae, Fructus Aurantii Immaturus eight taste medical materials, collect volatile oil simultaneously, then filter, by eight taste medical material alcohol reflux, extracting solution is merged and is condensed into after fluid extract, add volatile oil, mix with appropriate auxiliary material, make various shape agent in pharmacy meaning;
(3) the part pulverizing medicinal materials in Radix Scutellariae, Amaranthusspinosus L., Radix Angelicae Sinensis, Herba Verbenae, Herba Stephaniae Longae, Herba Ecliptae, Radix Saposhnikoviae, Fructus Aurantii Immaturus eight taste medical materials is become to fine powder, remaining medical material adopts water to decoct or with alcohol reflux, extracting solution is condensed into after fluid extract, mix with fine powder and appropriate auxiliary material, make various shape agent in pharmacy meaning;
(4) the part pulverizing medicinal materials in Radix Scutellariae, Amaranthusspinosus L., Radix Angelicae Sinensis, Herba Verbenae, Herba Stephaniae Longae, Herba Ecliptae, Radix Saposhnikoviae, Fructus Aurantii Immaturus eight taste medical materials is become to fine powder, remaining Radix Angelicae Sinensis, Radix Saposhnikoviae, Fructus Aurantii Immaturus adopts the method for water distillation to extract after volatile oil, adopt water to decoct with the medical material such as remaining Radix Scutellariae, Amaranthusspinosus L., Herba Verbenae, Herba Stephaniae Longae, Herba Ecliptae or with alcohol reflux, extracting solution is condensed into after fluid extract, add volatile oil, mix with fine powder and appropriate auxiliary material, make various shape agent in pharmacy meaning;
(5) by Radix Scutellariae, Amaranthusspinosus L., Radix Angelicae Sinensis, Herba Verbenae, Herba Stephaniae Longae, Herba Ecliptae, Radix Saposhnikoviae, Fructus Aurantii Immaturus, above-mentioned raw materials rinsing airing, vacuum drying, is crushed and screened into fine powder, mixes with appropriate auxiliary material, makes various shape agent in pharmacy meaning.
3. according to claim 1, the medicine that can also add has: Flos Lonicerae, Fructus Forsythiae, Radix Isatidis, Herba Houttuyniae, Herba Portulacae, the Radix Pulsatillae, native Lignum Dalbergiae Odoriferae, Radix Notoginseng, Radix Rehmanniae, Radix Et Rhizoma Rhei, Flos Sophorae, Fructus Cannabis, Poria, Rhizoma Coptidis, Rhizoma Imperatae, Herba Plantaginis, Cacumen Platycladi, Radix Sanguisorbae, the Fructus Sophorae, Radix Cirsii Japonici, Herba Cirsii, Pollen Typhae, Herba Agrimoniae, Folium Callicarpae Macrophyllae, the Radix Aucklandiae, Herba Acalyphae, Herba Schizonepetae, Radix Stephaniae Japonicae, Colla Corii Asini, Herba Taraxaci, Herba Violae, Cortex Magnoliae Officinalis, Herba Menthae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Alismatis, Semen Coicis, Herba Pogostemonis etc., the combination of wherein one or more.
4. according to claim 1, each composition weight ratio is: Radix Scutellariae (50-200) part, Amaranthusspinosus L. (150-800) part, Radix Angelicae Sinensis (60-300) part, Herba Verbenae (150-500) part, Herba Stephaniae Longae (150-600) part, Herba Ecliptae (100-800) part, Radix Saposhnikoviae (50-200) part, Fructus Aurantii Immaturus (50-200) part.
5. according to claim 1, in preparation method of the present invention, if water decocts, add the water of 4～10 times of weight, decoct 0.5 hour～3 hours, decoct 1～4 time; If with alcohol reflux, add the ethanol of 4～12 times of amounts, reflux, extract, 0.5～3 hour, extracts 1～4 time; If first water decocts, rear is the water that adds 4～10 times of amounts with alcohol reflux, decocts 0.5～2 hour, decocts 1～3 time, then adds the ethanol extraction 1～3 time of 4～12 times of amounts, each 0.5～3 hour.
6. according to claim 1, Radix Angelicae Sinensis, Radix Saposhnikoviae, Fructus Aurantii Immaturus adopt the method for water distillation and extraction volatile oil to be: the container that medical material is placed in to sealing, add the water of 4～10 times of weight, connect reflux, decoct or distill 2～4 hours, collecting volatile oil simultaneously, the volatile oil of collecting can directly add, also the volatile oil of collecting can be carried out to beta-cyclodextrin inclusion compound, join in powder or granule.
7. according to claim 1, each composition weight ratio is: Radix Scutellariae: Amaranthusspinosus L.: Radix Angelicae Sinensis: Herba Verbenae: Herba Stephaniae Longae: Herba Ecliptae: Radix Saposhnikoviae: Fructus Aurantii Immaturus=(1-2): (2-4): (1-2): (1-3): (1-3): (2-4): (1-2): (1-2).
8. according to claim 1, medicine of the present invention is prepared preferably capsule, tablet, granule, oral solutions, also can make any dosage form, as: powder, pill, unguentum, mixture, syrup, injection, note agent, liniment, suppository etc., in the time that said medicine combination is prepared into medicament, as required, can add other excipient, as: flavoring agent, solubilizing agent, suspensoid, dilution, disintegrating agent, lubricant etc., coating can be sugar-coat, film-coat, enteric coating etc.
9. according to claim 1, part pulverizing medicinal materials is become to fine powder, the medical material of pulverizing can be all or part of of single medical material, can be also a part for a few taste medicines.
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| CN105106749A (en) * | 2015-09-02 | 2015-12-02 | 江淑芬 | Traditional Chinese medicinal composition for haemorrhoids treatment in general surgery departments |
| CN105362735A (en) * | 2015-11-08 | 2016-03-02 | 薛学明 | Medicine for treating hemorrhoids and preparation method of medicine |
| CN106109768A (en) * | 2016-08-08 | 2016-11-16 | 孙爱荣 | A kind of Chinese medicine composition treating hemorrhoid |
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| CN1057680C (en) * | 1996-02-01 | 2000-10-25 | 王维 | Traditional Chinese medicine for curing dysentery |
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| CN105106749A (en) * | 2015-09-02 | 2015-12-02 | 江淑芬 | Traditional Chinese medicinal composition for haemorrhoids treatment in general surgery departments |
| CN105362735A (en) * | 2015-11-08 | 2016-03-02 | 薛学明 | Medicine for treating hemorrhoids and preparation method of medicine |
| CN106109768A (en) * | 2016-08-08 | 2016-11-16 | 孙爱荣 | A kind of Chinese medicine composition treating hemorrhoid |
| CN107184611A (en) * | 2017-04-20 | 2017-09-22 | 李锦英 | Outer coating of a kind of hemorrhoid and preparation method thereof |
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| CN109718317B (en) * | 2019-03-05 | 2023-12-12 | 上海中医药大学附属曙光医院 | Traditional Chinese medicine composition for treating ulcerative colitis |
| CN113288936A (en) * | 2021-06-28 | 2021-08-24 | 佛山科学技术学院 | Pharmaceutical composition for treating ulcerative colitis and application thereof |
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