CN105998409A - Traditional Chinese medicinal composition for treating hemorrhoid and preparation method thereof - Google Patents

Traditional Chinese medicinal composition for treating hemorrhoid and preparation method thereof Download PDF

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CN105998409A
CN105998409A CN201610594334.5A CN201610594334A CN105998409A CN 105998409 A CN105998409 A CN 105998409A CN 201610594334 A CN201610594334 A CN 201610594334A CN 105998409 A CN105998409 A CN 105998409A
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hemorrhoid
herba
chinese medicine
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邱泽文
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234Cnidium (snowparsley)
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
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    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The invention relates to a traditional Chinese medicinal composition for treating a hemorrhoid and a preparation method thereof. The traditional Chinese medicinal composition is prepared from traditional Chinese medicinal raw materials of all-grass of viola japonica, herba houttuyniae, all-grass of centella asiatica, herba rabdosiae lophanthoidis, folium eriobotryae, radix rehmanniae recens, herba centipedae, leaft of perilla frutescens, fructus cnidii and the like. The invention also provides the preparation method of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition provided by the invention is mainly used for treating the hemorrhoid.

Description

A kind of Chinese medicine composition treating hemorrhoid and preparation method thereof
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition treating hemorrhoid and preparation method thereof.
Background technology
The traditional Chinese medical science is thought, the pathogenic factors of hemorrhoid is with wind, wet, hot, dry, the deficiency of vital energy, blood deficiency are relevant." disease controls gist " cloud: " serum And the fresh person of color, for hemorrhoidal hamorrhage ... " " information record " say: " person of purifying the blood under pure, wind is also." illustrate that ailment said due to cold or exposure can cause hematochezia, and due to wind The characteristic of evil benefaction number change, color is scarlet, in spurting.Golden Mirror of Medicine is said: " anus encloses scrimp and ruptures just knot person, and fire is dry Also." indicating that the generation of this disease is many because of eating and drinking without temperance, surfeit is pungent, dryness-heat stagnating in the interior impairment of YIN, caused by constipation with dry stool." information record " Say: " color such as flue dust person, wet also ... " indicate no matter internal injury diet, addiction to greasy and sweet foods, or occupy wetland for a long time, all can make damp and hot accumulateing Resistance anus, meridians intercept, coagulation of QI-blood, and induce hemorrhoid." danxi's experiential therapy " cloud: " hemorrhoid person all because of internal organs deficiency in origin, wound rheumatism, Interior intrinsic heat poison ... " more explicitly pointed out burning hot impairment of body fluid, pyretic toxicity in accumulate and can induce hemorrhoid.Huangdi's Internal Classics is pointed out the most earlier: " having again married woman to give birth to too much, overcome blood depletion, collapse of QI, and children's's chronic dysentery, all can make anal prolapse." illustrate the deficiency of vital energy, nothing Power convergence is taken the photograph and received is this pathogenetic major reason." Ling Shu Miraculous Pivot or Divine Axis determine a gas piece " cloud: " middle Jiao is bullied extracting juice, change and red, be meaning Blood." illustrate that spleen and stomach function is poor, hemopoietic hypofunction can be caused, blood deficiency can not moisten foster anus, then there will be hemorrhoid, have blood in stool, otherwise, With the passing of time hemorrhoidal hemorrhage, can hyperamization void increase the weight of.In sum, Chinese medicine is thought, the reason of hemorrhoid morbidity, these are several outward, can be single Solely cause a disease, it is possible to exist simultaneously, thus established theoretical basis for Chinese traditional treatment hemorrhoid.
The traditional Chinese medical science is divided into 24 hemorrhoid about the classification of hemorrhoid, Ming Dynasty's " surgery opens profound ", in respect of anorectal carcinoma, anorectal carcinoma, hyperplastic hemorrhoids, inside and outside Hemorrhoid, syphilitic fistula, Semen Juglandis hemorrhoid, abscess of epiglottis, hemorroidsptosis etc..From these names of disease it can be seen that the point-score of hemorrhoid is mainly by author's Experience, the most directly perceived, majority is to divide by form.The sickness rate of hemorrhoid is the highest, reaches more than 60%, so there being saying of " ten people nine hemorrhoid ".
The pathogenic factor of hemorrhoid is mainly internal organs deficiency in origin, and " danxi's experiential therapy " is pointed out: " hemorrhoid person all because of internal organs deficiency in origin, so that gas Blood drops, and ties poly-anus, and dyspepsia does not dissipates, and conflicts for hemorrhoid." surfeit is rich, pungent, irregular diet, insobriety are also main Reason.Chronic diarrhea chronic dysentery, sitting stands for a long time, long journey of bearing a heavy burden, constipation, women passes through, conceived, childbirth, suckling, chronic disease, sexual life mistake Degree, feelings will pent-up, ponder over too, QI and blood drop, the heresy multiple abscess of damp and hot wind-dryness, conflict and be hemorrhoid.
Modern medicine is thought, the formation of hemorrhoid mainly has following factor: evolutionary factors, extremity reptile is without haemorrhoids, and it is former Because bowing before being probably quadrupeds body, anal orifice and rectal intestine is higher relative to position, beneficially rectum blood backflow.And the mankind's is upright Make anus position relatively low, be unfavorable for that rectum blood refluxes, pool in vein, then facilitate the formation of hemorrhoid.Heredity, abdominal pressure increase Height, dysentery, enteritis, parasite, skin of anus disease, anal abscess all can damage muscle layer under rectal mucosa and mucosa, make blood vessel etc. The brittle congested expansion of tissue.
Chinese traditional treatment:
Heat in blood intestinal dryness type, thirst and liking drink, the dry dry pharynx of lip, constipation, oliguria with reddish urine, have blood in stool more, drip or spouting, color Scarlet, or hold stasis of blood block under the arm, anus obituary is red scorching hot swells and ache, red tongue with yellow fur, wiry and frequent pulse.Belong to excess-heat of the large intestine, control suitable clearing heat and moistening dryness.As card is shown in Rectal tenesmus is felt bad, and hemorrhoid go out difficult receipts, and the light matter of color of having blood in stool is dilute, lustreless complexion person, controls suitable QI invigorating and rises sunken.
As card is shown in that rectal tenesmus is felt bad, hemorrhoid go out difficult receipts, and the light matter of color of having blood in stool is dilute, lustreless complexion person, control suitable QI invigorating and rise sunken.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine composition treating hemorrhoid;
It is a further object of the present invention to provide the preparation method of a kind of Chinese medicine composition treating hemorrhoid.
It is an object of the invention to by following technical scheme realization:
The Chinese medicine composition for the treatment of hemorrhoid of the present invention, is to be prepared from by the raw material of Chinese medicine of following weight portion:
Herba Violae japonicae 30-50 part, Herba Houttuyniae 8-25 part, Gotu Kola 8-25 part, Herba Rabdosiae Lophanthoidis 20-40 part, Folium Eriobotryae 20-40 part, the Radix Rehmanniae 20-40 part, Herba Centipedae 8-25 part, Folium Perillae 20-40 part, Fructus Cnidii 8-25 part.
Preferably, it is to be prepared from by the raw material of Chinese medicine of following weight portion:
Herba Violae japonicae 35-45 part, Herba Houttuyniae 10-20 part, Gotu Kola 10-20 part, Herba Rabdosiae Lophanthoidis 25-35 part, Folium Eriobotryae 25-35 part, life Ground 25-35 part, Herba Centipedae 25-35 part, Folium Perillae 25-35 part, Fructus Cnidii 10-20 part.
The following is the crude drug source of Chinese medicine preparation of the present invention:
Herba Violae japonicae, dish section Lepidium plant Herba Violae japonicae Viola japonica Langsd. or viola inconspicua Blume V. Inconspicua Blume, with all herbal medicine.[nature and flavor] are bitter, micro-pungent, cold.[function cures mainly] heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.With In acute conjunctivitis, pharyngolaryngitis, acute icterohepatitis, mastitis, carbuncle furuncle and phyma poison, suppurative osteomyelitis, venom.
Herba Houttuyniae, for the dry aerial parts of saururaceae plant houttuynia cordata Houttuynia cordata Thunb..[property Taste] pungent, it is slightly cold.[return through] returns lung meridian.[function cures mainly] heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome.For lung abscess vomiting pus, expectorant Dyspnea of heat type is coughed, hematodiarrhoea, pyretic stranguria, carbuncle sore tumefacting virus.
Gotu Kola, for the dry herb of samphire Herba Centellae Centella asiatica (L.) Urb..[nature and flavor] Bitter, acrid, cold.[return through] returns liver,spleen,kidney warp.[function cures mainly] clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.For jaundice due to damp-heat, heatstroke abdomen Rush down, sand Stranguria stranguria with blood, carbuncle sore tumefacting virus, injury from falling down.
Herba Rabdosiae Lophanthoidis, Labiatae Rabdosia plant Rabdosia lophanthoides Rabdosia lophanthoides (Ham. ex D. Don) Hara, herb.[nature and flavor] are bitter, cold.[function cures mainly] clearing away heat-damp and promoting diuresis, cool the blood dissipate blood stasis.For acute icterohepatitis, anxious Property cholecystitis, enteritis, dysentery, treating swelling and pain by traumatic injury.
Folium Eriobotryae, for the dried leaves of rosaceous plant Folium Eriobotryae Eriobotrya japonica (Thunb.) Lindl..[property Taste] bitter, it is slightly cold.[return through] attaches to the lung and stomach meridians.[function cures mainly] clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.For cough due to lung-heat, QI rising in reverse order dyspnea with rapid respiration, Gastric heat vomiting, dysphoria with smothery sensation is thirsty.
The Radix Rehmanniae, for the fresh or dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch.. [nature and flavor] are sweet, cold.[return through] GUIXIN, liver, kidney channel.[function cures mainly] clearing away heat and cooling blood, yin nourishing, promote the production of body fluid.For calentura crimson tongue excessive thirst, Yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis sends out speckle dermexanthesis.
Herba Centipedae, for feverfew Herba Centipedae Centipeda minima (L.) A. Br. et Aschers. Dry herb.[nature and flavor] are pungent, temperature.[return through] returns lung, Liver Channel.[function cures mainly] clearing the nasal passage, cough-relieving, for headche due to wind-cold, cough Cough abundant expectoration, have a stuffy nose obstructed, nasal sinusitis watery nasal discharge.
Folium Perillae, the band branch tender leaf of Labiatae Perilla plant Folium Perillae Perilla frutescens (L.) Britt..[property Taste] pungent, temperature.[function cures mainly] expelling cold and relieving exterior syndrome, regulating the flow of QI to ease the stomach.For anemofrigid cold, headache, cough, distension and fullness of the chest and abdomen.
Fructus Cnidii, for the dry mature fruit of samphire cnidium monnieri Cnidium monnieri (L.) Cuss..[property Taste] pungent, bitter, temperature.[return through] returns kidney channel.[function cures mainly] warming the kidney to invigorate YANG, dampness, dispel the wind, parasite killing.For sexual impotence, cold womb, cold-damp Leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago;External treatment vulval eczema, married woman's pudendal pruritus;Trichomonal vaginitis.
Another aspect of the present invention there is provided the preparation method of the active component of Chinese medicine composition of the present invention, and the method is Use water to carry or the ethanol extraction of 40-80% concentration expressed in percentage by volume is prepared from.Concrete preparation method is as follows:
Scheme one: take whole medical material, extracting in water 2-3 time after mixing, each amount of water is equivalent to 6-12 times of medical material gross weight, Extraction time is 1-3 hour every time, united extraction liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is 1.15-1.20 Clear paste, obtain active component.
Scheme two: take whole medical material, uses 40-80% alcohol reflux 2-3 time after mixing, and each ethanol consumption is medical material total amount 4-10 times, extraction time is 1-4 hour, united extraction liquid, filter, when filtrate is concentrated into 70-80 DEG C, relative density is 1.15-1.20 clear paste, obtain active component.
Scheme three: take whole medical material, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-of medical material gross weight 12 times, each extraction time is 1-3 hour, united extraction liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is The clear paste of 1.15-1.20, adds ethanol, and making alcohol content is 40-70%, stands 12-24 hour, filters, and filtrate is concentrated into 70-80 DEG C time relative density be the extractum of 1.10-1.25, obtain active component.
The Chinese medicine composition for the treatment of hemorrhoid of the present invention, it is also possible to pharmaceutically acceptable carrier combination, system Become various oral formulations, such as pill, tablet, capsule, oral liquid, syrup, mixture etc..
The pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Oral formulations:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc..
Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc..
Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc..
Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc..
Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, vegetable oil etc..
Correctives: sucrose, monosaccharide, aromatic etc..
Preservative: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc..
Method 1: tablet
Taking one of scheme one to scheme three gained active component, add tablet and commonly use adjuvant, production method is prepared into this routinely Invention tablet.
Above-mentioned tablet is commonly used adjuvant and is included one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 2: capsule
Taking one of scheme one to scheme three gained active component, add capsule and commonly use adjuvant, production method is prepared into routinely Capsule of the present invention.
Above-mentioned capsule is commonly used adjuvant and is included one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 3: syrup
Taking one of scheme one to scheme three gained active component, add syrup and commonly use adjuvant, production method is prepared into routinely Syrup of the present invention.
Above-mentioned syrup is commonly used adjuvant and is included one of correctives, preservative, cosolvent or whole.
Method 4: mixture
Taking one of scheme one to scheme three gained active component, add mixture and commonly use adjuvant, production method is prepared into this routinely Invention mixture.
Above-mentioned mixture is commonly used adjuvant and is included one of correctives, preservative or whole.
Method 5: oral liquid
Take one of scheme one to scheme three gained active component, dissolve after-purification, concentration, add oral liquid and commonly use adjuvant, by often Rule production method is prepared into oral liquid of the present invention.
The applicant is extensively reading document at all times, uses Traditional Chinese medical theory, in conjunction with modern clinic diagnosis and treatment experience, finds A kind of Chinese medicine composition of effective treatment hemorrhoid.In side, Herba Violae japonicae heat-clearing and toxic substances removing, removing heat from blood detumescence are monarch drug in side;Herba Rabdosiae Lophanthoidis, life Ground clearing away heat and cooling blood, Folium Eriobotryae heat clearing away soft stool, Folium Perillae heat clearing away cold expelling helps enterogastric peristalsis, is ministerial drug altogether;Herba Houttuyniae heat-clearing and toxic substances removing, Thunder God Root, Fructus Cnidii damp eliminating removing toxic substances, Herba Centipedae removing toxic substances is sensible, is adjuvant drug altogether.Full side cooperates, and plays clearing away heat and cooling blood, dampness removing solution altogether The merit of poison, for the treatment of hemorrhoid.
A kind of Chinese medicine composition treating hemorrhoid that the present invention provides has the advantage that
1, the composite preparation that the present invention provides is safe and effective, and full side cooperates, and plays the merit of clearing away heat and cooling blood, eliminating damp, detoxifying altogether, Treatment for hemorrhoid.
2, clinical tests prove that, after treating hemorrhoid patients by the present invention, effective percentage reaches 100%, shows energy of the present invention Effectively treat hemorrhoid.
3, the Chinese medicinal composition preparation that the present invention provides, scientific formulation is reasonable, and technique is simple, in good taste, low cost.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustrating The present invention rather than limitation of the present invention.The simple modifications that the present invention is carried out by the essence according to the present invention broadly falls into the present invention Claimed scope.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents solution Volume ratio.
Embodiment 1 tablet
Weigh Herba Violae japonicae 30g, Herba Houttuyniae 8g, Gotu Kola 8g, Herba Rabdosiae Lophanthoidis 20g, Folium Eriobotryae 20g, Radix Rehmanniae 20g, Herba Centipedae 8g, purple Soviet Union 20g, Fructus Cnidii 8g.Extracting in water 3 times, three times amount of water is respectively 12 times of medical material gross weight, 8 times, 6 times, extracts for three times Time is respectively 3 hours, 2 hours, 1 hour, united extraction liquid, filters, and when filtrate is concentrated into 70 DEG C, relative density is 1.25 Clear paste, adds supplementary product starch, ethanol, Pulvis Talci, prepares tablet.
Embodiment 2 granule
Weigh Herba Violae japonicae 50g, Herba Houttuyniae 25g, Gotu Kola 25g, Herba Rabdosiae Lophanthoidis 40g, Folium Eriobotryae 40g, Radix Rehmanniae 40g, Herba Centipedae 25g, Folium Perillae 40g, Fructus Cnidii 25g.With alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, and each ethanol is used Amount is respectively 10 times of medical material total amount, 8 times, and extraction time is respectively 4 hours, 3 hours, united extraction liquid, filters, and filtrate concentrates It is the extractum of 1.10 to relative density when 80 DEG C, adds starch, dextrin, pelletize, be dried, granulate and get final product.
Embodiment 3 syrup
Weigh Herba Violae japonicae 35g, Herba Houttuyniae 10g, Gotu Kola 10g, Herba Rabdosiae Lophanthoidis 25g, Folium Eriobotryae 25g, Radix Rehmanniae 25g, Herba Centipedae 25g, Folium Perillae 25g, Fructus Cnidii 10g.Extracting in water 2 times, each amount of water is respectively equivalent to 12 times of medical material gross weight, 10 times, Extraction time is respectively 3 hours, 2 hours every time, united extraction liquid, filters, and it is 1.05 that filtrate is concentrated into relative density at 80 DEG C Clear paste, add ethanol, making alcohol content is 70%, stands 12 hours, filtration, when filtrate is concentrated into 70 DEG C, relative density is 1.25 Extractum, in extractum, add syrup adjuvant sucrose, sorbic acid, water stir, and prepare syrup.
Embodiment 4 capsule
Weigh Herba Violae japonicae 45g, Herba Houttuyniae 20g, Gotu Kola 20g, Herba Rabdosiae Lophanthoidis 35g, Folium Eriobotryae 35g, Radix Rehmanniae 35g, Herba Centipedae 35g, Folium Perillae 35g, Fructus Cnidii 20g.With 40% alcohol reflux 3 times, each ethanol consumption be respectively 10 times of medical material total amount, 8 Times, 4 times, 3 hours, 2 hours, 1 hour respectively extraction time, united extraction liquid, filter, when filtrate concentrates 60 DEG C, relative density is The extractum of 1.25, adds supplementary product starch, ethanol, dextrin, magnesium stearate in extractum, makes capsule according to a conventional method.
Embodiment 5 granule
Weigh Herba Violae japonicae 32g, Herba Houttuyniae 9g, Gotu Kola 9g, Herba Rabdosiae Lophanthoidis 23g, Folium Eriobotryae 23g, Radix Rehmanniae 23g, Herba Centipedae 23g, Folium Perillae 23g, Fructus Cnidii 9g.Extracting in water 2 times, twice amount of water is respectively 10 times of medical material gross weight, 8 times, when extracting for twice Between be respectively 2 hours, 1 hour, united extraction liquid, filter, when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10.Add Starch, dextrin, pelletize, be dried, granulate and get final product.
Embodiment 6 tablet
Weigh Herba Violae japonicae 40g, Herba Houttuyniae 15g, Gotu Kola 15g, Herba Rabdosiae Lophanthoidis 30g, Folium Eriobotryae 30g, Radix Rehmanniae 30g, Herba Centipedae 30g, Folium Perillae 30g, Fructus Cnidii 15g.Extracting in water 3 times, three amount of water be respectively equivalent to 12 times of medical material gross weight, 8 times, 6 Times, 3 hours, 2 hours, 1 hour respectively each extraction time, united extraction liquid, filter, relative density when filtrate is concentrated into 70 DEG C Being the clear paste of 1.20, add ethanol, making alcohol content is 40%, stands 24 hours, filters, and filtrate is concentrated into filtrate and is concentrated into 70 DEG C Time relative density be the extractum of 1.10, add supplementary product starch, ethanol, Pulvis Talci, prepare tablet.
Embodiment 7 mixture
Weigh Herba Violae japonicae 38g, Herba Houttuyniae 12g, Gotu Kola 12g, Herba Rabdosiae Lophanthoidis 28g, Folium Eriobotryae 28g, Radix Rehmanniae 28g, Herba Centipedae 28g, Folium Perillae 28g, Fructus Cnidii 12g.Extracting in water 3 times, three amount of water be respectively equivalent to 12 times of medical material gross weight, 8 times, 6 Times, 3 hours, 2 hours, 1 hour respectively each extraction time, united extraction liquid, filter, it is that medical material is total that filtrate is concentrated into gross weight 3 times of weight, fill, addition mixture adjuvant sucrose, ethyl ester, water, sorbic acid stir, and prepare mixture.
Embodiment 8 oral liquid
Weigh Herba Violae japonicae 42g, Herba Houttuyniae 18g, Gotu Kola 18g, Herba Rabdosiae Lophanthoidis 32g, Folium Eriobotryae 32g, Radix Rehmanniae 32g, Herba Centipedae 32g, Folium Perillae 32g, Fructus Cnidii 18g.Extracting in water 2 times, twice amount of water is respectively 10 times of medical material gross weight, 8 times, carries for twice The time of taking is respectively 2 hours, 1 hour, united extraction liquid, filters, and when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10, In extractum, addition adjuvant mannitol, sorbic acid, water stir, and subpackage prepares oral liquid.
Embodiment 9 powder
Weigh Herba Violae japonicae 48g, Herba Houttuyniae 23g, Gotu Kola 23g, Herba Rabdosiae Lophanthoidis 38g, Folium Eriobotryae 38g, Radix Rehmanniae 38g, Herba Centipedae 38g, Folium Perillae 38g, Fructus Cnidii 23g.Pulverize, sieve, to obtain final product.
Clinical trial is summed up
1 physical data
Choose hemorrhoid patients 198 example, age 20-65 year, the maleest 102 examples, female 96 example, internal hemorrhoid 98 example, external hemorrhoid 67 example, mixed hemorrhoid 33 examples.
2 diagnostic criterias
With reference to " traditional Chinese medical science anorectum department disease Standardization of diagnosis and curative effect ".
3 Therapeutic Method
Give the embodiment of the present invention 6 tablet in treatment, each 2, every day 2 times.It was a course for the treatment of with 7 days, unites after treating 1 course for the treatment of Meter curative effect.
4 clinical efficacy evaluation criterias
The clinical therapeutic efficacy evaluation criterion of patient, with reference to the curative effect determinate standard of hemorrhoid in " hemorrhoid disease diagnosis and treatment tentative standard ", is divided into Recovery from illness, effective and invalid three opinion ratings, specific standards is as follows.
Recovery from illness: the clinical symptoms of patient is wholly absent, occurs without the situation such as hemafecia, proctalgia, in controlling of two courses for the treatment of Check anoscope after treatment, find that hemorrhoid are wholly absent;
Effective: the clinical symptoms of patient the most substantially alleviates, the clinical symptoms such as hemafecia, proctalgia and pruritus all makes moderate progress, in Routine examination anoscope after the treatment of two courses for the treatment of, finds that focus, i.e. blood stasis are obviously reduced;
Invalid: the clinical symptoms of patient is without significant change or has and increases the weight of trend, per anum spectroscopy finds, lesions position is through treatment After the most unchanged, without improvement phenomenon.
5 results
Table 1 efficacy result
Recovery from illness Effectively Invalid Effective percentage (%)
Curative effect 138 60 0 100
Clinical effectiveness shows: after treating hemorrhoid patients by the present invention, effective percentage reaches 100%, shows that the present invention can effectively treat hemorrhoid Skin ulcer.
Model case
1, limit X, man, 33 years old.Highlight pain be chief complaint for 3 days with the anal orifice thing that swells, caused to play row second day morning because of heavy drinking before 3 days The prominent swollen thing pain of anus occurs after an action of the bowels, receive can, sleep and feel unwell, two just adjust, red tongue, thick and greasy fur, stringy pulse.Training checks: calculi position, 1 to 6 anus edge edema, touches a tender spot substantially.Diagnosis: inflammatory external hemorrhoid.Giving the embodiment of the present invention 3 and treat further consultation after 3 days, anal orifice is ached Pain substantially alleviates, then after treating 3, original transference cure, toposcopy, anus edge edema disappears.
2, XX Wei, female, 26 years old.Readme is over more than 20 day, every time hemorrhage during stool, in a drop-wise, podex has the most not Suitable, pruritus and a little secretions.Anus and anoscopy: 3 °, 7 ° Ⅰ period internal hemorrhoid of calculi position, each one of 11 ° of Ⅱ period internal hemorrhoid, all Such as Semen arachidis hypogaeae size, the internal hemorrhoid mucosa at 7 ° is damaged, has oozing of blood, and podex is moist, without edema and tenderness.Give the present invention to implement Example 5 is treated 3 days, carries in addition to a little bloodstain and podex slightly discomfort except just time on toilet paper, and other is without uncomfortable, and continual cure is after 6 days, All transference cures.
Although, used general explanation, detailed description of the invention and test, the present invention made detailed retouching Stating, but on the basis of the present invention, can make some modifications or improvements it, this is apparent to those skilled in the art 's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed Scope.

Claims (7)

1. the Chinese medicine composition treating hemorrhoid, it is characterised in that it is to be prepared from by the raw material of Chinese medicine of following weight portion :
Herba Violae japonicae 30-50 part, Herba Houttuyniae 8-25 part, Gotu Kola 8-25 part, Herba Rabdosiae Lophanthoidis 20-40 part, Folium Eriobotryae 20-40 part, the Radix Rehmanniae 20-40 part, Herba Centipedae 8-25 part, Folium Perillae 20-40 part, Fructus Cnidii 8-25 part.
2. the Chinese medicine composition treating hemorrhoid as claimed in claim 1, it is characterised in that it is by including following weight portion Raw material of Chinese medicine is prepared from:
Herba Violae japonicae 35-45 part, Herba Houttuyniae 10-20 part, Gotu Kola 10-20 part, Herba Rabdosiae Lophanthoidis 25-35 part, Folium Eriobotryae 25-35 part, life Ground 25-35 part, Herba Centipedae 25-35 part, Folium Perillae 25-35 part, Fructus Cnidii 10-20 part.
3. the Chinese medicine composition treating hemorrhoid as claimed in claim 1 or 2, it is characterised in that its active component is to use water Carry or the ethanol extraction of 40-80% concentration expressed in percentage by volume is prepared from.
4. the Chinese medicine composition treating hemorrhoid as claimed in claim 3, it is characterised in that its active component is by following Method is prepared from: take whole medical material, extracting in water 2-3 time after mixing, and each amount of water is equivalent to the 6-of medical material gross weight 12 times, each extraction time is 1-3 hour, united extraction liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is 1.15-1.20 clear paste, obtain active component.
5. the Chinese medicine composition treating hemorrhoid as claimed in claim 3, it is characterised in that its active component is by following Method is prepared from: take whole medical material, uses 40-80% alcohol reflux 2-3 time after mixing, and each ethanol consumption is medical material 4-10 times of total amount, extraction time is 1-4 hour, united extraction liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is 1.15-1.20 clear paste, obtain active component.
6. the Chinese medicine composition treating hemorrhoid as claimed in claim 3, it is characterised in that its active component is by following Method is prepared from: take whole medical material, extracting in water 2-3 time after mixing, and each amount of water is equivalent to the 6-of medical material gross weight 12 times, each extraction time is 1-3 hour, united extraction liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is 1.15- The clear paste of 1.20, adds ethanol, and making alcohol content is 40-70%, stands 12-24 hour, filters, and filtrate is concentrated into 70-80 DEG C of phase It is the extractum of 1.10-1.25 to density, obtains active component.
7. treat a preparation for hemorrhoid, by the Chinese medicine composition of the treatment hemorrhoid described in claim 1-6 and pharmaceutically may be used The carrier combination accepted is prepared from.
CN201610594334.5A 2016-07-27 2016-07-27 Traditional Chinese medicinal composition for treating hemorrhoid and preparation method thereof Withdrawn CN105998409A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107753644A (en) * 2017-11-15 2018-03-06 广西博白县华春福家庭农场 A kind of Chinese medicine composition for treating external piles and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101947287A (en) * 2010-06-25 2011-01-19 邵书平 Oral traditional Chinese medicine for treating haemorrhoids

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101947287A (en) * 2010-06-25 2011-01-19 邵书平 Oral traditional Chinese medicine for treating haemorrhoids

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107753644A (en) * 2017-11-15 2018-03-06 广西博白县华春福家庭农场 A kind of Chinese medicine composition for treating external piles and preparation method thereof

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Application publication date: 20161012