CN103860702A

CN103860702A - Alcohol effect dispelling and liver protecting medicine

Info

Publication number: CN103860702A
Application number: CN201210528452.8A
Authority: CN
Inventors: 赵清香
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-12-10
Filing date: 2012-12-10
Publication date: 2014-06-18

Abstract

The invention relates to a traditional Chinese medicine, and concretely relates to an alcohol effect dispelling and liver protecting medicine. A problem that alcohol harms the health of human bodies is solved in the invention. The medicine is composed of 30 parts of pueraria flower, 50 parts of Hovenia acerba Lindl., 15 parts of dried orange peel, 15 parts of gynostemma pentaphylla and 20 parts of licorice root. A preparation method of the medicine comprises the following steps: extracting the above traditional Chinese medicines with alcohol for 24h two times, and filtering to obtain an alcohol extract liquid; respectively decocting the above obtained filter residues with water having an amount 15 times the amount of the residues and water having an amount 10 times the amount of the residues for 1.5h, and filtering to obtain a water decoction liquid; and mixing the alcohol extract liquid with the water decoction liquid, and carrying out 70DEG C reduced pressure concentration of the obtained liquid mixture to a paste (1.2-1.3g/mL). The above alcohol effect dispelling agent based on pueraria flower, Hovenia acerba Lindl., dried orange peel, licorice root and gynostemma pentaphylla has good alcohol effect dispelling and intoxication preventing effects, and can effectively reduce the concentration of ethanol in blood. Results of pharmacodynamic experiments of the medicine on mice show that if the alcohol effect dispelling agent is administrated by the mice 20min before and after wine drinking, the intoxication rate is low, the tolerance time is long before intoxication, and the maintenance time after the intoxication is short.

Description

A kind of medicine of Soboring-up liver-protecting

Technical field

The present invention relates to a kind of Chinese medicine, be specially a kind of medicine of Soboring-up liver-protecting.

Background technology

Wine is a kind of ardent drink indispensable in people's daily life, and under the driving of spirits culture, people have to drink in large quantities in various occasions, and the harm of ethanol is obvious.People are having in the face of drink in the situation that, of long duration, can give rise to diseases, and for example alcoholic liver, the even critical life of cardiovascular and cerebrovascular disease.Human body is a kind of normal physiological phenomenon to the catabolism of ethanol, the interior a small amount of ethanol of body can under alcoholdehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) effect, be metabolized to CO2 and water excretes, if but excessive ethanol can not be timely, when metabolism is fallen completely, easily cause organ injury, cause that disorderly 1. results of study of body function show, body free-radical generating too much or under removing ability general who has surrendered cause the accumulation of free radical, and this thereby cause just a large amount of storages of lipoprotein to stay to cause crapulent biochemical mechanism 2. alcoholism are worldwide problems, existing multiple Medicament for Alcoholism is come out at present, clear oral liquid 3 as vertical in wine with dregs, but these medicines are not too desirable, so can decomposing alcohol in the urgent need to one, the medicine of protection health.

Summary of the invention

The present invention is for the problem of the harm that solves ethanol and bring to health, and spy provides a kind of medicine of Soboring-up liver-protecting.

Technical scheme of the present invention is, a kind of medicine of Soboring-up liver-protecting, be made up of Flos puerariae lobatae 20-30 part, Japanese raisintree fruit 50-60 part, Pericarpium Citri Reticulatae 10-15 part, Herb Gynostemmae Pentaphylli 15-20 part, Radix Glycyrrhizae 15-20 part, preparation method is: in the ethanol alcohol extraction 2 times (24h/ time) of medicinal 10 times of amounts, filter to obtain alcohol extract; Filtering residue boils 1 time (1.5h/ time) with the decocting of 15 times and 10 times amounts respectively, filters to obtain water cooking liquid; Merge alcohol extract and water cooking liquid, be evaporated to paste (=1.2～1.3g/mL) through 70.

Zoopery part

2.1 material

1) animal Kunming kind white mice, body weight 202g, male and female dual-purpose,

2) medicine and reagent amethystic agent are medicine of the present invention, adopt Flos puerariae lobatae, Japanese raisintree fruit, Pericarpium Citri Reticulatae, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae compatibility to obtain through refining and form. be made into the test liquid containing crude drug amount 1g/mL with normal saline, test liquid normal saline in the time of 108 sterilizing 15min administration be made into 0.125g/mL for examination.

3) experiment is spent Fenyang wine with wine 53.

2.2 method

1) 108 white mice of effect experiment of relieving the effect of alcohol are divided into 6 groups at random, every group 18. mice to be tested is through overnight fasting (13h), next day with the heavy dosage ig of 40 degree wine 0.37mL/20g Mus to wine .20min after respectively with normal saline, self-control amethystic agent and commercially available Medicament for Alcoholism ig administration. self-control amethystic agent is with the heavy dosed administration of 0.32mL/20g Mus, all the other dosages are that 0.40mL/20g Mus is heavy. after administration, start timing, each group respectively at 30,60,90,120,150 with pluck eyeball when 180min and get blood, with the 3.8% citric acid three sodium solution anticoagulation of 0.3mL.

2) anti-intoxication effect experiment zoopery designs with method 1), but make first ig administration into, after 20min, ig, to wine, gives and starts after drinking timing again.

3) righting reflex loss situation and drunk rate 7 every batch of 120 white mice are divided into 6 groups at random, every group 20, carry out two batches. white mice overnight fasting to be tried (13h), next day, a collection of dosage ig weighing with 40 degree wine 0.45mL/20g Mus was to wine, after 20min, respectively organize respectively with normal saline, self-control amethystic agent and commercially available Medicament for Alcoholism ig administration, dosage is with method 1), after administration, start timing. another batch of first ig administration, 20min later again ig to wine, dosage is ditto a collection of, give and start after drinking timing. two batches are recorded the drunk number of white mice and sleeping duration and recovery time respectively, calculate the drunk rate of white mice, and tolerance time and holding time.

4) in blood plasma, ethanol content is measured 8 and is adopted gas chromatography (acetone is interior mark) mensuration.

5) in blood, SOD enzyme activity determination 9 adopts pyrogallol Autoxidation Method (DTT is terminator) to measure. test condition: pH=8.20 0.01, reaction temperature 30, pyrogallol concentration 0.098mmol/L, dithiothreitol, DTT concentration 27.3mol/L, erythrocyte sod crude extract application of sample amount 0.125mL, 721 type spectrophotometers, test wavelength 420nm (when pyrogallol autoxidation per minute is suppressed 50% by SOD, required enzyme amount is 1u).

3 experiments show

1) there is good relieving the effect of alcohol and anti-intoxication drug effect take Flos puerariae lobatae, Japanese raisintree fruit, Pericarpium Citri Reticulatae, Radix Glycyrrhizae and Herb Gynostemmae Pentaphylli as this amethystic agent of main formula, the concentration of alcohol white mice pharmacodynamic experiment that can effectively reduce in blood shows, before and after drinking, 20min takes in this amethystic agent, holds time short after low, the drunk front tolerance time of the drunk rate of white mice is long and drunk.

3) take in this amethystic agent before wine than take in after drinking have more relieve the effect of alcohol, anti-intoxication effect..

The specific embodiment

The medicine of embodiment 1, a kind of Soboring-up liver-protecting, is made up of 15 parts of 20 parts of Flos puerariae lobataes, 60 parts of Japanese raisintree fruit, 10 parts of Pericarpium Citri Reticulataes, 20 parts of Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae, and preparation method is: in the ethanol alcohol extraction 2 times (24h/ time) of medicinal 10 times of amounts, filter to obtain alcohol extract; Filtering residue boils 1 time (1.5h/ time) with the decocting of 15 times and 10 times amounts respectively, filters to obtain water cooking liquid; Merge alcohol extract and water cooking liquid, be evaporated to paste (=1.2～1.3g/mL) through 70.

The medicine of embodiment 2, a kind of Soboring-up liver-protecting, is made up of 20 parts of 30 parts of Flos puerariae lobataes, 50 parts of Japanese raisintree fruit, 15 parts of Pericarpium Citri Reticulataes, 15 parts of Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae, and preparation method is: in the ethanol alcohol extraction 2 times (24h/ time) of medicinal 10 times of amounts, filter to obtain alcohol extract; Filtering residue boils 1 time (1.5h/ time) with the decocting of 15 times and 10 times amounts respectively, filters to obtain water cooking liquid; Merge alcohol extract and water cooking liquid, be evaporated to paste (=1.2～1.3g/mL) through 70.

Claims

1. the medicine of a Soboring-up liver-protecting, it is characterized in that being formed by Flos puerariae lobatae 20-30 part, Japanese raisintree fruit 50-60 part, Pericarpium Citri Reticulatae 10-15 part, Herb Gynostemmae Pentaphylli 15-20 part, Radix Glycyrrhizae 15-20 part, preparation method is: in the ethanol alcohol extraction 2 times (24h/ time) of medicinal 10 times of amounts, filter to obtain alcohol extract; Filtering residue boils 1 time (1.5h/ time) with the decocting of 15 times and 10 times amounts respectively, filters to obtain water cooking liquid; Merge alcohol extract and water cooking liquid, be evaporated to paste (=1.2～1.3g/mL) through 70.