CN103844251A - Ultramicro maca powder, maca and flower health care granule and preparation method and purpose thereof - Google Patents
Ultramicro maca powder, maca and flower health care granule and preparation method and purpose thereof Download PDFInfo
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- CN103844251A CN103844251A CN201210504637.5A CN201210504637A CN103844251A CN 103844251 A CN103844251 A CN 103844251A CN 201210504637 A CN201210504637 A CN 201210504637A CN 103844251 A CN103844251 A CN 103844251A
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- pueraria root
- ultra micro
- agate
- powder
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/22—Agglomeration or granulation with pulverisation of solid particles, e.g. in a free-falling curtain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Insects & Arthropods (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Alternative & Traditional Medicine (AREA)
- Nutrition Science (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the technical field of foodstuff, health products and medicines, and particularly relates to ultramicro maca powder, a maca and flower health care granule and a preparation method and purpose thereof. The ultramicro maca powder has a granule size of 5 mum <= D90 <=74 mum, and is used for the foodstuff, health products and medicines. After superfine crushing, the ultramicro maca powder has strong adsorption capacity and affinity, has very good fragrance fixing property, dispersibility and solubility, and is easier to be absorbed and digested by the human body. The maca and flower health care granule is a granular product prepared from the ultramicro maca powder and bee pollen as main raw materials, has the physical power enhancing and anti fatigue effects by mixed use, and is better than mixing use of normal maca powder (D90 = 250 mu m) and the bee pollen.
Description
Technical field
The invention belongs to food, health products and medicine field, be specifically related to ultra micro pueraria root powder, agate flower health care particle and its production and use.
Background technology
Agate coffee (Lepedium meyenii Walp), originates in 4000 meters of above mountain areas, Peru Andean of height above sea level, belongs to Cruciferae separate row Vegetable spp, conventional Maca by name, and transliteration is " agate coffee ".Agate coffee edible part is its root.Agate coffee can be used as food and herbal medicine for strengthening muscle power, antifatigue, improve sexual function, improving fertility etc. traditionally.The generally attention that agate coffee obtains people is in the early 1990s, and researcher, in the time finding " vigour " substitute, finds that it is in the remarkable efficacy of improving in sexual function, becomes a nova in international health product and medicine.At present agate coffee in the international market main purposes be to be processed into fine powder after agate coffee root is dry, and then make health products or medicine, and make drinks after adding agate coffee extract.On May 18th, 2011, the Ministry of Public Health of China official approval pueraria root powder is new resource food (2011 No. 13 bulletin of the Ministry of Public Health).
The agate coffee dry powder that agate coffee root crushed after being dried is made has better nutritivity and is worth.Its protein content is 10.2/100g, is similar to cereal crops Protein Content in Wheat, a little more than rice.Tryptophan, methionine are respectively its first, second limiting amino acids, nonessential amino proline too high levels, and the protein nutritive value of overall AAS agate coffee is a little less than cereal crops.Its fat and content of fatty acid are lower, close to cereal crops.Though unsaturated fatty acid content accounts for the more than 55% of total fat, because total lipid content is low, therefore human nutrition is worth little.Carbohydrate content is 74.8/100g, and dietary fiber content is 21.3/100g, and wherein soluble dietary fiber is 5.3/100g.Agate coffee dry powder mineral content reaches 4.3/100g, contains abundant constant and trace element.B family vitamin rich content, vitamin B6 is 0.32mg/100g, cobalamin is 0.8ug/100g, high with based food.Except above-mentioned nutritional labeling, also contain distinctive secondary metabolite, as alkaloid, general flavone, phytosterol, saponin, agate coffee alkene and agate coffee enamine etc., and agate coffee alkene and agate coffee enamine are its distinctive functional components.
Agate coffee has traditionally as strengthening physical purposes, and proves to have anti-fatigue effect through zoopery.It is the main manifestations that anti-fatigue ability is strengthened that exercise tolerance improves.The animal experiment method of domestic general research anti-fatigue effect is to carry out mice burden swimming experiment at present, reacts the anti-fatigue effect of tested material with the index such as length and blood lactic acid, serum urea, hepatic glycogen or muscle glycogen of swimming time.The swimming with a load attached to the body experimental result positive, blood lactic acid, serum urea, hepatic glycogen or three kinds of indexs of muscle glycogen are appointed the binomial positive, can judge that sample has the effect of alleviating physical fatigue function.Research shows, agate coffee dry powder can increase the mice burden swimming time, reduces serum urea nitrogen level.
The present inventor wants to provide on this basis a kind of ultra micro pueraria root powder, for edible, for health care, medicinal.
Summary of the invention
First technical problem solved by the invention is to provide a kind of ultra micro pueraria root powder, for edible, for health care, medicinal.
The particle diameter of ultra micro pueraria root powder of the present invention is 5 μ m≤D
90<74 μ m, particle diameter is for can cross 3000-200 mesh sieve.
D
90corresponding particle diameter when the cumulative particle sizes distribution number that refers to a sample reaches 90%, its physical significance is that the particle that particle diameter is less than it accounts for 90%.
Further preferable particle size is 10 μ m<D
90<74 μ m.Be that particle diameter is to cross 1600-200 mesh sieve.
Most preferably particle diameter is 5 μ m<D
90≤ 10 μ m.Be that particle diameter is to cross 3000-1600 mesh sieve.
Ultramicro-powder refers to the particle of particle diameter below 100 μ m, its material table area and porosity significantly increase, there is very strong adsorption power and affinity through the food of miniaturization, there is well fragrance, dispersiveness and dissolubility admittedly, more easily assimilated by human body.Pueraria root powder is broken to ultra micro level by the present invention following benefit, as:
1, powder is thinner, can improve the dissolution rate of active principle in raw material.
2, after ultramicro grinding, can save raw material, reduce raw material consumption.
3, powder size is thinner, and raw material surface absorption affinity and affinity are stronger, has better fragrance, dispersiveness and dissolubility admittedly, is more easily assimilated by human body.
4,, according to the stronger fact of larger its BA of food specific area (physiological potency), ultramicronising has the potentiality that improve effect material absorbing utilization rate in material powder.Food service industry abroad, ultramicro grinding industrial applications in the cellulose physics " disintegration " of plant tissue, increase the release of nutrient in born of the same parents, as found in the ultramicronising research to tealeaves, the super fine tea powder of 1 μ m, it has improved nearly 100 times by digesting and assimilating the more conventional tealeaves of oxygen radical removing ability of generation, and and for example in research, the pea with seed coat is after ultramicro grinding, and the absorption of its nutrient and tiring all significantly improves.
Second technical problem solved by the invention is to provide the preparation method of ultra micro pueraria root powder of the present invention, and raw material is the root of agate coffee.Step is as follows:
A, smoke: agate coffee is at baked temperature 40-120 ℃; Smoke under the condition of time 1-6h and smoke; Smoke rear control moisture to 5%-15%.
Further preferred baked temperature 60-80 ℃; Smoke time 2-4h; Smoke rear control moisture to 7%-12%.
Most preferably 65 ℃ of baked temperatures; Smoke time 3h; Smoke rear control moisture to 8%.
Smoke object for drying agate coffee moisture, make it have fragility, be convenient to follow-up precomminution step.
If moisture is too high, agate coffee is partially soft, precomminution poor effect; Moisture is too low, and the time of smoking can too lengthen, and affects production efficiency, unnecessary property.
Baked temperature is too low can not reach drying requirement, and the too high agate coffee active component that can make is lost, and greatly reduces its effect.
B, precomminution: steps A gained is smoked to the precomminution of agate coffee, pulverize number of times 1-5 time, be crushed to particle diameter 74 μ m<D
90<840 μ m.Cross 200-20 mesh sieve.
Further preferably pulverize number of times 2-4 time, be crushed to particle diameter 150 μ m<D
90<840 μ m.Cross 100-20 mesh sieve.
Most preferably pulverize number of times 3 times, be crushed to particle diameter 74 μ m<D
90<150 μ m.Cross 200-100 mesh sieve.
Precomminution object provides powder material for follow-up ultramicro grinding.Pulverize number of times fewer, precomminution material particular diameter is excessive, and when ultramicro grinding, efficiency can reduce greatly.
C, ultramicro grinding: the agate coffee after step B precomminution is carried out to miniaturization pulverizing, and being crushed to particle diameter is 5 μ m≤D
90<74 μ m obtains ultra micro pueraria root powder.
Obtain grinding time that above-mentioned particle size range is spent and be about 10-50min, along with the prolongation of grinding time, the particle diameter of pueraria root powder is less.
Further preferably be crushed to particle diameter 10 μ m<D
90the ultra micro pueraria root powder of <74 μ m.
The most preferred particle diameter 5 μ m<D that are crushed to
90the ultra micro pueraria root powder of≤10 μ m.
To sum up, the present invention applies and provides Ultramicro-powder this brand-new product form for agate coffee, preparation method is simple to operation, production cost is low, for effectively utilizing agate coffee resource, improve raw material UD enhancing muscle power, antifatigue, improve sexual function, improve the effects such as fertility a kind of new selection is provided.
The 3rd technical problem solved by the invention is to provide take ultra micro pueraria root powder, Bee Pollen as primary raw material and prepares granular product, hereinafter referred to as agate flower health care particle.After inventor finds ultra micro pueraria root powder to mix with Bee Pollen and uses in development process, find that it strengthens muscle power, anti-fatigue effect and is better than common pueraria root powder (D90=250 μ m) mixes use with Bee Pollen.
Bee Pollen of the present invention is: honeybee gathers the pollen cell in angiosperm stamen flower pesticide or gymnosperm microsporangium, group's material shape thing of formation.Research according to Switzerland doctor A.Maurizio to tens thousand of pollen ball weights, honeybee approximately will be adopted 500 flowers and just can complete the amount of carrying of a pollen ball (4.2～10.7 milligrams).Be pollen just because of the food of honeybee, just can make them there is so powerful endurance and muscle power.Bee Pollen is the most comprehensive dietotherapy good merchantable brand of a kind of nutrition, has strong muscle power, increases spirit, eliminates rapidly tired, anti-ageing, control body weight, the effect such as cardiac and cerebral blood vessel nourishing, skin care and beauty treatment.
Bee Pollen is because of the difference of originating, there are rape pollen, pollen of Semen Fagopyri Esculenti, sesame pollen, sunflower powder, zasiokaurin, Pollen Astragali Melilotoidis (Pollen Astragali Sinici), Pollen Viciae fabae, Pulp Citrulli Pollen, cushaw pollen, citrus pollen, Pollen Codonopsis, dandelion pollen, lotus pollen, tea flower pollen, sophora flower pollen, lime tree pollen etc. according to the common Bee Pollen in source, all there is antifatigue, strengthen the effects such as muscle power, skin care and beauty treatment.
The particle diameter of agate flower health care particle of the present invention is 297 μ m≤D
90<2000 μ m.Cross 10-50 mesh sieve.
Further, described is the raw material that primary raw material prepares granular product and can be used as electuary, compressing tablet, capsule class product by ultra micro pueraria root powder, Bee Pollen.
Agate of the present invention is spent health care particle, comprises the raw material of following weight proportioning: 100 ~ 300 parts of ultra micro pueraria root powders, 50 ~ 150 parts of Bee Pollens.
Further, described agate is spent health care particle, comprises the raw material of following weight proportioning: 150 ~ 250 parts of ultra micro pueraria root powders, 80 ~ 130 parts of Bee Pollens.
Preferably, described agate is spent health care particle, comprises the raw material of following weight proportioning: 180 parts of ultra micro pueraria root powders, 100 parts of Bee Pollens.
Further, on the basis of aforementioned agate flower health care particle, can also add auxiliary material, comprise the auxiliary material of following weight proportion: 20 ~ 100 parts of xylitols, 10 ~ 80 parts, dextrin, 5 ~ 50 parts of dolomols.
Further, the auxiliary material weight proportion of described agate flower health care particle is as follows: 40 ~ 80 parts of xylitols, 20 ~ 60 parts, dextrin, 15 ~ 30 parts of dolomols.
Preferably, the auxiliary material weight proportion of described agate flower health care particle is as follows: 20 parts of 60 parts of xylitols, DEXTRIN part, dolomol.
The preparation method of agate flower health care particle of the present invention comprises the steps:
A, raw material mix: powder is mixed, and wherein powder comprises 100 ~ 300 parts of ultra micro pueraria root powders, 50 ~ 150 parts of Bee Pollens;
B, granulation: granulate mixing powder in step a, slowly add 20 ~ 100 parts of xylitols in pelletization, shaped granule particle diameter is 297 μ m≤D
90<2000 μ m; (being 10-50 order)
C, dry, cooling: by particle drying after pelletizing forming in step b;
After cooling, get product.
Further, in step a, powder also comprises 10 ~ 80 parts, dextrin, 5 ~ 50 parts of dolomols.
Further, 50 ~ 80 ℃ of baking temperatures in step c, be 15 ~ 20min drying time.
In the present invention, agate flower health care particle is take ultra micro pueraria root powder, Bee Pollen as primary raw material use; Xylitol uses as sweetener, can reduce glycemic index (GI value); Dextrin uses as adhesive; Dolomol, as lubricant, glidant, makes the particle of making have good mobility and compressibility.
Inventor was studied the granulation time in step b: overlong time can be destroyed grain forming, and the time is too short can not reach pelletizing forming effect, and can obtain shaped granule particle diameter is 297 μ m≤D
90<2000 μ m.
In step c drying time long or baking temperature is too high, can cause product to produce and be charred smell, mouthfeel is bitter; Drying time is too short or baking temperature is too low, and the loose degree of product can not reach requirement.
In agate of the present invention flower health care particle, after adopting ultra micro pueraria root powder to mix with Bee Pollen to use, it strengthens the effects such as muscle power, antifatigue, the sexual function of improving, raising fertility and is better than common pueraria root powder (D90=250 μ m) mixes the effect of use with Bee Pollen.
The specific embodiment
The specific embodiment of form by the following examples, is described in further detail foregoing of the present invention again, illustrates but does not limit the present invention.
At present, agate coffee application normality is:
1, pueraria root powder: approximately 60 orders, are equivalent to particle diameter 250 μ m.This class pueraria root powder powder particle diameter is bigger than normal, can not guarantee material to utilize to greatest extent in use procedure; Material surface absorption affinity and affinity are not strong, Gu fragrance, dispersiveness and dissolubility deficiency are difficult for being assimilated by human body; Reduce the absorption of its nutrient and tired.
Other raw materials that use in the following example of the present invention are the delicatessen food level raw material that field of food is conventional.
The source of the equipment using in following embodiment:
Micronizer: Chengdu Bang Bangwa Industrial Co., Ltd., model C BF-500;
Baking oven: Xinmai Machinery (Wuxi) Co., Ltd., model SV2;
Moisture teller: the full-automatic micro-water analyzer of SF101 type.Zibo Zi Fen Instrument Ltd.;
Bettersize2000B Intelligent Laser particle size analyzer.Baite Instrument Co., Ltd., Dandong;
Medicinal herb grinder, model 30B, the normal grand pharmaceutical machine instrument factory of Changsha;
Granulator: Kexu Pharmaceutic Machinery Mfg. Co., Ltd., Chongqing City
Fluid bed dryer: Kexu Pharmaceutic Machinery Mfg. Co., Ltd., Chongqing City
The preparation method of agate coffee submicron order powder of the present invention is as follows:
Embodiment 1 prepares ultra micro pueraria root powder
A, smoke: agate coffee is put into baking oven and smoke, 60 ℃ of baked temperatures; Smoke time 4h; Smoking rear determination of moisture is 9%.
B, precomminution: after drying, agate coffee drops into precomminution in medicinal herb grinder, pulverize number of times 3 times, and powder particle diameter is D
90=104 μ m.
C, ultramicro grinding: agate coffee after precomminution is put in micronizer and carried out miniaturization pulverizing, and grinding time 40min, obtains ultra micro pueraria root powder.Particle diameter is D after measured
90=6.5 μ m.
Embodiment 2 prepares ultra micro pueraria root powder
A, smoke: agate coffee is put into baking oven and smoke, 65 ℃ of baked temperatures; Smoke time 3h; Smoking rear determination of moisture is 8%.
B, precomminution: after drying, agate coffee drops into precomminution in medicinal herb grinder, pulverize number of times 2 times, and powder particle diameter is D
90=150 μ m.
C, ultramicro grinding: agate coffee after precomminution is put in micronizer and carried out miniaturization pulverizing, and grinding time 50min, obtains ultra micro pueraria root powder.Particle diameter is D after measured
90=5.5 μ m.
Embodiment 3 prepares ultra micro pueraria root powder
A, smoke: agate coffee is put into baking oven and smoke, 70 ℃ of baked temperatures; Smoke time 3.5h; Smoking rear determination of moisture is 7%.
B, precomminution: after drying, agate coffee drops into precomminution in medicinal herb grinder, pulverize number of times 4 times, and powder particle diameter is D
90=74 μ m.
C, ultramicro grinding: agate coffee after precomminution is put in micronizer and carried out miniaturization pulverizing, and time 60min, obtains ultra micro pueraria root powder.Particle diameter is D90=5 μ m after measured.
Embodiment 4 adopts the inventive method to prepare agate flower health care particle
Formula: 150 parts of ultra micro pueraria root powders (adopting embodiment 1 to prepare), 80 parts of rape pollens, 40 parts of xylitols, 30 parts, dextrin, 13 parts of dolomols.
Testing equipment: granulator, fluid bed dryer
Preparation:
1. raw material mixes: powder is mixed, and wherein powder comprises 150 parts of ultra micro pueraria root powders, 80 parts of rape pollens, 30 parts, dextrin, 13 parts of dolomols.
2. granulate: drop into pelletizing forming in granulator by mixing powder in step a, pelletization slowly adds 40 parts of xylitols, the time 2min that granulates, and shaped granule particle diameter is D90=840 μ m.3. dry: will be after pelletizing forming in step b particle drop in fluid bed dryer dry, drying time 15min.
4. cooling: dried particle to be placed on to chilling room, to be cooled to 4 ~ 7 ℃.
5. packing: make through the packaging bags with ultraviolet disinfection.
Embodiment 5 adopts the inventive method to prepare agate flower health care particle
Formula: 20 parts of 180 parts of ultra micro pueraria root powders (adopt embodiment 2 prepare), 100 parts of pollen of Semen Fagopyri Esculenti, 60 parts of xylitols, DEXTRIN part, dolomol.
Testing equipment: granulator, fluid bed dryer
Preparation:
1. raw material mixes: powder is mixed, and wherein powder comprises 20 parts of 180 parts of ultra micro pueraria root powders, 100 parts of pollen of Semen Fagopyri Esculenti, DEXTRIN part, dolomol.
2. granulate: drop into pelletizing forming in granulator by mixing powder in step a, pelletization slowly adds 60 parts of xylitols, the time 2.5min that granulates, and shaped granule particle diameter is D
90=840 μ m.3. dry: will be after pelletizing forming in step b particle drop in fluid bed dryer dry, drying time 18min.
4. cooling: dried particle to be placed on to chilling room, to be cooled to 4 ~ 7 ℃.
5. packing: make through the packaging bags with ultraviolet disinfection.
Embodiment 6 adopts the inventive method to prepare agate flower health care particle
Formula: 250 parts of ultra micro pueraria root powders (adopting embodiment 3 to prepare), 150 parts of Pollen Astragali Melilotoidis (Pollen Astragali Sinici)s, 80 parts of xylitols, 60 parts, dextrin, 30 parts of dolomols.
Testing equipment: granulator, fluid bed dryer
Preparation:
1. raw material mixes: powder is mixed, and wherein powder comprises 250 parts of ultra micro pueraria root powders, 150 parts of Pollen Astragali Melilotoidis (Pollen Astragali Sinici)s, 60 parts, dextrin, 30 parts of dolomols.
2. granulate: drop into pelletizing forming in granulator by mixing powder in step a, pelletization slowly adds 80 parts of xylitols, the time 3min that granulates, and shaped granule particle diameter is D90=710 μ m.3. dry: will be after pelletizing forming in step b particle drop in fluid bed dryer dry, drying time 20min.
4. cooling: dried particle to be placed on to chilling room, to be cooled to 4 ~ 7 ℃.
5. packing: make through the packaging bags with ultraviolet disinfection.
Embodiment 7 adopts the inventive method to prepare agate flower health care particle
Formula: 150 parts of ultra micro pueraria root powders (adopting embodiment 1 to prepare), 80 parts of sophora flower pollen, 40 parts of xylitols, 30 parts, dextrin, 13 parts of dolomols.
Testing equipment: granulator, fluid bed dryer
Preparation:
1. raw material mixes: powder is mixed, and wherein powder comprises 150 parts of ultra micro pueraria root powders, 80 parts of sophora flower pollen, 30 parts, dextrin, 13 parts of dolomols.
2. granulate: drop into pelletizing forming in granulator by mixing powder in step a, pelletization slowly adds 40 parts of xylitols, the time 2min that granulates, and shaped granule particle diameter is D
90=840 μ m.3. dry: will be after pelletizing forming in step b particle drop in fluid bed dryer dry, drying time 15min.
4. cooling: dried particle to be placed on to chilling room, to be cooled to 4 ~ 7 ℃.
5. packing: make through the packaging bags with ultraviolet disinfection.
Embodiment 8 adopts the inventive method to prepare agate flower health care particle
Formula: 20 parts of 180 parts of ultra micro pueraria root powders (adopt embodiment 2 prepare), 100 parts of zasiokaurins, 60 parts of xylitols, DEXTRIN part, dolomol.
Testing equipment: granulator, fluid bed dryer
Preparation:
1. raw material mixes: powder is mixed, and wherein powder comprises 20 parts of 180 parts of ultra micro pueraria root powders, 100 parts of zasiokaurins, DEXTRIN part, dolomol.
2. granulate: drop into pelletizing forming in granulator by mixing powder in step a, pelletization slowly adds 60 parts of xylitols, the time 2.5min that granulates, and shaped granule particle diameter is D
90=840 μ m.3. dry: will be after pelletizing forming in step b particle drop in fluid bed dryer dry, drying time 18min.
4. cooling: dried particle to be placed on to chilling room, to be cooled to 4 ~ 7 ℃.
5. packing: make through the packaging bags with ultraviolet disinfection.
Embodiment 9 adopts the inventive method to prepare agate flower health care particle
Formula: 250 parts of ultra micro pueraria root powders (adopting embodiment 3 to prepare), 150 parts of citrus pollen, 80 parts of xylitols, 60 parts, dextrin, 30 parts of dolomols.
Testing equipment: granulator, fluid bed dryer
Preparation:
1. raw material mixes: powder is mixed, and wherein powder comprises 250 parts of ultra micro pueraria root powders, 150 parts of citrus pollen, 60 parts, dextrin, 30 parts of dolomols.
2. granulate: drop into pelletizing forming in granulator by mixing powder in step a, pelletization slowly adds 80 parts of xylitols, the time 3min that granulates, and shaped granule particle diameter is D
90=710 μ m.3. dry: will be after pelletizing forming in step b particle drop in fluid bed dryer dry, drying time 20min.
4. cooling: dried particle to be placed on to chilling room, to be cooled to 4 ~ 7 ℃.
5. packing: make through the packaging bags with ultraviolet disinfection.
Embodiment 10 adopts common pueraria root powder to replace ultra micro pueraria root powder to prepare agate flower health care particle
Formula: common pueraria root powder (D
90m) 150 parts of=250 μ, 80 parts of rape pollens, 40 parts of xylitols, 30 parts, dextrin, 13 parts of dolomols.
Testing equipment: granulator, fluid bed dryer
Preparation:
1. raw material mixes: powder is mixed, and wherein powder comprises 150 parts of common pueraria root powders, 80 parts of rape pollens, 30 parts, dextrin, 13 parts of dolomols.
2. granulate: drop into pelletizing forming in granulator by mixing powder in step a, pelletization slowly adds 40 parts of xylitols, the time 2min that granulates, and shaped granule particle diameter is D
90=840 μ m.
3. dry: will be after pelletizing forming in step b particle drop in fluid bed dryer dry, drying time 15min.
4. cooling: dried particle to be placed on to chilling room, to be cooled to 4 ~ 7 ℃.
5. packing: make through the packaging bags with ultraviolet disinfection.
Below for the beneficial effect of ultra micro pueraria root powder of the present invention and agate flower health care particle proves test.
Experimental example 1 swimming with a load attached to the body experiment
1, experiment purpose
It is the macro manifestations that anti-fatigue ability improves that exercise tolerance improves.Test by mice burden swimming, react the degree of fatigue of mouse with the length of swimming time.Compare the length of its swimming time, can react the difference of the anti-fatigue effect of each group of tested material.
2, experiment material
(1) test raw material:
Pueraria root powder: common pueraria root powder (250 μ m), embodiment 1(6.5 μ m), embodiment 2(5.5 μ m), embodiment 3(5 μ m); The health care of agate flower particle: embodiment 4, embodiment 5, embodiment 6, embodiment 7, embodiment 8, embodiment 9, embodiment 10.
(2) mouse stomach sample liquid preparation: take different-grain diameter raw material 0.25g, add 10ml pure water, vibration 1min makes it to mix, and making concentration is 0.025g/ml suspension.Face with now joining.
(3) animal used as test: select no-special pathogen (SPF) level male inbred strais Kunming kind adult mice, body weight 18g-22g.
3, experimental technique
(1) animal adapted to after 3 days in feeding environment, by body weight, it was divided into 12 groups at random, i.e. 11 experimental group and 1 negative control group, every group of 13 animals.In Animal House, keep quite, clean, ventilation and suitable illumination state, 20～26 ℃ of temperature, relative humidity 50%～65%.Guarantee that animal freely drinks water and takes food (drinking-water and feed are all through aseptic process).
(2) the human body RD of pueraria root powder is 0.05g/kgBWd, 8 experimental group be respectively common pueraria root powder (250 μ m), embodiment 1, embodiment 2, embodiment 3, embodiment 4, embodiment 5, embodiment 6, embodiment 7, embodiment 8, embodiment 9, embodiment 10, its dosage is all set to 10 times of human body RD (3.0g/ people/day), and 11 experimental group gavage dosage are 0.5g/kgBWd.Different grain size pueraria root powder is made into the suspension that concentration is 0.025g/ml with distilled water, by 2% body weight to mouse stomach.Negative control group is pressed 2% body weight gavage with distilled water.It is 30 days that given the test agent gives the time.
(3) last gives after given the test agent 30min, and the load mouse of 5% body weight sheet lead of afterbody is placed in to swimming trunk went swimming.The depth of water is no less than 30cm, and 25 ℃ ± 1.0 ℃ of water temperatures record mouse and start to the time of dead (head does not continue 8s in water), i.e. mice burden swimming time from swimming.
4, results and analysis
The table 1 swimming with a load attached to the body time
(1) known by table 1,12 groups of mice burden swimming time datas by analysis, compared with control group, common flour group, 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, 4 groups of embodiment, 5 groups of embodiment, 6 groups of embodiment, 7 groups of embodiment, 8 groups of embodiment, 9 groups of embodiment, 10 groups of differences of embodiment all have statistical significance, can think that control group is different from experimental group population mean.
(2) pueraria root powder embodiment group experimental result shows, the pueraria root powder experimental mice swimming with a load attached to the body time is significantly higher than control group, shows that pueraria root powder has function of alleviating fatigue; In pueraria root powder experimental group, the ultra micro pueraria root powder group mice burden swimming time is significantly higher than agate coffee common flour group equally, show after the ultramicronising of pueraria root powder end, specific area increases, its BA (physiological potency) strengthens, have more the potentiality that improve effect material absorbing utilization rate in material powder than agate coffee ordinary powder, more can improve the absorption of its nutrient and tire.
(3) agate flower health care particle embodiment group experimental result shows, agate spends the health care particle experimental mice swimming with a load attached to the body time to be significantly higher than pueraria root powder embodiment 1,2,3, show in agate flower health care particle, agate coffee and Bee Pollen effect have synergy, and its function of alleviating fatigue is better than effect of single use pueraria root powder; In agate flower health care particle experimental group, 4,5,6,7,8, the 9 mice burden swimming times of embodiment are significantly higher than embodiment 10 equally, show after the ultramicronising of pueraria root powder end, specific area increases, its BA (physiological potency) strengthens, coordinate after granulation with Bee Pollen, its synergy is better than common pueraria root powder and directly coordinates Bee Pollen to granulate, thereby more can improve the potentiality of effect material absorbing utilization rate in agate coffee, Bee Pollen material powder, act synergistically more outstanding, more can improve the absorption of its nutrient and tire.
(4) in agate flower health care particle experimental group, embodiment 4,5,6,7,8,9 mice burden swimming time difference not statistically significants, can think the kind of different Bee Pollens, mix with ultra micro pueraria root powder after use, its antifatigue having, strengthen the functional similar of muscle power, and both synergies can not affect for final effect to some extent because the kind of Bee Pollen is different.
Experimental example 2 serum ureas are measured
1, experiment purpose
When mouse is long, after swimming, in blood, urea content raises, and understands mouse degree of fatigue by measuring its content, and the urea content of more different groups can be evaluated the anti-fatigue effect of tested material.
2, experiment material
(1) test raw material:
Pueraria root powder: common pueraria root powder (250 μ m), embodiment 1(6.5 μ m), embodiment 2(5.5 μ m), embodiment 3(5 μ m); The health care of agate flower particle: embodiment 4, embodiment 5, embodiment 6, embodiment 7, embodiment 8, embodiment 9, embodiment 10.
(2) mouse stomach sample liquid preparation: take different-grain diameter pueraria root powder 0.25g, add 10ml pure water, vibration 1min makes it to mix, and making concentration is 0.025g/ml suspension.Face with now joining.
Reagent application liquid preparation: the acid solution used time adds 2 times of volume distilled water, is made into acid application liquid (reagent application liquid), 4 ℃ of preservations.
(3) animal used as test: select no-special pathogen (SPF) level male inbred strais Kunming kind adult mice, body weight 18g ~ 22g.
3, experimental technique
(1) animal adapted to after 3 days in feeding environment, by body weight, it was divided into 12 groups at random, i.e. 11 experimental group and 1 negative control group, every group of 13 animals.In Animal House, keep quite, clean, ventilation and suitable illumination state, 20～26 ℃ of temperature, relative humidity 50%～65%.Assurance animal freely drinks water and take food (drinking-water and feed are all through aseptic process), within every 3 days, changes bedding and padding.
(2) the human body RD of pueraria root powder is 0.5g/kgBWd, and experimental group dosage is set to 10 times of human body RD, and 11 experimental group gavage dosage are 5g/kgBWd.Different grain size pueraria root powder is made into the suspension that concentration is 0.025g/ml with distilled water, by 2% body weight to mouse stomach.Negative control group is pressed 2% body weight to mouse stomach with distilled water equally.It is 30 days that given the test agent gives the time.
(3) last gives after given the test agent 30min, be not swimming with a load attached to the body 90min in the water of 30 ℃ in temperature, rest 60min, pulls out eyeball and adopts the about 0.5ml(of the whole blood 2.5ml volume loop epoxy resins blood sampling tube that adds in advance 100ul heparin (2%)), put standing 30min in 4 ℃ of refrigerators.The centrifugal 10min of supercentrifuge 2000r/min, gets serum for subsequent use.
4, results and analysis
Table 2 urea nitrogen content
(1) known by table 2, compared with control group, common flour group, 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, 4 groups of embodiment, 5 groups of embodiment, 6 groups of embodiment, 7 groups of embodiment, 8 groups of embodiment, 9 groups of embodiment, 10 groups of differences of embodiment all have statistical significance, can think that control group is different from experimental group population mean.
(2) this experimental result shows, after the not swimming with a load attached to the body of pueraria root powder experimental mice, serum urea nitrogen content, significantly lower than control group, shows that pueraria root powder has function of alleviating fatigue; In pueraria root powder experimental group, after the not swimming with a load attached to the body of ultra micro pueraria root powder group mouse, serum urea nitrogen content is equally significantly lower than agate coffee common flour group, show after the ultramicronising of pueraria root powder end, specific area increases, its BA (physiological potency) strengthens, have more the potentiality that improve effect material absorbing utilization rate in material powder than agate coffee ordinary powder, more can improve the absorption of its nutrient and tire.
(3) agate flower health care particle embodiment group experimental result shows, after the not swimming with a load attached to the body of agate flower health care particle experimental mice, serum urea nitrogen content is significantly lower than pueraria root powder embodiment 1,2,3, show in agate flower health care particle, agate coffee and Bee Pollen effect have synergy, and its function of alleviating fatigue is better than effect of single use pueraria root powder; In agate flower health care particle experimental group, after embodiment 4,5,6,7,8,9 not swimmings with a load attached to the body of mouse, serum urea nitrogen content is equally significantly lower than embodiment 10, show after the ultramicronising of pueraria root powder end, specific area increases, its BA (physiological potency) strengthens, coordinate after granulation with Bee Pollen, its synergy is better than common pueraria root powder and coordinates Bee Pollen to granulate, thereby more can improve the potentiality of effect material absorbing utilization rate in agate coffee, Bee Pollen material powder, act synergistically more outstanding, more can improve the absorption of its nutrient and tire.
(4) in agate flower health care particle experimental group, serum urea nitrogen content difference not statistically significant after embodiment 4,5,6,7,8,9 not swimmings with a load attached to the body of mouse, can think the kind of different Bee Pollens, mix with ultra micro pueraria root powder after use, its antifatigue having, strengthen the functional similar of muscle power, and both synergies can not affect for final effect to some extent because the kind of Bee Pollen is different.
Claims (18)
1. ultra micro pueraria root powder, is characterized in that: its particle diameter is 5 μ m≤D
90<74 μ m.
2. ultra micro pueraria root powder according to claim 1, is characterized in that: its particle diameter is 10 μ m<D
90<74 μ m.
3. ultra micro pueraria root powder according to claim 1, is characterized in that: its particle diameter is 5 μ m<D
90≤ 10 μ m.
4. the preparation method of ultra micro pueraria root powder claimed in claim 1, is characterized in that: step is as follows:
A, smoke: agate coffee baked temperature 40-120 ℃, smoke under the condition of time 1-6h and smoke; Smoke rear control moisture to 5%-15%;
B, precomminution: steps A gained is smoked to the precomminution of agate coffee, pulverize number of times 1-5 time, be crushed to particle diameter 74 μ m<D
90<840 μ m;
C, ultramicro grinding: the agate coffee after step B precomminution is carried out to miniaturization pulverizing, and being crushed to particle diameter is 5 μ m≤D
90<74 μ m obtains ultra micro pueraria root powder.
5. the preparation method of ultra micro pueraria root powder according to claim 4, is characterized in that: described in steps A, baked temperature is 60-80 ℃; The time of smoking is 2-4h; Smoke rear control moisture to 7%-12%;
The preferred baked temperature of steps A is 65 ℃; The time of smoking is 3h; Smoke rear control moisture to 8%.
6. the preparation method of ultra micro pueraria root powder according to claim 4, is characterized in that: described in step B, pulverizing number of times is 2-4 time, is crushed to particle diameter 150 μ m<D
90<840 μ m.
7. the preparation method of ultra micro pueraria root powder according to claim 4, is characterized in that: described in step B, pulverizing number of times is 3 times, is crushed to particle diameter 74 μ m<D
90<150 μ m.
8. the preparation method of ultra micro pueraria root powder according to claim 4, is characterized in that: it is 10 μ m<D that step C is crushed to particle diameter
90<74 μ m.
9. the preparation method of ultra micro pueraria root powder according to claim 4, is characterized in that: it is 5 μ m<D that step C is crushed to particle diameter
90≤ 10 μ m.
10. agate flower health care particle, is characterized in that: the raw material that comprises following weight proportioning:
100 ~ 300 parts of ultra micro pueraria root powders, 50 ~ 150 parts of Bee Pollens;
Preferably include the raw material of following weight proportioning:
150 ~ 250 parts of ultra micro pueraria root powders, 80 ~ 130 parts of Bee Pollens;
Further preferably include the raw material of following weight proportioning:
180 parts of ultra micro pueraria root powders, 100 parts of Bee Pollens.
11. agate flower health care particles according to claim 10, is characterized in that: the auxiliary material that also comprises following weight proportion:
20 ~ 100 parts of xylitols, 10 ~ 80 parts, dextrin, 5 ~ 50 parts of dolomols.
12. agate flower health care particles according to claim 11, is characterized in that: auxiliary material weight proportion is as follows:
40 ~ 80 parts of xylitols, 20 ~ 60 parts, dextrin, 15 ~ 30 parts of dolomols.
13. agate flower health care particles according to claim 12, is characterized in that: auxiliary material weight proportion is as follows:
20 parts of 60 parts of xylitols, DEXTRIN part, dolomol.
The preparation method of 14. agate flower health care particles claimed in claim 10, is characterized in that: comprise the steps:
A, raw material mix: powder is mixed, and wherein powder comprises 100 ~ 300 parts of ultra micro pueraria root powders, 50 ~ 150 parts of Bee Pollens;
B, granulation: granulate mixing powder in step a, slowly add 20 ~ 100 parts of xylitols in pelletization, shaped granule particle diameter is 297 μ m≤D
90<2000 μ m;
C, dry, cooling: by particle drying after pelletizing forming in step b, cooling after, get product.
The preparation method of 15. agate flower health care particles according to claim 14, is characterized in that: in step a, powder also comprises 10 ~ 80 parts, dextrin, 5 ~ 50 parts of dolomols.
The preparation method of 16. agate flower health care particles according to claim 14, is characterized in that: described in step c, baking temperature is 50 ~ 80 ℃, be 15 ~ 20min drying time.
The preparation method of 17. agate flower health care particles according to claim 14, is characterized in that: step c is cooled to 4 ~ 7 ℃.
Agate flower health care particle described in ultra micro pueraria root powder or claim 9-13 any one described in 18. claim 1-3 any one is in the purposes of preparing in the medicine of antifatigue, food, health food.
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