CN103830113A - Astaxanthin lipstick and making method thereof - Google Patents
Astaxanthin lipstick and making method thereof Download PDFInfo
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- CN103830113A CN103830113A CN201410045808.1A CN201410045808A CN103830113A CN 103830113 A CN103830113 A CN 103830113A CN 201410045808 A CN201410045808 A CN 201410045808A CN 103830113 A CN103830113 A CN 103830113A
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Abstract
The invention relates to an astaxanthin lipstick and a making method thereof. The making method specifically includes: preparation of esterified astaxanthin, preparation of an astaxanthin base oil mixed solution, preparation of an astaxanthin base oil wax mixed solution, and adding of vitamin E, honey and other auxiliary materials. The esterified astaxanthin has improved stability, absorption and utilization, and water resistance, has excellent antioxidant activity and anti-inflammatory effect, and also has anti-wrinkle, sunblocking, anti-inflammation, coloring and other functions. With the efficacy of water resistance, sunscreen, wrinkle resistance, color protection and the like, the astaxanthin lipstick provided by the invention also has health care functions to the human body, can reduce the incidence of cheilitis and prevent plateau cheilitis.
Description
Technical field
The present invention relates to a kind of cosmetics with health-care effect and preparation method thereof, be specifically related to a kind of lip pomade that is rich in astaxanthin and preparation method thereof.
Background technology
The endurance that lip Antagonistic Environment is invaded and harassed is the most weak in whole health skin, the most easily " aging ", and its organizational structure layer is very thin, only has the 1/3 thick of body skin.Because itself does not have pore, there is no sebaceous gland, so responsive especially to environment such as dry and low temperature, especially the autumn and winter are dried and cold weather, often make Mucosa of lip damage serious, easily bring out cheilitis.The pigmentation that daily ultraviolet radiation causes simultaneously, the problems such as sunburn and " photoaging ", very easily damage fragile lips, and the incidence rate of cheilitis is improved greatly.On the other hand, along with improving constantly of people's quality of life, people are not only to moisten lip to the requirement of lip pomade, also will reach color fixative, other the effect such as sun-proof.Therefore develop a kind of lip pomade that has moist color fixative, defying age and anti-inflammatory health effect concurrently, have great importance and very considerable market prospect.
Astaxanthin, as a kind of natural function coloring agent, is that the mankind find the antioxidant that nature is the strongest up to now.Doubly, stronger more than 100 times than vitamin E, non-oxidizability is ascorbic more than 6000 times to the energy force rate beta-carotene high more than 10 of its singlet-oxygen quenching and Mulberry Extract.Due to its natural antioxidant activity, it can effectively prevent skin photoaging, reduce UVA and injury, delaying cell aging, the minimizing melanin deposition of UVB to skin, enhancing human body immunity power; Astaxanthin has outstanding anti-inflammatory activity simultaneously, all has good treatment and preventive effect for the inflammation including cheilitis.In addition, the distinctive color and luster of astaxanthin can allow the more aobvious elasticity of lips, tension force and moist sense.But due to the astaxanthin poor stability of free state, under naturalness very easily occur oxidation fade, therefore limited its application in product, the esterification of astaxanthin that the present invention exists using occurring in nature and/or the esterification of astaxanthin prepared by chemosynthesis are as raw material, use it in the making of lip pomade, astaxanthin after esterification not only stability improves, specific ionization astaxanthin is easily absorbed (SHOWALTER L A by body tissue simultaneously, OSTERLIE M.Plasma appearance and tissue accumulation of non-esterified, free astaxanthin in C57BL/6mice after oral dosing of a disodium disuccinate diester of astaxanthin (HeptaxTM) [J] .Comp Biochem Phys C, 2004, 137:227-236), better bring into play the physiologically active of astaxanthin.In the situation that improving astaxanthin stability, the natural anti-oxidation function of astaxanthin and anti-inflammatory activity are applied to lip nursing, thereby reach better color fixative, sun-proof and antidotal object, more can effectively prevent and reduce the generation of cheilitis simultaneously.
Along with the development of lip pomade production industry, for having concurrently, the lip pomade demand of moistening with health-care effect is further strong.Application publication number is patent of invention " a kind of manufacture method of the honey lip balm " (applying date: 2010/04/07) of CN 101690709 A, that to adopt Mel, Aloe, vaseline be the lip gloss that primary raw material is made, can effectively solve the problem of lip pomade waterproof, sun-proof and color fixative, but likely cannot evade stimulation and the toxicity problem of mineral wax to lip skin.Application publication number is patent of invention " a kind of konjac glucomannan lip protector and preparation method thereof the " (applying date: 2011/05/28) of CN 102198056 A, adopting Rhizoma amorphophalli glucomannan, Cera Flava, lanoline is primary raw material, be equipped with vitamin E, food coloring and essence, there is the advantages such as waterproof, sun-proof, color fixative, have certain health-care effect concurrently, but effect may be less aspect the prevention of cheilitis and alleviation in this invention.And the patent of invention that application publication number is CN1116923 " alkannin bacteriostatic lipstick " (applying date: 1995/03/18), contain wax, oils and fats, pigment, spice, and 0.01～2% alkannin.This product color is stable, nature, little to the side effect of human body, can be antibacterial, antiinflammatory, antiviral, and the inflammation of lip is had to certain therapeutical effect.But this lip pomade is to moistening and persistent less demanding, and have some limitations solving aspect the problem of sun-proof, the waterproof of lip pomade.
Summary of the invention
The object of this invention is to provide one not only can moisturizing, color fixative, sun-proof, waterproof, and human body is had to the astaxanthin lip pomade of certain health care functions.First, astaxanthin, as a kind of natural pigment, can provide honorable color and luster, makes the more aobvious elasticity of lips, tension force and moist sense; Secondly, astaxanthin has natural strong anti-oxidation activity, can effectively prevent photoaging, minimizing UVA and injury, delaying skin aging, the minimizing melanin deposition of UVB to skin of skin, brings into play the function of its sun-proof U.S. flesh; And the anti-inflammatory activity that astaxanthin itself has, can effectively prevent and alleviate cheilitis.
Astaxanthin lip pomade of the present invention, prepares as raw material by esterification of astaxanthin.
Wherein esterification of astaxanthin is taking one or more in Haematocoocus Pluvialls, shrimp, Eriocheir sinensis as raw material, extracts with solvent extraction method or supercritical fluid extraction.
Esterification of astaxanthin can also be taking free state astaxanthin as raw material, prepares through esterification.
Astaxanthin lip pomade manufacture method of the present invention, its a kind of operating procedure is as follows:
1) prepare oily wax mixed liquor: after 1～10:1 mixes in mass ratio by base oil and wax, under 80～90 DEG C of conditions, heating and melting is made clear solution;
2) preparation astaxanthin base oil mixed liquor: esterification of astaxanthin is added in the middle of base oil in the ratio of mass fraction 0.1～10%, and be stirred to astaxanthin and dissolve form astaxanthin base oil mixed liquor completely;
3) preparation astaxanthin oil wax mixed liquor: oily wax mixed liquor prepared by step 1) is after the cooling 2～5min of room temperature, with step 2) the astaxanthin base oil mixed liquor prepared by volume 1～20:1 mixes, form the oily wax mixed liquor of astaxanthin;
4) batching: in the astaxanthin oil wax mixed liquor of step 3), add successively vitamin E, Mel and fruit essence, addition mass fraction is respectively 0.5～3%, and 0.1～3% and 0～1%, fully mix;
5) fill, molding: the mixed liquor that step 4) is added after adjuvant is placed in vacuum drying oven, at 65 DEG C, the de-bubbled that reduces pressure under 210Pa condition 5～60min, then takes out fill, is placed in 0～4 DEG C of temperature and solidifies 0.5～24h.
Base oil used is one or more the mixture in olive oil, Semen Tritici aestivi germ oil, Oleum Cocois, Semen pruni armeniacae oil and shea butter;
Wax used be Cera Flava, candelilla wax, may ground lira wax and lanoline in one or more mixture.
In preparation process, in step 4), be also added with a kind of 3,4,3',4'-tetraketo-.beta.-carotene derivant, its chemical general formula is:
Wherein, Sugar is any one or several in glucose, fructose, galactose, lactose or gentiobiose.
The 3,4,3',4'-tetraketo-.beta.-carotene derivant good water solubility of adding, and can increase the color of lip pomade, better embody U.S. lip effect.
It is primary raw material that the present invention selects through the astaxanthin of esterification, base oil and waxiness, taking vitamin E and Mel as adjuvant, containing harmful composition, can not produce harm to human body, is suitable for crowd extensive.The natural anti-oxidation of astaxanthin and anti-inflammatory activity are applied to lip nursing by the present invention, not only plays the effect of nourishing and moisturizing color fixative, and prevent the damage of ultraviolet and poor environment, plays the effect of sun-proof U.S. flesh; Can effectively prevent and reduce the generation of cheilitis, there is certain health care simultaneously.Astaxanthin lip pomade of the present invention is easy to use, and its manufacturing process is simple, safety, operability are high, aspect the development that promotes health care lip pomade, has positive meaning.
Detailed description of the invention
The present invention selects the astaxanthin after esterification, has retained the biological activity of free astaxanthin, has overcome again the drawback of free state astaxanthin poor stability.And the astaxanthin that the astaxanthin after esterification dissociates is more easily absorbed by tissue utilization; After esterification simultaneously, astaxanthin hydrophobicity strengthens, and makes the moisturizing water proofing property of the astaxanthin lip pomade making better.
In order fully to disclose astaxanthin lip pomade of the present invention and preparation method thereof, be illustrated below in conjunction with embodiment.
Embodiment 1
A kind of manufacture method of astaxanthin lip pomade, comprise the following steps: the preparation of (1) esterification of astaxanthin: the biological raw material using Haematocoocus Pluvialls as preparation esterification of astaxanthin, take a certain amount of haematococcus pluvialis powder, add the ethanol of 3 times～20 times raw materials quality (W/V), lixiviate 1 time～3 times repeatedly, each lixiviate 0.1h～12h, merge lixiviating solution, then lixiviating solution, through concentrating under reduced pressure, is removed solvent, the more purified esterification of astaxanthin for preparing; (2) prepare oily wax mixed liquor: by olive oil and Cera Flava in mass ratio 4:1 take, be placed on heating and melting under 80 DEG C of conditions, heat while stirring, until wax dissolves completely, solution clear; (3) preparation astaxanthin mixed with olive oil liquid: esterification of astaxanthin prepared by step (1) is added in the middle of olive oil in the ratio of mass fraction 2%, and be stirred to astaxanthin and dissolve completely, form the solution of homogeneous thickness, be made into astaxanthin mixed with olive oil liquid; (4) preparation astaxanthin oil wax mixed liquor: oily wax mixed liquor prepared by step (2) is after the cooling 2min of room temperature, the astaxanthin mixed with olive oil liquid of preparing with step (3) mixes by a certain percentage, mixed proportion is volume ratio 8:1, limit bevelling stirs, fully mix, i.e. astaxanthin oil wax mixed liquor; (5) batching: in the astaxanthin oil wax mixed liquor of step (4), add successively vitamin E, Mel and apple essence, addition (mass fraction) is respectively 0.5%, 1% and 0.1%, fully mixes; (6) fill, molding: the mixed liquor that step (5) is added after adjuvant is placed in vacuum drying oven, and at 65 DEG C, the de-bubbled that reduces pressure under 210Pa condition 20min, then takes out fill, is placed in 4 DEG C of temperature and solidifies 1h.
Embodiment 2
A kind of manufacture method of astaxanthin lip pomade, comprise the following steps: the preparation of (1) esterification of astaxanthin: taking Antarctic krill as raw material lixiviate, take a certain amount of Antarctic krill powder, add the ethyl acetate of 3 times～20 times raw materials quality (W/V), lixiviate 1 time～3 times repeatedly, each lixiviate 0.1h～12h, merge lixiviating solution, then lixiviating solution, through concentrating under reduced pressure, is removed solvent, the more purified esterification of astaxanthin for preparing; (2) prepare oily wax mixed liquor: by Oleum Cocois and may ground lira wax in mass ratio 8:1 take, be placed on heating and melting under 85 DEG C of conditions, heat while stirring, until wax dissolves completely, solution clear; (3) preparation astaxanthin Oleum Cocois mixed liquor: esterification of astaxanthin prepared by step (1) is added in the middle of Oleum Cocois in the ratio of mass fraction 0.5%, and be stirred to astaxanthin and dissolve completely, the solution that forms homogeneous thickness, is made into astaxanthin Oleum Cocois mixed liquor; (4) preparation astaxanthin oil wax mixed liquor: oily wax mixed liquor prepared by step (2) is after the cooling 5min of room temperature, the astaxanthin Oleum Cocois mixed liquor of preparing with step (3) mixes by a certain percentage, mixed proportion is volume ratio 3:1, limit bevelling stirs, fully mix, i.e. astaxanthin oil wax mixed liquor; (5) batching: in the astaxanthin oil wax mixed liquor of step (4), add successively vitamin E, Mel and Fructus Citri Limoniae essence, addition (mass fraction) is respectively 3%, 2% and 0.5%, fully mixes; (6) fill, molding: the mixed liquor that step (5) is added after adjuvant is placed in vacuum drying oven, and at 65 DEG C, the de-bubbled that reduces pressure under 210Pa condition 60min, then takes out fill, is placed in 0 DEG C of temperature and solidifies 20min.
Embodiment 3
A kind of manufacture method of Fructus Mangifera Indicae taste astaxanthin lip pomade, comprise the following steps: the preparation of (1) esterification of astaxanthin: take haematococcus pluvialis powder 100g, in the extraction kettle in 1L supercritical extraction unit, the Temperature Setting of extraction kettle is 40 DEG C, pressure setting is 30MPa, extractant CO
2flow set be 20L/h, the temperature and pressure of separation reactor I is respectively 35 DEG C and 10MPa, the temperature of separation reactor I I is 40 DEG C, CO
2the flow velocity of fluid is 20L/h～40L/h, and the dynamic extraction time is 3h continuously, and extract is emitted aperiodically from separating still, collects and is stored in container, and extract is bolarious thick material, and wherein astaxanthin is mainly esterification of astaxanthin; (2) prepare oily wax mixed liquor: by Semen pruni armeniacae oil and candelilla wax wax in mass ratio 5:1 take, be placed on heating and melting under 85 DEG C of conditions, heat while stirring, until wax dissolves completely, solution clear; (3) preparation astaxanthin Semen pruni armeniacae oil mixed liquor: esterification of astaxanthin prepared by step (1) is added in the middle of Semen pruni armeniacae oil in the ratio of mass fraction 5%, and be stirred to astaxanthin and dissolve completely, the solution that forms homogeneous thickness, is made into astaxanthin Oleum Cocois mixed liquor; (4) preparation astaxanthin oil wax mixed liquor: oily wax mixed liquor prepared by step (2) is after the cooling 4min of room temperature, the astaxanthin Semen pruni armeniacae oil mixed liquor of preparing with step (3) mixes by a certain percentage, mixed proportion is volume ratio 10:1, limit bevelling stirs, fully mix, i.e. astaxanthin oil wax mixed liquor; (5) batching: in the astaxanthin oil wax mixed liquor of step (4), add successively vitamin E, Mel and Fructus Mangifera Indicae essence, addition (mass fraction) is respectively 2.5%, 1% and 0.6%, fully mixes; (6) fill, molding: the mixed liquor that step (5) is added after adjuvant is placed in vacuum drying oven, and at 65 DEG C, the de-bubbled that reduces pressure under 210Pa condition 20min, then takes out fill, is placed in 0 DEG C of temperature and solidifies 40min.
Embodiment 4
A manufacture method for astaxanthin lip pomade, comprises the following steps: the preparation of (1) esterification of astaxanthin: take Antarctic krill powder 100g, be placed in 1L extraction kettle, add 100mL ethanol as cosolvent simultaneously.Set extraction parameters, extraction kettle temperature is 41 DEG C, and pressure is 30MPa, CO
2flow be 20L/h, separation reactor I temperature is 32 DEG C, pressure is 8MPa, separation reactor I I temperature is 37 DEG C, continuously dynamic extraction 2h collects to variable interval kermesinus liquid from separating still.Then extracting solution is removed to cosolvent through concentrating under reduced pressure, obtain bolarious thick material, wherein astaxanthin is mainly esterification of astaxanthin; (2) prepare oily wax mixed liquor: by Semen Tritici aestivi germ oil and Cera Flava in mass ratio 9:1 take, be placed on heating and melting under 90 DEG C of conditions, heat while stirring, until wax dissolves completely, solution clear; (3) preparation astaxanthin Semen pruni armeniacae oil mixed liquor: esterification of astaxanthin prepared by step (1) is added in the middle of Semen Tritici aestivi germ oil in the ratio of mass fraction 5%, and be stirred to astaxanthin and dissolve completely, the solution that forms homogeneous thickness, is made into astaxanthin Semen Tritici aestivi germ oil mixed liquor; (4) preparation astaxanthin oil wax mixed liquor: oily wax mixed liquor prepared by step (2) is after the cooling 4min of room temperature, the astaxanthin Semen Tritici aestivi germ oil mixed liquor of preparing with step (3) mixes by a certain percentage, mixed proportion is volume ratio 20:1, limit bevelling stirs, fully mix, i.e. astaxanthin oil wax mixed liquor; (5) batching: in the astaxanthin oil wax mixed liquor of step (4), add successively vitamin E, Mel and strawberry essence, addition (mass fraction) is respectively 2%, 1% and 0.6%, fully mixes; (6) fill, molding: the mixed liquor that step (5) is added after adjuvant is placed in vacuum drying oven, and at 65 DEG C, the de-bubbled that reduces pressure under 210Pa condition 40min, then takes out fill, is placed in 4 DEG C of temperature and solidifies 2h.
Embodiment 5
A manufacture method for astaxanthin lip pomade, comprises the following steps: the preparation of (1) esterification of astaxanthin: carry out chemosynthesis taking free astaxanthin as raw material.Take 2g free astaxanthin and 300g sad, added in reaction vessel, add immobilized-lipase 100g simultaneously, 30mL adds water, stir, under 45 DEG C of conditions, stir, until reaction reaches balance, filtered and recycled immobilized-lipase, then, through silicagel column purification, obtains esterification of astaxanthin.(2) prepare oily wax mixed liquor: by shea butter and lanoline in mass ratio 3:1 take, be placed on heating and melting under 90 DEG C of conditions, heat while stirring, until wax dissolves completely, solution clear; (3) preparation astaxanthin shea butter mixed liquor: the esterification of astaxanthin that step (1) is made is added in the middle of shea butter in the ratio of mass fraction 0.8%, and be stirred to astaxanthin and dissolve completely, the solution that forms homogeneous thickness, is made into astaxanthin shea butter mixed liquor; (4) preparation astaxanthin oil wax mixed liquor: oily wax mixed liquor prepared by step (2) is after the cooling 3min of room temperature, the astaxanthin shea butter mixed liquor of preparing with step (3) mixes by a certain percentage, mixed proportion is volume ratio 2:1, limit bevelling stirs, fully mix, i.e. astaxanthin oil wax mixed liquor; (5) batching: in the astaxanthin oil wax mixed liquor of step (4), add successively vitamin E, Mel and strawberry essence, addition (mass fraction) is respectively 1%, 3% and 0.1%, fully mixes; (6) fill, molding: the mixed liquor that step (5) is added after adjuvant is placed in vacuum drying oven, and at 65 DEG C, the de-bubbled that reduces pressure under 210Pa condition 15min, then takes out fill, is placed in 2 DEG C of temperature and solidifies 4h.
Embodiment 6
3,4,3',4'-tetraketo-.beta.-carotene derivant preparation: the preparation of the two succinic acid glucose ester derivants of 3,4,3',4'-tetraketo-.beta.-carotene
Take 1g 3,4,3',4'-tetraketo-.beta.-carotene powder, add the succinic anhydrides of 3 times of moles, be heated to 50 DEG C, reaction 2h; React in backward reaction system and slowly added water to stir, treated that it occurs precipitation, filtered collecting precipitation thing, obtained hydroxy esterification product; The hydroxy esterification product obtaining is dissolved in to 80% ethanol, adds the glucose of 3 times of moles, under 50 DEG C of conditions, reaction 2h after having reacted, slowly adds acetone to Precipitation in reaction system, collecting precipitation, then uses water dissolution, obtains 3,4,3',4'-tetraketo-.beta.-carotene derivant aqueous solution; Carry out dehydrate, obtain the two succinic acid glucose ester derivants of 3,4,3',4'-tetraketo-.beta.-carotene, its chemical structural formula is as follows:
Another kind of preparation method:
Take the acetone soln that 10mL contains 0.1g 3,4,3',4'-tetraketo-.beta.-carotene, add the succinic anhydrides of 4 times of moles, be heated to 60 DEG C, reaction 1.5h; React in backward reaction system and slowly added water to stir, treated that it occurs precipitation, filtered collecting precipitation thing, obtained hydroxy esterification product; The hydroxy esterification product obtaining is dissolved in to 95% ethanol, adds the fructose of 2 times of moles, under 65 DEG C of conditions, reaction 1h after having reacted, slowly adds ethylene glycol to Precipitation in reaction system, collecting precipitation, then uses water dissolution, obtains 3,4,3',4'-tetraketo-.beta.-carotene derivant aqueous solution; Carry out dehydrate, obtain the two succinic acid fructose ester derivants of 3,4,3',4'-tetraketo-.beta.-carotene, its chemical structural formula is as follows:
The 3,4,3',4'-tetraketo-.beta.-carotene derivant of preparation is compared with raw material 3,4,3',4'-tetraketo-.beta.-carotene, and the dispersion in aqueous phase solution is significantly improved, and water solublity increases; Solve and limited its research and application problem in aqueous phase solution because dissolubility is limited.
3,4,3',4'-tetraketo-.beta.-carotene derivant is added in lip pomade manufacturing process, specific as follows:
(1) preparation of esterification of astaxanthin: the biological raw material using Haematocoocus Pluvialls as preparation esterification of astaxanthin, take a certain amount of haematococcus pluvialis powder, add the ethanol of 3 times～20 times raw materials quality (W/V), lixiviate 1 time～3 times repeatedly, each lixiviate 0.1h～12h, merges lixiviating solution, and then lixiviating solution is through concentrating under reduced pressure, remove solvent, the more purified esterification of astaxanthin for preparing; (2) prepare oily wax mixed liquor: by olive oil and Cera Flava in mass ratio 4:1 take, be placed on heating and melting under 80 DEG C of conditions, heat while stirring, until wax dissolves completely, solution clear; (3) preparation astaxanthin mixed with olive oil liquid: esterification of astaxanthin prepared by step (1) is added in the middle of olive oil in the ratio of mass fraction 2%, and be stirred to astaxanthin and dissolve completely, form the solution of homogeneous thickness, be made into astaxanthin mixed with olive oil liquid; (4) preparation astaxanthin oil wax mixed liquor: oily wax mixed liquor prepared by step (2) is after the cooling 2min of room temperature, the astaxanthin mixed with olive oil liquid of preparing with step (3) mixes by a certain percentage, mixed proportion is volume ratio 8:1, limit bevelling stirs, fully mix, i.e. astaxanthin oil wax mixed liquor; (5) batching: in the astaxanthin oil wax mixed liquor of step (4), add successively vitamin E, Mel, apple essence, 3,4,3',4'-tetraketo-.beta.-carotene derivant (Compound I), addition (mass fraction) is respectively 0.5%, 1%, 0.1%, 0.005%, fully mixes; (6) fill, molding: the mixed liquor that step (5) is added after adjuvant is placed in vacuum drying oven, and at 65 DEG C, the de-bubbled that reduces pressure under 210Pa condition 20min, then takes out fill, is placed in 4 DEG C of temperature and solidifies 1h.
U.S. lip effect detection: lip pomade sample prepared by lip pomade sample prepared by the present embodiment and the embodiment of the present invention 1 carries out the comparison of upper chromatic effect, measures color of the lip with spectrophotometric color measurement instrument and changes (L
*what value characterized is the Black-White of skin, L
*larger, show that skin is whiter.Product uses difference DELTA L rear and the front skin Black-White of product use
*, can react the variation of skin Black-White).Result is as follows:
Test result demonstration, the improve lip pomade that effect be better than do not add 3,4,3',4'-tetraketo-.beta.-carotene derivant of the lip pomade of interpolation 3,4,3',4'-tetraketo-.beta.-carotene derivant to color of the lip, illustrates that 3,4,3',4'-tetraketo-.beta.-carotene derivant can increase the color of lip pomade, better embodies U.S. lip effect.Wherein the addition of 3,4,3',4'-tetraketo-.beta.-carotene derivant (mass fraction) is 0.001%～0.01%.
The effect of lip pomade prepared by the present invention is described below:
1. the anxious poison test of rat
The product of the embodiment of the present invention 1～5 is carried out to the anxious poison test of rat, and result shows that this product belongs to non-toxic type.
2. sun-proof and repair function test
Tested object is lip pomade sample and control sample (replacing the esterification of astaxanthin in test sample with the olive oil of equivalent in control sample) prepared by embodiment 1.
Choose 6 of quality (20 ± 2) g Kunming healthy mices, male and female half and half, are divided into 2 groups at random, 3 every group.Respectively mice is prophylactically smeared to test sample and control sample, every back is to 0.6mL, and every monaural, to 0.3mL, 2 times/d, is smeared 4d altogether.Mice is horizontally fixed on brandreth and is placed in and irradiate 6h apart from uviol lamp vertical dimension 10cm place, cause skin lesion mouse model.Taking mouse skin keratinization and decortication degree as evaluation index, observe mouse back change of skin situation, the protective effect of analytic sample to mouse skin opposing ultraviolet injury.
Skin lesion mouse model is continued to put to death with disconnected ridge after ultraviolet radiation 40h, weigh mice quality, get respectively more circular auricle and the skin graft of two ears and back 9mm diameter, its quality of accurate weighing, calculate ear index (ear index=auricle quality/mice quality) and skin index (skin index=skin graft quality/mice quality), analytic sample is shot the inhibitory action of mice edema wounded to ultraviolet.Get after the fixing 24h of back portion skin 10% formaldehyde, make sealing sample.Sealing sample is placed in to 10 times of Microscopic observation skin configurations, the skin of observing from the visual field under 40 times of mirrors again starts to clap the first pictures topmost, every mobile scale 2mm claps and gets one afterwards, bat is got after 5 and is chosen 5 points on every pictures with microimage analysing system, measure its epidermal thickness, every pictures is measured 25 points altogether, averages and is designated as epidermal thickness, and analytic sample is to the cornified inhibitory action of mouse skin.Every pictures is got 6 visuals field, counts fibroblast number in each visual field, averages and is designated as each visual field dermal fibroblast number.
Ultraviolet injury mouse ear index, skin index, epidermal thickness and fibroblast measurement result are in table 1.
Table 1: ultraviolet injury mouse ear index, skin index, epidermal thickness and fibroblast
Result shows, mice by ultraviolet radiation after, be coated with by the mouse ear index of test sample, skin index, epidermal thickness value all than being coated with low with control sample, in its dermal tissue, fibroblast number is used the many of control sample than being coated with.Therefore, above-mentioned result of the test shows, the damage epidermis that astaxanthin lip pomade prepared by the present invention can effectively suppress to be caused by ultraviolet radiation thickens, suppresses epidermis keratinization, reduce that inflammation occurs, induction fibroblast generates.Astaxanthin lip pomade of the present invention, when protection skin is avoided ultraviolet injury, can also improve barrier function and the self-protection ability of skin.
3. the sample that prepared by couple embodiment 1 carries out U.S. lip efficacy test
Choose healthy volunteer (without serious systemic disease, immunodeficiency or autoimmune disease, to cosmetics without allergy, facial NAI, do not use hormone medicine or immunosuppressant, do not participate in other clinical trials, do not smear external preparation) 20, wherein 6 of male, 14 of women, age 28-35 year, average 32 years old.Be divided at random 2 groups, be that embodiment 1 makes astaxanthin lip pomade test sample group and lip pomade substrate matched group (control sample is to replace the esterification of astaxanthin in test sample with the olive oil of equivalent, then the lip pomade substrate that the method for describing according to embodiment 1 prepares), 10 every group.
The volunteer's skin of lip that sample is applied to separately to place group, improves effect evaluation to volunteer's skin of lip after 4h.
Adopt moisture of skin measuring instrument to measure the water content (%) in skin of lip horny layer, skin elasticity tester test skin of lip elasticity (in test process negative pressure constant be 450Mpa), result cancels the recovery value of negative pressure skin after 0.1 second with springback capacity Ur() with the ratio value representation of the maximum tension amount Uf of skin, numerical value more approaches 1, illustrates that skin elasticity is better.
Adopt wrinkle of skin tester test skin of lip wrinkle (first to copy the wrinkle of skin model at measured position with silicon mould, computer carries out grade separation and statistical disposition according to the wrinkle of skin degree of depth), calculation sample use before, use after skin mean roughness R3(: 5 equal length, the measured R1 value of different segment are got to arithmetic mean number, wherein R1 is illustrated in the distance between the interior peak value of certain length and minimum, and μ m).Result uses Δ R3(: the difference of the skin mean roughness before using sample and after use sample) expression, numerical value is higher, represents that wrinkle improves effect better.
Adopt skin image analyser to make a video recording to same lip position, measure and show that the varied in thickness of lip after use sample (m), μ measures color of the lip and change (L by spectrophotometric color measurement instrument
*what value characterized is the Black-White of skin, L
*larger, show that skin is whiter.Product uses difference DELTA L rear and the front skin Black-White of product use
*, can react the variation of skin Black-White).
Said determination the results are shown in Table 2.
Table 2: the improve effect of each sample to skin of lip
Above-mentioned result of the test shows, compared with lip pomade substrate matched group, test sample to skin of lip degree of hydration, dry, coarse, elasticity, compact, wrinkle, lip thickness and color of the lip to improve effect all more obvious.The antioxidant activity of this explanation astaxanthin is brought into play in lip pomade, further illustrates astaxanthin lip pomade of the present invention and has significant lip care, U.S. lip effect.
4. treatment cheilitis effect test
Choosing 20 clinical diagnosises is chronic cheilitis patient, 15～60 years old age, be divided at random two groups, and first group is test group, smears the product that the present embodiment 1 makes; Second group is matched group, smears emulsion of hydrocortisone butyrate, every day twice, connects and is coated with two weeks, and its result is as shown in table 4.
Table 4: treatment cheilitis effect test result
And, the lip pomade product effect of the testing result of lip pomade product prepared by other embodiment of the present invention and embodiment is similar, show that astaxanthin lip pomade product prepared by the present invention has the effect of certain auxiliary treatment cheilitis, can be used as the use of the generation of auxiliary treatment, prevention and reduction cheilitis.
Finally it may be noted that; the embodiment of the present invention is preferably embodiment of the present invention; but embodiments of the present invention are not restricted to the described embodiments; other any do not deviate from change, the modification done under spirit of the present invention and principle, substitutes, combination, simplify; all should be considered as equivalent substitute mode, be included in protection scope of the present invention.
Claims (7)
1. an astaxanthin lip pomade, is characterized in that, described astaxanthin lip pomade is prepared as raw material by esterification of astaxanthin.
2. astaxanthin lip pomade as claimed in claim 1, is characterized in that, described esterification of astaxanthin is taking one or more in Haematocoocus Pluvialls, shrimp, Eriocheir sinensis as raw material, extracts with solvent extraction method or supercritical fluid extraction.
3. astaxanthin lip pomade as claimed in claim 1, is characterized in that, described esterification of astaxanthin can also be taking free state astaxanthin as raw material, prepares through esterification.
4. the manufacture method of astaxanthin lip pomade claimed in claim 1, its step is as follows:
1) prepare oily wax mixed liquor: after 1～10:1 mixes in mass ratio by base oil and wax, under 80～90 DEG C of conditions, heating and melting is made clear solution;
2) preparation astaxanthin base oil mixed liquor: esterification of astaxanthin is added in the middle of base oil in the ratio of mass fraction 0.1～10%, and be stirred to astaxanthin and dissolve form astaxanthin base oil mixed liquor completely;
3) preparation astaxanthin oil wax mixed liquor: oily wax mixed liquor prepared by step 1) is after the cooling 2～5min of room temperature, with step 2) the astaxanthin base oil mixed liquor prepared by volume 1～20:1 mixes, form the oily wax mixed liquor of astaxanthin;
4) batching: in the astaxanthin oil wax mixed liquor of step 3), add successively vitamin E, Mel and fruit essence, addition mass fraction is respectively 0.5～3%, and 0.1～3% and 0～1%, fully mix;
5) fill, molding: the mixed liquor that step 4) is added after adjuvant is placed in vacuum drying oven, at 65 DEG C, the de-bubbled that reduces pressure under 210Pa condition 5～60min, then takes out fill, is placed in 0～4 DEG C of temperature and solidifies 0.5～24h.
5. the manufacture method of astaxanthin lip pomade as claimed in claim 4, is characterized in that base oil used is one or more in olive oil, Semen Tritici aestivi germ oil, Oleum Cocois, Semen pruni armeniacae oil and shea butter.
6. the manufacture method of astaxanthin lip pomade as claimed in claim 4, it is characterized in that wax used be Cera Flava, candelilla wax, may ground lira wax and lanoline in one or more mixture.
7. the manufacture method of astaxanthin lip pomade as claimed in claim 4, is characterized in that in step 4), being also added with a kind of 3,4,3',4'-tetraketo-.beta.-carotene derivant, and its chemical general formula is:
Wherein, Sugar is any one or several in glucose, fructose, galactose, lactose or gentiobiose.
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| CN105581966A (en) * | 2016-02-29 | 2016-05-18 | 广西南岜仔科技有限公司 | Lithospermum erythrorhizon lipstick and preparation method thereof |
| CN106309316A (en) * | 2016-08-29 | 2017-01-11 | 李曼知 | All-natural lipstick containing no castor oil or synthetic raw materials |
| CN108618989A (en) * | 2018-08-14 | 2018-10-09 | 威海利达生物科技有限公司 | A kind of lipstick and its production method of addition astaxanthin |
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