CN103814001A - 方法和中间体 - Google Patents

方法和中间体 Download PDF

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Publication number
CN103814001A
CN103814001A CN201280034618.9A CN201280034618A CN103814001A CN 103814001 A CN103814001 A CN 103814001A CN 201280034618 A CN201280034618 A CN 201280034618A CN 103814001 A CN103814001 A CN 103814001A
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CN
China
Prior art keywords
formula
compound
alkyl
group
aliphatic series
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280034618.9A
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English (en)
Chinese (zh)
Inventor
G.J.塔诺里
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of CN103814001A publication Critical patent/CN103814001A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
CN201280034618.9A 2011-05-13 2012-05-11 方法和中间体 Pending CN103814001A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161486125P 2011-05-13 2011-05-13
US61/486,125 2011-05-13
PCT/US2012/037509 WO2012158513A1 (en) 2011-05-13 2012-05-11 Processes and intermediates

Publications (1)

Publication Number Publication Date
CN103814001A true CN103814001A (zh) 2014-05-21

Family

ID=47177277

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280034618.9A Pending CN103814001A (zh) 2011-05-13 2012-05-11 方法和中间体

Country Status (4)

Country Link
EP (1) EP2707347A1 (he)
CN (1) CN103814001A (he)
IL (1) IL229426A0 (he)
WO (1) WO2012158513A1 (he)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103435532B (zh) * 2013-09-02 2015-07-08 苏州永健生物医药有限公司 波普瑞韦中间体的合成方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1946692A (zh) * 2004-02-27 2007-04-11 先灵公司 作为丙型肝炎病毒ns3丝氨酸蛋白酶抑制剂的3,4－(环戊基)－稠合的脯氨酸化合物
CN101291909A (zh) * 2005-08-19 2008-10-22 弗特克斯药品有限公司 方法和中间体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SV2003000617A (es) 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
JP5431956B2 (ja) * 2006-12-20 2014-03-05 メルク・シャープ・アンド・ドーム・コーポレーション 重亜硫酸塩中間体を使用した６，６−ジメチル−３−アザビシクロ［３．１．０］ヘキサン化合物の調製方法
AU2011261349A1 (en) * 2010-06-03 2012-12-06 Vertex Pharmaceuticals Incorporated Processes and intermediates

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1946692A (zh) * 2004-02-27 2007-04-11 先灵公司 作为丙型肝炎病毒ns3丝氨酸蛋白酶抑制剂的3,4－(环戊基)－稠合的脯氨酸化合物
CN101291909A (zh) * 2005-08-19 2008-10-22 弗特克斯药品有限公司 方法和中间体

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
RUI ZHANG，ET AL.: "Design, Synthesis and Evaluationof Poly-L-Proline Type-II Peptide Mimics Based on the 3-Azabicyclo[3.1.0]hexane System", 《J.ORG.CHEM.》 *
SISKA HENDRATA，ET AL.: "Syntheses of dipeptides containing (1R,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2(S)-carboxylic acid (4),(1R,5S)-spiro[3-azabicyclo[3.1.0].....(1S,5R)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2(S)-carboxylic acid（6）", 《TETRAHEDRON LETTERS》 *
VALENTIN KÖHLER，ET AL.: "Enantioselective Biocatalytic Oxidative Desymmetrization of Substituted Pyrrolidines", 《ANGEW. CHEM. INT. ED.》 *

Also Published As

Publication number Publication date
WO2012158513A1 (en) 2012-11-22
EP2707347A1 (en) 2014-03-19
IL229426A0 (he) 2014-01-30

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