CN103800507A - Compound skin ulcer resisting suspension and preparation method thereof - Google Patents
Compound skin ulcer resisting suspension and preparation method thereof Download PDFInfo
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- CN103800507A CN103800507A CN201410094858.9A CN201410094858A CN103800507A CN 103800507 A CN103800507 A CN 103800507A CN 201410094858 A CN201410094858 A CN 201410094858A CN 103800507 A CN103800507 A CN 103800507A
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Abstract
The invention discloses a preparation method for a compound skin ulcer resisting suspension. The preparation method comprises following steps: (1) adding astragalus membranaceus, golden cypress, coptis chinensis, scutellaria baicalensis, angelica dahurica and sanguisorba officinalis into a heating container; adding water and decocting; filtering to obtain a filtering solution; (2) mixing salicylic acid, camphor, borneol, zinc oxide, phenol, glycerol and tragacanth to obtain a mixture; adding one part of the filtering solution obtained in the step (1) into the mixture and grinding until solid and liquid phases are uniformly mixed, thus obtaining a ground material; uniformly mixing the ground material and the residual filtering solution obtained by the step (1) to obtain a mixed solution; and (3) sealing the mixed solution obtained in the step (2) into a glass bottle, and heating in a water bath and disinfecting. The compound skin ulcer resisting suspension disclosed by the invention can be used for effectively treating skin ulcers and inflammation caused by traumas, infection and the like, and does not contain antibacterial medicines such as norfloxacin; and the drug resistance rate of bacteria is not increased and patients do not have untoward effects.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of Compound Resisting skin ulcer suspensoid and preparation method thereof.
Background technology
Skin ulcer is clinical common complication, take skin ulcer as main clinical manifestation, can not heal for a long time for Clinical symptoms, a kind of body surface disease of the damaged liquefaction infection and necrosis of skin histology, because skin ulcer face is difficult to healing and pain very, cause very large mental pressure and economic loss to patient, had a strong impact on patient's healthy and quality of life.
Much treat in the market in the medicine of skin ulcer and all contain the anti-microbial type medicines such as norfloxacin, because skin ulcer can not heal for a long time, patient needs this class medicine of life-time service, therefore be easy to cause the resistant rate of antibacterial to increase, cause dysbacteriosis, cause superinfection, make skin ulcer more be difficult for curing, and application anti-microbial type medicine is too much, can cause patient to produce untoward reaction, and damage human organ.
Summary of the invention
Technical problem to be solved by this invention is to provide one not containing anti-microbial type medicines such as norfloxacins, and Compound Resisting skin ulcer suspensoid evident in efficacy.
In order to solve the problems of the technologies described above, the invention provides a kind of Compound Resisting skin ulcer suspensoid, this Compound Resisting skin ulcer suspensoid makes by following steps:
(1) by weight, 712.5-787.5 the Radix Astragali, 712.5-787.5 Cortex Phellodendri, 712.5-787.5 Rhizoma Coptidis, 475.0-525.0 Radix Scutellariae, 475.0-525.0 the Radix Angelicae Dahuricae and 285.0-315.0 Radix Sanguisorbae are placed in heating container, add the water of 11400-12600 weight portions, under the condition of 100-150 ℃, decoct, make water loss of weight 53.95-62.30%, stop heating, then filter and obtain filtrate;
(2) by weight, 47.5-52.5 salicylic acid, 23.75-26.25 Camphora, 23.75-26.25 Borneolum Syntheticum, 47.5-52.5 zinc oxide, 9.5-10.5 phenol, 95-105 glycerol and 95-105 tragakanta are mixed to get to mixture, by volume percentage ratio is got 10-30% of step (1) gained filtrate and is joined in said mixture and grind, after being ground to solid liquid phase mix homogeneously, obtain abrasive, above-mentioned abrasive is obtained to mixed liquor with the filtrate mix homogeneously of remaining step (1) gained;
(3) mixed liquor of step (2) gained is packaged in vial, above-mentioned vial is carried out to heating in water bath, guarantee that water-bath flooded vial, be increased to gradually after boiling until bath temperature, continue, with more than boiling heating in water bath 30min, then vial to be taken out, be cooled to room temperature.
712.5-787.5 the Radix Astragali in step of the present invention (1), 712.5-787.5 Cortex Phellodendri, 712.5-787.5 Rhizoma Coptidis, 475.0-525.0 Radix Scutellariae, 475.0-525.0 the Radix Angelicae Dahuricae and 285.0-315.0 Radix Sanguisorbae can be encapsulated and are placed in heating container by cloth bag, convenient filtration.
The Radix Astragali, the Radix Astragali is " persons particularly liable to develop skin infection's panacea " since ancient times, energy benefiting QI for strengthening the superficies, promoting pus discharge and tissue regeneration strengthening, modern study shows that the Radix Astragali has antiinflammatory, analgesia, antiulcer effect.
Cortex Phellodendri, Cortex Phellodendri is conventional Chinese medicine, its cold in nature, bitter in the mouth, has the effect such as heat clearing and damp drying, eliminating fire and detoxication, is usually used in the diseases such as damp-heat dysentery, jaundice, leucorrhea and pyretic arthralgia, pyretic stranguria.Modern study shows, Cortex Phellodendri is containing main components such as berberine, obacunone, have antibacterial, convergence, antiinflammatory etc. effect.
Rhizoma Coptidis is also a kind of conventional Chinese medicine, just the most on the books in Shennong's Herbal, has effect of heat clearing and damp drying, eliminating fire and detoxication.
Radix Scutellariae, bitter in the mouth, cold in nature, energy heat clearing and damp drying, eliminating fire and detoxication, hemostasis, Radix Scutellariae is antibacterial in clinical practice, antiinflammation is sure, and is difficult for developing immunity to drugs.
Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae have heat clearing and damp drying, the effect of toxin expelling granulation promoting, and it is evident in efficacy that three is united and applied in intractable ulcer, can work in coordination with the healing that promotes ulcer surface.
The Radix Angelicae Dahuricae, has wind-damp dispelling, a function such as the evacuation of pus of invigorating blood circulation, granulation promoting pain relieving, cures mainly the diseases such as anemofrigid cold, headache, rhinitis, toothache, leucorrhea with red and white discharge, pain furuncle and phyma poison.
Radix Sanguisorbae, has blood on removing heat from blood, the functions such as heat-clearing and toxic substances removing, detumescence sore.
In addition, the Chinese medicine such as the Radix Angelicae Dahuricae, Radix Sanguisorbae, Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae can the skin injury of prescription for scalding, burning and cause; And other component such as Camphora has the effects such as removing the necrotic tissue and promoting granulation.
Salicylic acid, is white crystalline powder, odorless, and taste first turns pungent after micro-hardship, has antisepsis and sterilization, the effects such as relieving itching and eliminating swelling, analgesic antiphlogistic.
Camphora, a kind of cyclohexane extraction monoterpene derivative, can make from the bark of Lignum cinnamomi camphorae and wooden distillation, also can be synthetic from Oleum Terebinthinae.Camphora is pungent, hot, and GUIXIN, spleen channel have orifice opening, qi stagnation removing, ward off foul, killing parasites for relieving itching, the effect of reducing swelling and alleviating pain, can be used as clinically local anti-inflammatory and antipruritic varnish.Camphora is applied to skin gentle stimulation and antisepsis, has firmly embrocated to send out effect red, can antipruritic pain relieving, there is slight local anesthesia effect.
Borneolum Syntheticum, bitter in the mouth is pungent, and tepor has the effect of leading to all keys, loose stagnated fire, removing nebula improving eyesight, reducing swelling and alleviating pain.
Zinc oxide, has convergence and antibacterial action, can with oils and fats in free fatty generate zinc oleate and fat acid zinc, skin is shielded; Also absorb in cell by hair follicle, promote the synthetic of nucleic acid and nucleoprotein, participate in the energy metabolism of cell, play the effect that promotes tissue repair.Clinically be applicable to dislike acute dermatitis, eczema etc.
Phenol, has anticorrosion putrefaction removing sterilization, strengthens the effects such as tissue penetration.
Glycerol, without the sweet clear and bright thick liquid of color and taste, is a kind of extraordinary solvent, hygroscopic agent.
Tragakanta is a kind of well lubricant, suspending agent, binding agent, for improving viscosity.
Compound Resisting skin ulcer suspensoid provided by the invention can effectively be treated skin ulcer, the inflammation because the reason such as wound, infection causes, the skin ulcer patient's who treats by nearly hundred use Compound Resisting skin ulcer suspensoids of the present invention clinical practice, Compound Resisting skin ulcer suspensoid of the present invention reaches 76% to the cure rate of skin ulcer, effective percentage 95%.Compound Resisting skin ulcer suspensoid provided by the invention is not containing anti-microbial type medicines such as norfloxacins, primary raw material is Chinese herbal medicine, can not cause the resistant rate of antibacterial to increase, cause dysbacteriosis, cause superinfection, also can not make patient produce untoward reaction, infringement human organ.Compound Resisting skin ulcer suspensoid main raw material(s) of the present invention source is wide, cost is low, and its preparation method is simple and convenient, steady quality, and medicament is packaged in saline bottle and sterilizes through heating in water bath, more convenient to use and store.
The specific embodiment
Below in conjunction with embodiment, the invention will be further described:
General description is carried out to the material and the test method that use in the present invention's experiment in this part.Although be well known in the art for realizing many materials and the operational approach that the object of the invention uses, the present invention does to describe in detail as far as possible at this.It will be apparent to those skilled in the art that hereinafter, if not specified, material therefor of the present invention, equipment and operational approach are well known in the art.
Embodiment 1
A kind of Compound Resisting skin ulcer suspensoid, this Compound Resisting skin ulcer suspensoid is made by following steps:
(1) by weight, 750 the Radix Astragali, 750 Cortex Phellodendri, 750 Rhizoma Coptidis, 500 Radix Scutellariae, 500 the Radix Angelicae Dahuricae and 300 Radix Sanguisorbae are packaged in cloth bag, then cloth bag is placed in machine for decocting Chinese traditional herb medicines, add the water of 12000 weight portions, under the condition of 125 ℃, decoct, make water loss of weight 58%, stop heating, then filter and obtain filtrate;
(2) by weight, 50 salicylic acid, 25 Camphora, 25 Borneolum Syntheticum, 50 zinc oxide, 10 phenol, 100 glycerol and 100 tragakanta are mixed to get to mixture, by volume percentage ratio is got 20% of step (1) gained filtrate and is joined in said mixture and grind, after being ground to solid liquid phase mix homogeneously, obtain abrasive, above-mentioned abrasive is obtained to mixed liquor with the filtrate mix homogeneously of remaining step (1) gained;
(3) mixed liquor of step (2) gained is packaged in vial, above-mentioned vial is carried out to heating in water bath, guarantee that water-bath flooded vial, be increased to gradually after boiling until bath temperature, continue, with boiling heating in water bath 30min, then vial to be taken out, be cooled to room temperature.
Embodiment 2
A kind of Compound Resisting skin ulcer suspensoid, this Compound Resisting skin ulcer suspensoid is made by following steps:
(1) by weight, 712.5 the Radix Astragali, 787.5 Cortex Phellodendri, 712.5 Rhizoma Coptidis, 525 Radix Scutellariae, 475 the Radix Angelicae Dahuricae and 285 Radix Sanguisorbae are placed in machine for decocting Chinese traditional herb medicines, add the water of 12600 weight portions, under the condition of 100 ℃, decoct, make water loss of weight 62.30%, stop heating, then filter and obtain filtrate;
(2) by weight, 47.5 salicylic acid, 26.25 Camphora, 23.75 Borneolum Syntheticum, 52.5 zinc oxide, 9.5 phenol, 105 glycerol and 95 tragakanta are mixed to get to mixture, by volume percentage ratio is got 30% of step (1) gained filtrate and is joined in said mixture and grind, after being ground to solid liquid phase mix homogeneously, obtain abrasive, above-mentioned abrasive is obtained to mixed liquor with the filtrate mix homogeneously of remaining step (1) gained;
(3) mixed liquor of step (2) gained is packaged in vial, above-mentioned vial is carried out to heating in water bath, guarantee that water-bath flooded vial, be increased to gradually after boiling until bath temperature, continue, with boiling heating in water bath 40min, then vial to be taken out, be cooled to room temperature.
Embodiment 3
A kind of Compound Resisting skin ulcer suspensoid, this Compound Resisting skin ulcer suspensoid is made by following steps:
(1) by weight, 787.5 the Radix Astragali, 712.5 Cortex Phellodendri, 787.5 Rhizoma Coptidis, 475 Radix Scutellariae, 525 the Radix Angelicae Dahuricae and 315 Radix Sanguisorbae are packaged in cloth bag, then cloth bag is placed in machine for decocting Chinese traditional herb medicines, add the water of 11400 weight portions, under the condition of 150 ℃, decoct, make water loss of weight 53.95%, stop heating, then filter and obtain filtrate;
(2) by weight, 52.5 salicylic acid, 23.75 Camphora, 26.25 Borneolum Syntheticum, 47.5 zinc oxide, 10.5 phenol, 95 glycerol and 105 tragakanta are mixed to get to mixture, by volume percentage ratio is got 10% of step (1) gained filtrate and is joined in said mixture and grind, after being ground to solid liquid phase mix homogeneously, obtain abrasive, above-mentioned abrasive is obtained to mixed liquor with the filtrate mix homogeneously of remaining step (1) gained;
(3) mixed liquor of step (2) gained is packaged in vial, above-mentioned vial is carried out to heating in water bath, guarantee that water-bath flooded vial, be increased to gradually after boiling until bath temperature, continue, with boiling heating in water bath 50min, then vial to be taken out, be cooled to room temperature.
The using method of Compound Resisting skin ulcer suspensoid of the present invention is: first skin ulcer place is carried out to conventional ulcer skin ulcer face debridement treatment, wipe out slough, after drying ulcer surface, give Compound Resisting skin ulcer suspensoid of the present invention soak, change dressings every other day 1 time, and according to clinical ulcer surface performance consideration consumption and number of times, generally take 5～15 days as one course for the treatment of.
The skin ulcer patient's who treats by nearly hundred use Compound Resisting skin ulcer suspensoids of the present invention clinical practice, Compound Resisting skin ulcer suspensoid of the present invention reaches 76% to the cure rate of skin ulcer, effective percentage 95%, some cases is as follows:
Patient, female, 42 years old, when right hand the back of the hand carries out intravenous injection chemotherapeutics doxorubicin, there is drug extravasation, after a few days, there is the back of the hand to occur vesicle, there is skin holostrome damage afterwards, wound size 4.5cm × 3.9cm, does not prolongedly heal; Through Compound Resisting skin ulcer suspensoid of the present invention treatment after 8 days, slough remove, swell and ache disappearance, skin ulcer reduction of area in affected part is little by 2/3.
Patient, man, 58 years old, left foot suffered from pressure ulcer, wound size 0.5cm × 0.8cm, through Compound Resisting skin ulcer suspensoid treatment of the present invention after 19 days, slough remove, swell and ache disappearance, skin ulcer face in affected part healed completely.
Patient, female, 62 years old, sacrococcygeal region was carrying out after Abscess incision drain, formed wound, wound size 0.5cm × 2cm, through Compound Resisting skin ulcer suspensoid treatment of the present invention, after 6 days, skin ulcer face heals completely, the disappearance of swelling and ache.
Patient, female, 22 years old, left hand crush injury skin injury, wound size 2.5cm × 2.5cm, through Compound Resisting skin ulcer suspensoid treatment of the present invention, after 7 days, skin ulcer face heals completely, the disappearance of swelling and ache.
Patient, man, 21 years old, left lower extremity was scalded, and formed the blister of 1.5cm × 2.5cm, and through Compound Resisting skin ulcer suspensoid treatment of the present invention, after 5 days, blister is eliminated, and wound heals completely.
Patient, man, 68 years old, the improper appearance of left knee traumatic injury post processing was infected, and skin surface festers, and wound size 2cm × 3cm, uses common medicinal ointment therapy to have no improvement, and through Compound Resisting skin ulcer suspensoid treatment of the present invention, after 9 days, skin ulcer face heals completely, the disappearance of swelling and ache.
Patient, man, 48 years old, right lower extremity was suffered from chronic ulcer, red swelling of the skin, festered, and wound size 2.5cm × 5cm, does not prolongedly heal, and through Compound Resisting skin ulcer suspensoid treatment of the present invention, after 17 days, skin ulcer face heals completely, the disappearance of swelling and ache.
Patient, female, 45 years old, right hand middle finger was suffered from chronic dactylitis, and 1cm × 1.5cm is prolonged does not heal for wound surface size, and through Compound Resisting skin ulcer suspensoid treatment of the present invention, after 14 days, skin ulcer face heals completely, the disappearance of swelling and ache.
Patient, female, 73, right hand little finger of toe is suffered from paronychia, pulls out first postoperative, suppurating sore, through Compound Resisting skin ulcer suspensoid treatment of the present invention, after 9 days, skin ulcer face heals completely, the disappearance of swelling and ache.
Be to be understood that example as herein described and embodiment are only in order to illustrate, those skilled in the art can make various modifications or variation according to it, all belong to protection scope of the present invention.
Claims (2)
1. a preparation method for Compound Resisting skin ulcer suspensoid, comprises the following steps:
(1) by weight, 712.5-787.5 the Radix Astragali, 712.5-787.5 Cortex Phellodendri, 712.5-787.5 Rhizoma Coptidis, 475.0-525.0 Radix Scutellariae, 475.0-525.0 the Radix Angelicae Dahuricae and 285.0-315.0 Radix Sanguisorbae are placed in heating container, add the water of 11400-12600 weight portions, under the condition of 100-150 ℃, decoct, make water loss of weight 53.95-62.30%, stop heating, then filter and obtain filtrate;
(2) by weight, 47.5-52.5 salicylic acid, 23.75-26.25 Camphora, 23.75-26.25 Borneolum Syntheticum, 47.5-52.5 zinc oxide, 9.5-10.5 phenol, 95-105 glycerol and 95-105 tragakanta are mixed to get to mixture, by volume percentage ratio is got 10-30% of step (1) gained filtrate and is joined in said mixture and grind, after being ground to solid liquid phase mix homogeneously, obtain abrasive, above-mentioned abrasive is obtained to mixed liquor with the filtrate mix homogeneously of remaining step (1) gained;
(3) mixed liquor of step (2) gained is packaged in vial, above-mentioned vial is carried out to heating in water bath, guarantee that water-bath flooded vial, be increased to gradually after boiling until bath temperature, continue, with more than boiling heating in water bath 30min, then vial to be taken out, be cooled to room temperature.
2. the prepared Compound Resisting skin ulcer of the preparation method suspensoid of Compound Resisting skin ulcer suspensoid according to claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410094858.9A CN103800507A (en) | 2014-03-16 | 2014-03-16 | Compound skin ulcer resisting suspension and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410094858.9A CN103800507A (en) | 2014-03-16 | 2014-03-16 | Compound skin ulcer resisting suspension and preparation method thereof |
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| CN103800507A true CN103800507A (en) | 2014-05-21 |
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| CN201410094858.9A Pending CN103800507A (en) | 2014-03-16 | 2014-03-16 | Compound skin ulcer resisting suspension and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019080115A1 (en) * | 2017-10-27 | 2019-05-02 | 江苏奇力康皮肤药业有限公司 | Long-acting sustained-release traditional chinese medicine cold compress for treating skin ulcer |
-
2014
- 2014-03-16 CN CN201410094858.9A patent/CN103800507A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 忻志鸣等: "复方抗溃混悬液的制备及临床应用", 《中国药业》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019080115A1 (en) * | 2017-10-27 | 2019-05-02 | 江苏奇力康皮肤药业有限公司 | Long-acting sustained-release traditional chinese medicine cold compress for treating skin ulcer |
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Application publication date: 20140521 |
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