CN103800437A - Traditional Chinese medicine for treating entomophthoromycosis - Google Patents

Abstract

The invention relates to a traditional Chinese medicine for treating entomophthoromycosis, belonging to the technical field of traditional Chinese medicines. The traditional Chinese medicine for treating entomophthoromycosis is characterized in that a raw pharmaceutical material of the traditional Chinese medicine contains the following ingredients in parts by weight: 6-15 parts of balloon flower root, 10-25 parts of dandelion, 6-12 parts of honeysuckle flower, 10-20 parts of dahurian angelica root, 6-10 parts of selfheal spike and 6-15 parts of toad. The traditional Chinese medicine preparation disclosed by the invention is safe, reliable and effective and is free from toxic and side effects.

Description

A kind of Chinese medicine for the treatment of entomophthoromycosis

Technical field

The present invention relates to a kind of Chinese medicine for the treatment of entomophthoromycosis, belong to technical field of Chinese medicines.

Background technology

Entomophthoromycosis be take nasal mucosa polyp and widely palp subcutaneous localized mass as feature, pathogen is crown entomophthora (Conidiobolus coronatus), infection is initiated at nasal septum, gradually to nasal sinuses, the subcutaneous tissue in throat and center of face district, concha nasalis swelling before when onset, make progress slower, occasionally can make fast progress and involve mucosa, nostril, oral area and nasal sinuses, pathological changes is often bilateral, occasionally can be one-sided, lump expands can cause adjacent tissue's Silent Neuritis damage, in tissue, mycelia is more easily dyeed by HE, but PAS, easy coloring not of Gridly, CMS dyeing also a little less than, single or the cluster of mycelia, average diameter 8 μ m, isolation rule, wall is thinner, but more easily confirm, around with bright radial, what have granule has a liking for Yihong material, 2～6 μ m are thick, this has a liking for Yihong material and is finger-like or starlike arrangement, similar sporotrichosis aster, mycelia is not invaded blood vessel wall.

What treat clinically at present that entomophthoromycosis mainly adopts is potassium iodide, steroid and trimethoprim treatment, but the course for the treatment of is longer, and patient's health has often been produced to larger toxic and side effects, and therapeutic effect is undesirable.

Summary of the invention

The present invention aims to provide the Chinese medicine of a kind of safe and reliable, evident in efficacy, treatment no pain, the treatment entomophthoromycosis that has no side effect, and this Chinese medicine, by selecting rationally effectively raw medicinal material and proportioning thereof, reaches the object of safe and effective healing entomophthoromycosis.

The present invention is achieved by the following technical solutions:

Treat a Chinese medicine for entomophthoromycosis, special character is, formulated by the crude drug of following weight proportion: Radix Platycodonis 6-15 part, Herba Taraxaci 10-25 part, Flos Lonicerae 6-12 part, Radix Angelicae Dahuricae 10-20 part, Spica Prunellae 6-10 part, Bufo siccus 6-15 part.

More excellent raw material components is chosen as: 8 parts of Radix Platycodoniss, 15 parts of Herba Taraxacis, 8 parts of Flos Loniceraes, 15 parts of the Radixs Angelicae Dahuricae, 8 parts of Spica Prunellaes, 8 parts of Bufo siccuss.

Radix Platycodonis: be the dried roots of Campanulaceae Radix Platycodonis, bitter in the mouth, pungent, slightly warm in nature.Enter lung meridian.Energy expelling phlegm for arresting cough, and have lung qi dispersing, evacuation of pus effect.Lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, fill blood, mend five kinds of over strain, foster the spirit of nobility.Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.

Herba Taraxaci: the agglomerate of Chinese traditional drug taraxacum herb crinkle song, root is cylindrical, many bending long 3～7cm, sepia, root head has fine hair, leaf fragmentation, intact leaf is for falling lanceolar, the green or green and brown color of dull gray, and edge is shallow to be split or has pinniform and incise, the downward one-tenth handle of base portion shape, lower surface master pulse is obvious, and scape 1 is to several, head inflorescence top is raw, yellowish-brown or yellowish white, and the visible majority having has the oblong achene of white pappus, feeble QI, mildly bitter flavor.Sweet, micro-hardship, cold.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Upper respiratory tract infection, eye conjunctivitis, mumps, hyperglycemia, acute mastitis swells and ache, gastritis, dysentery, hepatitis, gallbladder is assisted inflammation, acute appendicitis, urinary system infection, pelvic inflammatory disease, carbuncle furuncle furuncle, pharyngitis, controls acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, urinary tract infection.

Flos Lonicerae: sweet, micro-hardship, delicate fragrance, pungent, cold.Return lung, stomach, the heart, large intestine channel.For Caprifoliaceae woodbine Radix Ophiopogonis and congener dry flower or the first flower of opening of band.Flos Lonicerae is described as the good medicine of heat-clearing and toxic substances removing from ancient times.The sweet cold fragrance of its property, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, also kind removing summer-heat blood poison, and for various febrile diseases, as fever of the body, dermexanthesis, send out the cards such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, all effect is remarkable.

The Radix Angelicae Dahuricae: warm in nature, acrid in the mouth.Wind-damp dispelling, the evacuation of pus of invigorating blood circulation, granulation promoting pain relieving.For headache, toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus.The cold expelling that induces sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis.Control headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Expelling pathogenic wind from the body surface: for cold, the cards such as headache, nasal obstruction, have dispersing wind and cold, an effect of the pain that relieves the pain.Wind-expelling pain-stopping: for wind syndrome of head pain, migraine, supraorbital bone pain, nasosinusitis headache, tooth pain etc., can wind-expelling pain-stopping.Dissipation evacuation of pus: with controlling carbuncle skin infection, from the beginning of dissipating, can evacuation of pus after bursting.A surname's clearing the nasal passage: for the long stream of turbid tears of nasal sinusitis, anosmia person.

Spica Prunellae: cold in nature, sweet in the mouth, pungent, micro-hardship, there is the effect of letting out clearly liver-fire, mass dissipating and swelling eliminating, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, cooling blood for hemostasis, be applicable to lymphoid tuberculosis, goiter, acute mastitis, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, metrorrhagia, leukorrhagia, Fiedeler's disease type hepatitis and bacillary dysentery etc.

Bufo siccus: acrid in the mouth; Cool in nature; GUIXIN; Liver; Spleen; Lung meridian.Detoxicating and resolving stagnation of pathogens; Removing food stagnancy diuretic; Destroying parasites for curing malnutrition.Main dysentery cellulitis; Furuncle; Carbuncle on the back; Scrofula; Malignant boil; The lump in the abdomen hypochondriac lump; Expand; Edema; Infantile malnutrition; Tetanus; Chronic cough and asthma.

Below in conjunction with clinical experiment data declaration beneficial effect of the present invention:

1, physical data

Inventor has collected the out-patient of 70 routine entomophthoromycosises altogether between year JIUYUE from May, 2010 to 2012, wherein male 45 examples, female's 25 examples, age 35-66 year, the course of disease 15 days to 1 month.70 routine patients are divided at random: treatment group 50 examples, matched group 20 examples.Two groups of patients' the data such as age, the course of disease, without significant difference, has comparability.

2, test method

2.1, the routine oral trimethoprim treatment of matched group 20, by specification is taken, 15 days courses for the treatment of.

2.2, treatment group 50 example adopts oral patent medicine of the present invention, the morning, noon and afternoon respectively once, 15 days courses for the treatment of.

3, criterion of therapeutical effect and therapeutic outcome

3.1, criterion of therapeutical effect

Recovery from illness: clinical symptoms all disappears, and lab testing project is normal.Take a turn for the better: clinical symptom relief, lab testing improves or be normal.Invalid: clinical symptoms is without being clearly better or increasing the weight of, and lab testing is without improvement.

3.2, treatment statistical result is in table 1

The Comparison of therapeutic of table 1 treatment group and matched group

Group	Case load	Recovery from illness	Take a turn for the better	Invalid	Total effective rate (%)
						Treatment group	50	32（64%）	15（30%）	3（6%）	96%
Matched group	20	10（50%）	3（15%）	7（35%）	65%

Show by above-mentioned experimental data, the medicine that the present invention makes can be pacified effective treatment entomophthoromycosis entirely.

The specific embodiment

In order to understand better and to implement the present invention, below in conjunction with the specific embodiment, be used for formation of the present invention to be further described.

Embodiment 1

Take: 6 grams of Radix Platycodoniss, 10 grams of Herba Taraxacis, 6 grams of Flos Loniceraes, 10 grams of the Radixs Angelicae Dahuricae, 6 grams of Spica Prunellaes, 6 grams of Bufo siccuss, the decocting that adds 6 times of amounts boils 1.5-2 hour, filtrate for later use after filtration, the decocting that filtering residue adds 6 times of amounts again boils 1-1.5 hour, the filtrate of filtering and the filtrate of last time merge, after concentrated, carry out dry packing, must meet the powder of one day consumption of normal adult.

Instructions of taking and dose are: morning, noon and afternoon every day take for three times.

Embodiment 2

Take: 15 grams of Radix Platycodoniss, 25 grams of Herba Taraxacis, 12 grams of Flos Loniceraes, 20 grams of the Radixs Angelicae Dahuricae, 10 grams of Spica Prunellaes, 15 grams of Bufo siccuss, the decocting that adds 6 times of amounts boils 1.5-2 hour, filtrate for later use after filtration, the decocting that filtering residue adds 6 times of amounts again boils 1-1.5 hour, the filtrate of filtering and the filtrate of last time merge, and after concentrating, are dried, and then add appropriate dextrin and correctives, after granulating according to this area common process, pack, must meet the granule of one day consumption of normal adult.

Embodiment 3

Take: 10 grams of Radix Platycodoniss, 18 grams of Herba Taraxacis, 9 grams of Flos Loniceraes, 16 grams of the Radixs Angelicae Dahuricae, 8 grams of Spica Prunellaes, 8 grams of Bufo siccuss.Preparation method is with embodiment 2.

Claims (2)

1. a Chinese medicine for the treatment of entomophthoromycosis, is characterised in that, formulated by the crude drug of following weight proportion: Radix Platycodonis 6-15 part, Herba Taraxaci 10-25 part, Flos Lonicerae 6-12 part, Radix Angelicae Dahuricae 10-20 part, Spica Prunellae 6-10 part, Bufo siccus 6-15 part.

2. a kind of Chinese medicine for the treatment of entomophthoromycosis as claimed in claim 1, is characterised in that, formulated by the crude drug of following weight proportion: 8 parts of Radix Platycodoniss, 15 parts of Herba Taraxacis, 8 parts of Flos Loniceraes, 15 parts of the Radixs Angelicae Dahuricae, 8 parts of Spica Prunellaes, 8 parts of Bufo siccuss.