CN103768338A - Preparation for anti-tumor compound medicine active ingredients - Google Patents
Preparation for anti-tumor compound medicine active ingredients Download PDFInfo
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- CN103768338A CN103768338A CN201210410109.3A CN201210410109A CN103768338A CN 103768338 A CN103768338 A CN 103768338A CN 201210410109 A CN201210410109 A CN 201210410109A CN 103768338 A CN103768338 A CN 103768338A
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Abstract
The invention provides preparation for anti-tumor compound medicine active ingredients. The compound comprises the following medicines: sculellaria barbata, Chinese lobelia, oldenlandia diffusa and windpipe trachea. The preparation for compound medicine active ingredients comprises the following steps: first, all the medicinal materials of the compound are crushed; second, extraction is carried out with medicinal ethanol for 3 times, filtration is carried out and the extraction solutions are mixed, ethanol is recycled and a dry extract is obtained; third, the dry exact is subjected to ultrasonic dissolution with water, a suspension is obtained, extraction is carried out for 3-5 times by utilization of isopyknic ethyl acetate, the extraction solutions are mixed, heating decolouring is carried out with active carbon, ethyl acetate is recycled and a solid is obtained; fourth, the solid is dissolved through squeezing with petroleum ether, filtration is carried out, insoluble substances are obtained, namely the active ingredients are obtained. The anti-tumor effects are stable, the active components are clear, the quality is controllable, the technology is simple, the preparation method is suitable for industrial production and the officinal prospect is wide.
Description
Technical field
The present invention relates to Chinese medicine preparation technical field, relate in particular to a kind of preparation of anti-tumor compound medicine activity component.
Background technology
Society now, tumor has been one of serious disease threatening human survival, first of its M & M hat various diseases, become the mankind's No.1 formidable enemy, therefore the treatment of tumor is also the focus of current medical research, in view of the more toxic and side effects of current Western medicine, Chinese medicine especially compound medicine with its gentle curative effect, slight toxic and side effects, is more and more subject to scientific research personnel's concern; Chinese medicine treatment tumor is particular about strengthening vital QI to eliminate pathogenic factors, medication is particular about and is got rid of illness and be not harmful to the health or be harmful to the health less, therefore the multiplex compound recipe of tcm prescription, use multiple Chinese herbal medicine compatibility, various Chinese herbal medicines are respectively executed its duty solidarity and cooperation again, play a role, still toward a target, under various quality standards control environment, complicated compound recipe composition is difficult to make steady quality unified.
According to the means that use now Western medicine research and development technology research and development Chinese medicine, we need to separate active component wherein to make preparation, could realize stable and controllable for quality.
Summary of the invention
In view of the defect that above-mentioned prior art exists, the object of the invention is to propose a kind of preparation method of anti-tumor compound medicine activity component, make antitumous effect stable, active component is clear and definite, quality controllable.
Object of the present invention will be achieved by the following technical programs:
A preparation for anti-tumor compound medicine activity component, its potion compound recipe comprises following medicine:
The preparation of its compound medicine active component comprises the steps:
Step 1, by all pulverizing medicinal materials in compound recipe, is used clear water washing and drying;
Step 2, the medicinal alcohol lixiviate that use purity is 95% 3 times, use for the first time the medicinal alcohol lixiviate of 3 times of medical material volumes, the time is 4 hours～6 hours, uses for the second time the medicinal alcohol lixiviate of 2 times of medical material volumes, time is 3 hours～5 hours, use for the third time the medicinal alcohol lixiviate of 1.5 times of medical material volumes, the time is 2 hours～4 hours, filters and merges lixiviating solution, reclaim ethanol, obtain dry extract;
Step 3, is used water ultrasonic dissolution gained dry extracts more than 5 times of dry extract volumes, becomes suspension, uses equal-volume ethyl acetate extraction 3～5 times, and combining extraction liquid uses heating activated carbon decolouring, reclaims ethyl acetate, obtains solids;
Step 4, is used petroleum ether to pinch molten gained solids at 70 degrees Celsius～90 degrees Celsius, filters, and leaching insoluble matter, obtains active component.
Show that through chromogenic reaction gained active component is mainly terpenoid and flavones ingredient.
Outstanding effect of the present invention is: proposed a kind of preparation method of anti-tumor compound medicine activity component, made antitumous effect stable, active component is clear and definite, quality controllable, and technique is simple, is applicable to suitability for industrialized production, and patent medicine has a extensive future.
The specific embodiment
Below by specific embodiment, method of the present invention is described, but the present invention is not limited thereto.Experimental technique described in following embodiment, if no special instructions, is conventional method; Described reagent and material, if no special instructions, all can obtain from commercial channels.
Embodiment:
The preparation of a kind of anti-tumor compound medicine activity component of the present embodiment, its potion compound recipe comprises following medicine:
The preparation of its compound medicine active component comprises the steps:
Step 1, by all pulverizing medicinal materials in compound recipe, is used clear water washing and drying;
Step 2, the medicinal alcohol lixiviate that use purity is 95% 3 times, use for the first time the medicinal alcohol lixiviate of 3 times of medical material volumes, the time is 4 hours～6 hours, uses for the second time the medicinal alcohol lixiviate of 2 times of medical material volumes, time is 3 hours～5 hours, use for the third time the medicinal alcohol lixiviate of 1.5 times of medical material volumes, the time is 2 hours～4 hours, filters and merges lixiviating solution, reclaim ethanol, obtain dry extract;
Step 3, is used water ultrasonic dissolution gained dry extracts more than 5 times of dry extract volumes, becomes suspension, uses equal-volume ethyl acetate extraction 3～5 times, and combining extraction liquid uses heating activated carbon decolouring, reclaims ethyl acetate, obtains solids;
Step 4, is used petroleum ether to pinch molten gained solids at 70 degrees Celsius～90 degrees Celsius, filters, and leaching insoluble matter, obtains active component.
Show that through chromogenic reaction gained active component is mainly terpenoid and flavones ingredient.
The outstanding effect of the present embodiment is: proposed a kind of preparation method of anti-tumor compound medicine activity component, made antitumous effect stable, active component is clear and definite, quality controllable, and technique is simple, is applicable to suitability for industrialized production, and patent medicine has a extensive future.
The present invention still has numerous embodiments, and all employing equivalents or equivalent transformation and all technical schemes of forming, within all dropping on protection scope of the present invention.
Claims (1)
1. a preparation for anti-tumor compound medicine activity component, is characterized in that: potion compound recipe comprises following medicine:
The preparation of compound medicine active component comprises the steps:
Step 1, by all pulverizing medicinal materials in compound recipe, is used clear water washing and drying;
Step 2, the medicinal alcohol lixiviate that use purity is 95% 3 times, use for the first time the medicinal alcohol lixiviate of 3 times of medical material volumes, the time is 4 hours～6 hours, uses for the second time the medicinal alcohol lixiviate of 2 times of medical material volumes, time is 3 hours～5 hours, use for the third time the medicinal alcohol lixiviate of 1.5 times of medical material volumes, the time is 2 hours～4 hours, filters and merges lixiviating solution, reclaim ethanol, obtain dry extract;
Step 3, is used water ultrasonic dissolution gained dry extracts more than 5 times of dry extract volumes, becomes suspension, uses equal-volume ethyl acetate extraction 3～5 times, and combining extraction liquid uses heating activated carbon decolouring, reclaims ethyl acetate, obtains solids;
Step 4, is used petroleum ether to pinch molten gained solids at 70 degrees Celsius～90 degrees Celsius, filters, and leaching insoluble matter, obtains active component.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210410109.3A CN103768338A (en) | 2012-10-25 | 2012-10-25 | Preparation for anti-tumor compound medicine active ingredients |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210410109.3A CN103768338A (en) | 2012-10-25 | 2012-10-25 | Preparation for anti-tumor compound medicine active ingredients |
Publications (1)
| Publication Number | Publication Date |
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| CN103768338A true CN103768338A (en) | 2014-05-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210410109.3A Pending CN103768338A (en) | 2012-10-25 | 2012-10-25 | Preparation for anti-tumor compound medicine active ingredients |
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| CN (1) | CN103768338A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547679A (en) * | 2014-12-25 | 2015-04-29 | 姜新帅 | Anti-cancer medicinal liquor |
| CN104815047A (en) * | 2015-04-22 | 2015-08-05 | 李建社 | Drug for treating cancer, preparation method and preparation |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1903274A (en) * | 2006-08-01 | 2007-01-31 | 姚茂龙 | Medicine for treating precancer |
| CN1970576A (en) * | 2005-06-08 | 2007-05-30 | 广东医学院 | Extraction and preparation process of polysaccharide of Pteris semipinnata L. with anticancer activity |
-
2012
- 2012-10-25 CN CN201210410109.3A patent/CN103768338A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1970576A (en) * | 2005-06-08 | 2007-05-30 | 广东医学院 | Extraction and preparation process of polysaccharide of Pteris semipinnata L. with anticancer activity |
| CN1903274A (en) * | 2006-08-01 | 2007-01-31 | 姚茂龙 | Medicine for treating precancer |
Non-Patent Citations (1)
| Title |
|---|
| 张赛丹: "几种传统中药中多糖的提取及抗肿瘤活性研究", 《中药材》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547679A (en) * | 2014-12-25 | 2015-04-29 | 姜新帅 | Anti-cancer medicinal liquor |
| CN104815047A (en) * | 2015-04-22 | 2015-08-05 | 李建社 | Drug for treating cancer, preparation method and preparation |
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Application publication date: 20140507 |