CN103751760A - 一种防治小儿龋齿的药剂的制备方法 - Google Patents
一种防治小儿龋齿的药剂的制备方法 Download PDFInfo
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Abstract
本发明涉及一种防治小儿龋齿的药剂的制备方法，该方法包括下列步骤：称取干姜5克、冬凌草8克、丝瓜络3克、地耳草2克、小野鸡尾4克、西河柳5克、刺五加2克、防风11克、白头翁6克、全叶青兰15克、百部5克、肉桂12克、伊贝母7克、冰凉花3克、麦冬2克和苍耳子5克，置于密封的烧瓶内，加入水1000毫升，在70℃的水浴下加热2小时，冷却至室温，然后过滤，收集滤液即为所述药剂。本发明所述的防治小儿龋齿的药剂处方简单，价格便宜，疗效明确，患者适应性强，适于在临床上大量推广。
Description
本发明是申请日为2012年12月6日、申请号为201210534910.9、发明名称为“一种防治小儿龋齿的药剂”的专利的分案申请
技术领域
本发明涉及医药领域，具体地说，涉及一种防治小儿龋齿的药剂的制备方法。
背景技术
小儿由于处理生长发育阶段，牙齿更换比较频繁，并且牙齿表面的防护表面还未成熟，加之小儿非常喜欢吃甜食，因此，小儿中患龋齿的比例很高。研制一种疗效确切、方便实用的防治龋齿的药物正在成为必然。
发明内容
本发明的目的是提供一种防治小儿龋齿的药剂的制备方法。
为了实现本发明的方法，本发明提供一种防治小儿龋齿的药剂的制备方法，其特征在于，该方法包括下列步骤：称取干姜5克、冬凌草8克、丝瓜络3克、地耳草2克、小野鸡尾4克、西河柳5克、刺五加2克、防风11克、白头翁6克、全叶青兰15克、百部5克、肉桂12克、伊贝母7克、冰凉花3克、麦冬2克和苍耳子5克，置于密封的烧瓶内，加入水1000毫升，在70℃的水浴下加热2小时，冷却至室温，然后过滤，收集滤液即为所述药剂。
本发明所述的防治小儿龋齿的药剂处方简单，均为常见中药，价格便宜，疗效明确，患者适应性强，适于在临床上大量推广。
具体实施方式
以下通过具体实施方式的描述对本发明作进一步说明，但这并非是对本发明的限制，本领域技术人员根据本发明的基本思想，可以做出各种修改或改进，但是只要不脱离本发明的基本思想，均在本发明的范围之内。
实施例1
称取干姜5克、冬凌草8克、丝瓜络3克、地耳草2克、小野鸡尾4克、西河柳5克、刺五加2克、防风11克、白头翁6克、全叶青兰15克、百部5克、肉桂12克、伊贝母7克、冰凉花3克、麦冬2克和苍耳子5克，置于密封的烧瓶内，加入水1000毫升，在70℃的水浴下加热2小时，冷却至室温。然后过滤，收集滤液即为漱口液。
实验例1：对口腔致龋菌的体外抑菌活性研究
变形链球菌、粘性放线菌被认为是最重要的致龋菌，它们通过对牙面的粘附，形成牙菌斑，使牙齿产生龋坏，因此抑制和杀灭致龋菌对防治龋齿具有重要的作用。在本实验例中，采用本领域中经典的滤纸片法来进行抑菌试验，其中：
1.材料
1.1供试菌种
粘性放线菌（A.viscosus ATCC15987）和变形链球菌（S.mutans ATCC25175）购自上海三踏生物科技有限公司。
1.2培养液
营养琼脂和营养肉汤，购自上海三踏生物科技有限公司。
1.3试验方法
将粘性放线菌（A.viscosus ATCC15987）和变形链球菌（S.mutans ATCC25175）接种于琼脂平板营养液平面上，接种时均匀密布。镊取无菌圆形滤纸片浸入实施例1中的漱口液，充分浸渍后，贴在已接种细菌的琼脂平板营养液平面上。将琼脂平板置于37℃的培养箱内，温育24小时。测量抑菌环的直径。测定3次取平均值。
1.4结果
粘性放线菌（A.viscosus ATCC15987）的抑菌环的平均直径为30.34mm，变形链球菌（S.mutans ATCC25175）的抑菌环的平均直径为26.47mm，表明本发明的漱口液具有明显的抑菌效果。
实验例2
1.临床资料
选择40例浅中龋儿童作为观察对象，均符合《龋病学》（岳松龄主编.第1版，成都:四川人民出版社,1983:224-225,280-281）的诊断及分度标准。随机分为试验组和对照组。其中试验组20例，年龄范围为3-7岁，平均5.2岁，其中男女各10例；对照组20例，年龄范围为3-7岁，平均4.9岁，其中男女各10例。
2.观察方法
试验组施用实施例1中制得的漱口液，每天3次，均在餐后漱口，每次20ml，漱口30秒即可，3个月为1个疗程。对照组按照和试验组相同的方式使用纯净水来进行漱口。试验组和对照组每日的饮食和起居习惯都相同。
3.疗效评定标准
采用菌斑指数变化作为疗效评定标准的标准。将菌斑指数减少1个以上评定为有效，将菌斑指数保持不变或增加1个以上评定为无效。
菌斑指数（plaque index，PLI）由Silness和Loe在1964年提出，根据压面菌斑的厚度记分而不根据菌斑覆盖面积记分。用于评价口腔卫生状况和衡量牙周病防治效果。
用视诊的结合探针的方法检查，检查是用探针轻划牙面，根据菌斑的量和厚度记分。菌斑指数科检查全口牙面，也可检查选定的几颗牙。每颗牙都检查4个牙面，即近中颊面、正中颊面、远中颊面以及舌面。每颗牙的记分为4个牙面记分之和除以4，个人记分为每颗牙几分之和除以受检牙数。
0=龈缘区无菌斑；
1=龈缘区的牙面有薄的菌斑，但视诊不可见，若用探针尖的侧面可挂出菌斑；
2=在龈缘或邻面可见中等量菌斑；
3=龈沟内或龈缘区即邻面有大量软够。
根据上述方法测定试验前和一个疗程后的菌斑指数，并根据菌斑指数变化得到下面的试验结果。
4.试验结果
对于试验组，有16例患者的菌斑指数减少2，4例患者的菌斑指数减少1。对于对照组，18例患者的菌斑指数增加1，2例患者的菌斑指数增加2。
Claims (1)
1.一种防治小儿龋齿的药剂的制备方法，其特征在于，该方法可以包括下列步骤：称取干姜5克、冬凌草8克、丝瓜络3克、地耳草2克、小野鸡尾4克、西河柳5克、刺五加2克、防风11克、白头翁6克、全叶青兰15克、百部5克、肉桂12克、伊贝母7克、冰凉花3克、麦冬2克和苍耳子5克，置于密封的烧瓶内，加入水1000毫升，在70℃的水浴下加热2小时，冷却至室温，然后过滤，收集滤液即为所述药剂。
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| CN1448081A (zh) * | 2002-12-18 | 2003-10-15 | 李永胜 | 一种预防治疗咳嗽气喘梨桃杏蜜糖块 |
| CN102688347A (zh) * | 2012-06-11 | 2012-09-26 | 张松波 | 一种治疗口腔炎症的中药制剂及其制备方法 |
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| CN1698779A (zh) * | 2005-05-25 | 2005-11-23 | 邵建国 | 一种治疗牙痛的口腔喷雾剂及其制备方法 |
| CN102266505B (zh) * | 2011-07-26 | 2014-09-17 | 天津市顶硕科贸有限公司 | 复方中药口腔粘膜修复液 |
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| CN1448081A (zh) * | 2002-12-18 | 2003-10-15 | 李永胜 | 一种预防治疗咳嗽气喘梨桃杏蜜糖块 |
| CN102688347A (zh) * | 2012-06-11 | 2012-09-26 | 张松波 | 一种治疗口腔炎症的中药制剂及其制备方法 |
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