CN103751549A - Preparation method of medicinal preparation for treating postpartum lochiorrhea - Google Patents
Preparation method of medicinal preparation for treating postpartum lochiorrhea Download PDFInfo
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- CN103751549A CN103751549A CN201410033410.6A CN201410033410A CN103751549A CN 103751549 A CN103751549 A CN 103751549A CN 201410033410 A CN201410033410 A CN 201410033410A CN 103751549 A CN103751549 A CN 103751549A
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- grams
- herba
- preparation
- postpartum lochiorrhea
- treatment
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- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 5
- 241000345811 Neocheiropteris ovata Species 0.000 claims abstract description 4
- 239000000706 filtrate Substances 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000003814 drug Substances 0.000 claims description 18
- 239000006210 lotion Substances 0.000 claims description 11
- 241000303791 Elatostema Species 0.000 claims description 6
- 239000003826 tablet Substances 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 5
- 241000256844 Apis mellifera Species 0.000 claims description 3
- 241000208340 Araliaceae Species 0.000 claims description 3
- 241000345998 Calamus manan Species 0.000 claims description 3
- 241000287828 Gallus gallus Species 0.000 claims description 3
- 241001299535 Iris speculatrix Species 0.000 claims description 3
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 3
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 3
- 235000008434 ginseng Nutrition 0.000 claims description 3
- 210000003205 muscle Anatomy 0.000 claims description 3
- 235000012950 rattan cane Nutrition 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 2
- 239000007919 dispersible tablet Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 2
- 241001519271 Ajuga Species 0.000 abstract 1
- 241000394746 Blumea densiflora Species 0.000 abstract 1
- 240000006248 Broussonetia kazinoki Species 0.000 abstract 1
- 235000006716 Broussonetia kazinoki Nutrition 0.000 abstract 1
- 241000945767 Calanthe discolor Species 0.000 abstract 1
- 241000084370 Catalpa bungei Species 0.000 abstract 1
- 241000317477 Elatostema oblongifolium Species 0.000 abstract 1
- 244000169656 Isodon coetsa Species 0.000 abstract 1
- 241001558443 Koenigia divaricata Species 0.000 abstract 1
- 241000007039 Leucosceptrum canum Species 0.000 abstract 1
- 241001571777 Lysimachia circaeoides Species 0.000 abstract 1
- 235000018997 Prunus tomentosa Nutrition 0.000 abstract 1
- 240000000191 Prunus tomentosa Species 0.000 abstract 1
- 241000690369 Schisandra lancifolia Species 0.000 abstract 1
- 241001610470 Selaginella kraussiana Species 0.000 abstract 1
- 244000148729 Spilanthes acmella Species 0.000 abstract 1
- 235000013474 Spilanthes acmella Nutrition 0.000 abstract 1
- 241000867801 Valeriana flaccidissima Species 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 description 6
- 208000032843 Hemorrhage Diseases 0.000 description 5
- 241000521257 Hydrops Species 0.000 description 5
- 206010030113 Oedema Diseases 0.000 description 5
- 206010046910 Vaginal haemorrhage Diseases 0.000 description 5
- 210000004291 uterus Anatomy 0.000 description 5
- 210000001215 vagina Anatomy 0.000 description 5
- 230000002159 abnormal effect Effects 0.000 description 4
- 230000008034 disappearance Effects 0.000 description 4
- 208000034423 Delivery Diseases 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 208000031220 Hemophilia Diseases 0.000 description 2
- 208000009292 Hemophilia A Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- QQCOAAFKJZXJFP-XAYIDPIISA-N 15-methyl-15R-PGF2alpha methyl ester Chemical compound CCCCC[C@](C)(O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(=O)OC QQCOAAFKJZXJFP-XAYIDPIISA-N 0.000 description 1
- 206010000084 Abdominal pain lower Diseases 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 240000001008 Dimocarpus longan Species 0.000 description 1
- 235000000235 Euphoria longan Nutrition 0.000 description 1
- 208000036365 Normal labour Diseases 0.000 description 1
- 208000018525 Postpartum Hemorrhage Diseases 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- 208000034790 Twin pregnancy Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000003679 cervix uteri Anatomy 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 108010052008 colla corii asini Proteins 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 206010034754 petechiae Diseases 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 210000005182 tip of the tongue Anatomy 0.000 description 1
- 238000012384 transportation and delivery Methods 0.000 description 1
- 230000009677 vaginal delivery Effects 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The invention relates to a preparation method of medicinal preparation for treating postpartum lochiorrhea, which includes the following steps: collecting 9g of catalpa bungei bark, 8g of neolepisorus ovatus, 6g of broussonetia kaempferi stem, 3g of chlonyction muricatum, 9g of calanthe discolor lindl, 3g of blumea densiflora, 5g of Ajuga pantantha, 5g of cerasus tomentosa, 8g of spilanthes paniculata, 7g of rabdosia coetsa, 9g of leucosceptrum canum, 6g of valeriana flaccidissima, 8g of demnacanthus indicus, 3g of elatostema oblongifolium, 5g of selaginella kraussiana, 3g of polygonum divaricatum, 7g of lysimachia circaeoides and 9g of schisandra lancifolia, adding 20,000 mL of water, heating in a flask equipped with a condenser at 90DEG C for 5h, filtering and collecting filtrate. The medicinal preparation for treating postpartum lochiorrhea prepared by the method of the invention has a reasonable prescription and a distinct effect, and can effectively treat postpartum lochiorrhea.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of preparation method for the treatment of the medicament of postpartum lochiorrhea.
Background technology
Postpartum lochiorrhea is commonly encountered diseases clinically, shows as repeated intermittent colporrhagia, lochia continue 3 weeks incessantly above, and not to the utmost dripping or repeatedly with lochia rubra.
Summary of the invention
The object of this invention is to provide a kind of preparation method for the treatment of the medicament of postpartum lochiorrhea.
In order to realize object of the present invention, the invention provides a kind of preparation method for the treatment of the medicament of postpartum lochiorrhea, the method can comprise the following steps: to get 9 grams of Cortex catalpae bungeis, 8 grams of Neolepisorus ovatus (Bedd.) Ching.s, 6 grams, paddy skin rattan, 3 grams of Herba Solani Surattensiss, 9 grams of Herba seu Radix Calanthess, 3 grams of Radix Inulae Pterocaulaes, 5 grams of mountain Herba vallisneriae Spiralis, 5 grams of Fructus Pruni Tomentosaes, 8 grams of Herba Spilanthis Acmellae, 7 grams of Iris speculatrix Hance, 9 grams of meter Tuan Hua, 6 grams of Radix et Rhizoma Iridis Sanguineae, 8 grams of chicken muscle ginsengs, 3 grams of Elatostema oblohgifolium Fu. (Elatostema bodinier Levl), 5 grams of honeybee medicines, 3 grams of Herba polygoni divaricati, 9 grams of 7 grams, Herba Lysimachiae Circaeoidis and Herba Schisandrae lancifoliaes, add 20000 milliliters, water, in being housed, at 90 ℃, heats 5 hours by the flask of condenser, filter, collect filtrate.
Preferably, described medicament can be tablet, dispersible tablet, disintegrating tablet, instant, enteric coatel tablets, capsule or lotion.
In order to understand better the present invention, with reference to < < Chinese medicine voluminous dictionary > > second edition (Shanghai science tech publishing house, 2005) explanation of the crude drug, using in the present invention sees the following form:
The drug prescription of the treatment postpartum lochiorrhea that the method for the invention makes is reasonable, and effect is clear and definite, can effectively treat postpartum lochiorrhea.
The specific embodiment
Below by embodiment, further illustrate the present invention.It should be understood that embodiments of the invention are for the present invention rather than limitation of the present invention are described.
Embodiment lotion of the present invention
Get 9 grams of 9 grams of Cortex catalpae bungeis, 8 grams of Neolepisorus ovatus (Bedd.) Ching.s, 6 grams, paddy skin rattan, 3 grams of Herba Solani Surattensiss, 9 grams of Herba seu Radix Calanthess, 3 grams of Radix Inulae Pterocaulaes, 5 grams of mountain Herba vallisneriae Spiralis, 5 grams of Fructus Pruni Tomentosaes, 8 grams of Herba Spilanthis Acmellae, 7 grams of Iris speculatrix Hance, 9 grams of meter Tuan Hua, 6 grams of Radix et Rhizoma Iridis Sanguineae, 8 grams of chicken muscle ginsengs, 3 grams of Elatostema oblohgifolium Fu. (Elatostema bodinier Levl), 5 grams of honeybee medicines, 3 grams of Herba polygoni divaricati, 7 grams, Herba Lysimachiae Circaeoidis and Herba Schisandrae lancifoliaes, add 20000 milliliters, water, in being housed, at 90 ℃, heats 5 hours by the flask of condenser, filter, collect filtrate.
Experimental example
Physical data
Select my institute to hospitalize 60 routine postpartum hemorrhage puerperas, puerpera age 20-34 year, year mean age (24.6 ± 2.1); Primipara's 36 examples wherein, multipara's 24 examples; Twin pregnancy 6 examples, more than be all singleton pregnancy; 8 routine patient's row cesarean section deliveries, 52 routine vaginal deliveries.60 routine patients are divided into treatment group and matched group, treatment group 30 examples wherein, year mean age (23.2 ± 1.8); Patient's average course of disease is (35.3 ± 3.2) day; Matched group 30 examples, year mean age (23.1 ± 2.4), average course of disease (37.3 ± 4.7) day.Learn and process by statistics, two groups of analysis no significant differences (P>0.05), have comparability.
Diagnostic criteria
Western medicine diagnose with reference to the modern Chinese and western medicine gynecology of < < > > (Niu Jianzhao. modern Chinese and western medicine gynecology [M]. Beijing: China Science Tech Publishing House, 1996:683.) be diagnosed as puerperal lochia rubra continue 3 weeks or more than, subinvolution of uterus.
Exclusion standard
Do not meet above-mentioned diagnostic criteria, merge hepatic and kidney function obstacle, merge the coagulation function mechanism impediment persons such as thrombocytopenia, the primary diseases such as hemopoietic system, allergic constitution person, the uncooperative patient of psychosis.
Matched group give carboprost methylate bolt (northeast pharmacy group Shenyang No. 1 Pharmaceutical Factory, 5mg), once a day, inserts anus, oral Fuyankan particles (Jiangxi Min Ji pharmaceutcal corporation, Ltd, every packed 9g) simultaneously, every day three times, each serving with 1 bag.Treatment is 7 days continuously.
Treatment group is treated with the lotion making in embodiment, is cooled to room temperature during use.One day three times, with the lotion of 500 milliliters, clean hemorrhage vagina 2 minutes at every turn.Treatment is 7 days continuously.
Criterion of therapeutical effect
Cure: through treatment vaginal hemorrhage, stop, B ultrasonic is shown in that in uterine cavity, abnormal echo district, uterine cavity and pelvic hydrops disappear, and follows clinical symptom disappearance; Effective: vaginal hemorrhage is front reduces 2/3, B ultrasonic is shown in that uterine cavity and pelvic hydrops reduce, and follow clinical symptom relief; Invalid: clinical symptoms and B ultrasonic are all not improved.
Result
Through treatment, the therapeutic outcome of two groups sees the following form:
| Group | Number of cases | Cure | Effective | Invalid | Total effective rate (%) |
| Treatment group | 30 | 23 | 6 | 1 | 96.7 |
| Matched group | 30 | 13 | 11 | 6 | 80.0 |
Model case
High certain, female, 26 years old, cadre.On January 6th, 2013 is medical, dripping 58 days not to the utmost of patient's readme lochia.Patient's full-term normal delivery one girl baby, within 2nd, start to take Fructus Jujubae Arillus Longan meat soup, take Colla Corii Asini 3 day because of prolonged lochiorrhea the 26th day puerperal, and existing lochia is not stopped, the a small amount of clot of the dark red folder of color, change sanitary towel every day 2～3 times, lower abdomen dull pain, the soreness of waist, constipation with dry stool, body of the tongue is partially red, the tip of the tongue has petechia, yellow and thin fur, thready and stringy pulse.Gynaecological examination: vagina is smooth, inside has a small amount of courageous and upright secretions, cervix uteri light, and without lifting pain, uterus prosposition, bigger than normal, the light tenderness of palace body; Bilateral adnexa is not different from.B ultrasonic prompting; Uterus anteroposterior diameter 2.8cm, upper and lower footpath 6.2cm, angle, palace, left side is looked into and is seen echo agglomerate, and border is clear, form rule, visible point shape echoless in it.With the lotion making in embodiment, treat, one day three times, with the lotion of 500 milliliters, clean hemorrhage vagina 2 minutes at every turn.Treatment is 7 days continuously.Through treatment vaginal hemorrhage, stop, B ultrasonic is shown in that in uterine cavity, abnormal echo district, uterine cavity and pelvic hydrops disappear, and follows clinical symptom disappearance.Gynaecological examination is not different from, and B ultrasonic check uterus adnexa is also not different from.
Lee, female, 28 years old, company clerk, normal labor one boy baby, postpartum vaginal haemophilia, color is red or dim red, has large clot, the lower abdominal pain at most of bleeding, after large clot flows out, stomachache is slightly alleviated.Postpartum vaginal haemophilia 1 month.Medical on April 8th, 2013, with the lotion making in embodiment, treat, one day three times, with the lotion of 500 milliliters, clean hemorrhage vagina 2 minutes at every turn.Treatment is 7 days continuously.Through treatment vaginal hemorrhage, stop, B ultrasonic is shown in that in uterine cavity, abnormal echo district, uterine cavity and pelvic hydrops disappear, and follows clinical symptom disappearance, and spirit is good.
Zhang, female, 30 years old.Cesarean one girl baby, in 5 weeks puerperal, lochia is not to the utmost dripping.Medical on February 16th, 2013.Be diagnosed as color light red, matter is rare, empty and bearing-down sensation of the lower abdomen sense.Lustreless complexion, coldness of the body with chills, poor appetite, it is real that stool is owed, white and thin fur, thready and moderate pulse.B ultrasonic is looked into and is seen uterus anteroposterior diameter 3.0cm, upper and lower footpath 6.9cm, and angle, palace, left side is looked into and is seen medium echo agglomerate, and border is clear, form rule, visible point shape echoless in it.With the lotion making in embodiment, treat, one day three times, with the lotion of 500 milliliters, clean hemorrhage vagina 2 minutes at every turn.Treatment is 7 days continuously.Through treatment vaginal hemorrhage, stop, B ultrasonic is shown in that in uterine cavity, abnormal echo district, uterine cavity and pelvic hydrops disappear, and follows clinical symptom disappearance, and spirit is good.
Claims (2)
1. a preparation method for the treatment of the medicament of postpartum lochiorrhea, it is characterized in that, the method comprises the following steps: to get 9 grams of 9 grams of Cortex catalpae bungeis, 8 grams of Neolepisorus ovatus (Bedd.) Ching.s, 6 grams, paddy skin rattan, 3 grams of Herba Solani Surattensiss, 9 grams of Herba seu Radix Calanthess, 3 grams of Radix Inulae Pterocaulaes, 5 grams of mountain Herba vallisneriae Spiralis, 5 grams of Fructus Pruni Tomentosaes, 8 grams of Herba Spilanthis Acmellae, 7 grams of Iris speculatrix Hance, 9 grams of meter Tuan Hua, 6 grams of Radix et Rhizoma Iridis Sanguineae, 8 grams of chicken muscle ginsengs, 3 grams of Elatostema oblohgifolium Fu. (Elatostema bodinier Levl), 5 grams of honeybee medicines, 3 grams of Herba polygoni divaricati, 7 grams, Herba Lysimachiae Circaeoidis and Herba Schisandrae lancifoliaes, add 20000 milliliters, water, in being housed, at 90 ℃, heats 5 hours by the flask of condenser, filter, collect filtrate.
2. the preparation method of the medicament for the treatment of postpartum lochiorrhea according to claim 1, is characterized in that, described medicament can be tablet, dispersible tablet, disintegrating tablet, instant, enteric coatel tablets, capsule or lotion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410033410.6A CN103751549B (en) | 2014-01-24 | 2014-01-24 | A kind of preparation method for the treatment of the medicament of postpartum lochiorrhea |
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| CN201410033410.6A CN103751549B (en) | 2014-01-24 | 2014-01-24 | A kind of preparation method for the treatment of the medicament of postpartum lochiorrhea |
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| Publication Number | Publication Date |
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| CN103751549A true CN103751549A (en) | 2014-04-30 |
| CN103751549B CN103751549B (en) | 2015-11-25 |
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| CN201410033410.6A Expired - Fee Related CN103751549B (en) | 2014-01-24 | 2014-01-24 | A kind of preparation method for the treatment of the medicament of postpartum lochiorrhea |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102935114A (en) * | 2012-11-27 | 2013-02-20 | 广西万寿堂药业有限公司 | Traditional Chinese medicine extracts for treating gynaecological blood stasis as well as preparation method and application of traditional Chinese medicine extracts |
| CN103263647A (en) * | 2013-04-27 | 2013-08-28 | 迟晓艳 | Traditional Chinese medicine for treating postnatal lochiorrhea and preparation method thereof |
| CN103301350A (en) * | 2013-07-05 | 2013-09-18 | 张召菊 | Traditional Chinese medicine for treating postpartum lochiorrhea |
| CN103316312A (en) * | 2013-05-04 | 2013-09-25 | 内蒙古瑞普大地生物药业有限责任公司 | Invigorating uterus-clearing mixture and preparation process thereof |
| CN103349766A (en) * | 2013-07-08 | 2013-10-16 | 黄传芬 | Pharmaceutical composition for endless postpartum lochia |
-
2014
- 2014-01-24 CN CN201410033410.6A patent/CN103751549B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102935114A (en) * | 2012-11-27 | 2013-02-20 | 广西万寿堂药业有限公司 | Traditional Chinese medicine extracts for treating gynaecological blood stasis as well as preparation method and application of traditional Chinese medicine extracts |
| CN103263647A (en) * | 2013-04-27 | 2013-08-28 | 迟晓艳 | Traditional Chinese medicine for treating postnatal lochiorrhea and preparation method thereof |
| CN103316312A (en) * | 2013-05-04 | 2013-09-25 | 内蒙古瑞普大地生物药业有限责任公司 | Invigorating uterus-clearing mixture and preparation process thereof |
| CN103301350A (en) * | 2013-07-05 | 2013-09-18 | 张召菊 | Traditional Chinese medicine for treating postpartum lochiorrhea |
| CN103349766A (en) * | 2013-07-08 | 2013-10-16 | 黄传芬 | Pharmaceutical composition for endless postpartum lochia |
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| CN103751549B (en) | 2015-11-25 |
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Granted publication date: 20151125 Termination date: 20170124 |