CN103751411A - Rose alcohol effect dispelling capsule - Google Patents
Rose alcohol effect dispelling capsule Download PDFInfo
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- CN103751411A CN103751411A CN201310506875.4A CN201310506875A CN103751411A CN 103751411 A CN103751411 A CN 103751411A CN 201310506875 A CN201310506875 A CN 201310506875A CN 103751411 A CN103751411 A CN 103751411A
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- rosae rugosae
- rose
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Abstract
A rose alcohol effect dispelling capsule is characterized by being prepared from the following raw medicinal materials: 20-30 g of rose, 8-12 g of roselle, 8-12 g of medlar, 8-12 g of cortex acanthopanacis, 8-12 g of Chinese magnoliavine, 8-12 g of safflower carthamus, 8-12 g of rhodiola rosea, and 8-12 g of hawthorn. A preparation method comprises the steps: respectively weighing the components according to the weight proportion of the raw medicinal materials, respectively grinding into fine powders, mixing, filling into a capsule, and thus obtaining the product. The rose alcohol effect dispelling capsule has the advantages that the rose alcohol effect dispelling capsule has the effect of protecting liver from being damaged by ethyl alcohol, is convenient to administer, and has no toxic or side effects.
Description
Technical field: the present invention relates to a kind of compound Chinese medicinal preparation field for protection hepatic impairment induced by alcohol.
Technical background:
Insobriety can cause that the acetaldehyde in human body can not be decomposed completely, produces the drunk symptoms such as the tending to vomit of feeling sick, stupor be uncomfortable after people is drunk.Show that somatization can have fatigue, headache, thirsty, dizzy, gastropathy, feels sick, vomiting, insomnia, hand tremor and hypertension or reduction; Mental symptom comprises acute anxiety, irritability, extrasensitivity, depression, or guilty-feeling.Drink for a long time and can cause liver cirrhosis.
Flos Rosae Rugosae is containing volatile oil, and in oil, main component is citronellol, Geraniol, nerol, eugenol, phenethanol.In addition, still containing Quercitroside, tannin, fatty oil, organic acid etc., Oleum Rosae Rugosae has the effect of the bile secretion of promotion to rat, and Flos Rosae Rugosae has certain protective effect to experimental animal models myocardial ischemia; Calyx Hibisci Sabdariffae sour in the mouth, cold in nature, the effect such as there is clearing away summer-heat, diuretic antihypertensive, skin care speckle removing, detoxify, relieve the effect of alcohol.Flos Carthami is warm in nature, acrid in the mouth, the latus rectum of invigorating blood circulation, eliminating stasis to stop pain, anoxia enduring.Fructus Lycii sweet in the mouth; Property is put down, and returns Liver Channel, kidney channel, lung meridian, has nourishing the liver; Nourishing kidney; The effect of lung moistening; Cortex Acanthopancis has wind-damp dispelling, and invigorating the liver and kidney is invigorated blood circulation, the effects such as bone and muscle strengthening; Fructus Schisandrae Chinensis herbal function is the power of strengthening by means of tonics, there is hepatoprotective function, be rich in organic acid, vitamin, flavonoid, phytosterol and have the lignan (for example schisandrin, schisandrin B or Fructus Schisandrae Chinensis fat element) of potent reactivation, can the strong liver of QI invigorating, the efficiency of promoting cells exclude refuse, supply more oxygen, construction and uses energy, raising memory and property endurance.The effect of Radix Rhodiolae and effect are energy the kidney invigorating, regulate the flow of vital energy and nourish blood, and have promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, antipyretic, and the effect under leukorrhagia stopping; Fructus Crataegi has important medical value, since ancient times, just becomes the good medicine of spleen benefiting and stimulating the appetite, relieving dyspepsia, phlegm reduction of blood circulation promoting.The main component of Fructus Crataegi is Flavonoid substances, and cardiovascular system is had to obvious pharmacological action.The flavone component separating from Fructus Crataegi has more than 30 to plant, and mainly contains flavonoid glycoside, flavonol and glycoside thereof, dioxygen flavonoid glycoside, polymerization flavonoid containing carbon bond.The composition of another kind of outbalance is triterpene substance, has heart tonifying, increases coronary blood flow, improves the important function such as blood circulation.In addition, in Fructus Crataegi, contain organic acid as chlorogenic acid, caffeic acid and tannin, the acid anhydride of tanning, epicatechol, choline, acetylcholine, Sitosterolum, carotene and a large amount of VitC etc.At present, from Fructus Crataegi, extract multienzyme fruit acid, the effect of multienzyme fruit acid Soboring-up liver-protecting.
Summary of the invention:
The object of this invention is to provide a kind of Flos Rosae Rugosae relieving alcoholic intoxication capsule, there is the effect of protection hepatic impairment induced by alcohol.
The present invention adopts the crude drug such as Flos Rosae Rugosae 20-30g, Calyx Hibisci Sabdariffae 8-12g, Fructus Lycii 8-12g, Cortex Acanthopancis 8-12g, Fructus Schisandrae Chinensis 8-12g, Flos Carthami 8-12g, Radix Rhodiolae 8-12g, Fructus Crataegi 8-12g to make, preparation method is, by the weight proportion of crude drug, take each component, pulverization respectively, mix, in incapsulating, obtain.
Advantage of the present invention is:
Have the effect of the hepatic injury that causes of protection ethanol, taking convenience, has no side effect.
Specific embodiments:
Embodiment 1: take respectively the crude drug such as Flos Rosae Rugosae 30g, Calyx Hibisci Sabdariffae 12g, Fructus Lycii 12g, Cortex Acanthopancis 8g, Fructus Schisandrae Chinensis 8g, Flos Carthami 8g, Radix Rhodiolae 8g, Fructus Crataegi 8g, by various crude drug pulverization respectively, mix, in incapsulating, obtain.
Embodiment 2: take respectively the crude drug such as Flos Rosae Rugosae 20g, Calyx Hibisci Sabdariffae 8g, Fructus Lycii 8g, Cortex Acanthopancis 12g, Fructus Schisandrae Chinensis 12g, Flos Carthami 12g, Radix Rhodiolae 12g, Fructus Crataegi 8g, by various crude drug pulverization respectively, mix, in incapsulating, obtain.
Embodiment 3: take respectively the crude drug such as Flos Rosae Rugosae 30g, Calyx Hibisci Sabdariffae 8g, Fructus Lycii 10g, Cortex Acanthopancis 10g, Fructus Schisandrae Chinensis 10g, Flos Carthami 10g, Radix Rhodiolae 10g, Fructus Crataegi 10g, by various crude drug pulverization respectively, mix, in incapsulating, obtain.
Embodiment 4: the impact of Flos Rosae Rugosae relieving alcoholic intoxication capsule on the ethanol incubation period length of one's sleep and duration.
Get 5 mices and be divided at random 5: high dose group, middle dosage group, low dose group, positive controls, normal group, every group of l0 is only.First fasting 12 h of each group mice, normal group is according to the dosage gavage normal saline of 0.2ml/10g; Positive controls gavage 1g/kg sea Wang Jin cup sheet; High, normal, basic dosage group gives respectively Flos Rosae Rugosae relieving alcoholic intoxication capsule 4.0g/kg, 2.0 g/kg, 1.0 g/kg gavages.After 30 min, each group mice is with strong, colourless liquor distilled from sorghum Chinese liquor 0.16 ml/10g gavage, incubation period, the duration of recording mice sleep.
Result: as table 1.Compared with normal group mice, the basic, normal, high dosage energy of Flos Rosae Rugosae relieving alcoholic intoxication capsule significance extends mice sleep incubation period (P<0.05), shortens the duration (P<0.05).
The impact of table 1 Flos Rosae Rugosae relieving alcoholic intoxication capsule on the ethanol incubation period length of one's sleep and duration (means ± s)
| ? | Medicine | Dosage | Animal number of elements | Incubation period (min) | Duration (min) |
| Model group | Normal saline | 0.2ml/10g | 10 | 5.2±3.4 | 45. 2±14.2* |
| Positive group | Hai Wangjin cup sheet | 1.0g/kg | 10 | 16. 8±8.4 | 22.2±17.4 |
| High dose group | Flos Rosae Rugosae relieving alcoholic intoxication capsule | 2.0g/kg | 10 | 14. 2±5.1* | 20. 2±7.2* |
| Middle dosage group | Flos Rosae Rugosae relieving alcoholic intoxication capsule | 1.0g/kg | 10 | 13.4±4.9* | 23.4±9.0* |
| Low dose group | Flos Rosae Rugosae relieving alcoholic intoxication capsule | 0.5g/kg | 10 | 11.8±3.3* | 25.8±8.2* |
* p<0.05, * * p<0.01 is compared with normal group
Conclusion: Flos Rosae Rugosae relieving alcoholic intoxication capsule can extend mice sleep incubation period, shortens the duration, has the effect of relieving alcoholic intoxication.
Embodiment 5: the impact of Flos Rosae Rugosae relieving alcoholic intoxication capsule on acute alcoholism mice glutamate pyruvate transaminase (ALT), glutamic oxaloacetic transaminase, GOT (AST) content.
50 mices, male and female half and half, be divided at random 5 groups, every group 10, be model group (normal saline group, 0.9%), positive controls (1g/kg sea Wang Jin cup sheet), complex low dose group (1.0g/kg), middle dosage group (2.0g/kg), high dose group (4.0g/kg).All gastric infusions, 1 time/d, continuous 10 d, after gavage volume is 0.2 ml/10 g. gastric infusion every day 30min, all the other are respectively organized the equal gavage 56 of mice and spend strong, colourless liquor distilled from sorghum Chinese liquor 0.16 ml/10g.Can't help water to for the 10th day fasting after drinking, survey ALT, AST.
Result is as shown in table 2: with model group comparison, positive drug group and low senior middle school dosage group be the rising of energy significance reduction ALT, AST all.
The impact of table 2 Flos Rosae Rugosae relieving alcoholic intoxication capsule on acute hepatic injury mice ALT, AST content (means ± s)
| ? | Medicine | Dosage | Animal number of elements | ALT (U/L ) | AST (U/L ) |
| Model group | Normal saline | 0.2ml/10g | 10 | 122.12± 26.24 | 98.10± 36.22 |
| Positive group | Hai Wangjin cup sheet | 1.0g/kg | 10 | 46.17±10.22* | 46.37±18.02* |
| High dose group | Flos Rosae Rugosae relieving alcoholic intoxication capsule | 4.0g/kg | 10 | 38.24± 13.41* | 42.21± 13.43* |
| Middle dosage group | Flos Rosae Rugosae relieving alcoholic intoxication capsule | 2.0g/kg | 10 | 46.73± 12.14* | 55.43± 10.84* |
| Low dose group | Flos Rosae Rugosae relieving alcoholic intoxication capsule | 1.0g/kg | 10 | 50.43± 19.30* | 58.32± 12.73* |
* p<0.05, * * p<0.01 is compared with model group
Conclusion: Flos Rosae Rugosae relieving alcoholic intoxication capsule significance reduces ALT, the AST rising that ethanol causes, has the effect protecting the liver.
Claims (1)
1. a Flos Rosae Rugosae relieving alcoholic intoxication capsule, is characterized in that: following crude drug, consist of: Flos Rosae Rugosae 20-30g, Calyx Hibisci Sabdariffae 8-12g, Fructus Lycii 8-12g, Cortex Acanthopancis 8-12g, Fructus Schisandrae Chinensis 8-12g, Flos Carthami 8-12g, Radix Rhodiolae 8-12g, Fructus Crataegi 8-12g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310506875.4A CN103751411A (en) | 2013-10-25 | 2013-10-25 | Rose alcohol effect dispelling capsule |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310506875.4A CN103751411A (en) | 2013-10-25 | 2013-10-25 | Rose alcohol effect dispelling capsule |
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| CN103751411A true CN103751411A (en) | 2014-04-30 |
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| CN201310506875.4A Pending CN103751411A (en) | 2013-10-25 | 2013-10-25 | Rose alcohol effect dispelling capsule |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104783165A (en) * | 2015-04-28 | 2015-07-22 | 安徽广生堂生物科技有限公司 | Method for preparing anti-alcohol raffinate from natural plant |
| CN107898925A (en) * | 2017-12-11 | 2018-04-13 | 廖海湘 | One kind is sobered up Chinese medicine |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1555735A (en) * | 2004-01-06 | 2004-12-22 | 澄 汪 | Health protection beverage and its preparation method |
| CN102988601A (en) * | 2012-10-25 | 2013-03-27 | 罗瑞雪 | Sober-up mate tea |
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2013
- 2013-10-25 CN CN201310506875.4A patent/CN103751411A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1555735A (en) * | 2004-01-06 | 2004-12-22 | 澄 汪 | Health protection beverage and its preparation method |
| CN102988601A (en) * | 2012-10-25 | 2013-03-27 | 罗瑞雪 | Sober-up mate tea |
Non-Patent Citations (2)
| Title |
|---|
| 古今等: "解酒药物的研究进展", 《中国药物应用与监测》 * |
| 吴晓冰等: "《解酒醒酒与护肝养胃》", 31 August 2007, 金盾出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104783165A (en) * | 2015-04-28 | 2015-07-22 | 安徽广生堂生物科技有限公司 | Method for preparing anti-alcohol raffinate from natural plant |
| CN107898925A (en) * | 2017-12-11 | 2018-04-13 | 廖海湘 | One kind is sobered up Chinese medicine |
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Application publication date: 20140430 |