CN101297888A - Medicament composition and preparation thereof - Google Patents
Medicament composition and preparation thereof Download PDFInfo
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- CN101297888A CN101297888A CNA2008101137063A CN200810113706A CN101297888A CN 101297888 A CN101297888 A CN 101297888A CN A2008101137063 A CNA2008101137063 A CN A2008101137063A CN 200810113706 A CN200810113706 A CN 200810113706A CN 101297888 A CN101297888 A CN 101297888A
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- radix
- pharmaceutical composition
- taurine
- ganoderma
- salviae miltiorrhizae
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Abstract
The invention discloses a pharmaceutical composition and a preparation method thereof; active ingredients of the pharmaceutical composition comprise membranous milkvetch root, lucid ganoderma, danshen root, white paeony root, tangerine peel, Mongolian dandelion herb, hawthorn fruit, liquoric root, taurine and sodium selenite. The pharmaceutical composition has significant effects on protecting liver and enhancing immunity.
Description
Technical field
The present invention relates to the field of Chinese medicines, relate to a kind of pharmaceutical composition and preparation method thereof particularly with hepatoprotective and enhancing immunity effect.
Background technology
Say in the Wang Bing of the Tang note " element is asked ": " liver controlling conveyance and dispersion, property happiness bar reaches; Main again store blood, liver opening at eye has again ' elite of the five internal organs all on annotate in order '; The liver being connected with tendons, its China are at pawl; The peptic effect of liver, the one, liver can promote biliary generation and drainage; The 2nd, keep the normal lifting of taste mechanism of qi.If the liver failing to maintain the normal flow of QI, functional activity of QI being not smooth can cause qi depression to blood stasis, causes many-sided unusual performance such as feelings will, digestion, the operation of QI and blood water liquid.
This product is sweet with Radix Astragali nature and flavor, tepor, returns spleen, lung meridian, is the QI invigorating key medicine.Put down in writing according to " traditional Chinese medical science voluminous dictionary ": " Ganoderma has another name called Ganoderma lucidum (Leyss. Ex Fr.) Karst., and is warm in nature, sweet in the mouth, and the useful motive, hemopoietic helps heart and tranquilizing mind, lung benefiting gas, hard muscles and bones, sharp joint, the multiple functions such as tonifying liver of calming the nerves "; The Radix Salviae Miltiorrhizae nature and flavor are bitter and be slightly cold, and specially go into conscience two warps, are longer than blood circulation promoting and blood stasis dispelling, and relieving restlessness is calmed the nerves, and the wonderful of promoting tissue regeneration by removing blood stasis arranged, so forefathers have the saying of " Radix Salviae Miltiorrhizae, same four things of merit " simply.Radix Paeoniae Alba nature and flavor picric acid and being slightly cold is mainly gone into the liver spleen channel, the merit yin fluid astringing of specially enriching blood, and easing the affected liver to relieve pain is for controlling the good medicine of all pains.Pericarpium Citri Reticulatae is stated from Shennong's Herbal: " nature and flavor suffering, hardship, temperature, the master returns spleen, lung meridian, fragrance is amusing, and is longer than regulating qi-flowing for strengthening spleen dampness ".Herba Taraxaci has the liver soothing and the spleen invigorating, the effect of removing damp-heat.Fructus Crataegi sour in the mouth and sweet, warm in nature and not hot is returned spleen, stomach, Liver Channel, has spleen benefiting and stimulating the appetite, the effect of blood circulation promoting and blood stasis dispelling.
In addition, modern study proves, contains the folic acid of astragalus polysaccharides, flavone, choline, aminoacid and trace in the Radix Astragali, has enhancing immunity, resisting fatigue, mutation, effect such as protects the liver.Modern medicine proves: Ganoderma contains several physiological active substances, can regulate, strengthen body immunity, and coronary heart disease, hypertension, hepatitis, diabetes etc. are had good synergistic therapeutic action.Current research shows: Ganoderma also has resisting fatigue, looks improving and the skin nourishing, and slow down aging is prevented and treated effects such as AIDS.Radix Salviae Miltiorrhizae can preclude blood smoulder and myocardial infarction, and can stop absorption ethanol, prevention hepatic fibrosis (fibrosis), blood sugar lowering.Be a kind of immunomodulator in the Radix Paeoniae Alba, liver protection effect, Radix Paeoniae Alba total glucosides still have pharmacological actions such as antioxidation, analgesia, convulsion.The T-1 composition has the effect of anti-hepatitis in the Herba Taraxaci, can promote bile secretion, promotes the effect of pituitary secretion.Contain compositions such as tartaric acid, citric acid, flavonoid in the Fructus Crataegi, cardiovascular disease is had therapeutical effect, help the conversion of cholesterol, blood vessel dilating has the effect of regulating myocardial function.Taurine is a kind of special aminoacid, is the requisite a kind of nutrient of human body, and taurine all has protective effect to the heart, lung, liver, gastrointestinal etc.The most significant effect of taurine just is enhancing immunity and resisting fatigue.
Selenium is that human immunity is regulated nutrient, can active cell immunity medium-sized lymphocyte, again can the immune stimulatory globulin and antibody produce.In addition, studies show that selenium has important protective effect to hepatic injury.Free radical is the arch-criminal who destroys liver plasma membrane and cell interior structure, and a large amount of free radicals is damaged liver plasma membrane and cell interior structure.Selenium is and the free radical active factors of antagonistic substance (glutathion peroxidase) mutually, strengthens the vigor of vitamin E simultaneously, thereby strengthen hepatocellular protective effect.
Pharmaceutical composition prescription of the present invention combines both in conjunction with principle and each herbal medicine modern pharmacological research data of tcm treatment according to syndrome differentiation, makes it to have the health care of auxiliary hepatoprotective and enhancing immunity.
Summary of the invention
(1) technical problem that will solve
The purpose of this invention is to provide a kind of pharmaceutical composition with hepatoprotective and enhancing immunity effect, another purpose of the present invention provides this preparation of drug combination method.
(2) technical scheme
The invention provides a kind of pharmaceutical composition, it is made up of acceptable auxiliary on effective ingredient and the materia medica, and described effective ingredient comprises the Radix Astragali, Ganoderma, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Herba Taraxaci, Fructus Crataegi, Radix Glycyrrhizae, taurine, sodium selenite.
Wherein, described effective ingredient proportion of composing is counted by weight: Radix Astragali 10-40, Ganoderma 10-40, Radix Salviae Miltiorrhizae 10-40, Radix Paeoniae Alba 5-30, Pericarpium Citri Reticulatae 5-30, Herba Taraxaci 5-30, Fructus Crataegi 5-30, Radix Glycyrrhizae 2-15, taurine 2-15, sodium selenite 0.001-0.01.
The present invention also provides this preparation of drug combination method, and it comprises the steps:
(1) with the Radix Astragali, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Fructus Crataegi, Radix Glycyrrhizae, Herba Taraxaci, Ganoderma eight flavor medical material water extraction, extracting solution concentrates, dry, pulverizing, gets dry extract;
(2) taurine, sodium selenite are sieved, get fine powder;
(3) with acceptable auxiliary mixing on step (1) and step (2) products therefrom and the materia medica, make this pharmaceutical composition.
The dosage form of pharmaceutical composition of the present invention comprises common dosage forms such as granule, tablet.
The invention also discloses the application of this pharmaceutical composition in the medicine of preparation hepatoprotective and enhancing immunity.
(3) beneficial effect
Pharmaceutical composition of the present invention has the effect of significant hepatoprotective and enhancing immunity, possesses good application prospects.
The specific embodiment
Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.
The preparation of embodiment 1 this medicament composition granule agent
Take by weighing supplementary material according to following ratio: Radix Astragali 3000g Ganoderma 3000g Radix Salviae Miltiorrhizae 3000g Radix Paeoniae Alba 1500g Pericarpium Citri Reticulatae 1000g Herba Taraxaci 1500g Fructus Crataegi 2000g Radix Glycyrrhizae 600g taurine 900g sodium selenite 200mg dextrin 2000g xylitol 500g
1, taurine and sodium selenite are crossed 80 mesh sieves respectively, mix mixed powder A.
2, cross 80 mesh sieves respectively with dextrin after the xylitol drying and crushing, again two kinds of fine powders are mixed mixed powder B.
3, mixed powder A and mixed powder B are mixed, get mixed powder C, standby.
4, extraction: the Radix Astragali, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Fructus Crataegi, Radix Glycyrrhizae, Herba Taraxaci, Ganoderma eight flavor medical materials water extraction 2 times, collect extracting solution and be condensed into thick extractum drying under reduced pressure, dry extract is pulverized, it is standby to get dry extract.
5, with dry extract and mixed powder C mixing, 80% ethanol is made wet granular, and 80 ℃ dry must do granule.
6, packing makes granule.
The preparation of embodiment 2 these pharmaceutical composition tablet doses
Take by weighing supplementary material according to following ratio: Radix Astragali 12000g Ganoderma 12000g Radix Salviae Miltiorrhizae 12000g Radix Paeoniae Alba 9000g Pericarpium Citri Reticulatae 9000g Herba Taraxaci 9000g Fructus Crataegi 9000g Radix Glycyrrhizae 4500g taurine 4500g sodium selenite 300mg dextrin 2000g xylitol 500g
1, extraction: the Radix Astragali, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Fructus Crataegi, Radix Glycyrrhizae, Herba Taraxaci, Ganoderma eight flavor medical materials water extraction 2 times, collect extracting solution and be condensed into thick extractum drying under reduced pressure, dry extract is pulverized, it is standby to get dry extract.
2, taurine and sodium selenite are crossed 80 mesh sieves respectively, mix mixed powder A.
3, cross 80 mesh sieves respectively with dextrin after the xylitol drying and crushing, again two kinds of fine powders are mixed mixed powder B.
4, mixed powder A and mixed powder B are mixed, get mixed powder C, standby.
5, with dry extract and mixed powder C mixing, 80 ℃ of dryings, tabletting obtains tablet.
Claims (5)
1, a kind of pharmaceutical composition, it is made up of acceptable auxiliary on effective ingredient and the materia medica, it is characterized in that described effective ingredient comprises the Radix Astragali, Ganoderma, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Herba Taraxaci, Fructus Crataegi, Radix Glycyrrhizae, taurine, sodium selenite.
2, pharmaceutical composition according to claim 1 is characterized in that described effective ingredient proportion of composing counts by weight: Radix Astragali 10-40, Ganoderma 10-40, Radix Salviae Miltiorrhizae 10-40, Radix Paeoniae Alba 5-30, Pericarpium Citri Reticulatae 5-30, Herba Taraxaci 5-30, Fructus Crataegi 5-30, Radix Glycyrrhizae 2-15, taurine 2-15, sodium selenite 0.001-0.01.
3, preparation of drug combination method according to claim 1 is characterized in that it comprises the steps:
(1) with the Radix Astragali, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Fructus Crataegi, Radix Glycyrrhizae, Herba Taraxaci, Ganoderma eight flavor medical material water extraction, extracting solution concentrates, dry, pulverizing, gets dry extract;
(2) taurine, sodium selenite are sieved, get fine powder;
(3) with acceptable auxiliary mixing on step (1) and step (2) products therefrom and the materia medica, make this pharmaceutical composition.
4, method according to claim 3 is characterized in that the dosage form of the pharmaceutical composition that makes comprises common dosage forms such as granule, tablet.
5, the application of pharmaceutical composition according to claim 1 in the medicine of preparation hepatoprotective and enhancing immunity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101137063A CN101297888A (en) | 2008-05-29 | 2008-05-29 | Medicament composition and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101137063A CN101297888A (en) | 2008-05-29 | 2008-05-29 | Medicament composition and preparation thereof |
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| Publication Number | Publication Date |
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| CN101297888A true CN101297888A (en) | 2008-11-05 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA2008101137063A Pending CN101297888A (en) | 2008-05-29 | 2008-05-29 | Medicament composition and preparation thereof |
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| CN (1) | CN101297888A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973907A (en) * | 2011-09-07 | 2013-03-20 | 菏泽普恩药业有限公司 | Compound preparation of traditional Chinese medicine and Western medicine for duck spleen necrosis control |
| CN103977154A (en) * | 2014-05-22 | 2014-08-13 | 曾艳平 | Pharmaceutical composition for protecting liver |
| CN104857434A (en) * | 2015-05-18 | 2015-08-26 | 邓鑫 | Composition prepared from natural taurine and used for treating liver cirrhosis with portal hypertension as well as preparation method of composition |
| CN105104770A (en) * | 2015-06-30 | 2015-12-02 | 赖亚从 | Laying hen feed containing Chinese herb components, and production method thereof |
| CN105663770A (en) * | 2016-02-18 | 2016-06-15 | 云南久丽康源石斛开发有限公司 | Dendrobium officinale capsule with liver caring function and making method thereof |
| CN110463799A (en) * | 2018-05-10 | 2019-11-19 | 岳怀芬 | A kind of wild plant composition of protect liver constipation-relieving tea |
| CN111110753A (en) * | 2019-12-14 | 2020-05-08 | 天马（安徽）国药科技股份有限公司 | Sesame and selenium compound decoction piece |
| CN113331422A (en) * | 2021-06-28 | 2021-09-03 | 海南净航科技发展有限公司 | Health food with health function of enhancing immunity |
-
2008
- 2008-05-29 CN CNA2008101137063A patent/CN101297888A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973907A (en) * | 2011-09-07 | 2013-03-20 | 菏泽普恩药业有限公司 | Compound preparation of traditional Chinese medicine and Western medicine for duck spleen necrosis control |
| CN103977154A (en) * | 2014-05-22 | 2014-08-13 | 曾艳平 | Pharmaceutical composition for protecting liver |
| CN104857434A (en) * | 2015-05-18 | 2015-08-26 | 邓鑫 | Composition prepared from natural taurine and used for treating liver cirrhosis with portal hypertension as well as preparation method of composition |
| CN104857434B (en) * | 2015-05-18 | 2018-06-08 | 邓鑫 | A kind of composition that treatment Cirrhotic Portal Hypertension is prepared with natural taurine and preparation method thereof |
| CN105104770A (en) * | 2015-06-30 | 2015-12-02 | 赖亚从 | Laying hen feed containing Chinese herb components, and production method thereof |
| CN105663770A (en) * | 2016-02-18 | 2016-06-15 | 云南久丽康源石斛开发有限公司 | Dendrobium officinale capsule with liver caring function and making method thereof |
| CN110463799A (en) * | 2018-05-10 | 2019-11-19 | 岳怀芬 | A kind of wild plant composition of protect liver constipation-relieving tea |
| CN111110753A (en) * | 2019-12-14 | 2020-05-08 | 天马（安徽）国药科技股份有限公司 | Sesame and selenium compound decoction piece |
| CN113331422A (en) * | 2021-06-28 | 2021-09-03 | 海南净航科技发展有限公司 | Health food with health function of enhancing immunity |
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Effective date of registration: 20090116 Address after: Beijing economic and Technological Development Zone, Rong Jingdong street, No. 6, zip code: 100176 Applicant after: Beijing Kawin Technology Co., Ltd. Address before: Beijing economic and Technological Development Zone, Rong Jingdong street, No. 6, zip code: 100176 Applicant before: Beijing Kawin Biotechnology Co., Ltd. |
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Owner name: BEIJING KAIYIN SCIENCE CO., LTD. Free format text: FORMER OWNER: BEIJING KAIYIN BIOISYSTECH CO., LTD. Effective date: 20090116 |
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Open date: 20081105 |