CN103747692A - 用于预防和/或治疗皮肤肤色缺陷的单不饱和脂肪酸 - Google Patents
用于预防和/或治疗皮肤肤色缺陷的单不饱和脂肪酸 Download PDFInfo
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- CN103747692A CN103747692A CN201180064169.8A CN201180064169A CN103747692A CN 103747692 A CN103747692 A CN 103747692A CN 201180064169 A CN201180064169 A CN 201180064169A CN 103747692 A CN103747692 A CN 103747692A
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Abstract
本发明涉及有效量的至少一种单不饱和脂肪酸、其盐和/或其酯的口服美容用途或营养食品用途。其中所述单不饱和脂肪酸、其盐和/或其酯用作治疗和/或预防皮肤肤色缺陷的活性剂。
Description
技术领域
本发明涉及用于护理皮肤肤色的美容制品和/或皮肤病用制品和食品补充剂的领域。
更具体地,本发明提出了一种用于治疗和/或预防皮肤肤色的皮肤审美缺陷的新型活性剂的用途。本发明还涉及适用于治疗和/或预防皮肤肤色的缺陷和均匀性缺陷的方法。
背景技术
多种因素可引起皮肤和皮肤的肤色上的缺陷。这些皮肤肤色缺陷是造成美容院或皮肤病诊所中咨询日益频繁的原因。
在容易影响皮肤肤色的外在因素中,可以提到的有:暴露于阳光之下、暴露于温度变化和/或湿度变化下、和接触污染物或香烟烟雾。在影响皮肤肤色的内在因素中,可以提到的有:压力、疲劳、荷尔蒙变化、表皮脱水、皮肤的屏障功能损伤、衰老或皮脂的过度分泌。
此外,遗传因素可影响个体对容易影响皮肤肤色的外部条件的敏感度。
因此,一定的种族,例如,亚洲来源或非洲来源的种族,具有的肌肤纹理更敏感且具有的皮肤肤色在诸如污染和香烟烟雾的外部条件下更容易或更强烈地受损。这对于老年人的情况也是如此。
这些各种因素会使肤色模糊、不均匀、暗淡、苍白或黄色并且带来或促进皮肤瑕疵或皮肤变色的出现。
在其轻微的形式中,这些缺陷涉及到几乎每个人,并且它们在青春期年龄中最为频繁。然而,它们可出现在早至7岁到9岁的年龄并且可持续到40岁,并且尤其可持续到60岁。因此,甚至在25岁之后,具有皮肤缺陷(尤其在脸上)如粗糙、暗淡和/或不均匀的肤色是常见的。在其轻微的形式中,这些皮肤缺陷可以主要通过模糊、暗淡和/或不均匀的肤色和存在皮肤变色或瑕疵来显现。
在其最严重的形式中,这些损伤可偶尔具有损伤性的社会心理的后果,对于由此受到影响的个人而言,这可导致孤独、或甚至沮丧或失业。
因此,切实需要能够预防、减少或治疗这些皮肤肤色缺陷。
还需要可以对皮肤肤色缺陷产生有效且有益作用的新型活性剂。
发明内容
本发明的目的是满足这些需要。
因此,根据第一方面,本发明涉及有效量的至少一种单不饱和脂肪酸、其盐和/或其酯的口服或营养美容用途,所述单不饱和脂肪酸、其盐和/或其酯用作治疗和/或预防皮肤肤色缺陷的活性剂。
单不饱和脂肪酸已经描述用于多种用途,诸如,在专利EP0709084中的干燥皮肤的保湿或者在专利EP0116439中的头皮屑和头皮瘙痒的治疗。
专利WO01/08651描述了包括岩芹酸的组合物,该组合物用于控制皮脂的分泌和使皮肤肤色亮化。
美国专利4097604指出各种脂肪酸的盐针对口腔病原菌是有效的,因此其在牙周炎发作时可以减少这些细菌的发病率。这些脂肪酸的功能因此受限于口腔菌群。
专利EP0355842描述了用于预防由于黑色素的过度产生导致的色素沉着的护肤霜,所述护肤霜可以含有岩芹酸。
专利EP1013178描述了岩芹酸作为消炎药的用途,以及用于治疗皮肤老化的迹象(诸如皱纹、皮肤松弛和老年斑(senescence mark))的用途。
专利WO99/47110描述了使用岩芹酸用来改善皮肤的外观的美容方法。
专利US6022890描述了包括α-羟基酸、岩芹酸和美容上可接受的载体的组合物。
然而,这些文献均没有提出:对需要的个体施用有效量的单不饱和脂肪酸、尤其岩芹酸可证实是特别有效地用于预防和/或治疗皮肤肤色缺陷。
发明人已经能够解释,单不饱和脂肪酸、尤其岩芹酸,导致在完美的体内平衡中复原正常皮肤组织,该正常皮肤组织呈现出有光泽的、年轻的和外观健康的肤色。
因此,根据本发明进行治疗的个体有利地看出其皮肤肤色缺陷的减少或甚至消失。皮肤肤色可变得均匀,而没有皮肤变色或暗淡的外观且没有瑕疵。
此外,有利地,本发明可以赋予皮肤、尤其是面部皮肤有光泽的和泛着光芒的外观。
出于本发明的目的,根据本发明,术语“皮肤”旨在表示个体、尤其是人的所有皮肤,且更具体地面部、颈部和领口的皮肤。术语“皮肤”包括体毛覆盖的表面。
优选地,本发明更具体地适用于护理面部、颈部和领口的皮肤,优选用于护理面部皮肤。
根据另一方面,本发明的主题是一种用于治疗和/或预防有需要的个体的皮肤肤色缺陷的口服美容治疗方法,所述方法包括将有效量的至少一种单不饱和脂肪酸、其盐和/或其酯施用至所述个体的至少一个步骤。
本发明有利地能够预防和/或治疗皮肤肤色缺陷。
根据一个实施方式,本发明有利地能够预防和/或治疗模糊的、暗淡的和/或不均匀的皮肤肤色。
根据另一实施方式,本发明有利地能够预防和/或治疗选自粉刺、干斑(drypatch)、皮肤变色和黑头的皮肤肤色缺陷。
根据另一实施方式,根据本发明的用途有利地能够预防和/或治疗苍白的、发黄的或甚至病态的肤色。
根据本发明的单不饱和脂肪酸必须以有效量使用,即,使脂肪酸对于待预防和/或待治疗的皮肤肤色缺陷显示出其活性剂特性的量。
出于本发明的目的,术语“预防”是指给定现象(即,本发明的皮肤肤色缺陷)的发生风险或发生概率降低到较轻的程度。
单不饱和脂肪酸
出于本发明的目的,术语“单不饱和脂肪酸”是指仅包括一个双键的烃基链的脂肪酸。
这样的脂肪酸更具体地是含有长烃基链的脂肪酸。在本发明中适合使用的单不饱和脂肪酸尤其是包括含有12个到22个碳原子的烃基链的单不饱和脂肪酸。
在本发明中适合使用的单不饱和脂肪酸可以以酸或盐的形式使用,或者可替选地以衍生物的形式,尤其是脂肪酸酰胺和酯类。
当它们是盐的形式时,本发明的单不饱和脂肪酸更具体地是美容上可接受的盐,即,无机盐,诸如,铵盐、碱金属(诸如,锂、钾或钠)的盐、碱土金属(诸如,镁或钙)的盐,或者铝盐。
具体地,在本发明中适合使用的单不饱和脂肪酸可以是钙盐的形式。
当它们是酯的形式时,本发明的单不饱和脂肪酸可以利用单酰、二酰或三酰形式的甘油;诸如甲醇和乙醇的醇类;糖类(尤其是单糖或双糖)、生育酚、三烯生育酚、诸如胆固醇的固醇或者诸如β-谷甾醇的植物甾醇;或者脂肪酸、尤其是C8至C18的脂肪酸来酯化。
应该理解,考虑包括这些物质的组合物的最终用途来选择本发明的单不饱和脂肪酸。
根据本发明的单不饱和脂肪酸被口服给药。
本发明的单不饱和脂肪酸、其盐和/或其酯可以用于口服的组合物中,其中,所述单不饱和脂肪酸、其盐和/或其酯的含量为:日剂量在从0.5mg/天到2500mg/天且尤其在从5mg/天到500mg/天的范围内。
在本发明中适合使用的单不饱和脂肪酸中,尤其适合使用油酸或岩芹酸。岩芹酸尤其适用于本发明。
根据本发明的一个变型,单不饱和脂肪酸以分离的形式使用,即,在从单不饱和脂肪酸的来源中提取出来然后进行使用。
根据本发明的另一个变型,单不饱和脂肪酸以诸如油的植物提取物使用。
因此,本发明尤其涉及富含本发明的单不饱和脂肪酸的油的美容用途,尤其是富含岩芹酸的油的美容用途。
富含岩芹酸的油类更具体地选自伞形科(Umbellifera)植物油。
术语“富含岩芹酸的油类”是指包含至少40%岩芹酸的油。
伞形科植物是其花呈伞形排列的植物,并且特别地富含岩芹酸的物种是伞形科(Umbelliferea-Apiacea)植物和五茄科(Araliaceae)植物。毒胡萝卜属(Thapsia)的植物也是岩芹酸的来源(Avato等,Lipids,2001,36,845)。
在本发明中优选使用的物种是芫荽、细叶芹(chervil)、胡萝卜、芹菜、枯茗(cumin)、葛缕子(caraway)、欧芹和莳萝(dill)。
根据本发明所用的伞形科植物油可以从伞形科植物的种子提取,例如,通过碾磨或压制,随后精炼。
伞形科植物油具有的岩芹酸含量根据进行提取的伞形科植物种子而变化。对于同样的伞形科植物,岩芹酸含量还根据伞形科植物的来源国和大体上完成的提取过程而变化。
岩芹酸还是一种来自红花老鹳草(Gernium sanguneum)的种子的油中的丰富的化合物(约48%)(Tsevegsuren等,Lipids,2004,39,571)。
根据一个实施方式,更具体地,在本发明中考虑的单不饱和脂肪酸是岩芹酸。
具体地,岩芹酸可以以伞形科植物油或红花老鹳草油的形式来使用。
根据另一实施方式,本发明考虑的伞形科植物油可以选自芫荽的种子油、细叶芹的种子油、胡萝卜的种子油、芹菜的种子油、枯茗的种子油、葛缕子的种子油、欧芹的种子油和莳萝的种子油、以及它们的混合物。
用途
本发明可以改善、统一或恢复皮肤的肤色。
根据一个美容实施方式,本发明旨在预防和/或治疗皮肤肤色缺陷。
出于本发明的目的,术语“皮肤肤色缺陷”是指健康皮肤的自然外观的损伤。
本发明中考虑的皮肤肤色缺陷不包括由诸如发炎红肿的炎症现象产生的皮肤损伤。
本发明中考虑的皮肤肤色缺陷不包括与黑色素的过度产生关联的皮肤缺陷。
本发明中考虑的皮肤肤色缺陷不包括诸如粗糙或开裂的皮肤表面缺陷。
出于本发明的目的,皮肤肤色缺陷不包括肤色亮度缺陷,且本发明的用途不旨在亮化皮肤肤色或漂白皮肤。
更具体地,本发明中考虑的皮肤肤色缺陷可尤其选自模糊的皮肤、暗淡的皮肤、不均匀肤色的皮肤、或者具有瑕疵的皮肤或皮肤变色。
出于本发明的目的,术语“皮肤瑕疵”是指具有皮肤变色或者没有皮肤变色的囊肿、黑头粉刺或疤痕。
更具体地,使用根据本发明的单不饱和脂肪酸可以显示出肤色的光泽。
出于本发明的目的,表述“显示出皮肤肤色的光泽”在任何情况下不能比作旨在亮化皮肤肤色的作用。出于本发明的目的,皮肤肤色的光泽表现出年轻、健康皮肤的皮肤肤色特征的自然光泽。
因此,本发明可以提供较少暗淡的、较少模糊的和较少灰暗的、且更具光泽的皮肤肤色。
剂型
根据本发明的组合物可以口服给药。根据本发明的组合物可以是根据使用途径正常使用的任何剂型。
根据本发明的组合物包括生理上或药学上可接受的介质。
口服途径和/或肠胃外途径的优点是更全面地作用于整个皮肤和皮肤的深层上。
术语“口服组合物”是指,例如,滋养组合物、营养组合物或药用化妆组合物,该组合物包括根据本发明的至少一种单不饱和脂肪酸、其盐和/或其酯。
对于适用于口服给药的组合物而言,优选使用可吸收的载体。根据考虑的组合物类型,可吸收的载体可具有不同的性质。
为了摄入,口服组合物尤其是食品补充剂的多个实施方式是可行的。
借助对于本领域的技术人员已知的任一常用的用于制备例如可饮用溶液、糖衣片、凝胶胶囊、凝胶、乳剂、吞咽片或咀嚼片、胶囊(尤其是软胶囊和硬胶囊)、溶解颗粒、糖浆、固体食品或液体食品和缓释水凝胶的方法,可以进行这种口服组合物的配制。
药片、凝胶胶囊或菱形块糖、悬浮液、干式口服补充剂和液体形式的口服补充剂例如适合用作食品载体。
具体地,根据本发明的活性剂可以被并入任何形式的食品补充剂或强化营养食品中,例如,食品条、或压实的或疏松的粉末。该粉末可以用水、苏打、乳制品或大豆衍生物稀释,或可以加入到食品条中。
根据一个优选的实施方式,根据本发明的口服给药的组合物可以被配制成糖衣药片、凝胶胶囊、凝胶、乳剂、片剂、胶囊、水凝胶、食品条、压缩的或疏松的粉末、悬浮液或液体溶液、糕点、发酵乳、发酵乳酪、口香糖、牙膏或喷雾液的形式。
适用的食品载体的示例包括乳、酸奶、乳酪、发酵乳、基于牛奶的发酵制品、冰淇淋、基于发酵的或者未发酵的谷物的制品、基于牛奶的粉末、婴幼儿配方、尤其用于宠物的动物饲料、片剂或菱形块糖、液体细菌悬浮液、干式口服补充剂和液体形式的口服补充剂。
所述口服组合物根据皮肤美容指征可以为无水形式或含水的形式。
根据本发明的活性剂可以由赋形剂和对于这样的口服组合物或食品补充剂常见的成分配制而成,所述常见的成分即尤其是脂肪成分和/或水性的成分、湿润剂、增稠剂、防腐剂、肌理剂(texture agent)、增味剂和/或包覆剂、抗氧化剂、防腐剂和着色剂,这些物质在食品部门中是常见的。
用于口服组合物且尤其是用于食品补充剂的配方试剂和赋形剂在本领域中是已知的并且将不是本文中详细描述的主题。
具体地,根据本发明的组合物可以为用于人类消费的食品组合物。该组合物尤其可以为下列的情况:营养的天然食品、饮料、矿泉水、汤、膳食补充剂和替代食品、营养条、糕点、基于发酵或未发酵的乳制品、酸奶、基于乳的粉末、肠内营养制品、婴儿组合物和/或幼儿组合物、基于发酵或未发酵的谷物的制品、冰淇淋、巧克力、咖啡或例如为蛋黄酱、番茄酱或沙拉酱的“烹调”制品。
根据本发明的组合物还可以用于动物,尤其是例如为猫和狗的宠物,并且可以被配制成用于动物的饲料或食品补充剂的形式。
另外的活性剂
根据本发明的单不饱和脂肪酸可有利地与尤其是美容活性剂或药物活性剂的另外的活性剂组合使用。
有利地,这样的另外的美容活性剂或药物活性剂可以用于对皮肤、头发、睫毛、体毛和/或头皮且优选地对皮肤施加美容护理或卫生效果。
由本领域的技术人员选取不损害本发明的单不饱和脂肪酸的效果的另外的活性剂。
尤其是,在本发明中适合使用的另外的活性剂可选自用于治疗和/或预防油性皮肤或易于油性的皮肤的活性剂。
根据另一实施方式,根据本发明的用于预防和/或治疗皮肤病的活性剂可以与微生物组合。
关于可以使用的另外的活性剂,可以提到的有:
-维生素,例如维生素A、维生素B5、维生素B6、维生素B8、维生素C、维生素D、维生素E或维生素PP(维生素B3或烟酸),
-抗氧化剂,例如:类姜黄色素;类胡萝卜素,尤其是选自β-胡萝卜素、番茄红素和其衍生物(例如,顺式番茄红素或者乳酸番茄红素(lactolycopene))、虾青素、玉米黄质和叶黄素,或含有玉米黄质和叶黄素的化合物(例如,枸杞、乳酸枸杞(lactowolfberry))的类胡萝卜素;多酚类化合物,类黄酮例如儿茶素、橙皮苷、原花青素、花青素和PCO(原矢车菊酚低聚物);泛醌;含有多酚类和/或二萜类的咖啡提取物;菊苣提取物;银杏(Ginkgo biloba)提取物;富含原花青素的葡萄提取物;甜椒提取物;大豆提取物;可可或可可乳;石榴;余柑子(Emblica);
-矿物质,例如锌、钙、镁、铜、铁、碘、锰、硒或铬(III),
-糖,
-氨基酸,尤其是含硫氨基酸和含硒氨基酸,所述含硫氨基酸例如为谷胱甘肽前体、牛磺酸,
-三元和六元的聚不饱和脂肪酸,
-益生素,尤其选自从例如葡萄糖、半乳糖、木糖、麦芽糖、蔗糖、乳糖、淀粉、木聚糖、半纤维素、菊糖、阿拉伯树胶类型的口香糖或它们的混合物制成的低聚糖。更具体地,该低聚物包括至少一种低聚果糖。更具体地,该益生素可包括低聚果糖和菊糖的混合物,
-植物甾醇,例如白藜芦醇,
-橙皮苷,以及
-它们的混合物。
根据一个优选的实施方式,根据本发明的单不饱和脂肪酸、其盐和/或其酯可以与至少一种另外的化妆活性剂组合使用,该另外的化妆活性剂可尤其选自维生素B3、维生素B5、维生素B6、维生素B8、维生素C、维生素E或维生素PP、类胡萝卜素、类姜黄素、烟酸、类黄酮、一种或多种二价矿物阳离子、细菌或细菌提取物(来自非光合的、非结实(non-fructifying)的丝状菌),益生菌微生物、尤其乳酸微生物、益生素营养素或者益生菌微生物的混合物和/或益生素营养素的混合物。
具体地,可以使用抗氧化剂复合物,该抗氧化剂复合物包括维生素C和维生素E,和至少一种类胡萝卜素、尤其是选自β-胡萝卜素、番茄红素和其衍生物(例如,顺式番茄红素或者乳酸番茄红素)、虾青素、玉米黄质和叶黄素、或含有玉米黄质和叶黄素的化合物(例如,枸杞、乳酸枸杞)的类胡萝卜素;类黄酮(例如儿茶素、橙皮苷、原花青素和花青素);白藜芦醇;可可或可可乳;石榴和余柑子。
本发明的组合物还可以含有以各种形式的一种或多种二价矿物阳离子。
因此,二价矿物阳离子可以是无水或水合的矿物或有机盐或螯合的络合物的形式。这些盐例如可以是碳酸盐、碳酸氢盐、硫酸盐、甘油磷酸盐、氯化物、氮化物、醋酸盐、氢氧化物、氧化物、α-羟基酸盐(柠檬酸盐、酒石酸盐、乳酸盐、苹果酸盐)或果酸盐,或可替选地氨基酸盐(天冬氨酸盐、精氨酸盐、延胡索酸盐)或脂肪酸盐(棕榈酸盐、油酸盐、酪蛋白盐、山嵛酸盐)。
二价矿物阳离子可以选自锰、铜和/或锌或者选自碱土金属。作为可以在本发明中使用的碱土金属,可以提到的是钡、钙、镁、锶和/或铍。
有利地,二价矿物阳离子,尤其是碱土金属,在本发明中以盐的形式使用。具体地,该盐可以选自硝酸盐、柠檬酸盐、氯化物、葡萄糖酸盐、硫酸盐、乳酸盐和/或醋酸盐。
二价矿物阳离子还可以以螯合的络合物的形式来使用,尤其螯合到晶体蛋白或离子化的蛋白。
二价矿物阳离子还可以是通过微生物(例如,酵母菌如硒酵母)存储的特定形式。
根据另一实施方式,本发明的组合物可含有如根据伯杰氏系统细菌学手册(Bergey’s Manual of Systemic Bacteriology,第3卷,第23部分,第9版本,1989年)分类所限定的非光合的、非结实的丝状菌,或者来自非光合作用的、非结实的丝状细菌的细菌提取物。
可以特别提到的是:属于贝日阿托氏菌目(Beggiatoales)的细菌,以及尤其是属于贝日阿托氏菌(Beggiatoa)属的细菌。此外,还可以提到的是属于透明颤菌(Vitreoscilla)属,其类似于贝日阿托氏菌属。在可以使用的细菌中,例如,可以提到的是类贝氏菌透明颤菌(Vitreoscilla beggiatoides,ATCC43181)和白硫丝菌(Beggiatoa alba,ATCC33555),和优选地使用线状透明颤菌(Vitreoscilla filiformis)的提取物,尤其是菌株ATCC15551、其代谢物和其部分(fraction)可以使用。
本发明的组合物还可以包括至少一种益生菌微生物、益生素试剂、或者益生菌微生物的混合物和益生素试剂的混合物。
在本发明中适合使用的益生菌微生物的具体示例是青春双岐杆菌(Bifidobacterium adolescentis)、动物双歧杆菌(Bifidobacterium animalis)、两歧双歧杆菌(Bifidobacterium bifidum)、短双歧杆菌(Bifidobacterium breve)、乳双歧杆菌(Bifidobacterium lactis)、长双歧杆菌(Bifidobacterium longum)、婴儿双歧杆菌(Bifidobacterium infantis)、假链状双歧杆菌(Bifidobacteriumpseudocatenulatum)、嗜酸乳杆菌(Lactobacillus acidophilus,LC1,NCFB1748);噬淀粉乳杆菌(Lactobacillus amylovorus)、干酪乳杆菌(Lactobacillus casei,Shirota)、鼠李糖乳杆菌(Lactobacillus rhamnosus,GG株系)、短乳杆菌(Lactobacillus brevis)、卷曲乳杆菌(Lactobacillus crispatus)、德氏乳杆菌乳亚种(Lactobacillus delbrueckii subsp.bulgaricus,lactis)、发酵乳杆菌(Lactobacillusfermentum)、瑞士乳杆菌(Lactobacillus helveticus)、鸡乳杆菌(Lactobacillusgallinarum)、格氏乳杆菌(Lactobacillus gasseri)、约氏乳杆菌(Lactobacillusjohnsonii)、副干酪乳杆菌(Lactobacillus paracasei)、胚芽乳杆菌(Lactobacillusplantarum)、罗伊氏乳杆菌(Lactobacillus reuteri)、鼠李糖乳杆菌(Lactobacillusrhamnosus)、唾液乳杆菌(Lactobacillus salivarius)、消化乳杆菌(Lactobacillusalimentarius)、弯曲乳杆菌(Lactobacillus curvatus)、干酪乳杆菌干酪亚种(Lactobacillus casei subsp.casei)、清酒乳杆菌(Lactobacillus sake)、乳酸乳球菌(Lactococcus lactis,)、粪肠球菌(Enterococcus faecalis)或屎肠球菌(Enterococcus faecium)、乳酸乳球菌(Lactococcus lactis,乳酸亚种或乳脂亚种)、肠膜明串珠菌葡聚糖亚种(Leuconostoc mesenteroides subsp.dextranicum)、乳酸片球菌(Pediococcus acidilactici)、菊糖芽孢乳杆菌(Sporolactobacillus inulinus)、唾液链球菌嗜热亚种(Streptococcus salvarius subsp.thermophilus)、嗜热链球菌(Streptococcus thermophilus)、肉葡萄球菌(Staphylococcus carnosus)、木糖葡萄球菌(Staphylococcus xylosus)、酵母菌(Saccharomyces,啤酒酵母(Saccharomyces cerevisiae)或布拉酵母菌(Saccharomyces boulardii))、芽孢杆菌(Bacillus cereus var.toyo)或枯草芽孢杆菌(Bacillus subtilis)、凝结芽孢杆菌(Bacillus coagulans)、地衣芽孢杆菌(Bacillus licheniformis)、大肠杆菌(Escherichia coli)菌株nissle、费氏丙酸菌(Propionibacterium freudenreichii)和它们的混合物。
这些微生物可以被制成粉末的形式(即干的形式),或者悬浮液或溶液的形式。
更具体地,这些微生物可以是选自乳酸菌属和/双歧杆菌属的微生物、其部分和/或其代谢物的益生菌微生物。作为这些微生物的说明,可以特别提到的是:约氏乳杆菌、罗伊氏乳杆菌、鼠李糖乳杆菌、副干酪乳杆菌、干酪乳杆菌、两歧双歧杆菌、短双歧杆菌、长双歧杆菌、动物双歧杆菌、乳酸双歧杆菌、婴儿双歧杆菌、青春双岐杆菌、和假链状双歧杆菌、和它们的混合物。
特别适合使用的物种为根据布达佩斯条约在1992年6月30日、1999年1月12日、1999年4月15日、1999年4月15日和2005年6月7日,在巴斯德研究所(28,rue du Docteur Roux,F-75024Paris cedex15)保藏的保藏号为CNCMI-1225、CNCM I-2116、CNCM I-2168、CNCM I-2170和CNCM I-3446的约氏乳杆菌、副干酪乳杆菌、青春双岐杆菌、长双歧杆菌和乳酸双歧杆菌NCC2818(也称为Bb12ATCC27536),以及长双歧杆菌属(BB536)。乳酸双歧杆菌(ATCC27536)的菌株可以来自于Hansen(Chr.Hansen A/S,10-12Boege Alle,P.O.Box407,DK-2970,郝斯霍尔姆,丹麦)。
根据本发明的一个具体实施方式,该组合物包括至少两种不同的微生物,这些微生物尤其是益生菌,和/或代谢物和/或其部分。这些微生物可根据性质(例如,细菌和真菌)、可替选地根据它们的科、它们的属或它们的种、或仅通过它们的株系来区分。
在本发明中适合使用的益生素试剂可以选自低聚糖,该低聚糖例如产自葡萄糖、半乳糖、木糖、麦芽糖、蔗糖、乳糖、淀粉、木聚糖、半纤维素、菊糖、阿拉伯树胶类型的口香糖或它们的混合物。更具体地,该低聚糖包括至少一种果糖低聚糖。更具体地,该益生素可包括果糖低聚糖和菊糖的混合物。
本发明的组合物还可以有利地含有尤其选自ω-3脂肪酸和ω-6脂肪酸的聚不饱和脂肪酸。
具体地,在本发明中适合使用的不饱和脂肪酸可选自包括18个到22个碳原子的脂肪酸,具体地聚不饱和脂肪酸,尤其是ω-3脂肪酸和ω-6脂肪酸。
在本发明的组合物中可以使用的ω-6系列的聚不饱和脂肪酸中,尤其可以提到的有:含有18个碳原子和两处不饱和的亚油酸(18:2ω-6)、含有18个碳原子和三处不饱和的γ-亚麻酸(18:3ω-6)、含有20个碳原子和三处不饱和的二高-γ-亚麻酸(20:3ω-6)、花生四烯酸、5,8,11,14-二十碳四烯酸(20:4ω-6)和二十二碳四烯酸(22:4,ω-6)。
ω-3系列的不饱和的脂肪酸可尤其选自:α-亚麻酸(18:3ω-3)、十八碳四烯酸(18:4ω-3)、5,8,11,14,17-二十碳五烯酸或EPA(20:5ω-3)、4,7,10,13,16,19-二十二碳六烯酸或DHA(22:6ω-3)、二十二碳五烯酸(22:5ω-3)和正丁基-5,11,14-二十二碳三烯酸。
α-亚麻酸、γ-亚麻酸、十八碳四烯酸、二十碳五烯酸、二十二碳六烯酸、它们的混合物或者包括这些酸的提取物尤其适合于在本发明中使用。
γ-亚麻酸的来源可以选自植物油,例如,月见草油、琉璃苣油、黑醋栗果仁油、蓝蓟(Ecchium)油和大麻籽油、以及微藻螺旋藻类(极大螺旋藻(Spirulinamaxima)和钝顶螺旋藻(Spirulina platensis))的提取物。
例如,来自核桃、榛子、杏仁(Juglans regia)、芫荽、大豆(Glycina max)、油菜籽(Brassica naptus)、芡欧鼠尾草、亚麻、麝香玫瑰的植物油和鱼油富含ω-3系列的聚不饱和脂肪酸。ω-3聚不饱和脂肪酸还可以在浮游动物、甲壳类/软体动物和鱼类中发现。
鱼油是EPA和DHA的主要工业来源。
微藻生物质还可以构成用于提取ω-3不饱和脂肪酸的材料。
因此,本发明的组合物中可以使用的聚不饱和脂肪酸的形式选自以下油类的至少一种油:月见草油、琉璃苣油、黑醋栗果仁油、核桃油、豆油、鱼油、向日葵油、小麦胚芽油、大麻籽油、胡芦巴油、麝香玫瑰油、蓝蓟油、摩洛哥坚果油、猴面包树油(baobab oil)、米糠油、芝麻油、杏仁油、核桃油、榛子油、芡欧鼠尾草籽油、亚麻籽油、麝香玫瑰油、橄榄油、鳄梨油、红花油、芫荽油和/或从微藻生物质(例如,螺旋藻)中提取或者从浮游动物中提取的油。
根据一个实施方式,本发明的组合物可包括另外的亲水性活性剂。可以使用的亲水性活性剂包括蛋白质或蛋白质水解物、氨基酸、多元醇(尤其是C2到C10的醇,例如,甘油、山梨醇、丁二醇或聚乙二醇)、尿素、尿囊素、糖和糖衍生物、水溶性维生素、淀粉,和细菌提取物或植物提取物(例如,来自芦荟(Aloe vera)的提取物)。
根据另一实施方式,本发明的组合物还可以包括亲油性活性剂。
可以使用的亲油性活性剂包括视黄醇(维生素A)及其衍生物、生育酚(维生素E)及其衍生物、神经酰胺和香精油。
根据本发明的活性剂还可以与尤其旨在用于预防和/或治疗皮肤病的活性剂组合。
根据另一实施方式,还可以使用活性剂:
-其参与真皮的内聚,例如,葡萄糖胺、迷迭香、肉毒碱、蓝莓、鼠尾草(sage)、菠菜、草莓、绿咖啡或苹果,
-其辅助细胞更新,例如类维生素A和植物激素(例如,黄豆苷元或薯蓣皂苷元),
-消炎化合物,例如橙皮苷或乳铁蛋白,
-脱落剂(pro-desquamating agent),
-抗氧化剂,
-抗溢脂剂,
-抗菌药物,例如抗生素,例如,红霉素。
方法
根据另一方面,本发明涉及一种用于治疗皮肤肤色和/或相关的审美皮肤病的口服美容方法,根据用于这些美容组合物的常规技术,其尤其可以通过施用如上文所限定的美容组合物来使用。
根据一个实施方式,本发明涉及一种用于预防和/或治疗有需要的个体的皮肤肤色缺陷的口服美容方法,所述方法包括对所述个体施用至少有效量的的单不饱和脂肪酸(特别是岩芹酸)、其盐和/或其酯且的至少一个步骤。
根据本发明的方法可包括观察皮肤肤色缺陷的减少或甚至消失的步骤。
根据一个实施方式,本发明的方法可优选地被应用到老年个体、成年女性、具有亚洲人类型的皮肤的个体或者具有非洲人类型的皮肤的个体。
有利地,本发明的方法的应用可以减少或甚至消除皮肤瑕疵,且优选地来自面部皮肤的皮肤瑕疵,恢复均匀的、一致的肤色和/或不具有暗淡外观的肤色并且促进形成有光泽的肤色。
尤其可以通过施用如上文限定的食品组合物来执行根据本发明的美容方法。
本发明的方法可以每天进行,例如,以每天施用一次或者一天施用两次(例如,早上一次和晚上一次)的频率进行。
根据本发明的美容方法可以通过口服给药来进行,例如,通过每日给药配制的组合物,根据配制的组合物的形式每日给药足够的量和次数,例如,形式为凝胶胶囊、凝胶、洗剂、糖衣片剂、乳剂、片剂、胶囊或小瓶口服液(drinkablevials)。
有效量的单不饱和脂肪酸可以每天单次剂量或者一天中的分多次的剂量,例如,每天两次到三次。
根据本发明的方法优选包括单次给药。
本发明的美容方法可以在一周到数周、或甚至数月的时间段中进行,而且,该时间段在未治疗的时间段之后可以重复持续数月或甚至数年。
例如,根据本发明的活性剂的施用可以通常在至少4周、或甚至4周到15周的长时间段中例如每天2次到3次或更多次重复,在适当地情况下,停用一个时间段或多个时间段。
口服美容方法可以在一周到数周、或甚至数月的时间段中进行,此外,该时间段在未治疗的时间段之后可以重复持续数月或甚至数年。
例如,根据本发明的单不饱和脂肪酸的口服给药可以在通常至少4周、或甚至4周到15周的长时间段中以例如每天3次的频率进行,该长时间段可选地包括一个或多个停用时间段或在停用时间段之后重复。
具体实施方式
在该描述和下文的实施例中,除非另外说明,否则百分比为重量百分比以及以“在…和…之间”的形式表述的值的范围包括所述下限和上限。在配制之前,按顺序并且在本领域技术人员可容易地确定的条件下将成分混合到一起。
以下实施例作为本发明的非限制性说明示出。
实施例
实施例1
口服组合物
实施例1A:粉棒
活性成分 | |
副干酪乳杆菌ST11 | 1010cfu |
乳酸双歧杆菌Bb12 | 1010cfu |
柠檬酸钙 | 50mg |
岩芹酸 | 100mg |
赋形剂 | |
黄原胶 | 0.8mg |
苯甲酸钠 | 0.2mg |
麦芽糖糊精 | 补足至30g |
一天可以服用一个棒。
每天服用这样的棒持续约1周可以使皮肤具有均匀的和发亮的肤色。
实施例1B:粉棒
活性成分 | |
葡萄糖酸镁 | 50 |
副干酪乳杆菌ST11 | 5×10。cfu |
乳酸双歧杆菌Bb12 | 5×10。cfu |
柠檬酸钙 | 200 |
芫荽油 | 250 |
赋形剂 | |
黄原胶 | 0.8 mg |
苯甲酸钠 | 0.2 mg |
麦芽糖糊精 | 补足至30g |
一天可以服用一个棒。
每天服用这样的棒持续约一周可以明显减少皮肤变色并且使皮肤呈现均匀、发光和有光泽的肤色。
实施例1C:胶囊
活性成分 | mg/胶囊 |
芫荽油 | 150 |
维生素C | 60 |
硬脂酸镁 | 0.02 |
每天可以服用一个到三个这样的胶囊。
每天服用这样的胶囊持续约一周可以明显减少皮肤变色、发红和皮肤缺陷并且使皮肤呈现均匀的、发光的和有光泽的肤色。
实施例1D:糖衣片类型的制剂
活性物质 | mg/包衣片 |
芫荽油 | 550 |
包衣片的芯的赋形剂 | |
微晶纤维素 | 70 |
EncompressTM | 60 |
硬脂酸镁 | 3 |
无水硅胶 | 1 |
涂覆剂 | |
虫胶 | 5 |
滑石粉 | 61 |
蔗糖 | 250 |
聚维酮 | 6 |
二氧化钛 | 0.3 |
着色剂 | 5 |
服用该类型的糖衣片可以每天1次到3次。
每天服用这样的糖衣片持续约一周可以明显减少皮肤变色和皮肤缺陷并且可以使皮肤具有均匀、发亮和有光泽的肤色。
实施例1E:糖衣片类型的制剂
活性物质 | mg/包衣药片 |
芫荽油 | 250 |
约氏乳杆菌 | 109cfu |
包衣片的芯的赋形剂 | |
微晶纤维素 | 70 |
EncompressTM | 60 |
硬脂酸镁 | 3 |
无水硅胶 | 1 |
涂覆剂 | |
虫胶 | 5 |
滑石粉 | 61 |
蔗糖 | 250 |
聚维酮 | 6 |
二氧化钛 | 0.3 |
着色剂 | 5 |
服用该类型的糖衣药片可以每天1次到3次。
每天服用这样的糖衣药片持续约一周可以明显减少皮肤变色和皮肤缺陷并且可以使皮肤具有均匀、发亮和有光泽的肤色。
Claims (11)
1.有效量的至少一种单不饱和脂肪酸、其盐和/或其酯的口服用途或营养美容用途,所述单不饱和脂肪酸、其盐和/或其酯用作治疗和/或预防皮肤肤色缺陷的活性剂,所述缺陷不是由炎症现象产生的损伤、与黑色素的过度产生无关、不是皮肤表面缺陷且不是皮肤肤色的亮度缺失。
2.根据前一项权利要求所述的用途,所述单不饱和脂肪酸、其盐和/或其酯用于预防和/或治疗模糊的皮肤、暗淡的皮肤、肤色不均的皮肤、或者具有瑕疵的皮肤或皮肤变色、和/或用于展现肤色的光泽。
3.根据权利要求1或2所述的用途,其中,所述皮肤是面部的皮肤、颈部的皮肤和/或领口位置的皮肤,并且优选是面部皮肤。
4.根据前述权利要求中任一项所述的用途,其中,所述单不饱和脂肪酸、其盐和/或其酯是分离的形式或者植物提取物的形式。
5.根据前述权利要求中任一项所述的用途,其中,所述单不饱和脂肪酸、其盐和/或其酯被用在口服组合物中,并且其中所述单不饱和脂肪酸、其盐和/或其酯的含量为:日剂量在从0.5mg/天到2500mg/天的范围内,且尤其在从5mg/天到500mg/天的范围内。
6.根据前述权利要求中任一项所述的用途,其中,所述单不饱和脂肪酸是岩芹酸。
7.根据前一项权利要求中所述的用途,其中,所述岩芹酸以来自伞形科植物或来自红花老鹳草的油的形式使用。
8.根据前一项权利要求中所述的用途,其中,所述伞形科植物油选自芜荽种子油、细叶芹种子油、胡萝卜种子油、芹菜种子油、枯茗种子油、葛缕子种子油、欧芹种子油、莳萝种子油和它们的混合物。
9.根据前述权利要求中任一项所述的用途,其中,所述单不饱和脂肪酸与至少一种另外的美容活性剂组合使用,所述至少一种另外的美容活性剂尤其选自维生素B3、维生素B5、维生素B6、维生素B8、维生素C、维生素E或维生素PP、类胡萝卜素、类姜黄素、烟酸、类黄酮、一种或多种二价矿物阳离子、细菌或来源于非光合的、非结实的丝状菌的细菌提取物,益生菌微生物、尤其是乳酸微生物、益生素营养素或者益生菌微生物的混合物和/或益生素营养素的混合物。
10.根据前一项权利要求所述的用途,其中所述益生菌微生物选自乳酸杆菌属和/或双歧杆菌属、其部分和/或其代谢物。
11.一种口服美容治疗方法,所述方法用于治疗和/或预防有需要的个体的皮肤肤色缺陷,所述方法包括对所述个体施用有效量的至少一种单不饱和脂肪酸、其盐和/或其酯的至少一个步骤,所述缺陷不是由炎症现象产生的损伤、与黑色素的过度产生无关、不是皮肤表面缺陷且不是皮肤肤色的亮度缺失。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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FR1059144 | 2010-11-05 | ||
FR1059144A FR2967070B1 (fr) | 2010-11-05 | 2010-11-05 | Acide gras monoinsature pour prevenir et/ou traiter les imperfections du teint de la peau |
PCT/IB2011/054895 WO2012059880A1 (fr) | 2010-11-05 | 2011-11-03 | Acide gras monoinsature pour prevenir et/ou traiter les imperfections du teint de la peau |
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CN103747692A true CN103747692A (zh) | 2014-04-23 |
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US (1) | US9730905B2 (zh) |
EP (1) | EP2635140A1 (zh) |
CN (1) | CN103747692A (zh) |
BR (1) | BR112013011064A2 (zh) |
CA (1) | CA2816732C (zh) |
CL (1) | CL2013001232A1 (zh) |
FR (1) | FR2967070B1 (zh) |
MX (1) | MX353580B (zh) |
RU (1) | RU2013120495A (zh) |
WO (1) | WO2012059880A1 (zh) |
Cited By (1)
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CN107427461A (zh) * | 2015-01-14 | 2017-12-01 | 婴幼儿细菌治疗公司 | 活化乳酸细菌的方法 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2982150B1 (fr) | 2011-11-09 | 2016-05-20 | Oreal | Acide gras mono-insature pour le soin des ongles |
FR3005410A1 (fr) * | 2013-05-07 | 2014-11-14 | Inneov Lab | Association d'acide petroselinique et de zinc pour une administration par voie orale pour lutter contre le vieillissement des cheveux |
FR3005411B1 (fr) | 2013-05-07 | 2016-09-30 | Laboratoires Inneov | Association d'actifs pour une administration par voie orale pour ameliorer la qualite des ongles. |
JP6204174B2 (ja) * | 2013-12-10 | 2017-09-27 | 日清ペットフード株式会社 | ペットフード |
WO2015121455A1 (fr) * | 2014-02-14 | 2015-08-20 | Vesale Pharma Sa | Composition comprenant au moins un probiotique |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0709084A2 (fr) * | 1994-10-07 | 1996-05-01 | L'oreal | Utilisation d'une huile riche en acide pétrosélinique comme agent hydratant |
WO1999047110A1 (en) * | 1998-03-16 | 1999-09-23 | Unilever Plc | Cosmetic method of treating skin |
EP1013178A1 (en) * | 1998-12-22 | 2000-06-28 | Loders Croklaan B.V. | Petroselinic acid and its use in food, fat compositions containing petroselinic acid |
CN1365272A (zh) * | 1999-07-30 | 2002-08-21 | 荷兰联合利华有限公司 | 含岩芹酸的护肤组合物 |
WO2008078050A2 (fr) * | 2006-12-14 | 2008-07-03 | L'oreal | Utilisation d'au moins un acide gras mono-insature pour le traitement des peaux, muqueuses ou semi-muqueuses et cuirs chevelus fragiles |
CN101646415A (zh) * | 2006-12-14 | 2010-02-10 | 欧莱雅公司 | 至少一种单不饱和脂肪酸用于改善头发的口服用途 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE38141E1 (en) * | 1997-10-17 | 2003-06-10 | International Flora Technologies Ltd. | Dry emollient compositions |
EP1212093B1 (en) * | 1999-08-26 | 2004-07-07 | Ganeden Biotech, Inc. | Use of emu oil as a carrier for antifungal, antibacterial and antiviral medications |
-
2010
- 2010-11-05 FR FR1059144A patent/FR2967070B1/fr not_active Expired - Fee Related
-
2011
- 2011-11-03 MX MX2013005025A patent/MX353580B/es active IP Right Grant
- 2011-11-03 BR BR112013011064A patent/BR112013011064A2/pt active Search and Examination
- 2011-11-03 US US13/883,700 patent/US9730905B2/en not_active Expired - Fee Related
- 2011-11-03 RU RU2013120495/13A patent/RU2013120495A/ru not_active Application Discontinuation
- 2011-11-03 EP EP11797362.8A patent/EP2635140A1/fr not_active Ceased
- 2011-11-03 WO PCT/IB2011/054895 patent/WO2012059880A1/fr active Application Filing
- 2011-11-03 CA CA2816732A patent/CA2816732C/fr not_active Expired - Fee Related
- 2011-11-03 CN CN201180064169.8A patent/CN103747692A/zh active Pending
-
2013
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Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0709084A2 (fr) * | 1994-10-07 | 1996-05-01 | L'oreal | Utilisation d'une huile riche en acide pétrosélinique comme agent hydratant |
WO1999047110A1 (en) * | 1998-03-16 | 1999-09-23 | Unilever Plc | Cosmetic method of treating skin |
EP1013178A1 (en) * | 1998-12-22 | 2000-06-28 | Loders Croklaan B.V. | Petroselinic acid and its use in food, fat compositions containing petroselinic acid |
CN1365272A (zh) * | 1999-07-30 | 2002-08-21 | 荷兰联合利华有限公司 | 含岩芹酸的护肤组合物 |
WO2008078050A2 (fr) * | 2006-12-14 | 2008-07-03 | L'oreal | Utilisation d'au moins un acide gras mono-insature pour le traitement des peaux, muqueuses ou semi-muqueuses et cuirs chevelus fragiles |
CN101646415A (zh) * | 2006-12-14 | 2010-02-10 | 欧莱雅公司 | 至少一种单不饱和脂肪酸用于改善头发的口服用途 |
Non-Patent Citations (1)
Title |
---|
TSEVEGSUREN N ET AL: "Geranium sanguineum (Geraniaceae) seed oil: a new source of petroselinic and vernolic acid", 《LIPIDS》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107427461A (zh) * | 2015-01-14 | 2017-12-01 | 婴幼儿细菌治疗公司 | 活化乳酸细菌的方法 |
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Publication number | Publication date |
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MX353580B (es) | 2018-01-19 |
EP2635140A1 (fr) | 2013-09-11 |
US20130302297A1 (en) | 2013-11-14 |
CL2013001232A1 (es) | 2013-12-20 |
WO2012059880A1 (fr) | 2012-05-10 |
FR2967070B1 (fr) | 2013-07-05 |
MX2013005025A (es) | 2013-06-03 |
BR112013011064A2 (pt) | 2016-07-19 |
CA2816732A1 (fr) | 2012-05-10 |
US9730905B2 (en) | 2017-08-15 |
FR2967070A1 (fr) | 2012-05-11 |
CA2816732C (fr) | 2020-02-18 |
RU2013120495A (ru) | 2014-12-10 |
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