CN103736137A - Preparation method of silver-bearing foam material for wound dressing - Google Patents
Preparation method of silver-bearing foam material for wound dressing Download PDFInfo
- Publication number
- CN103736137A CN103736137A CN201310709902.8A CN201310709902A CN103736137A CN 103736137 A CN103736137 A CN 103736137A CN 201310709902 A CN201310709902 A CN 201310709902A CN 103736137 A CN103736137 A CN 103736137A
- Authority
- CN
- China
- Prior art keywords
- polyvinyl alcohol
- chitin
- preparation
- silver particles
- wound dressing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention discloses a preparation method of a silver-bearing foam material for wound dressing. The preparation method comprises the following steps: I, proportioning: weighing the following raw materials in percentage by weight: 2-7% of chitin, 5-7% of polyvinyl alcohol, 15-20% of sulfuric acid, 3-4% of formaldehyde, 1-3% of sodium hydrogen carbonate, 0.1-10% of silver particles and the balance of distilled water; II, thermally dissolving polyvinyl alcohol: first, heating and dissolving chitin, polyvinyl alcohol and distilled water to obtain mixed liquor, wherein the heating temperature is 83-93 DEG C; III, compounding chitin: adding sulfuric acid, formaldehyde and sodium hydrogen carbonate into the mixed liquor to blend and mix, and then adding the silver particles; IV, pouring the blend in the step III into a mould to be thermally moulded, wherein the thermal moulding temperature is 70-85 DEG C and the thermal moulding time is 3-4 hours; V, cleaning a thermally moulded product to obtain a chitin/polyvinyl alcohol composite foam material.
Description
Technical field
The present invention relates to a kind of preparation method of the argentiferous foamed materials for wound dressing.
Background technology
Chitin molecule amount is high, nontoxic, biocompatibility is better, and degradable has the wound healing of promotion and hemostatic function, is a kind of reasonable bio-medical material.Many hydroxyls that distributing on chitin macromolecular chain, also have some acetylaminos, thereby many metal ions are had to stable coordination, aspect water treatment, have important application.Silver particles has antibiotic and sterilizing function.At present about the report of polyvinyl alcohol porous foam is all less both at home and abroad, mainly concentrate on the research to pure polyvinyl alcohol foam plastics, and the chitin/polyvinyl alcohol perforated foams of making without interpolation silver particles, existing technique greatly improves production efficiency and product bacteria resistance function in prior art.
Summary of the invention
The preparation method that the invention provides a kind of argentiferous foamed materials for wound dressing, the dressing that it is prepared has the characteristic of water suction, good mechanical properties, good biocompatibility.
The present invention has adopted following technical scheme: a kind of preparation method of the argentiferous foamed materials for wound dressing, it comprises the following steps: step 1, batching: take chitin, polyvinyl alcohol, sulphuric acid, formaldehyde, sodium bicarbonate, silver particles and distilled water, the shared percentage by weight of each raw material is: chitin 2～7%, polyvinyl alcohol 5～7%, sulphuric acid 15～20%, formaldehyde 3～4%, sodium bicarbonate 1～3%, silver particles 0.1～10%, distilled water surplus;
Step 2, polyvinyl alcohol heat of solution: first chitin, polyvinyl alcohol and distilled water heating for dissolving are obtained to mixed solution, heating-up temperature is 83～93 ℃;
Step 3, chitin compound: sulphuric acid, formaldehyde and sodium bicarbonate are added to blending and stirring in mixed solution, then add silver particles;
Step 4, pours step 3 kind blend in mould into and carries out thermoforming, and the temperature of thermoforming is 70～85 ℃, and the time of thermoforming is 3～4 hours;
Step 5, after the product of thermoforming is cleaned, obtains chitin/polyvinyl alcohol composite foam material.
In described step 2, the degree of polymerization of polyvinyl alcohol is 1800～1900.In described step 3, silver particles is nanometer silver, and mean diameter is at 10-20nm.
The present invention has following beneficial effect: histocompatibility and mechanical property that the present invention is good in view of polyvinyl alcohol has, have no side effect, pliability is good, tensile strength is higher, be widely used in peritoneal dialysis, suture material, the features such as the treatment of burn or wound, the present invention prepares chitin/polyvinyl alcohol perforated foams by polyvinyl alcohol and chitin blending.Because polyvinyl alcohol and chitin all possess good biocompatibility, therefore described foamed materials can be applicable to novel wound dressing.Chitin/polyvinyl alcohol perforated foams stable preparation process provided by the invention, is easy to realize suitability for industrialized production, and good antibacterial functions, the production time is short, cost is low, environmental protection, technique are simple.The degree of polymerization of polyvinyl alcohol is controlled at 1800～1900, can significantly shorten the production time.And prepared foamed materials specific surface area is large, with good biocompatibility, has intensity high, and abrasive resistance is strong, long service life.And possess some special medical function, and thering are the potentiality of applying, market prospect is wide.Add silver particles to significantly improve product antibacterial functions, greatly improve its properties of product as wound dressing.
The specific embodiment
The present invention, by the simple and effective method of this raising macromolecular material performance of blending and modifying, is dissolved blend by chitin and polyvinyl alcohol, to obtaining the comparatively desirable chitin/polyvinyl alcohol composite foam material of combination property.
Below in conjunction with embodiment, the invention will be further described.
Embodiment mono-: the preparation of argentiferous chitin/polyvinyl alcohol composite foam material and shortening production time, by weight, by polyvinyl alcohol 6%, chitin 4% and distilled water 62.5% at 80 ℃ after heating for dissolving, in solution, add sulphuric acid 17%, formaldehyde 3.5%, sodium bicarbonate 2%, after the abundant mechanical agitation of silver particles 5%, blend is poured in mould, 72 ℃ of thermoformings in baking oven, finally by cleaning and get final product.The degree of polymerization of polyvinyl alcohol is controlled at 1800～1900, detects 5 batches, thermoforming time average out to 3.1h, and the degree of polymerization of polyvinyl alcohol is 1900～2600, thermoforming time, on average at 6 ~ 8h, adopts the polyvinyl alcohol that the degree of polymerization is 1800～1900, can significantly shorten the production time.
Embodiment bis-: argentiferous chitin/polyvinyl alcohol composite foam material anti-bacteria detects, by weight, by polyvinyl alcohol 5.2%, chitin 3% and distilled water 69% at 80 ℃ after heating for dissolving, in solution, add sulphuric acid 15%, formaldehyde 3.8%, sodium bicarbonate 2%, after the abundant mechanical agitation of silver particles 2%, blend is poured in mould, 72 ℃ of thermoformings 3.5 hours in baking oven, finally by cleaning and obtain argentiferous chitin/polyvinyl alcohol composite foam material.Get the foamed materials of preparation, under rotating speed 200rpm/min, 25 ℃ of condition of culture, action time, the shake-flask method of 1h detected 4 batches: argentiferous chitin/polyvinyl alcohol composite foam material has good anti-microbial property, it is respectively 97% to the bacteriostasis rate of staphylococcus aureus, to the bacteriostasis rate of Candida albicans, is respectively 93%.
Embodiment tri-: argentiferous chitin/polyvinyl alcohol composite foam material is for wound healing, by weight, by polyvinyl alcohol 5.2%, chitin 3% and distilled water 69% at 80 ℃ after heating for dissolving, in solution, add sulphuric acid 15%, formaldehyde 3.8%, sodium bicarbonate 2%, after the abundant mechanical agitation of silver particles 2%, blend is poured in mould, 72 ℃ of thermoformings 3.5 hours in baking oven, finally by cleaning and obtain argentiferous chitin/polyvinyl alcohol composite foam material.After γ ray sterilization, material is covered to 6 patient skin wound surface, the average healing is 7 days, and use the conventional dressing healing times such as gauze, is 16 days.
Claims (3)
1. the preparation method for the argentiferous foamed materials of wound dressing, it comprises the following steps: step 1, batching: take chitin, polyvinyl alcohol, sulphuric acid, formaldehyde, sodium bicarbonate, silver particles and distilled water, the shared percentage by weight of each raw material is: chitin 2～7%, polyvinyl alcohol 5～7%, sulphuric acid 15～20%, formaldehyde 3～4%, sodium bicarbonate 1～3%, silver particles 0.1～10%, distilled water surplus;
Step 2, polyvinyl alcohol heat of solution: first chitin, polyvinyl alcohol and distilled water heating for dissolving are obtained to mixed solution, heating-up temperature is 83～93 ℃;
Step 3, chitin compound: sulphuric acid, formaldehyde and sodium bicarbonate are added to blending and stirring in mixed solution, then add silver particles;
Step 4, pours step 3 kind blend in mould into and carries out thermoforming, and the temperature of thermoforming is 70～85 ℃, and the time of thermoforming is 3～4 hours;
Step 5, after the product of thermoforming is cleaned, obtains chitin/polyvinyl alcohol composite foam material.
2. the preparation method of the argentiferous foamed materials for wound dressing according to claim 1, is characterized in that the degree of polymerization of polyvinyl alcohol in described step 2 is 1800～1900.
3. the preparation method of the argentiferous foamed materials for wound dressing according to claim 1, is characterized in that in described step 3, silver particles is nanometer silver, and mean diameter is at 10-20nm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310709902.8A CN103736137A (en) | 2013-12-22 | 2013-12-22 | Preparation method of silver-bearing foam material for wound dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310709902.8A CN103736137A (en) | 2013-12-22 | 2013-12-22 | Preparation method of silver-bearing foam material for wound dressing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103736137A true CN103736137A (en) | 2014-04-23 |
Family
ID=50493249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310709902.8A Pending CN103736137A (en) | 2013-12-22 | 2013-12-22 | Preparation method of silver-bearing foam material for wound dressing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103736137A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008031601A1 (en) * | 2006-09-13 | 2008-03-20 | Dsm Ip Assets B.V. | Antimicrobial hydrophilic coating comprising metallic silver particles |
| CN101381500A (en) * | 2008-10-16 | 2009-03-11 | 武汉理工大学 | Chitin/polyvinyl alcohol composite foam material and preparation method thereof |
| CN101927029A (en) * | 2010-08-06 | 2010-12-29 | 华南理工大学 | Preparation method of chitosan/polyvinyl alcohol sponge dressing containing nano-silver |
| CN101954115A (en) * | 2010-10-22 | 2011-01-26 | 佘振定 | Medical antibacterial sponge dressing and preparation method thereof |
| CN102108172A (en) * | 2010-01-20 | 2011-06-29 | 威海世创新材料科技有限公司 | Chitosan/polyvinyl alcohol (PVA) porous composite material and preparation method thereof |
| US20130108670A1 (en) * | 2011-10-25 | 2013-05-02 | Biomimetic Therapeutics, Inc. | Compositions and methods for treating full thickness burn injuries |
| CN103446621A (en) * | 2013-05-07 | 2013-12-18 | 哈尔滨工程大学 | Nano-silver-containing sodium alginate based antibacterial medical dressing and preparation method thereof |
-
2013
- 2013-12-22 CN CN201310709902.8A patent/CN103736137A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008031601A1 (en) * | 2006-09-13 | 2008-03-20 | Dsm Ip Assets B.V. | Antimicrobial hydrophilic coating comprising metallic silver particles |
| CN101381500A (en) * | 2008-10-16 | 2009-03-11 | 武汉理工大学 | Chitin/polyvinyl alcohol composite foam material and preparation method thereof |
| CN102108172A (en) * | 2010-01-20 | 2011-06-29 | 威海世创新材料科技有限公司 | Chitosan/polyvinyl alcohol (PVA) porous composite material and preparation method thereof |
| CN101927029A (en) * | 2010-08-06 | 2010-12-29 | 华南理工大学 | Preparation method of chitosan/polyvinyl alcohol sponge dressing containing nano-silver |
| CN101954115A (en) * | 2010-10-22 | 2011-01-26 | 佘振定 | Medical antibacterial sponge dressing and preparation method thereof |
| US20130108670A1 (en) * | 2011-10-25 | 2013-05-02 | Biomimetic Therapeutics, Inc. | Compositions and methods for treating full thickness burn injuries |
| CN103446621A (en) * | 2013-05-07 | 2013-12-18 | 哈尔滨工程大学 | Nano-silver-containing sodium alginate based antibacterial medical dressing and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101381500B (en) | Chitin/polyvinyl alcohol composite foam material and preparation method thereof | |
| CN101445636A (en) | A sodium alginate and polyvinyl alcohol compound sponges material and preparation method thereof | |
| CN101381906B (en) | Alginate nano Ag antibacterial fiber and method for making same | |
| CN101927029B (en) | Preparation method of chitosan/polyvinyl alcohol sponge dressing containing nano-silver | |
| CN103446621A (en) | Nano-silver-containing sodium alginate based antibacterial medical dressing and preparation method thereof | |
| CN103656730A (en) | Medical chitosan dressing | |
| CN103656731A (en) | Medical chitosan dressing | |
| WO2017092233A1 (en) | Antibacterial polyester fiber based on silver-containing zirconium phosphate, and method for preparation thereof | |
| CN103835025B (en) | A kind of preparation method of permanent antibacterial poly-guanidine alginate fibre | |
| CN111068404B (en) | Preparation method of antibacterial liquid filtering material | |
| CN101974189B (en) | Succinyl-chitosan/polyvinyl alcohol composite sponge and preparation method thereof | |
| CN109354836A (en) | A kind of high intensity antibacterial polyethylene terephthalate plastic cup and preparation method thereof | |
| KR101407612B1 (en) | Spinning solution for industrially producing pure chitosan fiber and preparation method thereof | |
| CN102432895B (en) | Preparation method of temperature-sensitive cellulose quaternary ammonium salt/beta-sodium glycerophosphate hydrogel | |
| CN103709452A (en) | Chitin/polyvinyl alcohol composite foam material and preparation method thereof | |
| CN109235038A (en) | A kind of preparation method of antibacterial facial mask fabric | |
| CN102757625B (en) | A kind of chitosan-polylactic acid is composite porous and preparation method thereof | |
| CN103736137A (en) | Preparation method of silver-bearing foam material for wound dressing | |
| KR100912644B1 (en) | The preparing method of chemically transformed chitosan fiber | |
| CN103480038B (en) | Preparation method for chitosan/hydroxyapatite composite hydrogel | |
| CN109400930A (en) | Tourmaline powder/meyer sedge fiber-antibacterial latex film preparation method | |
| CN112341708B (en) | Novel wormwood PP plastic applied to toilet lid | |
| CN104353107A (en) | Medical hemostatic sponge material and preparation method thereof | |
| CN105506770A (en) | Quantum energy polyamide 66 fibers and preparation method thereof | |
| CN101831723B (en) | Gelatin bacteriostatic fiber modified by trivalent cerium and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20140423 |
|
| RA01 | Restoration of patent right |
Former decision: deemed withdrawal of patent application after publication Former decision publication date: 20160302 |
|
| REIN | Reinstatement of patent application or patent right | ||
| REIN | Reinstatement of patent application or patent right | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20140423 |
|
| WD01 | Invention patent application deemed withdrawn after publication |