CN104353107A - Medical hemostatic sponge material and preparation method thereof - Google Patents
Medical hemostatic sponge material and preparation method thereof Download PDFInfo
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- CN104353107A CN104353107A CN201410626611.7A CN201410626611A CN104353107A CN 104353107 A CN104353107 A CN 104353107A CN 201410626611 A CN201410626611 A CN 201410626611A CN 104353107 A CN104353107 A CN 104353107A
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Abstract
The invention belongs to the field of novel medical materials, and discloses a medical hemostatic sponge material and a preparation method thereof; and the medical hemostatic sponge material comprises xanthan gum, polyethylene glycol 400, fimbrin, polyvinylpyrrolidone, tripolyglycerol monostearates and hydroxy propyl distarch phosphate. The preparation method disclosed by the invention comprises the following steps of: (1), dissolving xanthan gum, polyethylene glycol 400, fimbrin and polyvinylpyrrolidone by using a proper amount of water, and then, stirring; (2), adding tripolyglycerol monostearates and hydroxy propyl distarch phosphate and stirring; and (3), cooling to room temperature, cutting a colloid material into a square material, freezing and drying the square material, thus obtaining the medical hemostatic sponge material.
Description
Technical field
The invention belongs to medical field of new, relate to a kind of sponge material and preparation method thereof, particularly relate to a kind of loose porous, medical sthptic sponge material that imbibe rate is high and preparation method thereof.
Background technology
Sponge is a kind of porous material, has good water absorption, can be used in clean article.The sponge that people commonly use is made up of wood cellulose fibers or foamed plastic polymer.In addition, the synthetic sponge also having three class other materials to make, is respectively low-density polyethers (not water-absorbing sponge), polyvinyl alcohol (high-absorbent material, without obvious pore) and polyester.Current domestic daily civilian wound hemostasis material mainly bandage, surgical operation hemostatic material is gelfoam.Though the two has hemostasia effect, its anti-inflammation hemostasia effect is poor.Medical sponge material require hydrophilic for stopping blooding is excellent, easy to use, and the ability adhering to wound is excellent, and bleeding stopping period is short.Apply at wound surface, wound surface is dry, not easily infects, and wound surface also needs healing rapidly; After internal organs of the body hemostasis, the best degradable of sponge material, absorbability are good.In addition, medical sponge material also needs low rejection, needs good biocompatibility.Medical sponge material also needs to possess higher porosity and pick up, license notification number is that the patent of invention of CN102585273 discloses a kind of sponge material, continues reaction after the mixed reaction solution of its polyvinyl alcohol water solution that two bursts of acetalation degree be there are differences, formaldehyde and mineral acid mixes by a certain percentage; Size and the flexibility in material aperture is regulated by the relative amounts changing two strands of materials.The pick up of sea material disclosed in this patent document is at about 20 times.There is more space in sponge material simultaneously.But its pick up is comparatively common, still need the pick up and the porosity that improve sponge material.
Summary of the invention
The technical problem solved: the material medically for stopping blooding is more, there is the high-molecular organic material etc. of natural macromolecular material, synthesis, but the above-mentioned pick up for the medical material stopped blooding is lower, a large amount of imbibitions can not be used for, therefore the object of the present invention is to provide medical sthptic sponge material that a kind of loose porous pick up is very high and preparation method thereof.
Technical scheme: in order to improve porosity and the imbibe rate of hemostatic material in medical use, the invention discloses a kind of medical sthptic sponge material and preparation method thereof, described medical sthptic sponge material comprises the composition of following weight parts:
Xanthan gum 8-15 part,
PEG400 5-11 part,
Tripolyglycerol monostearates 3-5 part,
Fimbrin 3-8 part,
Polyvinylpyrrolidone 12-19 part.
Further, described a kind of medical sthptic sponge material, comprises the composition of following weight parts:
Xanthan gum 8-15 part,
PEG400 5-11 part,
Tripolyglycerol monostearates 3-5 part,
Hydroxypropyl PASELLI EASYGEL 5-10 part,
Fimbrin 3-8 part,
Polyvinylpyrrolidone 12-19 part.
Preferably, described a kind of medical sthptic sponge material, comprises the composition of following weight parts:
Xanthan gum 10-13 part,
PEG400 7-9 part,
Tripolyglycerol monostearates 4-5 part,
Hydroxypropyl PASELLI EASYGEL 6-8 part,
Fimbrin 4-7 part,
Polyvinylpyrrolidone 14-17 part.
A preparation method for medical sthptic sponge material, comprises the following steps:
(1) get suitable quantity of water, coolant-temperature gage is set as 60 DEG C, get xanthan gum 8-15 part by weight, PEG400 is 5-11 part,
Fimbrin 3-8 part, polyvinylpyrrolidone are 12-19 part, stir after above-mentioned xanthan gum, PEG400, fimbrin and polyvinylpyrrolidone water dissolution, and speed of agitator is 50-100rpm, and mixing time is 30min;
(2) in the colloid of step (1), add Tripolyglycerol monostearates 3-5 part, hydroxypropyl PASELLI EASYGEL 5-10 part, carry out stir process while adding, after adding, under rotating speed is 50-100rpm, stir 1h again;
(3) colloidal materials after stirring is cooled to room temperature, colloidal materials is cut into square material, square material is carried out lyophilization, lyophilization temperature is-50 to-5 DEG C, lyophilization vacuum is 3-500Pa, sublimation drying is 8h-36h, then takes out the porous material after finish-drying, is the medical sthptic sponge material of preparation.
Further, the preparation method of described a kind of medical sthptic sponge material, wherein xanthan gum is 10-13 part, PEG400 is 7-9 part, Tripolyglycerol monostearates is 4-5 part, hydroxypropyl PASELLI EASYGEL is 6-8 part, fimbrin is 4-7 part, polyvinylpyrrolidone is 14-17 part.
Further, the preparation method of described a kind of medical sthptic sponge material, wherein lyophilization temperature is-30 to-10 DEG C.
Further, the preparation method of described a kind of medical sthptic sponge material, wherein lyophilization vacuum is 10-50Pa.
Further, the preparation method of described a kind of medical sthptic sponge material, wherein sublimation drying is 12h-24h.
Beneficial effect: medical sthptic sponge material of the present invention adds Tripolyglycerol monostearates and hydroxypropyl PASELLI EASYGEL at xanthan gum, polyvinylpyrrolidone, PEG400 and fimbrin, a large amount of gas has been filled with in colloidal materials after carrying out fully stirring, in addition directly lyophilization is being carried out to colloidal materials, effectively substantially increase porosity and the pick up of the medical sthptic sponge material of preparation, provide a kind of new method to the preparation of hemostatic material in medical use.
Detailed description of the invention
Embodiment 1
(1) suitable quantity of water is got, coolant-temperature gage is set as 60 DEG C, get xanthan gum 8g by weight, PEG400 is 11g, fimbrin 3g, polyvinylpyrrolidone be 19g, stir after above-mentioned xanthan gum, PEG400, fimbrin and polyvinylpyrrolidone water dissolution, speed of agitator is 100rpm, and mixing time is 30min; (2) in the colloid of step (1), add Tripolyglycerol monostearates 5g, hydroxypropyl PASELLI EASYGEL 5g, carry out stir process while adding, after adding, under rotating speed is 100rpm, stir 1h again; (3) colloidal materials after stirring is cooled to room temperature, colloidal materials is cut into square material, square material is carried out lyophilization, lyophilization temperature is-50 DEG C, lyophilization vacuum is 3Pa, sublimation drying is 36h, then takes out the porous material after finish-drying, is the medical sthptic sponge material of preparation.
Embodiment 2
(1) suitable quantity of water is got, coolant-temperature gage is set as 60 DEG C, get xanthan gum 15g by weight, PEG400 is 5g, fimbrin 8g, polyvinylpyrrolidone be 12g, stir after above-mentioned xanthan gum, PEG400, fimbrin and polyvinylpyrrolidone water dissolution, speed of agitator is 50rpm, and mixing time is 30min; (2) in the colloid of step (1), add Tripolyglycerol monostearates 3g, hydroxypropyl PASELLI EASYGEL 10g, carry out stir process while adding, after adding, under rotating speed is 50rpm, stir 1h again; (3) colloidal materials after stirring is cooled to room temperature, colloidal materials is cut into square material, square material is carried out lyophilization, lyophilization temperature is-5 DEG C, lyophilization vacuum is 500Pa, sublimation drying is 8h, then takes out the porous material after finish-drying, is the medical sthptic sponge material of preparation.
Embodiment 3
(1) suitable quantity of water is got, coolant-temperature gage is set as 60 DEG C, get xanthan gum 13g by weight, PEG400 is 9g, fimbrin 4g, polyvinylpyrrolidone be 17g, stir after above-mentioned xanthan gum, PEG400, fimbrin and polyvinylpyrrolidone water dissolution, speed of agitator is 100rpm, and mixing time is 30min; (2) in the colloid of step (1), add Tripolyglycerol monostearates 5g, hydroxypropyl PASELLI EASYGEL 6g, carry out stir process while adding, after adding, under rotating speed is 100rpm, stir 1h again; (3) colloidal materials after stirring is cooled to room temperature, colloidal materials is cut into square material, square material is carried out lyophilization, lyophilization temperature is-30 DEG C, lyophilization vacuum is 50Pa, sublimation drying is 12h, then takes out the porous material after finish-drying, is the medical sthptic sponge material of preparation.
Embodiment 4
(1) suitable quantity of water is got, coolant-temperature gage is set as 60 DEG C, get xanthan gum 10g by weight, PEG400 is 7g, fimbrin 7g, polyvinylpyrrolidone be 14g, stir after above-mentioned xanthan gum, PEG400, fimbrin and polyvinylpyrrolidone water dissolution, speed of agitator is 50rpm, and mixing time is 30min; (2) in the colloid of step (1), add Tripolyglycerol monostearates 4g, hydroxypropyl PASELLI EASYGEL 8g, carry out stir process while adding, after adding, under rotating speed is 50rpm, stir 1h again; (3) colloidal materials after stirring is cooled to room temperature, colloidal materials is cut into square material, square material is carried out lyophilization, lyophilization temperature is-10 DEG C, lyophilization vacuum is 10Pa, sublimation drying is 24h, then takes out the porous material after finish-drying, is the medical sthptic sponge material of preparation.
Embodiment 5
(1) suitable quantity of water is got, coolant-temperature gage is set as 60 DEG C, get xanthan gum 11g by weight, PEG400 is 8g, fimbrin 6g, polyvinylpyrrolidone be 16g, stir after above-mentioned xanthan gum, PEG400, fimbrin and polyvinylpyrrolidone water dissolution, speed of agitator is 100rpm, and mixing time is 30min; (2) in the colloid of step (1), add Tripolyglycerol monostearates 4g, hydroxypropyl PASELLI EASYGEL 7g, carry out stir process while adding, after adding, under rotating speed is 100rpm, stir 1h again; (3) colloidal materials after stirring is cooled to room temperature, colloidal materials is cut into square material, square material is carried out lyophilization, lyophilization temperature is-20 DEG C, lyophilization vacuum is 30Pa, sublimation drying is 18h, then takes out the porous material after finish-drying, is the medical sthptic sponge material of preparation.
Embodiment 6
(1) suitable quantity of water is got, coolant-temperature gage is set as 60 DEG C, get xanthan gum 15g by weight, PEG400 is 5g, fimbrin 8g, polyvinylpyrrolidone be 12g, stir after above-mentioned xanthan gum, PEG400, fimbrin and polyvinylpyrrolidone water dissolution, speed of agitator is 50rpm, and mixing time is 30min; (2) in the colloid of step (1), add Tripolyglycerol monostearates 3g, while adding, carry out stir process, after adding, under rotating speed is 50rpm, stir 1h again; (3) colloidal materials after stirring is cooled to room temperature, colloidal materials is cut into square material, square material is carried out lyophilization, lyophilization temperature is-5 DEG C, lyophilization vacuum is 500Pa, sublimation drying is 8h, then takes out the porous material after finish-drying, is the medical sthptic sponge material of preparation.
Comparative example 1
(1) suitable quantity of water is got, coolant-temperature gage is set as 60 DEG C, get xanthan gum 15g by weight, PEG400 is 5g, fimbrin 8g, polyvinylpyrrolidone be 12g, stir after above-mentioned xanthan gum, PEG400, fimbrin and polyvinylpyrrolidone water dissolution, speed of agitator is 50rpm, and mixing time is 30min; (2) colloidal materials after stirring is cooled to room temperature, colloidal materials is cut into square material, square material is carried out lyophilization, lyophilization temperature is-5 DEG C, lyophilization vacuum is 500Pa, sublimation drying is 8h, then takes out the porous material after finish-drying, is the medical sthptic sponge material of preparation.
Comparative example 2
Referenced patent Authorization Notice No. is the patent of invention of CN102585273: in the there-necked flask that band stirs, add 5gPVA-1799 and 50g water, is heated to 85 DEG C to complete clearly molten.Then cool the temperature to 60 DEG C, under stirring, add 15g18%(mass percent, lower with) hydrochloric acid and 5g 37%(mass percent, lower with) formalin, react 50 minutes at 60 DEG C.
In another there-necked flask, add 50gPVA-1799 and 500g water, heating for dissolving, to clear, then cool the temperature to 60 DEG C, adds 150g18% hydrochloric acid and 50g37% formalin under stirring.Stirring is continued 2 minutes at 60 DEG C.Above-mentioned two feed liquids are mixed, continues to react 10 minutes at 60 DEG C.Pour in mould by completely reacted feed liquid, be placed in baking oven and at 65 DEG C, be incubated 12 hours, the then demoulding, cleaning, obtain clean spongy body, cut into the sample of given shape after freezing through less than 0 DEG C, its specification is long 8cm, wide 2cm, thick 1.5cm.
Measurement method method: be cut into identical with the specification of comparative example 2 by the sponge material of embodiment 1 to 6, comparative example 1, observes the multiple of pure water under its water suction room temperature.Pick up and the sponge material porosity of embodiment 1 to 6, comparative example 1 and 2 are as follows:
| Imbibition multiple | Porosity | |
| Embodiment 1 | 23 | 92% |
| Embodiment 2 | 24 | 91% |
| Embodiment 3 | 28 | 94% |
| Embodiment 4 | 27 | 94% |
| Embodiment 5 | 31 | 95% |
| Embodiment 6 | 20 | 89% |
| Comparative example 1 | 16 | 82% |
| Comparative example 2 | 15 | 85% |
Must know from imbibition multiple measurement result, in medical sthptic sponge material of the present invention, add hydroxypropyl PASELLI EASYGEL, substantially increase porosity and the pick up of the medical sthptic sponge material of preparation.
Claims (8)
1. a medical sthptic sponge material, is characterized in that, described medical sthptic sponge material comprises the composition of following weight parts:
Xanthan gum 8-15 part,
PEG400 5-11 part,
Tripolyglycerol monostearates 3-5 part,
Fimbrin 3-8 part,
Polyvinylpyrrolidone 12-19 part.
2. a kind of medical sthptic sponge material according to claim 1, is characterized in that, described medical sthptic sponge material comprises the composition of following weight parts:
Xanthan gum 8-15 part,
PEG400 5-11 part,
Tripolyglycerol monostearates 3-5 part,
Hydroxypropyl PASELLI EASYGEL 5-10 part,
Fimbrin 3-8 part,
Polyvinylpyrrolidone 12-19 part.
3. a kind of medical sthptic sponge material according to claim 2, is characterized in that, described medical sthptic sponge material comprises the composition of following weight parts:
Xanthan gum 10-13 part,
PEG400 7-9 part,
Tripolyglycerol monostearates 4-5 part,
Hydroxypropyl PASELLI EASYGEL 6-8 part,
Fimbrin 4-7 part,
Polyvinylpyrrolidone 14-17 part.
4. a preparation method for medical sthptic sponge material, is characterized in that, the preparation method of described medical sthptic sponge material comprises the following steps:
(1) get suitable quantity of water, coolant-temperature gage is set as 60 DEG C, get xanthan gum 8-15 part by weight, PEG400 is 5-11 part,
Fimbrin 3-8 part, polyvinylpyrrolidone are 12-19 part, stir after above-mentioned xanthan gum, PEG400, fimbrin and polyvinylpyrrolidone water dissolution, and speed of agitator is 50-100rpm, and mixing time is 30min;
(2) in the colloid of step (1), add Tripolyglycerol monostearates 3-5 part, hydroxypropyl PASELLI EASYGEL 5-10 part, carry out stir process while adding, after adding, under rotating speed is 50-100rpm, stir 1h again;
(3) colloidal materials after stirring is cooled to room temperature, colloidal materials is cut into square material, square material is carried out lyophilization, lyophilization temperature is-50 to-5 DEG C, lyophilization vacuum is 3-500Pa, sublimation drying is 8h-36h, then takes out the porous material after finish-drying, is the medical sthptic sponge material of preparation.
5. the preparation method of a kind of medical sthptic sponge material according to claim 4, it is characterized in that, in the preparation method of described medical sthptic sponge material, xanthan gum is 10-13 part, PEG400 is 7-9 part, Tripolyglycerol monostearates is 4-5 part, hydroxypropyl PASELLI EASYGEL is 6-8 part, fimbrin is 4-7 part, polyvinylpyrrolidone is 14-17 part.
6. the preparation method of a kind of medical sthptic sponge material according to claim 4, is characterized in that, in the preparation method of described medical sthptic sponge material, lyophilization temperature is-30 to-10 DEG C.
7. the preparation method of a kind of medical sthptic sponge material according to claim 4, is characterized in that, in the preparation method of described medical sthptic sponge material, lyophilization vacuum is 10-50Pa.
8. the preparation method of a kind of medical sthptic sponge material according to claim 4, is characterized in that, in the preparation method of described medical sthptic sponge material, sublimation drying is 12h-24h.
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| CN104906628A (en) * | 2015-05-22 | 2015-09-16 | 苏州市贝克生物科技有限公司 | Method for preparing medical antisepsis and anti-inflammation sponge |
| CN107519528A (en) * | 2017-08-30 | 2017-12-29 | 山东省立医院 | A kind of bone wax of biological absorbable and preparation method thereof |
| CN113350566A (en) * | 2021-07-23 | 2021-09-07 | 北京金硕康医疗科技有限公司 | Preparation method of medical sponge hemostatic material |
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| CN1380109A (en) * | 2002-04-17 | 2002-11-20 | 苗九昌 | Chitosan collagen and calcium alginate compounded spongy biological dressing and its preparation process |
| CN1772311A (en) * | 2004-11-09 | 2006-05-17 | 深圳市清华源兴生物医药科技有限公司 | Wound dressing containing Ag-Zn composition |
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| CN104906628A (en) * | 2015-05-22 | 2015-09-16 | 苏州市贝克生物科技有限公司 | Method for preparing medical antisepsis and anti-inflammation sponge |
| CN107519528A (en) * | 2017-08-30 | 2017-12-29 | 山东省立医院 | A kind of bone wax of biological absorbable and preparation method thereof |
| CN113350566A (en) * | 2021-07-23 | 2021-09-07 | 北京金硕康医疗科技有限公司 | Preparation method of medical sponge hemostatic material |
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Effective date of registration: 20170331 Address after: 200000 Fengxian District City, the town of Shanghai in the town of Road No. 233 Patentee after: MDK (SHANGHAI) MEDICAL PACKING Co.,Ltd. Address before: Tianhe District Tong East Road Guangzhou city Guangdong province 510665 B-101 No. 5, room B-118 Patentee before: GUANGDONG GAOHANG INTELLECTUAL PROPERTY OPERATION Co.,Ltd. Effective date of registration: 20170331 Address after: Tianhe District Tong East Road Guangzhou city Guangdong province 510665 B-101 No. 5, room B-118 Patentee after: GUANGDONG GAOHANG INTELLECTUAL PROPERTY OPERATION Co.,Ltd. Address before: 266000 Licang, Qingdao, No. nine East water road, No. 320, No. Patentee before: Gu Yukui |