CN103736073B - 一种人流术后促子宫复旧的药物组合物及其应用 - Google Patents

一种人流术后促子宫复旧的药物组合物及其应用 Download PDF

Info

Publication number
CN103736073B
CN103736073B CN201410044291.4A CN201410044291A CN103736073B CN 103736073 B CN103736073 B CN 103736073B CN 201410044291 A CN201410044291 A CN 201410044291A CN 103736073 B CN103736073 B CN 103736073B
Authority
CN
China
Prior art keywords
pharmaceutical composition
herba
parts
radix
uterus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201410044291.4A
Other languages
English (en)
Other versions
CN103736073A (zh
Inventor
王广霞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Qidong planting valve factory
Original Assignee
Qingdao Huazhicao Medical Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qingdao Huazhicao Medical Technology Co Ltd filed Critical Qingdao Huazhicao Medical Technology Co Ltd
Priority to CN201610043443.8A priority Critical patent/CN105944046A/zh
Priority to CN201610043441.9A priority patent/CN105944044A/zh
Priority to CN201610043438.7A priority patent/CN105944043A/zh
Priority to CN201610043442.3A priority patent/CN105944045A/zh
Priority to CN201610043437.2A priority patent/CN105963651A/zh
Priority to CN201410044291.4A priority patent/CN103736073B/zh
Publication of CN103736073A publication Critical patent/CN103736073A/zh
Application granted granted Critical
Publication of CN103736073B publication Critical patent/CN103736073B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

本发明涉及一种人流术后促子宫复旧的药物组合物及其应用，该药物组合物由如下重量份的中药材原料制备而成：泽兰28-42份、苦参27-39份、马齿苋8-15份、败酱草20-32份、党参13-22份、炮姜8-15份、荔枝核8-15份、续断12-20份、黄精12-20份。本发明的药物组合物经人工流产后的女性服用后能更好地修复子宫内膜，效果显著，无不良反应。

Description

一种人流术后促子宫复旧的药物组合物及其应用
技术领域
本发明属于中医药技术领域，具体涉及一种人流术后促子宫复旧的药物组合物及其应用。
背景技术
近年来，无痛人流广泛普及，年轻女性中人工流产及重复流产的比例明显增加。人工流产手术是一种创伤性手术，它是通过负压吸引配合刮宫完成的，手术器械的操作必然会造成子宫内膜的损伤。单次正规安全的流产一般不会对女性生殖系统造成危害，但多次人流会给子宫内膜造成十分严重的危害，会引起子宫内膜不可逆的损伤且难以恢复，这样必然会引发月经不调、闭经、妇科炎症、继发不孕不育等严重后果。因此，在加强避孕常识的宣传教育同时，人流后及时有效的进行子宫内膜修复等复旧措施是非常必要的，这可以一定程度上减少人工流产对于女性患者造成的损伤。
发明内容
本发明的目的在于提供一种人流术后促子宫复旧的药物组合物及应用。
本发明的目的是这样实现的：
一种人流术后促子宫复旧的药物组合物，它由包含如下重量份的中药材原料制备而成：泽兰28-42份、苦参27-39份、马齿苋8-15份、败酱草20-32份、党参13-22份、炮姜8-15份、荔枝核8-15份、续断12-20份、黄精12-20份。
优选地，如上所述的人流术后促子宫复旧的药物组合物，它由如下重量份的中药材原料制备而成：泽兰32-36份、苦参30-35份、马齿苋10-12份、败酱草24-27份、党参16-18份、炮姜10-12份、荔枝核10-12份、续断15-16份、黄精15-16份。
在本发明的一个最优选的实施例中，如上所述的人流术后促子宫复旧的药物组合物由如下重量份的中药材原料制备而成：泽兰35份、苦参32份、马齿苋11份、败酱草25份、党参16份、炮姜10份、荔枝核10份、续断15份、黄精15份。
通过试验研究发现，人工流产后口服本发明的中药方剂能更好地修复子宫内膜，可开发后作为人工流产术后子宫内膜修复的一线用药。因此，本发明的第二个目的在于提供一种制药用途，即上述药物组合物在制备人流术后促子宫复旧的药物中的应用。
本发明涉及的药物组合物的制备方法包括如下步骤：称取泽兰28-42份、苦参27-39份、马齿苋8-15份、败酱草20-32份、党参13-22份、炮姜8-15份、荔枝核8-15份、续断12-20份和黄精12-20份，洗净去杂，晾干，粉碎；再将上述颗粒状药材加水漫过药面2cm，浸泡1-1.2h，捞出药材置多功能提取灌中加水煎煮二次，第一次加总药材8-10倍量的水，煎煮2h，取煎液，滤过，第二次加总药材6-8倍量的水，煎煮1h，取两次煎液合并，滤过，浓缩至90℃时相对密度为1.15g/mL的浓缩液；将浓缩液置0-5℃低温冷藏24h，将冷藏液加0.3%的助滤剂硅藻土，滤过，滤液再浓缩至每毫升含4-5g生药量，置0-5℃低温冷藏24h，将冷藏液滤过，得药液。
与现有技术相比，本发明的药物组合物经人工流产后的女性服用后，能更好地修复子宫内膜，其效果甚至优于一些常规的西药，且无恶心、呕吐，头昏以及乳腺小叶增生等不良反应，因此其可被开发后作为人工流产术后子宫复旧的一线用药。
具体实施方式
本发明采用的中药材原料的来源如下：泽兰选用唇形科植物毛叶地瓜儿苗LycopuslucidusTurcz.var.hirtusRegel的干燥地上部分。苦参选用多年生落叶亚灌木植物苦参的根。马齿苋选用马齿苋科植物马齿苋的干燥幼嫩茎叶。败酱草又名山苦荬，选用菊科植物山苦荬的全草或根。党参选用桔梗科植物党参Codonopsispilosula（Franch.）Nannf.的干燥根。炮姜选用姜科植物姜干燥根茎的炮制品。荔枝核选用无患子科植物荔枝LitchichinensisSonn.的干燥成熟种子。续断选用川续断科多年生草本植物川续断的根。黄精选自百合科植物滇黄精（PolygonatumkingianumColl.etHemsl.）的干燥根茎。
以下是本发明的具体实施例，对本发明的技术方案做进一步作描述，但是本发明的保护范围并不限于这些实施例。凡是不背离本发明构思的改变或等同替代均包括在本发明的保护范围之内。
实施例1中药口服液的制备
生药处方：泽兰3.5公斤、苦参3.2公斤、马齿苋1.1公斤、败酱草2.5公斤、党参1.6公斤、炮姜1.0公斤、荔枝核1.0公斤、续断1.5公斤、黄精1.5公斤。
制备方法：称取处方量的上述中药材原料，洗净去杂，晾干，粉碎；再将上述颗粒状药材加水漫过药面2cm，浸泡1-1.2h，捞出药材置多功能提取灌中加水煎煮二次，第一次加总药材10倍量的水，煎煮2h，取煎液，滤过，第二次加总药材8倍量的水，煎煮1h，取两次煎液合并，滤过，浓缩至90℃时相对密度为1.15g/mL的浓缩液；将浓缩液置0-5℃低温冷藏24h，将冷藏液加0.3%的助滤剂硅藻土，滤过，滤液再浓缩至每毫升含4g生药量，置0-5℃低温冷藏24h，将冷藏液滤过，得药液。
实施例2中药口服液的制备
生药处方：泽兰3.2公斤、苦参3.9公斤、马齿苋1.5公斤、败酱草2.7公斤、党参1.3公斤、炮姜1.2公斤、荔枝核0.8公斤、续断1.2公斤、黄精1.5公斤。
制备方法：称取处方量的上述中药材原料，洗净去杂，晾干，粉碎；再将上述颗粒状药材加水漫过药面2cm，浸泡1-1.2h，捞出药材置多功能提取灌中加水煎煮二次，第一次加总药材8倍量的水，煎煮2h，取煎液，滤过，第二次加总药材8倍量的水，煎煮1h，取两次煎液合并，滤过，浓缩至90℃时相对密度为1.15g/mL的浓缩液；将浓缩液置0-5℃低温冷藏24h，将冷藏液加0.3%的助滤剂硅藻土，滤过，滤液再浓缩至每毫升含5g生药量，置0-5℃低温冷藏24h，将冷藏液滤过，得药液。
实施例3中药口服液的制备
生药处方：泽兰4.2公斤、苦参3.0公斤、马齿苋0.8公斤、败酱草2.0公斤、党参2.2公斤、炮姜0.8公斤、荔枝核1.5公斤、续断2.0公斤、黄精1.2公斤。
制备方法：称取处方量的上述中药材原料，洗净去杂，晾干，粉碎；再将上述颗粒状药材加水漫过药面2cm，浸泡1-1.2h，捞出药材置多功能提取灌中加水煎煮二次，第一次加总药材8倍量的水，煎煮2h，取煎液，滤过，第二次加总药材6倍量的水，煎煮1h，取两次煎液合并，滤过，浓缩至90℃时相对密度为1.15g/mL的浓缩液；将浓缩液置0-5℃低温冷藏24h，将冷藏液加0.3%的助滤剂硅藻土，滤过，滤液再浓缩至每毫升含4g生药量，置0-5℃低温冷藏24h，将冷藏液滤过，得药液。
实施例4中药方剂对人工流产术后子宫复旧的疗效研究
进行两次及以上的人工流产女性(暂无生育要求，以后有生育要求)共54例，年龄18-26岁，平均22.4±1.5岁。随机分成试验组（27例）和对照组（27例）。两组患者的年龄、孕周和孕次等一般资料经统计学分析，差异无统计学意义，具有可比性。试验组于人流术后第5日开始服用服用中药汤剂，处方为：泽兰35g、苦参32g、马齿苋11g、败酱草25g、党参16g、炮姜10g、荔枝核10g、续断15g、黄精15g。每天1剂，煎成汤剂约300mL，均分为2份，早、晚各服1次，连续服用3周。对照组于人流术后第5日给予安官黄体酮(浙江仙琚制药股份有限公司，规格为2mg)，每日10mg，1次/d，连续服用3周。停药时采用B超复查子宫内膜线厚度，内膜厚径取子宫纵、横切面最大测值的平均值。观察两组月经量和不良反应发生情况。同时告知所有患者术后1个月禁止坐浴和房事。
试验结果显示，子宫内膜厚度服药前后两组患者的子宫内膜厚度如表1所示，两组患者在治疗前的子宫内膜厚度均小于5.0mm，且差异无统计学意义(P＞0.05)。3周治疗后两组患者的子宫内膜均显示增厚，且服用本发明中药方剂的试验组的患者显示了更佳的效果，与服用安宫黄体酮相比，差异有统计学意义(P＜0.05)。另外，两组患者治疗3周后，其月经量比治疗前的明显增多。再者，对照组患者给药后偶而出现恶心、呕吐，头昏以及乳腺小叶增生等不良反应，但试验组患者无此不良反应。
表1两组患者用药前后子宫内膜厚度、月经量比较
与治疗前比较，* P＜0.05，** P＜0.01；与对照组比较，￥ P＜0.05，￥￥ P＜0.01。

Claims (4)

1.一种人流术后促子宫复旧的药物组合物，其特征在于：所述的药物组合物由如下重量份的中药材原料制备而成：泽兰28-42份、苦参27-39份、马齿苋8-15份、败酱草20-32份、党参13-22份、炮姜8-15份、荔枝核8-15份、续断12-20份、黄精12-20份。
2.根据权利要求1所述的人流术后促子宫复旧的药物组合物，其特征在于：所述的药物组合物由如下重量份的中药材原料制备而成：泽兰32-36份、苦参30-35份、马齿苋10-12份、败酱草24-27份、党参16-18份、炮姜10-12份、荔枝核10-12份、续断15-16份、黄精15-16份。
3.根据权利要求2所述的人流术后促子宫复旧的药物组合物，其特征在于：所述的药物组合物由如下重量份的中药材原料制备而成：泽兰35份、苦参32份、马齿苋11份、败酱草25份、党参16份、炮姜10份、荔枝核10份、续断15份、黄精15份。
4.权利要求1-3任一项所述的药物组合物在制备人流术后促子宫复旧的药物中的应用。
CN201410044291.4A 2014-02-01 2014-02-01 一种人流术后促子宫复旧的药物组合物及其应用 Active CN103736073B (zh)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN201610043443.8A CN105944046A (zh) 2014-02-01 2014-02-01 一种制备人流术后促子宫复旧的药物组合物的方法
CN201610043441.9A CN105944044A (zh) 2014-02-01 2014-02-01 一种药物组合物在制备人流术后促子宫复旧的药物中的应用
CN201610043438.7A CN105944043A (zh) 2014-02-01 2014-02-01 一种人流术后促子宫复旧的药物组合物
CN201610043442.3A CN105944045A (zh) 2014-02-01 2014-02-01 一种药物组合物在制备人流术后促子宫复旧的药物中的应用
CN201610043437.2A CN105963651A (zh) 2014-02-01 2014-02-01 一种人流术后促子宫复旧的药物组合物
CN201410044291.4A CN103736073B (zh) 2014-02-01 2014-02-01 一种人流术后促子宫复旧的药物组合物及其应用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410044291.4A CN103736073B (zh) 2014-02-01 2014-02-01 一种人流术后促子宫复旧的药物组合物及其应用

Related Child Applications (5)

Application Number Title Priority Date Filing Date
CN201610043437.2A Division CN105963651A (zh) 2014-02-01 2014-02-01 一种人流术后促子宫复旧的药物组合物
CN201610043443.8A Division CN105944046A (zh) 2014-02-01 2014-02-01 一种制备人流术后促子宫复旧的药物组合物的方法
CN201610043442.3A Division CN105944045A (zh) 2014-02-01 2014-02-01 一种药物组合物在制备人流术后促子宫复旧的药物中的应用
CN201610043438.7A Division CN105944043A (zh) 2014-02-01 2014-02-01 一种人流术后促子宫复旧的药物组合物
CN201610043441.9A Division CN105944044A (zh) 2014-02-01 2014-02-01 一种药物组合物在制备人流术后促子宫复旧的药物中的应用

Publications (2)

Publication Number Publication Date
CN103736073A CN103736073A (zh) 2014-04-23
CN103736073B true CN103736073B (zh) 2016-03-02

Family

ID=50493189

Family Applications (6)

Application Number Title Priority Date Filing Date
CN201610043441.9A Withdrawn CN105944044A (zh) 2014-02-01 2014-02-01 一种药物组合物在制备人流术后促子宫复旧的药物中的应用
CN201410044291.4A Active CN103736073B (zh) 2014-02-01 2014-02-01 一种人流术后促子宫复旧的药物组合物及其应用
CN201610043443.8A Withdrawn CN105944046A (zh) 2014-02-01 2014-02-01 一种制备人流术后促子宫复旧的药物组合物的方法
CN201610043438.7A Withdrawn CN105944043A (zh) 2014-02-01 2014-02-01 一种人流术后促子宫复旧的药物组合物
CN201610043442.3A Withdrawn CN105944045A (zh) 2014-02-01 2014-02-01 一种药物组合物在制备人流术后促子宫复旧的药物中的应用
CN201610043437.2A Withdrawn CN105963651A (zh) 2014-02-01 2014-02-01 一种人流术后促子宫复旧的药物组合物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201610043441.9A Withdrawn CN105944044A (zh) 2014-02-01 2014-02-01 一种药物组合物在制备人流术后促子宫复旧的药物中的应用

Family Applications After (4)

Application Number Title Priority Date Filing Date
CN201610043443.8A Withdrawn CN105944046A (zh) 2014-02-01 2014-02-01 一种制备人流术后促子宫复旧的药物组合物的方法
CN201610043438.7A Withdrawn CN105944043A (zh) 2014-02-01 2014-02-01 一种人流术后促子宫复旧的药物组合物
CN201610043442.3A Withdrawn CN105944045A (zh) 2014-02-01 2014-02-01 一种药物组合物在制备人流术后促子宫复旧的药物中的应用
CN201610043437.2A Withdrawn CN105963651A (zh) 2014-02-01 2014-02-01 一种人流术后促子宫复旧的药物组合物

Country Status (1)

Country Link
CN (6) CN105944044A (zh)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1919330A (zh) * 2006-08-22 2007-02-28 夏金陵 一种治疗慢性结肠炎的中药组合物及制备方法
CN101623416A (zh) * 2009-08-03 2010-01-13 刘秀英 一种用于妇女产后康复的中药制剂
CN102935211A (zh) * 2012-11-13 2013-02-20 陈维爱 一种治疗产后或流产后子宫复旧不良的药物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1919330A (zh) * 2006-08-22 2007-02-28 夏金陵 一种治疗慢性结肠炎的中药组合物及制备方法
CN101623416A (zh) * 2009-08-03 2010-01-13 刘秀英 一种用于妇女产后康复的中药制剂
CN102935211A (zh) * 2012-11-13 2013-02-20 陈维爱 一种治疗产后或流产后子宫复旧不良的药物

Also Published As

Publication number Publication date
CN105944044A (zh) 2016-09-21
CN105944043A (zh) 2016-09-21
CN103736073A (zh) 2014-04-23
CN105963651A (zh) 2016-09-28
CN105944046A (zh) 2016-09-21
CN105944045A (zh) 2016-09-21

Similar Documents

Publication Publication Date Title
CN104147194B (zh) 一种治疗慢性鼻窦炎的中药组合物
CN103736073B (zh) 一种人流术后促子宫复旧的药物组合物及其应用
CN104547523A (zh) 一种增强免疫力的药物及其制备方法
CN104288417A (zh) 一种治疗痛经的中药组合物及其制备方法
CN105770691A (zh) 一种用于治疗宫颈癌的药物制剂及其用途
CN100431585C (zh) 一种健胸丰乳的中药制剂
CN104189770A (zh) 一种治疗结核性胸膜炎的药物组合物及其制备方法
CN103550372B (zh) 一种用于药物流产的药剂
CN103860869A (zh) 一种用于治疗妊娠高血压的中药
CN103520437B (zh) 一种治疗痛经的中药贴剂及其制备方法和应用
CN102552541B (zh) 一种预防或治疗乳腺癌的药物组合物
CN105770693A (zh) 一种用于小儿腹泻的口腔崩解片及其制备方法
CN105535466A (zh) 一种治疗青春期多囊卵巢综合征的药物组合物
CN105535658A (zh) 一种治疗口腔溃疡的中药组合物及其制备方法
CN105663577A (zh) 一种产后护理的中药组合物及其制备方法
CN105327219A (zh) 一种治疗女性盆腔性炎症的中药组合物及其制备方法
CN105311396A (zh) 一种治疗子宫内膜薄致月经过少的中药制剂
CN105456316A (zh) 一种鸡蛋花滴丸及其制备方法
CN102038771B (zh) 翻白草在制备治疗子宫肌瘤药物的应用
CN103736009A (zh) 一种平滑肌瘤护理药物及其制备方法
CN105456952A (zh) 一种制备治疗宫外孕的药物组合物的方法
CN102935184B (zh) 一种抑制子宫肌瘤生长的中药组合物
CN104873572A (zh) 一种治疗产后少乳的中药组合物及其制备方法
CN101559145A (zh) 一种新型预防和治疗早衰的纯中药胶囊制剂及其制备方法
CN105412491A (zh) 一种治疗月经过少伴子宫内膜炎的药物制剂

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20160202

Address after: Twenty-seventh, No. 396, Emei Mountain Road, Huangdao District, Shandong City, Qingdao Province, Qingdao 266000, Optics Valley Software Park, second floors

Applicant after: QINGDAO HUAZHICAO MEDICAL TECHNOLOGY CO., LTD.

Applicant after: Wang Guangxia

Address before: 266200 Jimo, Qingdao, the Yellow River, No. two, No. Road, building 25, building 182

Applicant before: Wang Xueyan

C14 Grant of patent or utility model
GR01 Patent grant
C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20160713

Address after: Twenty-seventh, No. 396, Emei Mountain Road, Huangdao District, Shandong City, Qingdao Province, Qingdao 266000, Optics Valley Software Park, second floors

Patentee after: QINGDAO HUAZHICAO MEDICAL TECHNOLOGY CO., LTD.

Address before: Twenty-seventh, No. 396, Emei Mountain Road, Huangdao District, Shandong City, Qingdao Province, Qingdao 266000, Optics Valley Software Park, second floors

Patentee before: QINGDAO HUAZHICAO MEDICAL TECHNOLOGY CO., LTD.

Patentee before: Wang Guangxia

CB03 Change of inventor or designer information
CB03 Change of inventor or designer information

Inventor after: Wang Guangxia

Inventor after: Chen Zhaojie

Inventor after: Liu Ruilei

Inventor after: Sun Xiangxiu

Inventor after: Chen Ying

Inventor after: Yan Xiuhui

Inventor after: Lu Shifen

Inventor before: Wang Guangxia

TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20170524

Address after: 226200 No. 46 Industrial Park, Nanyang Town, Nantong, Jiangsu, Qidong

Patentee after: Qidong planting valve factory

Address before: Twenty-seventh, No. 396, Emei Mountain Road, Huangdao District, Shandong City, Qingdao Province, Qingdao 266000, Optics Valley Software Park, second floors

Patentee before: QINGDAO HUAZHICAO MEDICAL TECHNOLOGY CO., LTD.