CN103735974A - Nursing medicament for preventing discomfort after healing of surgical incision - Google Patents
Nursing medicament for preventing discomfort after healing of surgical incision Download PDFInfo
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- CN103735974A CN103735974A CN201310746233.1A CN201310746233A CN103735974A CN 103735974 A CN103735974 A CN 103735974A CN 201310746233 A CN201310746233 A CN 201310746233A CN 103735974 A CN103735974 A CN 103735974A
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Abstract
The invention discloses a nursing medicament for preventing discomfort after healing of a surgical incision, and aims to eliminate discomfort of the surgical incision after surgery. The nursing medicament is characterized by being prepared from the following bulk pharmaceuticals in a certain weight ratio: unpleasant swallowwort herb, Chinese buckeye seed, medicinal cyathula root, large-flower jasmine flower, lychee seed, sunflower flower, platycodon root, mulberry, alpinia japonica, mustard draft powder, lodestone and kudzuvine root. Clinical tests prove that the nursing medicament has the characteristics of good curative effect and relatively high safety when used for treating discomfort of the surgical incision after surgery, and is worthy of clinical application and popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of care drug uncomfortable after surgery wound healing of preventing.
Background technology
After operation, otch state is the problem that doctors and patients are generally concerned about, mainly concentrates on prevention infection, reduces pain at present, or even how to reduce in cicatrix reaction for the nursing of otch.But a multicenter clinical investigation shows, the in the situation that of primary healing, local without red, swollen, hot, bitterly and ooze out, when having 32.63% patient one month after surgery, still have obvious otch sense of discomfort, showing as numbness, pain, paraesthesia and local skin and harden, three months is after surgery that the Proportion of patients with otch sense of discomfort is still 24.67%.Its reason complexity is various, in doctor's art, needs successively to cut on the one hand, and cortex, connective tissue layer, flesh layer, tegumentary nerve has damage in various degree; On the other hand in local soft tissue repair process, due to patient body quality factor, cause interstitial fibers connective tissue (extracellular matrix) hyperplasia degree higher than normal parenchyma cytothesis process, what only remedy due to this kind of fibrous connective tissue is local form rather than the 26S Proteasome Structure and Function of local parenchyma, causes local discomfort and skin hardening.
Still lack at present the therapeutic scheme for sense of discomfort after this kind of postoperative wound healing, clinician is many causes local stagnation of QI-blood to explain according to local operation, and recommend patient's external safflower oil blood circulation promoting and blood stasis dispelling, but because there is no stagnation of QI-blood, this pathogenesis system exists, so this kind of therapeutic scheme is substantially invalid.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provide a kind of curative effect certainly and prevention surgery wound healing that side effect is little after uncomfortable care drug.
The technical scheme that the present invention solves its technical problem is: a kind ofly prevent care drug uncomfortable after surgery wound healing, it is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts of Radix Tylophorae arenicolaes, 3 ~ 10 parts of 6 ~ 12 parts, nine layers wind of Semen Aesculi, 6 ~ 12 parts of Flos jasmini, 3 ~ 10 parts of Semen Litchis, 6 ~ 12 parts of Flos Helianthis, 6 ~ 12 parts of Radix Platycodoniss, 6 ~ 12 parts of Fructus Mori, 6 ~ 12 parts of Alpinia japonica (Thunb.) Miq.s, 1 ~ 5 part, emplastra sinapis powder, 3 ~ 10 parts of Magnetitums, 10 ~ 25 parts of Radix Puerariaes.
Chinese medicine of the present invention is to be prepared from by the raw material of following optimum weight part proportioning: 20 parts of Radix Tylophorae arenicolaes, 6 parts of 10 parts, nine layers wind of Semen Aesculi, 10 parts of Flos jasmini, 6 parts of Semen Litchis, 10 parts of Flos Helianthis, 10 parts of Radix Platycodoniss, 10 parts of Fructus Mori, 10 parts of Alpinia japonica (Thunb.) Miq.s, 2 parts, emplastra sinapis powder, 6 parts of Magnetitums, 20 parts of Radix Puerariaes.
Wherein said: Radix Tylophorae arenicolae is the asclepiadaceae plant bamboo spirit Cynanchum inamoenum(Maxim. that disappears) root or the aerial parts of Loes..Nature and flavor hardship; Micro-pungent; Property is put down.Return lung meridian.Merit can the kidney invigorating, spleen invigorating, removing toxic substances.
Semen Aesculi is the dry mature seed of Hippocastanaceae plant Aesculus chinensis Bunge Aesculus chinensis Bge., Radix Aesculi Aesculus chinensis Bge. var. chekiangensis (Hu et Fang) Fang or Aesculus Aesculus wilsonii Rehd..Nature and flavor are sweet, temperature.Return liver, stomach warp.Merit can regulating the flow of QI to ease the stomach, and stomach and alleviating pain.
Nine layers of wind are the dry rattan of leguminous plant spatholobus suberectus Spatholobus suberectus Dunn.Nature and flavor hardship, sweet, temperature.Return liver, kidney channel.Merit can be enriched blood, invigorates blood circulation, and dredging collateral.
Flos jasmini is Oleaceae plants Flos jasmini Jasminu, the dry flower of grandiflorum L..Property mildly bitter flavor, property is flat.Return Liver Channel.Merit can soothing liver-QI for relieving depression, promoting the circulation of QI to relieve pain.
Semen Litchi is the dry mature seed of sapindaceous plant Fructus Litchi Litchichinensis Sonn..Sweet, the micro-hardship of nature and flavor, temperature.Return liver, kidney channel.Merit can promoting QI to circulate and dispersing the agglomeration of the pathogens, cold-dispelling pain-relieving.
Flos Helianthi is the flower of feverfew Helianthi Helianthus annuus L..Taste is micro-sweet; Property is put down.Merit can be dispeled the wind; Suppressing the hyperactive liver; Dampness removing.
Radix Platycodonis, is the dried roots of Campanulaceae Radix Platycodonis, and merit can expelling phlegm for arresting cough, and has lung qi dispersing, evacuation of pus effect.
Fructus Mori is the dry fruit ear of moraceae plants Mulberry Morus alba L..Nature and flavor are sweet, sour, cold.GUIXIN, liver, kidney channel.The merit YIN nourishing of can enriching blood, promotes the production of body fluid and moisturizes.
Alpinia japonica (Thunb.) Miq., for Zingiberaceae Alpinia plants Alpinia japonica (Thunb.) Miq. Alpinia japonica Miq., is used as medicine with root stock.Nature and flavor are pungent, warm.Return lung, spleen, Liver Channel.Merit can dispelling wind and removing obstruction in the collateral, regulating QI to relieve pain.
Emplastra sinapis powder is crucifer Caulis et Folium Sinapis albee Sinapis alba L. or mustard Brassica juncea(L.) dry mature seed of Czern. et Coss., after dry grinds, remove fatty oil and obtain.Nature and flavor are pungent, temperature.Return lung meridian.Merit can warming the lung eliminating phlegm promoting the circulation of QI, resolving mass and removing the obstruction of the collateral pain relieving.
Magnetitum, is oxide-based mineral spinelle family magnetic iron ore, main containing ferroso-ferric oxide (Fe3O4).Nature and flavor are salty, cold.Return liver, the heart, kidney channel.Merit can suppressing the hyperactive liver and subsiding YANG, hearing-improing and eyesight improving, tranquillizing the mind by relieving convulsion, helping inspiration to relieve asthma.
Radix Puerariae, Radix Puerariae is the root of leguminous plant Pachyrhizua angulatus.Sweet, pungent, flat.Enter spleen, stomach warp.Merit can be induced sweat, rash, and relaxing muscles and tendons, promotes the production of body fluid, antidiarrheal.
Composition principle: postoperative wound does not feel like oneself, refers to primary healing, local without red, swollen, hot, bitterly and ooze out in the situation that, and patient has obvious otch sense of discomfort, shows as numbness, pain, paraesthesia and local skin and hardens.This kind of its reason complexity of sense of discomfort is various, in doctor's art, need successively to cut on the one hand, and cortex, connective tissue layer, flesh layer, tegumentary nerve has damage in various degree; On the other hand in local soft tissue repair process, due to patient body quality factor, cause interstitial fibers connective tissue (extracellular matrix) hyperplasia degree higher than normal parenchyma cytothesis process, what only remedy due to this kind of fibrous connective tissue is local form rather than the 26S Proteasome Structure and Function of local parenchyma, causes local discomfort and skin hardening.Still lack at present the therapeutic scheme for sense of discomfort after this kind of postoperative wound healing, clinician is many causes local stagnation of QI-blood to explain according to local operation, and recommend patient's external safflower oil blood circulation promoting and blood stasis dispelling, but because there is no stagnation of QI-blood, this pathogenesis system exists, so this kind of therapeutic scheme is substantially invalid.
Compared with prior art, the present invention has following characteristics:
1, we adopt Radix Tylophorae arenicolae and Semen Aesculi to coordinate for monarch drug: lung and skin phase the exterior and the interior, described Radix Tylophorae arenicolae enters lung meridian, can be by adjusting being entangled with of lung network skin, the albumen that Radix Tylophorae arenicolae decocting liquid can improve due to the inflammation cyst that antagonism mice carboxymethyl cellulose causes oozes out and leukocyte migration, promotes parenchyma hypertrophy; And the total Saponin 5mg/kg of Semen Aesculi is applied topically to, in rat Ovum Gallus domesticus album connective tissue stimulation model, can suppress fibrous connective tissue hypertrophy;
2, inventor's clinical empirical summary draws, postoperative operative incision does not feel like oneself relevant with local channels apoplexy cold-damp after wound, so we adopt Flos Helianthi, Alpinia japonica (Thunb.) Miq., Flos jasmini, Semen Litchi wind-damp dispelling, the meridian dredging; The reason of choosing this three herbal medicine in numerous related drugs is, these three kinds of Drugs are gentle, and non-dispelling the damp pathogen with drugs of bitter in taste and cold in nature does not have the anxiety of impairment of YIN.Add Radix Platycodonis, have priming to enter to defend the effect of table channels, contribute to passages through which vital energy circulates unobstructed;
3, postoperative operative incision discomfort is also relevant with the dry impairment of YIN of local blood, and stirring of wind due to deficiency of YIN and numbness, fiber crops itch, so we adopt the Fructus Mori YIN nourishing of enriching blood, promote the production of body fluid and moisturize, and nine layers of wind promoting blood circulation to remove obstruction in the collateral of enriching blood, the two coordinates reinforcement and elimination in combination.Nine layers of wind total saponins, for mouse skin cell culture experiments, have the effect that suppresses fibrous connective tissue hypertrophy;
4, Semen Sinapis eliminating phlegm eliminating stagnation, postoperative operative incision discomfort belongs to the operative incision of primary healing, this kind of operative incision acute stage mistake, cold-phlegm residual in meridians is all more obstinate, so add Semen Sinapis coordinate Semen Litchi to help tonneau.Semen Sinapis is containing potassium myronate, potassium myronate is met water and is generated volatile oil through the effect of myrosase, and main component is allyl isosulfocyanate, has stimulation, be applied to skin, there is warm sensation and make it rubescent, even causing blister, pustule, so adopt emplastra sinapis powder in prescription of the present invention, be that mustard flour is removed gained after fatty oil, this kind of de-fatty oil method is for conventional in the industry, and emplastra sinapis powder can directly be buied from market, sufficient raw.But because the present invention need to exceed 3 hours in local action, so coordinate Radix Puerariae, Radix Puerariae contains much starch, can alleviate the skin irritation of Semen Sinapis;
5, Magnetitum is originally the product in important city, but rat local topical, and can make local neutrophilic granulocyte engulf reaction increases.
6, avoid using the promoting the circulation of blood medicine of taking offence, reducing local fibroplasia initiating stimulates.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: 20 parts of Radix Tylophorae arenicolaes, 6 parts of 10 parts, nine layers wind of Semen Aesculi, 10 parts of Flos jasmini, 6 parts of Semen Litchis, 10 parts of Flos Helianthis, 10 parts of Radix Platycodoniss, 10 parts of Fructus Mori, 10 parts of Alpinia japonica (Thunb.) Miq.s, 2 parts, emplastra sinapis powder, 6 parts of Magnetitums, 20 parts of Radix Puerariaes.
The preparation method of embodiment 1 is: Radix Tylophorae arenicolae, Semen Aesculi, nine layers of wind, Flos jasmini, Semen Litchi, Flos Helianthi, Radix Platycodonis, Fructus Mori, Alpinia japonica (Thunb.) Miq., emplastra sinapis powder (decocting a drug wrapped), Magnetitum, Radix Puerariae mixing and water adding are decocted, after 30 minutes, get filtrate, medicinal residues add water continuation decoction and get filtrate after 20 minutes, twice filtrate merges, be condensed into thick paste, appropriate soak is in healing on operative incision.
Embodiment 2, crude drug weight proportion: 10 parts of Radix Tylophorae arenicolaes, 3 parts of 6 parts, nine layers wind of Semen Aesculi, 6 parts of Flos jasmini, 3 parts of Semen Litchis, 6 parts of Flos Helianthis, 6 parts of Radix Platycodoniss, 6 parts of Fructus Mori, 6 parts of Alpinia japonica (Thunb.) Miq.s, 1 part, emplastra sinapis powder, 3 parts of Magnetitums, 10 parts of Radix Puerariaes.
Embodiment 3, crude drug weight proportion: 20 parts of Radix Tylophorae arenicolaes, 6 parts of 10 parts, nine layers wind of Semen Aesculi, 10 parts of Flos jasmini, 6 parts of Semen Litchis, 10 parts of Flos Helianthis, 10 parts of Radix Platycodoniss, 10 parts of Fructus Mori, 10 parts of Alpinia japonica (Thunb.) Miq.s, 2 parts, emplastra sinapis powder, 6 parts of Magnetitums, 20 parts of Radix Puerariaes.
Embodiment 4, crude drug weight proportion: 30 parts of Radix Tylophorae arenicolaes, 10 parts of 12 parts, nine layers wind of Semen Aesculi, 12 parts of Flos jasmini, 10 parts of Semen Litchis, 12 parts of Flos Helianthis, 12 parts of Radix Platycodoniss, 12 parts of Fructus Mori, 12 parts of Alpinia japonica (Thunb.) Miq.s, 5 parts, emplastra sinapis powder, 10 parts of Magnetitums, 25 parts of Radix Puerariaes.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Semen Aesculi, Semen Litchi coarse powder are extracted to volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) emplastra sinapis powder, Magnetitum, Radix Puerariae were pulverized respectively to 150 mesh sieves, and became fine powder standby;
(3) Radix Tylophorae arenicolae, Radix Platycodonis, Alpinia japonica (Thunb.) Miq., Fructus Mori, Flos Helianthi, Flos jasmini, nine layers of wind mix and add 10 times of water yields, decoct with water 2 times, and each 1 hour, collecting decoction, standing; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, standing 15 minutes, then with 3000rpm/min centrifugal 20 minutes, get precipitation, spraying is dry, draws just material;
(4) gained volatile oil in step 1 is sprayed in the first material of step 3 gained, add gained fine powder in step 2 to mix, cross 60 mesh sieves, sterilizing, subpackage form.
During use, with warm water dress in healing after operative incision place.
Effective combination of said medicine, coordinates mutually, effectively reach the object that treatment postoperative wound does not feel like oneself, and side effect is less.The above results is that clinical data fully proves, interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: in May, 2011 ~ 2013 one-level otch patient 110 examples of choosing date for operation a year May.Wherein incision of abdominal wall 43 examples, lower back otch 19 examples, extremity otch 38 examples.Be divided into matched group 37 examples, thick paste group 37 examples and dress group 36 examples.Before three groups of patient treatments, on sex, age, operative incision distribute, compare, difference not statistically significant (P>0.05), has comparability.
1.1.2 inclusive criteria is: the one-level of 1. choosing date for operation otch, postoperative operative incision primary healing; 2. after surgery without other post-operative complication; 3. non-diabetic and mental sickness medical history.
1.2 method.
1.2.1 Therapeutic Method: matched group is taked conventional postoperative wound nursing care mode.Thick paste group and dress group on the nursing basis of matched group, day of certainly taking out stitches, thick paste group with gained thick paste part in the embodiment of the present invention 1 in right amount soak in healing on operative incision, 2 times/d.Dress group and dress in healing on operative incision with the local appropriate warm water of gained medicated powder in the embodiment of the present invention 2,2 times/d, these two groups all take 14 days as 1 course for the treatment of.During three groups of patients all 1 month after surgery, 3 months, follow up a case by regular visits to patient main suit, sign.
1.2.2 the postoperative wound criterion that does not feel like oneself: 1. main suit's otch does not feel like oneself, comprises local pain, fiber crops, itches, referred pain, formication, paraesthesia; 2. sign: accompany or do not accompany otch surrounding skin and subcutaneous hardening; 3. without deep layer, infect or liquefaction of fat performance.
1.2.3 the postoperative wound degree integration standard that does not feel like oneself: without any discomfort, be 0 point; Slight uncomfortable, non-sustainable existence, is 1 point; Slight uncomfortable, sustainable existence, is 2 points; Uncomfortable impact life, paroxysm, is 3 points; Uncomfortable impact life, sustainable existence, is 4 points.
1.2.4 statistical analysis: SPSS 13.0 carries out statistical analysis.Measurement data is checked with t, enumeration data χ
2check.
2 results.
During 2.1 3 groups of month after operations, there is the situation comparison that postoperative wound does not feel like oneself: matched group 35.14%(13/37); Thick paste group 13.51%(5/37); Dress group 13.89%(5/36).Can find out, incidence rate and the bibliographical information of blank group are basically identical, and thick paste group is starkly lower than matched group (thick paste group χ with the incidence rate that dresses group
2=4.70, P<0.05; Dress group χ
2=4.43, P<0.05).
During 2.1 3 groups of 3 months after operations, there is the situation comparison that postoperative wound does not feel like oneself: matched group 21.62%(8/37); Thick paste group 5.41%(2/37); Dress group 5.41%(2/37).Can find out, incidence rate and the bibliographical information of blank group are basically identical, and thick paste group is starkly lower than matched group (thick paste group χ with the incidence rate that dresses group
2=4.16, P<0.05; Dress group χ
2=3.98, P<0.05).
2.3 three groups there is the degree integration situation comparison that does not feel like oneself of patient's postoperative wound that postoperative wound does not feel like oneself during month after operation: matched group 13 examples, integration mean is 2.82 ± 0.34, and in thick paste group 5 examples, 3 examples are 1 point, and 2 examples are 2 points; Dressing 3 examples in group is 1 point, and 1 example is 2 points, and 1 example is 3 points.Due to positive sample very little, so cannot do statistical analysis, but can find out matched group integration mean higher than thick paste group and dress group.
2.4 adverse reaction rates: thick paste group and dress group and all do not occur obvious adverse reaction.
3. conclusion.
This result of study shows, use thick paste group of the present invention and dress the group postoperative wound situation about occurring that does not feel like oneself to be starkly lower than blank group, illustrate the present invention prevention of postoperative healed operative incision have aspect doing not feel like oneself untoward reaction gently, the higher advantage of safety.
Claims (2)
1. prevent a care drug uncomfortable after surgery wound healing, it is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts of Radix Tylophorae arenicolaes, 3 ~ 10 parts of 6 ~ 12 parts, nine layers wind of Semen Aesculi, 6 ~ 12 parts of Flos jasmini, 3 ~ 10 parts of Semen Litchis, 6 ~ 12 parts of Flos Helianthis, 6 ~ 12 parts of Radix Platycodoniss, 6 ~ 12 parts of Fructus Mori, 6 ~ 12 parts of Alpinia japonica (Thunb.) Miq.s, 1 ~ 5 part, emplastra sinapis powder, 3 ~ 10 parts of Magnetitums, 10 ~ 25 parts of Radix Puerariaes.
2. a kind of care drug uncomfortable after surgery wound healing of preventing according to claim 1, is characterized in that being prepared from by the crude drug of following weight proportion: 20 parts of Radix Tylophorae arenicolaes, 6 parts of 10 parts, nine layers wind of Semen Aesculi, 10 parts of Flos jasmini, 6 parts of Semen Litchis, 10 parts of Flos Helianthis, 10 parts of Radix Platycodoniss, 10 parts of Fructus Mori, 10 parts of Alpinia japonica (Thunb.) Miq.s, 2 parts, emplastra sinapis powder, 6 parts of Magnetitums, 20 parts of Radix Puerariaes.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105902861A (en) * | 2016-05-31 | 2016-08-31 | 王丽 | Externally used pharmaceutical composition for ophthalmic operation pre-operative prevention |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102861313A (en) * | 2012-10-24 | 2013-01-09 | 徐贵星 | Traditional Chinese medicine composition for promoting healing of post-operation scars |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102861313A (en) * | 2012-10-24 | 2013-01-09 | 徐贵星 | Traditional Chinese medicine composition for promoting healing of post-operation scars |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105902861A (en) * | 2016-05-31 | 2016-08-31 | 王丽 | Externally used pharmaceutical composition for ophthalmic operation pre-operative prevention |
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