CN103735942B - A kind of pharmaceutical composition for the treatment of dysentery and its production and use - Google Patents
A kind of pharmaceutical composition for the treatment of dysentery and its production and use Download PDFInfo
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Abstract
The invention provides a kind of pharmaceutical composition for the treatment of dysentery, it is the preparation being prepared from by the bulk drug of following weight proportion: 70～90 parts of 25～35 parts of verdolagas or purslane fresh goods, 10～14 parts of the coptiss, 10～14 parts of the roots of large-flowered skullcap, 8～12 parts of golden cypresses, 10～14 parts of the barks of ash, 17～23 parts of the Chinese bulbuls, 21～27 parts of the roots of kudzu vine, 13～17 parts of the root of herbaceous peonys, 10～14 parts of the radix paeoniae rubrathe, 10～14 parts of the root barks of tree peony, 10～14 parts of hawthorn, 13～17 parts, Fructus Hordei Germinatus, 13～17 parts of rice sprouts, 13～17 parts of Fructus Aurantiis, 13～17 parts of the barks of official magnolia, 6～10 parts, Radix Glycyrrhizae. The present invention also provides preparation method and the purposes of this pharmaceutical composition. Drug regimen composition formula of the present invention is precise and appropriate, can effectively treat the Severe Acute dysentery of Western medicine unsatisfactory curative effect, for clinical application provides a kind of new selection.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of dysentery and its production and use.
Background technology
Dysentery is a kind of acute infectious intestinal disease, ancient claim intestines ward off (Bleach), stagnant under, generating heat, stomachache, abdomenRush down, tenesmus, just lower red white purulence blood or not poisoning, the yellow and greasy fur of defecation with blood and pus, companion's whole body, slippery and rapid pulseDeng being cardinal symptom. Dysentery is from the beginning of, foreknowledge stomachache, diarrhea then, day and night for several times to tens of times not etc.,Be mainly in summer and autumn. Baby is not strong to infecting reaction, and onset is more slow, and stool is indigestion at first moreSample is just rare, and the course of disease is easily delayed. More than 3 years old infant onset is anxious, to generate heat, to suffer from diarrhoea, to suffer from abdominal pain as mainSymptom, and can faint from fear, vomit.
This disease is taking colon or terminal ileum purulent inflammation as major lesions, in producing after shigella dysenteriae invasion and attack,Exotoxin makes intestinal mucosa impaired, and diseased region has apocyte to infiltrate, and forms abscess or ulcer, pathology officeThe congested enlargement of portion's lymphonodi mesenterici. Acute dysentery is generally divided into 4 types by clinical manifestation, plain edition,Light-duty, heavy type and toxic type. Heavy visible high heat, vomiting, stomachache, tenesmus obvious, apocenosis bloodJust, reaching every day tens of times, there is dehydration and acidosis symptom in severe patient.
The traditional Chinese medical science thinks, the many gas damp and hot because being subject to outward, that epidemic disease is malicious of this disease, internal injury diet raw food, undermine taste andInternal organs, cause the dysfunction of the spleen in transport, and stomach loses treatment for relieving indigestion and constipation, more hold under the arm stagnantly, accumulate long-pending enteron aisle and form. Damp and hot heresy is invaded intestinesStomach, causes qi and blood retardance and obstructed, and stagnation of QI and blood may bring about pain, therefore stomachache is tenesmus; Damp and hot stasis is in large intestine,Channels is impaired, compels the absurd row of blood, therefore the red white purulence blood of diarrhea; Yellow and greasy fur, slippery and rapid pulse are being just damp and hot resembling. ItsCard type is divided into that these are several conventionally: dysentery characterized by white mucous stool, also claims wet dysentery: sticky white thing under dysentery and there is no purulence blood, or as beansJuice, heavy after stomachache, chest abdomen ruffian is vexed. For heresy is felt frustrated point, the wet heat that is contained in. Dysentery characterized by blood in the stool, the also hot dysentery of name: under dysenteryBe just yellow redness of the skin or complexion, or pure redness of the skin or complexion, or as fish brain, stomachache, tenesmus, urine red heat, polydipsia is drawnDrink, or see high heat. Divide for evil blood trouble, heat is better than wet. Dysentery, also name hygropyretic dysentery: under red white mixing,Shape is as fish brain, stench abnormal, polydipsia, and stomachache, arteries and veins moistens and counts. Be for damp and hot accumulate long-pending, impairment of both QI and blood.Dysentery with vomiting: diarrhea is red white, vomits contrary, can not receive food, and chest gastral cavity ruffian is vexed, spiritlessness and weakness. How not change because of damp and hot,The appetite of being jammed, or foul obstruct gastral cavilty, affect due to stomach receives. If infect epidemic disease poison, sharply, companion is prominent in morbiditySo high heat, coma, convulsions person, be to be fulminant dysentery. And weakened body resistance heresy falls into, linger on stomach, dysentery does not heal for a long time,Or send out more repeatly repeatly, be recurrent dysentery.
Doctor trained in Western medicine is generally taked antibiotherapy and fluid replacement therapy etc. to this disease, but during its methods for the treatment of can not show a candle toDoctor's methods for the treatment of is abundant, and (Chinese medicine has hundreds of can be according to the original pure science permutation and combination of tcm treatment according to syndrome differentiationGo out hundreds of effective prescriptions), and its curative effect also not as tcm therapy, better (treatment time and patient feelAspect is all not as the traditional Chinese medical science). Particularly solve the tenesmus symptom of patient and passing stool with pus and blood symptom, Chinese traditional treatment is trueAnswer the good effect of small wooden raft just like drum, and the side effect of traditional Chinese medical science antidysenteric totally nontoxic, only this item is better than chemistryMedicine antibiotic.
It is more that at present report can be used for treating the Chinese medicine preparation of dysentery, as Ren Jiangping has reported a kind of for filling withThe Chinese medicinal herbs decoction of intestines treatment acute bacillary dysentery, by coptis 3g, folium sennae 3g, root of herbaceous peony 10g, woodFragrant 6g, Radix Glycyrrhizae 3g soaks and forms with boiling water, and cure rate 97.5% is efficient 98.75%, inefficiency 1.25%(Ren Jiangping, Chinese medicine BF retention-enema treatment acute bacillary dysentery 80 examples. the Chinese combination of Chinese tradiational and Western medicineDigestion magazine, 2007, the 2 phases).
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition for the treatment of dysentery. Another object of the present inventionBe to provide preparation method and the purposes of this pharmaceutical composition.
The invention provides a kind of pharmaceutical composition for the treatment of dysentery, it is the raw material by following weight proportionThe preparation that medicine is prepared from:
70～90 parts of 25～35 parts of verdolagas or purslane fresh goods, 10～14 parts of the coptiss, the root of large-flowered skullcap 10～14Part, 8～12 parts of golden cypresses, 10～14 parts of the barks of ash, 17～23 parts of the Chinese bulbuls, 21～27 parts of the roots of kudzu vine, the root of herbaceous peony13～17 parts, 10～14 parts of the radix paeoniae rubrathe, 10～14 parts of the root barks of tree peony, 10～14 parts of hawthorn, 13～17 parts, Fructus Hordei Germinatus,13～17 parts of rice sprouts, 13～17 parts of Fructus Aurantiis, 13～17 parts of the barks of official magnolia, 6～10 parts, Radix Glycyrrhizae.
Preferably, it is the preparation being prepared from by the bulk drug of following weight proportion:
80 parts of 30 parts of verdolagas or purslane fresh goods, 12 parts of the coptiss, 12 parts of the roots of large-flowered skullcap, golden cypress 10Part, 12 parts of the barks of ash, 20 parts of the Chinese bulbuls, 24 parts of the roots of kudzu vine, 15 parts of the root of herbaceous peonys, 12 parts of the radix paeoniae rubrathe, the root bark of tree peony12 parts, 12 parts of hawthorn, 15 parts, Fructus Hordei Germinatus, 15 parts of rice sprouts, 15 parts of Fructus Aurantiis, 15 parts of the barks of official magnolia, Radix Glycyrrhizae 8Part.
Wherein, the described hawthorn hawthorn of making a living; Described Fructus Hordei Germinatus is Fructus Hordei Germinatus; The described rice sprout rice sprout of making a living; InstituteState the Radix Glycyrrhizae Radix Glycyrrhizae of making a living.
Further, described pharmaceutical composition is water or the organic solvent by the bulk drug of described weight proportionExtract is active component, adds the preparation that pharmaceutically conventional auxiliary material or complementary composition are prepared from.
Further, described preparation is oral formulations. Oral formulations of the present invention, refers to oral administration,And at the preparation of gastrointestinal absorption.
Further, described oral formulations be granule, powder, pill, pill, capsule,Soft capsule, tablet or oral liquid.
The present invention also provides the preparation method of aforementioned pharmaceutical compositions, and it comprises the steps:
(1) by described weight proportion weighting raw materials;
(2) add water or organic solvent extracts, merge extract, concentrated after, add pharmaceutically can use auxiliaryMaterial or complementary composition are prepared into conventional formulation.
The present invention further provides the purposes of aforementioned pharmaceutical compositions in the medicine of preparation treatment dysentery.
Further, described medicine is treatment gas damp and hot because being subject to outward, that epidemic disease is malicious, and internal injury diet raw food, damagesThe medicine of dysentery due to the impairment of the spleen and internal organs etc.
Further, described medicine is the medicine for the treatment of acute dysentery.
Further, described medicine is the medicine for the treatment of Severe Acute dysentery.
Generally acknowledged at present " organic conception ", " diagnosis and treatment based on an overall analysis of the illness and the patient's condition ", " compound use ", " compound compatibility medication asUse military forces " be most scientific the most several large advantages, wherein " compound compatibility medication is as used military forces " right and wrong of the traditional Chinese medical scienceThe original theory of traditional Chinese medicine of Chang Kexue. In traditional Chinese medical science prescription, each medicine is all linked with one another tight as arrayed troops for battleCompatibility is its effective means that is better than Western medicine formula. Tcm prescription theory is thought, each prescription, not onlyNeed to select the appropriate compatibility of suitable medicine according to etiology and pathogenesis, also should meet the basic structure of prescription simultaneously,The i.e. prescription compatibility theory of " monarch, minister, help, make ", the prescription of so-called " monarch, minister, help, make " is joined5, be exactly that it is based upon the scientific matching on the comprehensive judgement basis of the disease interpretation of the cause, onset and process of an illness. In medical square tubeCross too many levels, many target spots and integrate the biological mechanism regulating, to this Western medicine (chemical drugs) unsatisfactory curative effectThe sufferer of Severe Acute bacillary dysentery is recuperated under medical treatment, can obtain better than Western medicine, more green natural withoutThe result for the treatment of of toxic and side effect, and this curative effect is the correct finger that is based upon the original theory of above-mentioned traditional Chinese medical science traditionOn leading, prescription of the present invention is just being followed this principle.
Prescription of the present invention is taking purslane as monarch drug in a prescription, brings into play its clearing heat and detoxicating, sharp water clearing damp, merit removes heat from the blood and relieve diarrheaEffect. The coptis, the root of large-flowered skullcap, golden cypress, the bark of ash, the Chinese bulbul all have clearing heat and detoxicating eliminating dampness effect, therefore appoint as ministerMedicine, assists the synergy of monarch drug in a prescription purslane. The root of kudzu vine is good at heat-clearing expelling pathogenic factors from muscles and skin, rise sun promotes the production of body fluid, and contributes to alleviate diarrhea,The body Tianjin of supplementing nutrition; Red white two Chinese herbaceous peonies not only be good at that slow it is urgent, treat and control stomachache, and the kind blood of adjusting, and the root bark of tree peony is also longer thanCooling and activating blood, is just suiting in this and is controlling dysentery theory; Divine Comedy, hawthorn, rice sprout, Fructus Hordei Germinatus maintenance diarrhea injure itThe gas of stomach and intestine, has aid digestionly, and hawthorn still can help red Chinese herbaceous peony to adjust blood; The promoting the circulation of qi regulating the qi flowing in the channels of Fructus Aurantii, the bark of official magnolia, both canExcept it " tenesmus " symptom of dysentery, can urge again turbid dysentery speed and go, also can help bent short, bristly hair or beard bud digestion and the stomach and intestine of livingGas, thereby, using above four traditional Chinese medicine as adjutant, assist a ruler in governing a country the monarch and his subjects and receive merit. Radix Glycyrrhizae, not only can delay middle solutionContraction coordinates the root of herbaceous peony, again can sour-sweet herbs nourishing yin coordinates the root of kudzu vine, also can coordinating the drug actions of a prescription for making, therefore with for making medicine.
Below respectively organize flavour of a drug post clearly demarcated, complement each other, given full play to the exclusive compound of traditional Chinese medicine and joined5 medications are as the analyze mentally sexology research methodology marrow of row army as structuring the formation, for Western medicine (chemical drugs) curative effectNot good Severe Acute bacillary dysentery has good result for the treatment of, can alleviate comparatively rapidly its symptom,The larger drawback of also having avoided chemical drugs antibiotic to cause to human body, for clinical application provides a kind of newSelect.
Detailed description of the invention
The preparation of embodiment 1 pharmaceutical composition of the present invention
Get verdolaga 30 ɡ, the refined coptis 12 ɡ, the root of large-flowered skullcap 12 ɡ, golden cypress 10 ɡ, the bark of ash 12 ɡ, hoary hairFather-in-law 20 ɡ, RADIX PUERARIAE 24 ɡ, the root of herbaceous peony 15 ɡ, the radix paeoniae rubrathe 12 ɡ, the root bark of tree peony 12 ɡ, raw hawthorn 12 ɡ, Fructus Hordei Germinatus15 ɡ, raw rice sprout 15 ɡ, Fructus Aurantii 15 ɡ, the bark of official magnolia 15 ɡ, raw Radix Glycyrrhizae 8 ɡ. Each flavour of a drug take according to quantity, add waterAfter being fried boiling, be adjusted to little fire, after approximately 8 minutes to 10 minutes, collect decocting liquid; Dregs of a decoction boiling 2 times again,Merge decocting liquid each time, obtain decoction.
The preparation of embodiment 2 pharmaceutical compositions of the present invention
Get verdolaga 25 ɡ, the refined coptis 10 ɡ, the root of large-flowered skullcap 10 ɡ, golden cypress 8 ɡ, the bark of ash 10 ɡ, the Chinese bulbul17 ɡ, RADIX PUERARIAE 21 ɡ, the root of herbaceous peony 13 ɡ, the radix paeoniae rubrathe 10 ɡ, the root bark of tree peony 10 ɡ, raw hawthorn 10 ɡ, Fructus Hordei Germinatus 13 ɡ,Raw rice sprout 13 ɡ, Fructus Aurantii 13 ɡ, the bark of official magnolia 13 ɡ, raw Radix Glycyrrhizae 6 ɡ. It is first with after 70%v/v alcohol extract 2 times,Merge alcohol extract, the dregs of a decoction boil 2 times with decocting again, merge decocting liquid. Respectively that alcohol extract, decocting liquid is denseAfter contracting, mix, then add suitable dextrin, soluble starch, granulate, obtain granule.
The preparation of embodiment 3 pharmaceutical compositions of the present invention
Get verdolaga 35 ɡ, the refined coptis 14 ɡ, the root of large-flowered skullcap 14 ɡ, golden cypress 12 ɡ, the bark of ash 14 ɡ, hoary hairFather-in-law 23 ɡ, RADIX PUERARIAE 27 ɡ, the root of herbaceous peony 17 ɡ, the radix paeoniae rubrathe 14 ɡ, the root bark of tree peony 14 ɡ, raw hawthorn 14 ɡ, Fructus Hordei Germinatus17 ɡ, raw rice sprout 17 ɡ, Fructus Aurantii 17 ɡ, the bark of official magnolia 17 ɡ, raw Radix Glycyrrhizae 10 ɡ. First with 70%v/v alcohol extractAfter 2 times, merge alcohol extract, the dregs of a decoction boil 2 times with decocting again, merge decocting liquid. Respectively by alcohol extract,After decocting liquid is concentrated, mixes, then add suitable dextrin, soluble starch, granulate, compressing tablet, obtains sheetAgent.
The preparation of embodiment 4 pharmaceutical compositions of the present invention
Get purslane fresh goods 80 ɡ, the refined coptis 12 ɡ, the root of large-flowered skullcap 12 ɡ, golden cypress 10 ɡ, the bark of ash 12 ɡ, hoary hairFather-in-law 20 ɡ, RADIX PUERARIAE 24 ɡ, the root of herbaceous peony 15 ɡ, the radix paeoniae rubrathe 12 ɡ, the root bark of tree peony 12 ɡ, raw hawthorn 12 ɡ, Fructus Hordei Germinatus15 ɡ, raw rice sprout 15 ɡ, Fructus Aurantii 15 ɡ, the bark of official magnolia 15 ɡ, raw Radix Glycyrrhizae 8 ɡ. Each flavour of a drug take according to quantity, add waterAfter being fried boiling, be adjusted to little fire, after approximately 8 minutes to 10 minutes, collect decocting liquid; Dregs of a decoction boiling 2 times again,Merge decocting liquid each time, obtain decoction.
The preparation of embodiment 5 pharmaceutical compositions of the present invention
Get decoction prepared by embodiment 1, leave standstill, get supernatant, after concentrating, dry, pulverize, for subsequent use;Get appropriate Macrogol 4000, after melting, above-mentioned medicinal powder is added in melting matrix, protect at 75～85 DEG CTemperature; Adopt various pill dripping machine, drip inside/outside footpath and a speed appropriateness, splashed in dimethicone, receivesCollection dripping pill, obtains pill.
Illustrate beneficial effect of the present invention by test example below.
Clinical (outpatient service) treatment situation of test example 1 pharmaceutical composition of the present invention
(1) accept patient's situation for medical treatment
Patient age and sex scope: old children all has, and mainly taking teenager as many, there are men and women for sex,Possess following symptom feature (possess major part, needn't also can not completely all possess), accept for medical treatment altogether41 examples.
Symptom feature:
Severe Acute dysentery: onset is more anxious, high heat, body temperature can reach 39 DEG C～40 DEG C, and diarrhoea diarrhea is everyTime not etc. just, for just rare or be watery diarrhea, continuing is not pus and blood stool, or red assorted mutually in vain to tens of for day stool ten times,Left lower quadrant tenderness, companion's gurgling sound is hyperfunction, tenesmus obvious. Normal companion feels sick, vomiting, stomachache etc. are clinicalPerformance, can there is dehydration and acidosis symptom in severe patient. The common red tongue with yellowish and greasy fur of tongue arteries and veins feature, slippery and rapid pulseDeng. Most patients are reflected Western medicine (chemical drugs) unsatisfactory curative effect.
(2) treatment standard
Recovery from illness: above-mentioned symptom feature disappears completely, through suitably very soon can after rest and daily life conditioningRecover normal work, health check-up no abnormality seen.
Evident in efficacy: above-mentioned symptom obviously alleviates, or comparatively fast can restore one's working ability, or health check-up has no differentOften.
Have certain effect: patient's symptom alleviates to some extent, or remission time is slower, or can not recovers work for a long timeDo and daily routines.
Invalid: symptom still, is not improved completely.
(3) methods for the treatment of
1, the made decoction of embodiment 1, takes potion every day, and the first day takes 1 time every about 4 hours, fromRise next day and take 3 every day, generally take 5 to 10.
2, note also science conditioning daily life, observe some necessary points for attention, as:
(1) to conscientiously wash one's hands after an action of the bowels ante cibum, not drink unboiled water, not eat rotten and putrid food, not eat by flyThe food of being stained with.
(2) do not eat and drink immoderately, not " cold and hot with eating ", as Hot Coffee and ice cream, showing tremendous enthusiasm pot and cold tea etc.,In order to avoid cause mucous membrane to the intestines and stomach, stomach and intestine resistance reduces.
(3) do not drink plain boiled water in a large number or take food, and should first drink a little sugar-salt-waters, supplementing electrolyte, avoiding sending outLife is dewatered and is caused blood circulation disorder.
(4) should lie up, and isolated and adopt disinfectant measure. Diet is taking liquid food or half liquid food as main,If vomiting and diarrhoea, abdominal distension severe one, can short-term fasting.
(5) after alleviating, must (if do not drunk, smoking, not eat and drink immoderately, not eat by science conditioning daily lifeThe food of pungent frying, delicious food savoury etc. " heat-dissipating of getting angry " and the cold and cool food of raw food, suitably eat fresh,Light, easily digestion and more nutritious food; Play habitat environment and answer health clean and tidy, door and window ventilates, and keepsRoom air is fresh but can not room temperature too high or too low; Have a rest and movable appropriateness, and more regular; WithIn time, keeps pleasant with happy. Etc.).
(6) in order to prevent dysentery, environmental sanitation be should note doing well, fly breeding site lavatory and ight soil strengthenedManagement, fly-killing. And strengthen the management at dietetic hygiene and water source, especially individual diet street pedlar is doneGood hygienic supervise work. Cook to collective unit and mechanism of nursery schools and childcare centres, nurse should make regular check on that it is largeJust, do Bacteria Culture, prevent trouble before it happens.
(4) treatment results
In these sick men and women patient's 41 examples of medicine composite for curing of the present invention, obtain good curative effect. ControlThe treatment time, according to the difference of the concrete conditions such as each conditions of patients weight, age size, physical strength and slightlyDifference to some extent, within general 2 days, left and right symptom can alleviate, and within 5 days to 10 days, the various symptoms in left and right can be completeFull disappearance or disappearance substantially, by above-mentioned science conditioning daily life, sincerely abides by points for attention, can receive merit.
By above-mentioned treatment standard, in 41 routine patients, there are 37 example recoveries from illness, cure rate reaches 90.2%; 3 examples are treatedEffect significantly, accounts for 7.3%; 1 example has certain effect, is 2.5%. Total effective rate reaches 100%.
Model case
Patient, female, 17 years old, student, diarrhea 2 days, suddenly, day is rushed down twenty or thirty, is purulence blood in morbidityJust, stomachache, tenesmus, feel sick and want to vomit, high heat, doctor trained in Western medicine is combined use with Ampicillin, SMZcoMedicine antibacterial therapy, has no improvement, and symptom still. While examining, have a medical check-up 39.5 DEG C, described symptom as above,Depending on its tongue, sharp limit is red, the white greasy micro-Huang of tongue, in have small red dot, wiry and rolling pulse is counted disease, is to be Western medicine (chemical drugs)The Severe Acute bacillary dysentery of unsatisfactory curative effect. Through inquiry, not between menstrual period, so sentence thisBright pharmaceutical composition (fresh goods 80 ɡ for purslane, prepare by embodiment 1), and it is above-mentioned to exhort that patient observesThe method of administration of " methods for the treatment of " it " 1 " and the science of " 2 " conditioning daily life and points for attention.Patient takes medicine only 1 day, the symptom solution that slows; Take medicine 2, remission is more obvious, temperature decline;Take medicine 3, curative effect is more obvious, and body temperature has been down to normal value; Within 5th, recover to attend class study; ExtremelyThe 6th, symptom disappeared substantially; After (the 8th day) on the 2nd, recover as before completely, it is different that health check-up has noOften, follow up a case by regular visits to and also have no recurrence.
In sum, drug regimen composition formula of the present invention is precise and appropriate, can effectively treat Western medicine (chemical drugs) curative effectNot good Severe Acute dysentery, for clinical application provides a kind of new selection.
Claims (9)
1. a pharmaceutical composition for the treatment of dysentery, is characterized in that: it is former by following weight proportionThe preparation that material medicine is prepared from:
80 parts of 30 parts of verdolagas or purslane fresh goods, 12 parts of the coptiss, 12 parts of the roots of large-flowered skullcap, golden cypress 10Part, 12 parts of the barks of ash, 20 parts of the Chinese bulbuls, 24 parts of the roots of kudzu vine, 15 parts of the root of herbaceous peonys, 12 parts of the radix paeoniae rubrathe, the root bark of tree peony12 parts, 12 parts of raw hawthorn, 15 parts, Fructus Hordei Germinatus, 15 parts of rice sprouts, 15 parts of Fructus Aurantiis, 15 parts of the barks of official magnolia, sweet8 parts of grass.
2. pharmaceutical composition according to claim 1, is characterized in that: described Fructus Hordei Germinatus is Fructus Hordei Germinatus;The described rice sprout rice sprout of making a living; The described Radix Glycyrrhizae Radix Glycyrrhizae of making a living.
3. pharmaceutical composition according to claim 1 and 2, is characterized in that: described drug regimenThing is to be active component by the water of the bulk drug of described weight proportion or extractive with organic solvent, adds pharmacyThe preparation that upper conventional auxiliary material or complementary composition are prepared from.
4. pharmaceutical composition according to claim 3, is characterized in that: described preparation is oral systemAgent.
5. the preparation method of pharmaceutical composition described in claim 1～4 any one, is characterized in that: itComprise the steps:
(1) by described weight proportion weighting raw materials;
(2) add water or organic solvent extracts, merge extract, concentrated after, add pharmaceutically can use auxiliaryMaterial or complementary composition are prepared into conventional formulation.
6. the pharmaceutical composition described in claim 1～4 any one is in the medicine of preparation treatment dysenteryPurposes.
7. purposes according to claim 6, is characterized in that: described medicine is that treatment is because being wet outwardHeat, the malicious gas of epidemic disease, the medicine of dysentery due to internal injury diet raw food or impairing the spleen and stomach and internal organs.
8. purposes according to claim 6, is characterized in that: described medicine is treatment acute dysenteryMedicine.
9. purposes according to claim 7, is characterized in that: described medicine is treatment Severe AcuteThe medicine of dysentery.
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