CN103735942A - Medicament composition for treating dysentery as well as preparation method and use of medicament composition - Google Patents
Medicament composition for treating dysentery as well as preparation method and use of medicament composition Download PDFInfo
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Abstract
The invention provides a medicament composition for treating dysentery. The medicament composition comprises the following raw material medicaments in parts by weight: 25-35 parts of purslane dried product or 70-90 parts of purslane fresh product, 10-14 parts of coptis chinensis, 10-14 parts of scutellaria baicalensis, 8-12 parts of golden cypress, 10-14 parts of the bark of ash, 17-23 parts of the root of Chinese pulsatilla, 21-27 parts of the root of kudzu vine, 13-17 parts of radix paeoniae alba, 10-14 parts of red peony root, 10-14 parts of the root bark of the peony tree, 10-14 parts of fructus crataegi, 13-17 parts of malt, 13-17 parts of rice sprout, 13-17 parts of fructus aurantii, 13-17 parts of mangnolia officinalis and 6-10 parts of liquorice. The invention also provides a preparation method and use of the medicament composition. A formula of the medicament composition is precise and appropriate. By utilizing the medicament composition, acute severe dysentery which can not be well treated by western medicine can be efficiently treated, and a new choice is provided for clinical medication.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of dysentery and its production and use.
Background technology
Dysentery is a kind of acute infectious intestinal disease, ancient claims intestinal to ward off (Bleach), dysentery, take generate heat, stomachache, diarrhoea, tenesmus, just lower red white pus and blood or poisoning, the yellow and greasy fur of defecation with blood and pus, companion's whole body, slippery and rapid pulse etc. are not cardinal symptom.Dysentery is from the beginning of, foreknowledge stomachache, dysentery then, day and night for several times to tens of times not etc., be mainly in summer and autumn.Baby is not strong to infecting reaction, and onset is more slow, and stool is dyspepsia sample loose stool at first more, and the course of disease is easily delayed.Onset is anxious for 3 years old above infants, take and generates heat, suffers from diarrhoea, suffers from abdominal pain as cardinal symptom, and can faint from fear, vomit.
It is major lesions that primary disease be take colon or terminal ileum suppurative inflammation, produces inside and outside toxin and makes intestinal mucosa impaired after dysentery bacterium invasion and attack, and diseased region has apocyte to infiltrate, and forms abscess or ulcer, the congested enlargement of the local mesenteric lymph node of pathological changes.Acute dysentery is generally divided into 4 types by clinical manifestation, i.e. plain edition, light-duty, heavy type and toxic type.Heavy visible high heat, vomiting, stomachache, tenesmus are obvious, and evacuation of pus hemafecia, reaches tens of every day, and dewatering and acidosis symptom appears in severe patient.
The traditional Chinese medical science thinks, the many gas damp and hot because of being subject to outward, that epidemic disease is malicious of primary disease, and internal injury diet raw food, undermines taste and internal organs, causes dysfunction of the spleen in transportation, and stomach loses food stagnation removing, more holds under the arm stagnantly, accumulates and amasss intestinal and form.Damp and hot heresy is invaded the intestines and stomach, causes QI and blood retardance and obstructed, stagnation of QI and blood may bring about pain, thus stomachache, tenesmus; Damp and hot stasis is in large intestine, and channels is impaired, and the absurd row of forcing blood, therefore the red white pus and blood of dysentery; Yellow and greasy fur, slippery and rapid pulse are being just damp and hot resembling.Its pattern of syndrome is divided into that these are several conventionally: Hakuri, also claims wet dysentery: sticky white thing under dysentery and there is no pus and blood, or as fermented bean drink, after stomachache, weigh, breast abdomen painful abdominal mass is vexed.For heresy is felt frustrated minute, the wet heat that is contained in.Bloody dysentery, also name hematodiarrhoea: just dysentery purgation is yellow redness of the skin or complexion, or pure redness of the skin or complexion, or as fish brain, stomachache, tenesmus, urine is fervid, excessive thirst taking fluids profusely, or see high heat.For evil blood trouble is divided, domination of heat is in wet.Dysentery with red and white feces, also name dysentery due to damp-heat: red white assorted under, shape is as fish brain, stench abnormal, excessive thirst, stomachache, soft pulse and counting.Be for damp and hot accumulate long-pending, impairment of both QI and blood.Fasting dysentery: dysentery is red white, vomiting, can not receive food, and breast gastral cavity painful abdominal mass is vexed, spiritlessness and weakness.How because of damp and hot, not changing, the appetite of being jammed, or foul obstruct gastral cavilty, affect due to stomach receives.If infect epidemic disease poison, sharply, companion is high heat suddenly in morbidity, and coma, convulsions person, be to be fulminant dysentery.And positive exogenous pathogen falls into, linger on the intestines and stomach, dysentery does not heal for a long time, or sends out more repeatly repeatly, is chronic dysentery with frequent relapse.
Doctor trained in Western medicine is generally taked antibiotherapy and fluid replacement therapy etc. to primary disease, but its Therapeutic Method can not show a candle to Chinese traditional treatment method abundant (Chinese medicine has hundreds of to go out hundreds of effective prescriptions according to the original abstract science permutation and combination of tcm treatment according to syndrome differentiation), and its curative effect is also not as tcm therapy better (treatment time and patient feel aspect all not as the traditional Chinese medical science).Particularly solve patient's tenesmus symptom and passing stool with blood and pus symptom, Chinese traditional treatment truly has the good effect of answering small wooden raft as drum, and the side effect of traditional Chinese medical science antidysenteric totally nontoxic, and only this item is better than chemical drugs antibiotic.
It is more that at present report can be used for treating the Chinese medicine formula of dysentery, as Ren Jiangping has reported a kind of Chinese medicinal herbs decoction for enema treatment acute bacillary dysentery, by Rhizoma Coptidis 3g, Folium Sennae 3g, Radix Paeoniae Alba 10g, Radix Aucklandiae 6g, Radix Glycyrrhizae 3g soaks and forms with boiling water, cure rate 97.5%, effective percentage 98.75%, inefficiency 1.25%(appoints river flat, Chinese medicine blister fluid retention-enema treatment acute bacillary dysentery 80 examples. Chinese combination of Chinese and Western medicine digestion magazine, 2007, the 2 phases).
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition for the treatment of dysentery.Another object of the present invention is to provide preparation method and the purposes of this pharmaceutical composition.
The invention provides a kind of pharmaceutical composition for the treatment of dysentery, it is the preparation that the crude drug by following weight proportion is prepared from:
70～90 parts of 25～35 parts of verdolagas or Herba Portulacae fresh goods, 10～14 parts of Rhizoma Coptidis, 10～14 parts of Radix Scutellariaes, 8～12 parts of Cortex Phellodendris, 10～14 parts of Cortex Fraxinis, 17～23 parts of the Radix Pulsatillaes, 21～27 parts of Radix Puerariaes, 13～17 parts of the Radix Paeoniae Albas, 10～14 parts of Radix Paeoniae Rubra, 10～14 parts of Cortex Moutans, 10～14 parts of Fructus Crataegis, 13～17 parts, Fructus Hordei Germinatus, 13～17 parts of Fructus Setariae Germinatuss, 13～17 parts of Fructus Aurantiis, 13～17 parts of Cortex Magnoliae Officinalis, 6～10 parts, Radix Glycyrrhizae.
Preferably, it is the preparation that the crude drug by following weight proportion is prepared from:
80 parts of 30 parts of verdolagas or Herba Portulacae fresh goods, 12 parts of Rhizoma Coptidis, 12 parts of Radix Scutellariaes, 10 parts of Cortex Phellodendris, 12 parts of Cortex Fraxinis, 20 parts of the Radix Pulsatillaes, 24 parts of Radix Puerariaes, 15 parts of the Radix Paeoniae Albas, 12 parts of Radix Paeoniae Rubra, 12 parts of Cortex Moutans, 12 parts of Fructus Crataegis, 15 parts, Fructus Hordei Germinatus, 15 parts of Fructus Setariae Germinatuss, 15 parts of Fructus Aurantiis, 15 parts of Cortex Magnoliae Officinalis, 8 parts, Radix Glycyrrhizae.
Wherein, described Fructus Crataegi is Fructus Crataegi; Described Fructus Hordei Germinatus is Fructus Hordei Germinatus; The described Fructus Setariae Germinatus Fructus Setariae Germinatus of making a living; Described Radix Glycyrrhizae is Radix Glycyrrhizae.
Further, described pharmaceutical composition is to be active component by the water of the crude drug of described weight proportion or extractive with organic solvent, adds the preparation that pharmaceutically conventional adjuvant or complementary composition are prepared from.
Further, described preparation is oral formulations.Oral formulations of the present invention, refers to oral administration, and at the preparation of gastrointestinal absorption.
Further, described oral formulations is granule, powder, pill, drop pill, capsule, soft capsule, tablet or oral liquid.
The present invention also provides the preparation method of aforementioned pharmaceutical compositions, and it comprises the steps:
(1) by described weight proportion weighting raw materials;
(2) add water or organic solvent extraction, merge extractive liquid,, after concentrating, adds that pharmaceutically available adjuvant or complementary composition are prepared into conventional formulation.
The present invention further provides the purposes of aforementioned pharmaceutical compositions in the medicine of preparation treatment dysentery.
Further, described medicine is treatment gas damp and hot because of being subject to outward, that epidemic disease is malicious, and internal injury diet is raw and cold, the medicine of dysentery due to impairing the spleen and stomach and internal organs etc.
Further, described medicine is the medicine for the treatment of acute dysentery.
Further, described medicine is the medicine for the treatment of Severe Acute dysentery.
Generally acknowledged that at present " organic conception ", " determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs ", " compound recipe use ", " compound compatibility medication is as used military forces " are the most scientific the most several large advantages of the traditional Chinese medical science, wherein " compound compatibility medication is as used military forces " is the original theory of Chinese medicine of very science.Each medicine tight compatibility all linked with one another as arrayed troops for battle in traditional Chinese medical science prescription is its effective means that is better than Western medicine formula.Tcm prescription theory is thought, each prescription, not only need to select the appropriate compatibility of suitable medicine according to etiology and pathogenesis, also should meet the basic structure of prescription simultaneously, the i.e. prescription compatibility theory of " monarch, minister, help, make ", the prescription compatibility of so-called " monarch, minister, help, make " is exactly that it is based upon the scientific matching on the comprehensive judgement basis of disease pathogenesis.In medical square tube cross too many levels, many target spots and integrate the biological mechanism regulating, sufferer to the Severe Acute bacillary dysentery of this Western medicine (chemical drugs) unsatisfactory curative effect is recuperated under medical treatment, can obtain therapeutic effect better than Western medicine, that more green natural has no side effect, and this curative effect is to be based upon on the accurate instruction of the original theory of above-mentioned traditional Chinese medical science tradition, prescription of the present invention is just being followed this principle.
Prescription of the present invention be take Herba Portulacae as monarch drug, brings into play its heat-clearing and toxic substances removing, diuretic damp eliminating, eliminating pathogenic heat from blood to cure dysentery effect.Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Cortex Fraxini, the Radix Pulsatillae all have heat-clearing and toxic substances removing dampness effect, therefore appoint as ministerial drug, assist the potentiation of monarch drug Herba Portulacae.Radix Puerariae is good at heat clearing away expelling pathogenic factors from muscles, yang invigorating promotes the production of body fluid, and contributes to alleviate dysentery, the body Tianjin of supplementing nutrition; Red white two Chinese herbaceous peonies not only be good at that slow it is urgent, treat and control stomachache, and the kind blood of adjusting, and Cortex Moutan is also longer than removing heat from blood and promoting blood circulation, is just suiting in this and is controlling dysentery theory; The gas of the gastrointestinal that Massa Medicata Fermentata, Fructus Crataegi, Fructus Setariae Germinatus, Fructus Hordei Germinatus maintenance dysentery injure, has aid digestionly, and Fructus Crataegi still can help red Chinese herbaceous peony to adjust blood; The circulation of qi promoting regulating QI of Fructus Aurantii, Cortex Magnoliae Officinalis, both can remove it " tenesmus " symptom of dysentery, can urge again turbid dysentery speed and go, and also can help bent short, bristly hair or beard bud digestion and the gas of the gastrointestinal of living, thereby, using above four Chinese medicine as adjuvant drug, assist a ruler in governing a country the monarch and his subjects and receive merit.Radix Glycyrrhizae, not only can delay middle solution contraction and coordinate the Radix Paeoniae Alba, can coordinate Radix Puerariae by sour and sweet drugs can transforme into YIN again, also can coordinating the actions of various ingredients in a prescription for making, therefore with for making medicine.
Below respectively organize flavour of a drug post clearly demarcated, complement each other, given full play to the sexology research methodology marrow of analyzing mentally as the exclusive compound compatibility medication Ru Pai army of Chinese medicine structures the formation, Severe Acute bacillary dysentery for Western medicine (chemical drugs) unsatisfactory curative effect has good therapeutic effect, can alleviate comparatively rapidly its symptom, the larger drawback of also having avoided chemical drugs antibiotic to cause to human body, for clinical application provides a kind of new selection.
The specific embodiment
The preparation of embodiment 1 pharmaceutical composition of the present invention
Get verdolaga 30 ɡ, refined Rhizoma Coptidis 12 ɡ, Radix Scutellariae 12 ɡ, Cortex Phellodendri 10 ɡ, Cortex Fraxini 12 ɡ, the Radix Pulsatillae 20 ɡ, RADIX PUERARIAE 24 ɡ, the Radix Paeoniae Alba 15 ɡ, Radix Paeoniae Rubra 12 ɡ, Cortex Moutan 12 ɡ, Fructus Crataegi 12 ɡ, Fructus Hordei Germinatus 15 ɡ, raw Fructus Setariae Germinatus 15 ɡ, Fructus Aurantii 15 ɡ, Cortex Magnoliae Officinalis 15 ɡ, Radix Glycyrrhizae 8 ɡ.Each flavour of a drug take according to quantity, are adjusted to little fire after being boiled in water, and after approximately 8 minutes to 10 minutes, collect decocting liquid; Medicinal residues decoct with water 2 times again, merge decocting liquid each time, obtain decoction.
The preparation of embodiment 2 pharmaceutical compositions of the present invention
Get verdolaga 25 ɡ, refined Rhizoma Coptidis 10 ɡ, Radix Scutellariae 10 ɡ, Cortex Phellodendri 8 ɡ, Cortex Fraxini 10 ɡ, the Radix Pulsatillae 17 ɡ, RADIX PUERARIAE 21 ɡ, the Radix Paeoniae Alba 13 ɡ, Radix Paeoniae Rubra 10 ɡ, Cortex Moutan 10 ɡ, Fructus Crataegi 10 ɡ, Fructus Hordei Germinatus 13 ɡ, raw Fructus Setariae Germinatus 13 ɡ, Fructus Aurantii 13 ɡ, Cortex Magnoliae Officinalis 13 ɡ, Radix Glycyrrhizae 6 ɡ.First, with after 70%v/v ethanol extraction 2 times, merge alcohol extract, medicinal residues boil 2 times with decocting again, merge decocting liquid.After respectively alcohol extract, decocting liquid being concentrated, mix, then add suitable dextrin, soluble starch, granulate, obtain granule.
The preparation of embodiment 3 pharmaceutical compositions of the present invention
Get verdolaga 35 ɡ, refined Rhizoma Coptidis 14 ɡ, Radix Scutellariae 14 ɡ, Cortex Phellodendri 12 ɡ, Cortex Fraxini 14 ɡ, the Radix Pulsatillae 23 ɡ, RADIX PUERARIAE 27 ɡ, the Radix Paeoniae Alba 17 ɡ, Radix Paeoniae Rubra 14 ɡ, Cortex Moutan 14 ɡ, Fructus Crataegi 14 ɡ, Fructus Hordei Germinatus 17 ɡ, raw Fructus Setariae Germinatus 17 ɡ, Fructus Aurantii 17 ɡ, Cortex Magnoliae Officinalis 17 ɡ, Radix Glycyrrhizae 10 ɡ.First, with after 70%v/v ethanol extraction 2 times, merge alcohol extract, medicinal residues boil 2 times with decocting again, merge decocting liquid.After respectively alcohol extract, decocting liquid being concentrated, mix, then add suitable dextrin, soluble starch, granulate, tabletting, obtains tablet.
The preparation of embodiment 4 pharmaceutical compositions of the present invention
Get Herba Portulacae fresh goods 80 ɡ, refined Rhizoma Coptidis 12 ɡ, Radix Scutellariae 12 ɡ, Cortex Phellodendri 10 ɡ, Cortex Fraxini 12 ɡ, the Radix Pulsatillae 20 ɡ, RADIX PUERARIAE 24 ɡ, the Radix Paeoniae Alba 15 ɡ, Radix Paeoniae Rubra 12 ɡ, Cortex Moutan 12 ɡ, Fructus Crataegi 12 ɡ, Fructus Hordei Germinatus 15 ɡ, raw Fructus Setariae Germinatus 15 ɡ, Fructus Aurantii 15 ɡ, Cortex Magnoliae Officinalis 15 ɡ, Radix Glycyrrhizae 8 ɡ.Each flavour of a drug take according to quantity, are adjusted to little fire after being boiled in water, and after approximately 8 minutes to 10 minutes, collect decocting liquid; Medicinal residues decoct with water 2 times again, merge decocting liquid each time, obtain decoction.
The preparation of embodiment 5 pharmaceutical compositions of the present invention
Get the decoction of embodiment 1 preparation, standing, get supernatant, after concentrating, dry, pulverize, standby; Get appropriate Macrogol 4000, after melting, above-mentioned medicated powder is added in melting substrate, insulation at 75～85 ℃; Adopt various pill dripping machine, drip inside/outside footpath and a speed appropriateness, splashed in dimethicone, collects drop pill, obtains drop pill.
By test example, illustrate beneficial effect of the present invention below.
Clinical (outpatient service) treatment situation of test example 1 pharmaceutical composition of the present invention
(1) accept patient's situation for medical treatment
Patient age and sex scope: old children all has, and mainly take teenager as many, and there are men and women for sex, possess following symptom feature (possess major part, needn't also can not completely all possess), accepts altogether 41 examples for medical treatment.
Symptom feature:
Severe Acute dysentery: onset is more anxious, high heat, body temperature can reach 39 ℃～40 ℃, and diarrhoea dysentery is not defecated ten times to tens of times every day not etc., and just for loose stool or be watery diarrhea, continuing is bloody purulent stool, or red assorted mutually in vain, left lower quadrant tenderness, companion's bowel sound hyperaction, tenesmus is obvious.The clinical manifestations such as normal companion feels sick, vomiting, stomachache, can there is dehydration and acidosis symptom in severe patient.The common red tongue with yellowish and greasy fur of tongue arteries and veins feature, slippery and rapid pulse etc.Most patients are reflected Western medicine (chemical drugs) unsatisfactory curative effect.
(2) treatment standard
Recovery from illness: above-mentioned symptom feature disappears completely, through suitably recovering normal work very soon, health check-up no abnormality seen after rest and daily life conditioning.
Evident in efficacy: above-mentioned symptom obviously alleviates, or comparatively fast can restore one's working ability, or health check-up no abnormality seen.
Have certain effect: patient's symptom alleviates to some extent, or remission time is slower, or can not resumes work for a long time and daily routines.
Invalid: symptom still, is not improved completely.
(3) Therapeutic Method
1, the made decoction of embodiment 1, takes potion every day, and the first day takes 1 time every about 4 hours, and from next day, take 3 every day, generally takes 5 to 10.
2, note also science conditioning daily life, observe some necessary points for attention, as:
(1) to conscientiously wash one's hands after an action of the bowels ante cibum, not drink unboiled water, not eat rotten and putrid food, not eat the food of being stained with by fly.
(2) eating and drinking too much at one meal not, not " cold and hot with eating ", as Hot Coffee and ice cream, showing tremendous enthusiasm pot and cold tea etc., in order to avoid cause mucous membrane to the intestines and stomach, the reduction of gastrointestinal resistance.
(3) do not drink plain boiled water in a large number or take food, and should first drink a little sugar-salt-waters, electrolyte supplement, avoids generation to dewater and causes disturbance of blood circulation.
(4) should lie up, and isolated and adopt disinfectant measure.Diet be take liquid food or half liquid food as main, if vomit and diarrhoea, abdominal distention severe one, and can short-term fasting.
(5) must science conditioning daily life after alleviating (if do not drunk, smoking, eating and drinking too much at one meal, does not eat food and the cold and cool food of raw food of " heat-dissipatings of getting angry " such as pungent frying, delicious food savoury, suitably eat fresh, light, easily digest and more nutritious food; Play habitat environment and answer health clean and tidy, door and window ventilates, and keeps room air fresh but can not room temperature too high or too low; Have a rest and movable appropriateness, and more regular; Keep pleasant with happy simultaneously.Etc.).
(6) in order to prevent dysentery, should note doing well environmental health, strengthen the management of fly breeding site lavatory and feces, fly-killing.And strengthen the management at dietetic hygiene and water source, especially individual diet street pedlar is carried out to hygienic supervise work.To the cook of collective unit and mechanism of nursery schools and childcare centres, nurse, should make regular check on its stool, do antibacterial culturing, prevent trouble before it happens.
(4) therapeutic outcome
In medicine composite for curing primary disease men and women patient of the present invention 41 examples, obtained good curative effect.Treatment time, institute's difference according to the difference of the concrete conditions such as each conditions of patients weight, age size, physical strength and slightly, within general 2 days, left and right symptom can alleviate, within 5 days to 10 days, the various symptoms in left and right can disappear completely or substantially disappear, by above-mentioned science conditioning daily life, sincerely abide by points for attention, can receive merit.
By above-mentioned treatment standard, in 41 routine patients, there are 37 example recoveries from illness, cure rate reaches 90.2%; 3 examples are evident in efficacy, account for 7.3%; 1 example has certain effect, is 2.5%.Total effective rate reaches 100%.
Model case
Patient, female, 17 years old, student, dysentery 2 days, suddenly, day is rushed down twenty or thirty, is bloody purulent stool in morbidity, stomachache, tenesmus, the nausea of feeling sick, high heat, doctor trained in Western medicine, with Ampicillin, bactrim drug combination antibacterial therapy, has no improvement, and symptom is still.While examining, have a medical check-up 39.5 ℃, as above, depending on its tongue, sharp limit is red for described symptom, the white greasy micro-Huang of tongue, in have small red dot, stringy and rolling pulse is counted disease, is the Severe Acute bacillary dysentery for Western medicine (chemical drugs) unsatisfactory curative effect.Through inquiry, not between menstrual period, so sentence pharmaceutical composition of the present invention (fresh goods 80 ɡ for Herba Portulacae, by embodiment 1 preparation), and exhort that patient observes the method for administration of above-mentioned " Therapeutic Method " it " 1 " and the science of " 2 " conditioning daily life and points for attention.Patient takes medicine only 1 day, the symptom solution that slows; Take medicine 2, remission is more obvious, temperature decline; Take medicine 3, curative effect is more obvious, and body temperature has been down to normal value; Within 5th, recover to attend class study; To the 6th day, symptom disappeared substantially; After (the 8th day) on the 2nd, recover as before completely, health check-up no abnormality seen, follows up a case by regular visits to and also has no recurrence.
In sum, drug regimen composition formula of the present invention is precise and appropriate, can effectively treat the Severe Acute dysentery of Western medicine (chemical drugs) unsatisfactory curative effect, for clinical application provides a kind of new selection.
Claims (10)
1. treat a pharmaceutical composition for dysentery, it is the preparation that the crude drug by following weight proportion is prepared from:
70～90 parts of 25～35 parts of verdolagas or Herba Portulacae fresh goods, 10～14 parts of Rhizoma Coptidis, 10～14 parts of Radix Scutellariaes, 8～12 parts of Cortex Phellodendris, 10～14 parts of Cortex Fraxinis, 17～23 parts of the Radix Pulsatillaes, 21～27 parts of Radix Puerariaes, 13～17 parts of the Radix Paeoniae Albas, 10～14 parts of Radix Paeoniae Rubra, 10～14 parts of Cortex Moutans, 10～14 parts of Fructus Crataegis, 13～17 parts, Fructus Hordei Germinatus, 13～17 parts of Fructus Setariae Germinatuss, 13～17 parts of Fructus Aurantiis, 13～17 parts of Cortex Magnoliae Officinalis, 6～10 parts, Radix Glycyrrhizae.
2. pharmaceutical composition according to claim 1, is characterized in that: it is the preparation that the crude drug by following weight proportion is prepared from:
80 parts of 30 parts of verdolagas or Herba Portulacae fresh goods, 12 parts of Rhizoma Coptidis, 12 parts of Radix Scutellariaes, 10 parts of Cortex Phellodendris, 12 parts of Cortex Fraxinis, 20 parts of the Radix Pulsatillaes, 24 parts of Radix Puerariaes, 15 parts of the Radix Paeoniae Albas, 12 parts of Radix Paeoniae Rubra, 12 parts of Cortex Moutans, 12 parts of Fructus Crataegi, 15 parts, Fructus Hordei Germinatus, 15 parts of Fructus Setariae Germinatuss, 15 parts of Fructus Aurantiis, 15 parts of Cortex Magnoliae Officinalis, 8 parts, Radix Glycyrrhizae.
3. pharmaceutical composition according to claim 1 and 2, is characterized in that: described Fructus Crataegi is Fructus Crataegi; Described Fructus Hordei Germinatus is Fructus Hordei Germinatus; The described Fructus Setariae Germinatus Fructus Setariae Germinatus of making a living; Described Radix Glycyrrhizae is Radix Glycyrrhizae.
4. according to the pharmaceutical composition described in claim 1～3 any one, it is characterized in that: described pharmaceutical composition is to be active component by the water of the crude drug of described weight proportion or extractive with organic solvent, adds the preparation that pharmaceutically conventional adjuvant or complementary composition are prepared from.
5. pharmaceutical composition according to claim 4, is characterized in that: described preparation is oral formulations.
6. the preparation method of pharmaceutical composition described in claim 1～5 any one, is characterized in that: it comprises the steps:
(1) by described weight proportion weighting raw materials;
(2) add water or organic solvent extraction, merge extractive liquid,, after concentrating, adds that pharmaceutically available adjuvant or complementary composition are prepared into conventional formulation.
7. the purposes of the pharmaceutical composition described in claim 1～5 any one in the medicine of preparation treatment dysentery.
8. purposes according to claim 7, is characterized in that: described medicine is treatment gas damp and hot because of being subject to outward, that epidemic disease is malicious, and internal injury diet is raw and cold, the medicine of dysentery due to impairing the spleen and stomach and internal organs etc.
9. pharmaceutical composition according to claim 7, is characterized in that: described medicine is the medicine for the treatment of acute dysentery.
10. purposes according to claim 8, is characterized in that: described medicine is the medicine for the treatment of Severe Acute dysentery.
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Cited By (2)
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| CN103977378A (en) * | 2014-05-28 | 2014-08-13 | 宋秀花 | Traditional Chinese medicine for treating toxic bacillary dysentery |
| CN104288416A (en) * | 2014-10-28 | 2015-01-21 | 王慧 | Traditional Chinese medicine composition for treating acute bacillary dysentery and for clearing heat and promoting diuresis and preparation method thereof |
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2014
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103977378A (en) * | 2014-05-28 | 2014-08-13 | 宋秀花 | Traditional Chinese medicine for treating toxic bacillary dysentery |
| CN104288416A (en) * | 2014-10-28 | 2015-01-21 | 王慧 | Traditional Chinese medicine composition for treating acute bacillary dysentery and for clearing heat and promoting diuresis and preparation method thereof |
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| CN103735942B (en) | 2016-05-04 |
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