CN103735793A - Traditional Chinese medicine for treating limb numbness of diabetics after stroke and preparation method thereof - Google Patents
Traditional Chinese medicine for treating limb numbness of diabetics after stroke and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine for treating limb numbness of diabetics after stroke and a preparation method thereof. The traditional Chinese medicine for treating the limb numbness of the diabetics after the stroke consists of the following raw traditional Chinese medicines in parts by weight: 50-70 parts of astragalus membranaceus, 15-25 parts of codonopsis pilosula, 7-13 parts of lumbricus, 7-13 parts of leech, 7-13 parts of scorpio, 7-13 parts of centipede, 25-35 parts of geranium wilfordii, 15-25 parts of caulis spatholobi, 15-25 parts of sargentgloryvine stem, 7-13 parts of pinellia ternate, 15-25 parts of parasitic loranthus, 10-25 parts of ramulus mori, 7-13 parts of herba aristolochiae, 7-13 parts of caulis sinomenii, 7-13 parts of Chinese starjasmine stem, 7-13 parts of uncaria rhynchophylla, and 7-13 parts of cassia twig. The traditional Chinese medicine has the effects of tonifying qi and yin, cooling and activating blood, relieving dizziness, reducing phlegm, dispelling wind, eliminating dampness, activating meridians and stopping pain, and is applied to the limb numbness of the diabetics after the stroke; the symptoms are limb numbness, pain, hemiplegia and the like; the traditional Chinese medicine has the advantages of quick effect, short treatment course, safety and reliability.
Description
Technical field
The invention belongs to medical technical field, be specifically related to Chinese medicine of numb limbs and tense tendons after a kind of diabetes patient's for the treatment of apoplexy and preparation method thereof.
Background technology
Apoplexy is the general designation of Chinese medicine to acute cerebrovascular disease.It is suddenly to faint, syncope, distortion of commissure, dysphonia and occur that hemiplegia is a class disease of cardinal symptom occur together, because primary disease sickness rate is high, mortality rate is high, disability rate is high, relapse rate is high and complication is many, so medical circle is listed as its same coronary heart disease, cancer one of three large diseases that threaten human health.After apoplexy, numb hand and foot is comparatively common apoplexy sequela, and the end of the limbs of patient's Ipsilateral, especially limbs as the face skin of cheek of finger, toe or hemiplegia side has ant to climb sensation, or have prickling sensation, or it is blunt to show as irritant reaction.Numb normal relevant with Changes in weather, weather drastic shift, humid, or rain in the situations such as front and back, cold weather, it is especially obvious that numbness is felt; Be characterized in course of disease length, weak curative effect, take effect slowly, patient suffering is larger, and treatment specific aim is poor, causes great impact to patient's daily life.Because itself just there is the common complication of diabetic peripheral neuropathy (DPN) in diabetes patient, its often show as numb limbs and tense tendons pain, sensory disturbance, hypokinesia, amyotrophy even the useless apraxia of flaccidity be feature, spontaneous pain shows as very serious pain, obvious during rest, increase the weight of night to see.Both are added together, and make numb limbs and tense tendons nominal price after diabetes patient's apoplexy be difficult to treatment.
Summary of the invention
In order to solve above-mentioned technical problem, the invention provides Chinese medicine of numb limbs and tense tendons after a kind of diabetes patient's for the treatment of apoplexy and preparation method thereof.Can effectively solve by the problem of wind-induced numb limbs and tense tendons, safe and reliable, short treating period, instant effect.
The present invention realizes by following technical scheme:
Treat a Chinese medicine for numb limbs and tense tendons after diabetes patient's apoplexy, by the raw material of Chinese medicine medicine of following weight portion, formed:
Radix Astragali 50-70 part, Radix Codonopsis 15-25 part, Pheretima 7-13 part, Hirudo 7-13 part, Scorpio 7-13 part, Scolopendra 7-13 part, Herba Erodii 25-35 part, Caulis Spatholobi 15-25 part, Caulis Sargentodoxae 15-25 part, Rhizoma Pinelliae 7-13 part, Herba Taxilli 15-25 part, Ramulus Mori 10-25 part, Herba Aristolochiae 7-13 part, Caulis Sinomenii 7-13 part, Caulis Trachelospermi 7-13 part, Ramulus Uncariae Cum Uncis 7-13 part, Ramulus Cinnamomi 7-13 part, Cortex Eucommiae 7-13 part, Rhizoma Dioscoreae 50-70 part, Radix Rehmanniae 25-35 part, Radix Scrophulariae 15-25 part, Radix Cynanchi Atrati 7-13 part.
Preferably, the Chinese medicine of numb limbs and tense tendons after above-mentioned treatment diabetes patient apoplexy, is comprised of the raw material of Chinese medicine medicine of following weight portion:
Radix Astragali 55-65 part, Radix Codonopsis 17-23 part, Pheretima 8-12 part, Hirudo 8-12 part, Scorpio 8-12 part, Scolopendra 8-12 part, Herba Erodii 27-33 part, Caulis Spatholobi 17-23 part, Caulis Sargentodoxae 17-23 part, Rhizoma Pinelliae 8-12 part, Herba Taxilli 17-23 part, Ramulus Mori 12-18 part, Herba Aristolochiae 8-12 part, Caulis Sinomenii 8-12 part, Caulis Trachelospermi 8-12 part, Ramulus Uncariae Cum Uncis 8-12 part, Ramulus Cinnamomi 8-12 part, Cortex Eucommiae 8-12 part, Rhizoma Dioscoreae 55-65 part, Radix Rehmanniae 27-33 part, Radix Scrophulariae 17-23 part, Radix Cynanchi Atrati 8-12 part.
Preferred, the Chinese medicine of numb limbs and tense tendons after above-mentioned treatment diabetes patient apoplexy, is comprised of the raw material of Chinese medicine medicine of following weight portion:
60 parts of the Radixs Astragali, 20 parts of Radix Codonopsis, 10 parts of Pheretimas, 10 parts of Hirudos, 10 parts of Scorpios, 10 parts of Scolopendras, 30 parts of Herba Erodiis, 20 parts of Caulis Spatholobis, 20 parts of Caulis Sargentodoxae, 10 parts of the Rhizoma Pinelliaes, 20 parts of Herba Taxillis, 15 parts of Ramulus Moris, 10 parts of Herba Aristolochiaes, 10 parts of Caulis Sinomeniis, 10 parts of Caulis Trachelospermis, 10 parts of Ramulus Uncariae Cum Uncis, 10 parts of Ramulus Cinnamomi, 10 parts of the Cortexs Eucommiae, 60 parts of Rhizoma Dioscoreaes, 30 parts, the Radix Rehmanniae, 20 parts of Radix Scrophulariaes, 10 parts of Radix Cynanchi Atratis.
The Chinese medicine of numb limbs and tense tendons after above-mentioned treatment diabetes patient apoplexy, the dosage form of this Chinese medicine is oral formulations.
Preferably, the Chinese medicine of numb limbs and tense tendons after above-mentioned treatment diabetes patient apoplexy, the dosage form of this Chinese medicine is granule.
After above-mentioned treatment diabetes patient apoplexy, the preparation method of the Chinese medicine of numb limbs and tense tendons, comprises the steps:
(a) Radix Astragali, Radix Codonopsis, Herba Erodii, Caulis Spatholobi, Caulis Sargentodoxae, the Rhizoma Pinelliae, Herba Taxilli, Ramulus Mori, Herba Aristolochiae, Caulis Sinomenii, Caulis Trachelospermi, Ramulus Uncariae Cum Uncis, Ramulus Cinnamomi, the Cortex Eucommiae, Rhizoma Dioscoreae, the Radix Rehmanniae, Radix Scrophulariae, Radix Cynanchi Atrati decocts with water 2 times, the 8-10 that amount of water is drug weight for the first time doubly, decoct 1.5-2.5 hour, the 4-6 that amount of water is drug weight for the second time doubly, decoct 1-2 hour, collecting decoction, filter, filtrate is condensed into the thick paste that relative density is 1.16-1.19, add ethanol make containing alcohol amount be 70%, standing 8 hours, filter, 60 ℃ of concentrating under reduced pressure of filtrate reclaim ethanol, then medicine is condensed into thick paste, 60 ℃ of drying under reduced pressure are crossed 100 mesh sieves after pulverizing, be prepared into extract powder,
(b) Pheretima, Hirudo, Scorpio, Scolopendra superfine powder are broken into the drug powder of superfine powder particle size range 5-45 μ m;
(c) drug powder that medicated powder step (a) being obtained and step (b) make mixes, and obtains middle the effective elements of the medicine of the present invention;
(d) effective ingredient of step (c) gained adds pharmaceutically acceptable adjuvant to make preparation.
The acceptable adjuvant of described medicine is selected from: starch, magnesium stearate, mannitol, sorbitol, sorbic acid or potassium salt, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin A, vitamin C, tie up main plain E, vitamin D, azone, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, dextran, glycine, lactose, mannitol, silicon derivative, cellulose and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, propylene glycol, ethanol, polysorbate60～80, department class～80, Cera Flava, lanoline, liquid paraffin, hexadecanol, gallate ester, fine jade, triethanolamine, basic amino acid, carbamide, allantoin, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, β～cyclodextrin, phospholipid material, Kaolin, Pulvis Talci, calcium stearate etc.
Preferably, after above-mentioned treatment diabetes patient apoplexy in the preparation method of the Chinese medicine of numb limbs and tense tendons, in described step (a), amount of water is drug weight 9 times for the first time, decocts 2 hours, and amount of water is drug weight 5 times for the second time, decocts 1.5 hours.
After treatment of the present invention diabetes patient apoplexy in the raw material of Chinese medicine medicine of numb limbs and tense tendons, each herbal medicine is the Chinese medicine of recording in 2005 editions one of one of Chinese Pharmacopoeia version in 2010 or Chinese Pharmacopoeia.
Chinese medicine of the present invention, has supplementing QI and nourishing YIN, removing heat from blood and promoting blood circulation, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. reduce phlegm, the effect of expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, for the numb limbs and tense tendons after apoplexy, disease sees that disease sees numb limbs and tense tendons, pain, hemiplegia etc.
Apoplexy is clinical common harm middle-aged and elderly people life and affects one of three large diseases of quality of life.Its being seen numb limbs and tense tendons is meciless brings endless worries to patient especially.Motherland's medical science is divided into middle warp, appoplexy involving the collateral, apoplexy involving ZANG-organ, apoplexy involving FU-organ by apoplexy.Thinking that limbs numbness of the skin is meciless mostly is due to appoplexy involving the collateral.Meridians appoplexy involving the collateral is acral, and general medicine is difficult to reach, therefore this disease course of disease is long, weak curative effect, takes effect slow.Diabetes patient is most itself just there is acral microcirculation disturbance, therefore it is slower to take effect, the course for the treatment of is longer.
On the basis of discussing at ancient Chinese medicine doctor, applicant, in conjunction with clinical experience, thinks that paralytic's group of people at high risk mostly is old age or presenium patient, over fifty and half of YIN QI consumed.Qi being the governor of blood.The normal operation of blood, depends on the normal operation of gas, blood being the material foundation of QI, blood can carry QI, QI and blood homology.Apoplexy be take blood stasis as main pathogenesis, and blood stasis also runs through primary disease all the time.Internal organs hypofunction and vigour are from declining, and postapoplectic special circumstances, must consume and hinder healthy energy in addition, and the state of body QI and blood deficiency is increased the weight of, and of a specified duration can develop as syndrome of blood stasis due to qi deficiency, because of the stagnant pathological change of the unable promoting the circulation of blood hyperamization of deficiency of vital energy clots absorbing.A variety of causes divides in the blood stasis causing and stops, and retardance venation, had both increased the weight of the retardance of mechanism of qi, can be further as heavy stagnation of QI-blood, and this is the main pathogenesis of stroke in convalescent stage just also.Internal organs hypofunction, insufficiency of the spleen transporting is unable, raw retardance meridians in phlegm-damp, old caused by liver and kidney deficiency in addition, liver governing tendons arteries and veins, muscle arteries and veins loses supports, and sees numb limbs and tense tendons or alters pain, and half body apraxia, speech are not smoothgoing puckery, and the disease of the deficiency of vital energys such as deficiency of QI with disinclination to talk, has again the performance of paralysis, blood stasis.Diabetes more show as serious nourishing kidney-yin interior-heat.Control when supplementing QI and nourishing YIN, removing heat from blood and promoting blood circulation, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. reduce phlegm, expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.After the treatment diabetes patient apoplexy of invention in the Chinese prescription of numb limbs and tense tendons, the Radix Astragali, Radix Codonopsis strongly invigorating primordial QI, the Radix Rehmanniae, Radix Scrophulariae nourishing YIN and clearing away heat, removing heat from blood and promoting blood circulation; Pheretima, Hirudo, Caulis Spatholobi, Caulis Sargentodoxae blood circulation promoting and blood stasis dispelling, the Rhizoma Pinelliae, Ramulus Uncariae Cum Uncis relieve dizziness, high fever, infantile convulsions, epilepsy, etc. and reduce phlegm, and Scorpio, Scolopendra are searched wind, Herba Taxilli, the Cortex Eucommiae, the large invigorating the liver and kidney of Rhizoma Dioscoreae, Ramulus Mori, Herba Aristolochiae, Caulis Sinomenii, Caulis Trachelospermi expelling wind and removing dampness removing obstruction in the collateral to relieve pain, the Radix Cynanchi Atrati minute deficiency-heat that purifies the blood, Ramulus Cinnamomi tying-in is promoted blood circulation.All medicines share, and play altogether and there is benefiting QI for activating blood circulation, expelling wind and removing dampness, the effect of removing obstruction in the collateral to relieve pain, is clinically mainly used in after apoplexy numb limbs and tense tendons after numb limbs and tense tendons, the especially Stroke In Aged of body void.After treatment diabetes patient apoplexy of the present invention, in the Chinese prescription of numb limbs and tense tendons, having used a large amount of rattan class medicines, is according to the analogy of image extracting draw in theory of Chinese medical science, get rattan class and be apt to away meridians, the network of the meridians end that can go directly, thereby the curative effect of raising medicine, make medicine instant effect, short treating period.
The invention has the advantages that:
(1) the invention provides the Chinese medicine of numb limbs and tense tendons after a kind of new treatment diabetes patient apoplexy, met clinical needs.In this Chinese prescription, having used a large amount of rattan class medicines, is according to the analogy of image extracting draw in theory of Chinese medical science, get rattan class and be apt to away meridians, and the network of the meridians end that can go directly, thus the curative effect of raising medicine makes medicine instant effect, short treating period.
(2) the present invention becomes preparation by the Chinese drug preparation of numb limbs and tense tendons after treatment treatment diabetes patient apoplexy, both kept decoction to absorb fast, effective feature rapidly, overcome again decoction and taken front interim decoction, be long placed in and easily mouldly lose rotten shortcoming, and can cover the bitterness of Chinese medicine.Chinese medicine preparation Chinese crude drug of the present invention all extracts through refining, and volume-diminished is transported, carried, taking convenience.
(3) clinical test results shows, treatment group cure rate is 40.0%, and total effective rate is 93.3%: matched group cure rate is 10%, and total effective rate is 13.3%.Treatment group is compared with matched group, and both curative effects have significant difference (P<O.01).Wherein in the routine patient of matched group 30,1 the course for the treatment of healing person be 2 examples, 2 the course for the treatment of healing person reach 6 examples, three courses for the treatment of, healing person reached 12 examples; In the routine patient of matched group 30,1 the course for the treatment of healing person be 0 example, 2 the course for the treatment of healing person reach 1 example, three courses for the treatment of, healing person reached 3 examples.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1
Prescription:
Radix Astragali 600g, Radix Codonopsis 200g, Pheretima 100g, Hirudo 100g, Scorpio 100g, Scolopendra 100g, Herba Erodii 300g, Caulis Spatholobi 200g, Caulis Sargentodoxae 200g, Rhizoma Pinelliae 100g, Herba Taxilli 200g, Ramulus Mori 150g, Herba Aristolochiae 100g, Caulis Sinomenii 100g, Caulis Trachelospermi 100g, Ramulus Uncariae Cum Uncis 100g, Ramulus Cinnamomi 100g, Cortex Eucommiae 100g, Rhizoma Dioscoreae 600g, Radix Rehmanniae 300g, Radix Scrophulariae 200g, Radix Cynanchi Atrati 100g.
Preparation method:
(a) Radix Astragali, Radix Codonopsis, Herba Erodii, Caulis Spatholobi, Caulis Sargentodoxae, the Rhizoma Pinelliae, Herba Taxilli, Ramulus Mori, Herba Aristolochiae, Caulis Sinomenii, Caulis Trachelospermi, Ramulus Uncariae Cum Uncis, Ramulus Cinnamomi, the Cortex Eucommiae, Rhizoma Dioscoreae, the Radix Rehmanniae, Radix Scrophulariae, Radix Cynanchi Atrati decocts with water 2 times, amount of water is drug weight 9 times for the first time, decoct 2 hours, amount of water is drug weight 5 times for the second time, decoct 1.5 hours, collecting decoction, filter, filtrate is condensed into the thick paste that relative density is 1.16-1.19, add ethanol make containing alcohol amount be 70%, standing 8 hours, filter, 60 ℃ of concentrating under reduced pressure of filtrate reclaim ethanol, then medicine is condensed into thick paste, 60 ℃ of drying under reduced pressure are crossed 100 mesh sieves after pulverizing, be prepared into extract powder,
(b) Pheretima, Hirudo, Scorpio, Scolopendra superfine powder are broken into the drug powder of superfine powder particle size range 5-45 μ m;
(c) drug powder that medicated powder step (a) being obtained and step (b) make mixes, and obtains middle the effective elements of the medicine of the present invention;
(d) effective ingredient xylitol, mannitol and the β～cyclodextrin of step (c) gained, the appropriate granulation agent of binding agent.
Prepare altogether 100 bags, every bag heavy 10g.
Usage and dosage: each 1 bag, every day 3 times, one after each meal.Avoid pungent raw and cold diet.
Embodiment 2
Prescription:
Radix Astragali 550g, Radix Codonopsis 230g, Pheretima 80g, Hirudo 120g, Scorpio 80g, Scolopendra 120g, Herba Erodii 270g, Caulis Spatholobi 230g, Caulis Sargentodoxae 170g, Rhizoma Pinelliae 120g, Herba Taxilli 170g, Ramulus Mori 180g, Herba Aristolochiae 80g, Caulis Sinomenii 120g, Caulis Trachelospermi 80g, Ramulus Uncariae Cum Uncis 120g, Ramulus Cinnamomi 80g, Cortex Eucommiae 120g, Rhizoma Dioscoreae 550g, Radix Rehmanniae 330g, Radix Scrophulariae 170g, Radix Cynanchi Atrati 120g.
Preparation method:
(a) Radix Astragali, Radix Codonopsis, Herba Erodii, Caulis Spatholobi, Caulis Sargentodoxae, the Rhizoma Pinelliae, Herba Taxilli, Ramulus Mori, Herba Aristolochiae, Caulis Sinomenii, Caulis Trachelospermi, Ramulus Uncariae Cum Uncis, Ramulus Cinnamomi, the Cortex Eucommiae, Rhizoma Dioscoreae, the Radix Rehmanniae, Radix Scrophulariae, Radix Cynanchi Atrati decocts with water 2 times, amount of water is drug weight 8 times for the first time, decoct 1.5 hours, amount of water is drug weight 4 times for the second time, decoct 1 hour, collecting decoction, filter, filtrate is condensed into the thick paste that relative density is 1.16-1.19, add ethanol make containing alcohol amount be 70%, standing 8 hours, filter, 60 ℃ of concentrating under reduced pressure of filtrate reclaim ethanol, then medicine is condensed into thick paste, 60 ℃ of drying under reduced pressure are crossed 100 mesh sieves after pulverizing, be prepared into extract powder,
(b) Pheretima, Hirudo, Scorpio, Scolopendra superfine powder are broken into the drug powder of superfine powder particle size range 5-45 μ m;
(c) drug powder that medicated powder step (a) being obtained and step (b) make mixes, and obtains middle the effective elements of the medicine of the present invention;
(d) effective ingredient xylitol, mannitol and the β～cyclodextrin of step (c) gained, the appropriate granulation agent of binding agent.
Prepare altogether 100 bags, every bag heavy 10g.
Usage and dosage: each 1 bag, every day 3 times, one after each meal.Avoid pungent raw and cold diet.
Embodiment 3
Prescription:
Radix Astragali 650g, Radix Codonopsis 170g, Pheretima 120g, Hirudo 80g, Scorpio 120g, Scolopendra 80g, Herba Erodii 330g, Caulis Spatholobi 170g, Caulis Sargentodoxae 230g, Rhizoma Pinelliae 80g, Herba Taxilli 230g, Ramulus Mori 120g, Herba Aristolochiae 120g, Caulis Sinomenii 80g, Caulis Trachelospermi 120g, Ramulus Uncariae Cum Uncis 80g, Ramulus Cinnamomi 120g, Cortex Eucommiae 80g, Rhizoma Dioscoreae 650g, Radix Rehmanniae 270g, Radix Scrophulariae 230g, Radix Cynanchi Atrati 80g.
Preparation method:
(a) Radix Astragali, Radix Codonopsis, Herba Erodii, Caulis Spatholobi, Caulis Sargentodoxae, the Rhizoma Pinelliae, Herba Taxilli, Ramulus Mori, Herba Aristolochiae, Caulis Sinomenii, Caulis Trachelospermi, Ramulus Uncariae Cum Uncis, Ramulus Cinnamomi, the Cortex Eucommiae, Rhizoma Dioscoreae, the Radix Rehmanniae, Radix Scrophulariae, Radix Cynanchi Atrati decocts with water 2 times, amount of water is drug weight 10 times for the first time, decoct 2.5 hours, amount of water is drug weight 6 times for the second time, decoct 1.5 hours, collecting decoction, filter, filtrate is condensed into the thick paste that relative density is 1.16-1.19, add ethanol make containing alcohol amount be 70%, standing 8 hours, filter, 60 ℃ of concentrating under reduced pressure of filtrate reclaim ethanol, then medicine is condensed into thick paste, 60 ℃ of drying under reduced pressure are crossed 100 mesh sieves after pulverizing, be prepared into extract powder,
(b) Pheretima, Hirudo, Scorpio, Scolopendra superfine powder are broken into the drug powder of superfine powder particle size range 5-45 μ m;
(c) drug powder that medicated powder step (a) being obtained and step (b) make mixes, and obtains middle the effective elements of the medicine of the present invention;
(d) effective ingredient xylitol, mannitol and the β～cyclodextrin of step (c) gained, the appropriate granulation agent of binding agent.
(d) effective ingredient xylitol, mannitol and the β～cyclodextrin of step (c) gained, the appropriate granulation agent of binding agent.
Prepare altogether 100 bags, every bag heavy 10g.
Usage and dosage: each 1 bag, every day 3 times, one after each meal.Avoid pungent raw and cold diet.
Embodiment 4
Prescription:
Radix Astragali 500g, Radix Codonopsis 250g, Pheretima 70g, Hirudo 130g, Scorpio 70g, Scolopendra 130g, Herba Erodii 250g, Caulis Spatholobi 250g, Caulis Sargentodoxae 150g, Rhizoma Pinelliae 130g, Herba Taxilli 150g, Ramulus Mori 250g, Herba Aristolochiae 70g, Caulis Sinomenii 130g, Caulis Trachelospermi 70g, Ramulus Uncariae Cum Uncis 130g, Ramulus Cinnamomi 70g, Cortex Eucommiae 70g, Rhizoma Dioscoreae 700g, Radix Rehmanniae 250g, Radix Scrophulariae 250g, Radix Cynanchi Atrati 70g.
Preparation method and usage and dosage are with embodiment 1.
Embodiment 5
Prescription:
Radix Astragali 700g, Radix Codonopsis 150g, Pheretima 130g, Hirudo 70g, Scorpio 130g, Scolopendra 70g, Herba Erodii 350g, Caulis Spatholobi 150g, Caulis Sargentodoxae 250g, Rhizoma Pinelliae 70g, Herba Taxilli 250g, Ramulus Mori 100g, Herba Aristolochiae 130g, Caulis Sinomenii 70g, Caulis Trachelospermi 130g, Ramulus Uncariae Cum Uncis 70g, Ramulus Cinnamomi 130g, Cortex Eucommiae 130g, Rhizoma Dioscoreae 500g, Radix Rehmanniae 350g, Radix Scrophulariae 150g, Radix Cynanchi Atrati 130g.
Preparation method and usage and dosage are with embodiment 1.
Chinese medicine to embodiment 1 preparation has carried out clinical trial, and Details as Follows:
1. clinical data
After selecting the medical diabetes apoplexy of my institute, numb hand and foot patient 60 examples, for clinical observation object, the in the situation that of informed consent, are divided into each 30 examples for the treatment of group and matched group at random.Two groups at sex, age, the course of disease, coincident with severity degree of condition and accompanying diseases etc. relatively, and no significant difference (p>0.05), has comparability.The physical data difference not statistically significants such as two groups of patient ages, sex
2, diagnostic criteria:
Western medicine diagnose standard meets the diagnostic criteria that the 4th the cerebrovascular meeting in the whole nation formulated, and post-stroke left over inclined to one side body numb limbs and tense tendons, with feeling cold, generate heat, be in a cold sweat, the impaired performance of Yi Hanggandeng function of nervous system.Doctor's diagnosis meets State Administration of Traditional Chinese Medicine's encephalopathy emergency case cooperative groups apoplexy in Chinese medicine diagnostic criteria in 1996.Chinese medical discrimination belongs to blood stasis due to qi deficiency, damp-phlegm resistance network type patient.Disease is seen numbness of the skin, or companion's hypalgesia, and extremity are tired heavy, heaviness of the head as if it were tightly bandaged, and loss of appetite, enlarged tongue tongue is greasy in vain, and rolling pulse is slow; Or numbness of the skin, spiritlessness and weakness, the few China of pallor, pale tongue has petechia, white and thin fur, deep-thready pulse or string are puckery.
3. Therapeutic Method
Matched group gives doctor trained in Western medicine conventional therapy, comprises brain protection, improves cerebral circulation, trophic nerve etc., and accompanied with hypertension, diabetes, coronary disease patient give blood pressure lowering, control the processing such as blood glucose and coronary dilating.Ischemic Stroke adds antiplatelet aggregation, anticoagulant therapy.
Treatment group adds Chinese medicine granules of the present invention on matched group basis.Each 1 bag, every day 3 times, one after each meal.Avoid pungent raw and cold diet.It within 7 days, is a course for the treatment of.After 3 courses for the treatment of, observe therapeutic outcome.
4, observation index
4.1.1 health giving quality index patient subjective symptoms, comprises numbness, pain etc., before and after treatment, patient is carried out to symptom and judges each once.
4.1.2 the general health check-up project of safety indexes (body temperature, blood pressure, breathing, pulse), hematuria stool routine, darling renal function inspection etc., with begin a project all before medication and clinical research each checks once after finishing, observe at any time untoward reaction.
4.2 statistical method total datas are all through SPSS10.0 software processes, and measurement data adopts t check, and enumeration data adopts chi-square criterion, and ranked data are checked with Ridit.
5. criterion of therapeutical effect
Criterion of therapeutical effect: the < < traditional Chinese medical science disease Standardization of diagnosis and curative effect > > that the national traditional Chinese medical science pharmacology of reference office promulgates nineteen ninety-five determines.Cure: all paraesthesia symptoms numb and that follow disappear completely, the numbness obstacle of having a medical check-up; Effective: pain and numbness alleviates, simultaneous phenomenon improves or alleviates, and primary symptom is still brought out unhappy emotion or impact life; Invalid: pain and numbness is unchanged, simultaneous phenomenon improves or without improvement.
6, result: the comparison of two groups of patient's curative effects, in Table 1
From table l, treatment group cure rate is 40.0%, and total effective rate is 93.3%: matched group cure rate is 10%, and total effective rate is 13.3%.Treatment group is compared with matched group, and both curative effects have significant difference (P<O.01).Wherein in the routine patient of matched group 30,1 the course for the treatment of healing person be 2 examples, 2 the course for the treatment of healing person reach 6 examples, three courses for the treatment of, healing person reached 12 examples; In the routine patient of matched group 30,1 the course for the treatment of healing person be 0 example, 2 the course for the treatment of healing person reach 1 example, three courses for the treatment of, healing person reached 3 examples.
| Group | Cure | Effectively | Invalid | Cure rate (%) | Total effective rate (%) |
| Treatment group (30) | 12 | 16 | 2 | 40.0** | 93.3** |
| Matched group (30) | 3 | 10 | 17 | 10.0 | 43.3 |
Note: * * and matched group comparison, P<O.01.
4.3 safety indexes are observed two groups of front and back of this clinical observation treatment general health check-up project of patient, the inspection of hematuria stool routine, cardiac inspection etc. and are had no significant change.Viewing duration, two groups there is not serious adverse events during this clinical observation.Through t check, before and after two groups of treatments, hepatic and renal function and routine blood test index of correlation are all without significant difference, and P>O.05, all has no significant effect hepatic and renal function and hemogram during pointing out two groups of medications.
Claims (7)
1. a Chinese medicine for the treatment of numb limbs and tense tendons after diabetes patient's apoplexy, is characterized in that, the raw material of Chinese medicine medicine of following weight portion, consists of:
Radix Astragali 50-70 part, Radix Codonopsis 15-25 part, Pheretima 7-13 part, Hirudo 7-13 part, Scorpio 7-13 part, Scolopendra 7-13 part, Herba Erodii 25-35 part, Caulis Spatholobi 15-25 part, Caulis Sargentodoxae 15-25 part, Rhizoma Pinelliae 7-13 part, Herba Taxilli 15-25 part, Ramulus Mori 10-25 part, Herba Aristolochiae 7-13 part, Caulis Sinomenii 7-13 part, Caulis Trachelospermi 7-13 part, Ramulus Uncariae Cum Uncis 7-13 part, Ramulus Cinnamomi 7-13 part, Cortex Eucommiae 7-13 part, Rhizoma Dioscoreae 50-70 part, Radix Rehmanniae 25-35 part, Radix Scrophulariae 15-25 part, Radix Cynanchi Atrati 7-13 part.
2. the Chinese medicine of numb limbs and tense tendons after treatment according to claim 1 diabetes patient apoplexy, is characterized in that, the raw material of Chinese medicine medicine of following weight portion, consists of:
Radix Astragali 55-65 part, Radix Codonopsis 17-23 part, Pheretima 8-12 part, Hirudo 8-12 part, Scorpio 8-12 part, Scolopendra 8-12 part, Herba Erodii 27-33 part, Caulis Spatholobi 17-23 part, Caulis Sargentodoxae 17-23 part, Rhizoma Pinelliae 8-12 part, Herba Taxilli 17-23 part, Ramulus Mori 12-18 part, Herba Aristolochiae 8-12 part, Caulis Sinomenii 8-12 part, Caulis Trachelospermi 8-12 part, Ramulus Uncariae Cum Uncis 8-12 part, Ramulus Cinnamomi 8-12 part, Cortex Eucommiae 8-12 part, Rhizoma Dioscoreae 55-65 part, Radix Rehmanniae 27-33 part, Radix Scrophulariae 17-23 part, Radix Cynanchi Atrati 8-12 part.
3. the Chinese medicine of numb limbs and tense tendons after treatment according to claim 2 diabetes patient apoplexy, is characterized in that, the raw material of Chinese medicine medicine of following weight portion, consists of:
60 parts of the Radixs Astragali, 20 parts of Radix Codonopsis, 10 parts of Pheretimas, 10 parts of Hirudos, 10 parts of Scorpios, 10 parts of Scolopendras, 30 parts of Herba Erodiis, 20 parts of Caulis Spatholobis, 20 parts of Caulis Sargentodoxae, 10 parts of the Rhizoma Pinelliaes, 20 parts of Herba Taxillis, 15 parts of Ramulus Moris, 10 parts of Herba Aristolochiaes, 10 parts of Caulis Sinomeniis, 10 parts of Caulis Trachelospermis, 10 parts of Ramulus Uncariae Cum Uncis, 10 parts of Ramulus Cinnamomi, 10 parts of the Cortexs Eucommiae, 60 parts of Rhizoma Dioscoreaes, 30 parts, the Radix Rehmanniae, 20 parts of Radix Scrophulariaes, 10 parts of Radix Cynanchi Atratis.
4. according to the Chinese medicine of numb limbs and tense tendons after the treatment diabetes patient apoplexy described in claim 1 or 2 or 3, it is characterized in that, the dosage form of this Chinese medicine is oral formulations.
5. the Chinese medicine of numb limbs and tense tendons after treatment diabetes patient apoplexy according to claim 4, is characterized in that, the dosage form of this Chinese medicine is granule.
6. the preparation method of the Chinese medicine of numb limbs and tense tendons after the treatment diabetes patient apoplexy described in claim 1 or 2 or 3, comprises the steps:
(a) Radix Astragali, Radix Codonopsis, Herba Erodii, Caulis Spatholobi, Caulis Sargentodoxae, the Rhizoma Pinelliae, Herba Taxilli, Ramulus Mori, Herba Aristolochiae, Caulis Sinomenii, Caulis Trachelospermi, Ramulus Uncariae Cum Uncis, Ramulus Cinnamomi, the Cortex Eucommiae, Rhizoma Dioscoreae, the Radix Rehmanniae, Radix Scrophulariae, Radix Cynanchi Atrati decocts with water 2 times, the 8-10 that amount of water is drug weight for the first time doubly, decoct 1.5-2.5 hour, the 4-6 that amount of water is drug weight for the second time doubly, decoct 1-2 hour, collecting decoction, filter, filtrate is condensed into the thick paste that relative density is 1.16-1.19, add ethanol make containing alcohol amount be 70%, standing 8 hours, filter, 60 ℃ of concentrating under reduced pressure of filtrate reclaim ethanol, then medicine is condensed into thick paste, 60 ℃ of drying under reduced pressure are crossed 100 mesh sieves after pulverizing, be prepared into extract powder,
(b) Pheretima, Hirudo, Scorpio, Scolopendra superfine powder are broken into the drug powder of superfine powder particle size range 5-45 μ m;
(c) drug powder that medicated powder step (a) being obtained and step (b) make mixes, and obtains middle the effective elements of the medicine of the present invention;
(d) effective ingredient of step (c) gained adds pharmaceutically acceptable adjuvant to make preparation.
7. the preparation method of the Chinese medicine of numb limbs and tense tendons after treatment according to claim 6 diabetes patient apoplexy, it is characterized in that, in described step (a), amount of water is drug weight 9 times for the first time, decocts 2 hours, amount of water is drug weight 5 times for the second time, decocts 1.5 hours.
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| CN105853508A (en) * | 2016-05-25 | 2016-08-17 | 刘猛 | Traditional Chinese medicine composition for treating cold and cool numbness of hands and feet and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1086429A (en) * | 1993-05-27 | 1994-05-11 | 高齐崧 | The compound method of hard paralysed health |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1086429A (en) * | 1993-05-27 | 1994-05-11 | 高齐崧 | The compound method of hard paralysed health |
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| Title |
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| 曹晓岚等: "心脑同治学说的涵义及临床应用", 《世界中西医结合杂志》 * |
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| CN105853508A (en) * | 2016-05-25 | 2016-08-17 | 刘猛 | Traditional Chinese medicine composition for treating cold and cool numbness of hands and feet and preparation method thereof |
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