CN105477069A - External medical composition for treating tinea pedis - Google Patents

External medical composition for treating tinea pedis Download PDF

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Publication number
CN105477069A
CN105477069A CN201610020206.XA CN201610020206A CN105477069A CN 105477069 A CN105477069 A CN 105477069A CN 201610020206 A CN201610020206 A CN 201610020206A CN 105477069 A CN105477069 A CN 105477069A
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parts
tinea pedis
herba
medical composition
external medical
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潘剑崎
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/52—Juglandaceae (Walnut family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to an external medical composition for treating tinea pedis. The external medical composition is prepared from the raw materials of 5 parts of xanthium sibiricum, 10 parts of eclipta prostrata, 10 parts of sculellaria barbata, 5 parts of campsis grandiflora, 3 parts of flos magnolia, 12 parts of cynanchum paniculatum, 15 parts of centella asiatica, 10 parts of leaves of carya cathayensis, 5 parts of mulberry, 4 parts of platycladus orientalis twigs and leaves, 15 parts of mimosa pudica and 5 parts of incarvilla compacta according to a certain weight ratio. Clinical trials prove that the external medical composition can be used for safely and effectively treating tinea pedis.

Description

A kind of externally-applied medicinal composition for the treatment of tinea pedis
Technical field
The present invention relates to a kind of Chinese medicine, especially relate to a kind of externally-applied medicinal composition for the treatment of tinea pedis.
Background technology
Tinea pedis (being commonly called as beriberi) is a kind of extremely common fungal infection dermatoses.In adult, the people of 70-80% has beriberi, and just weight is different.Be everlasting and increase the weight of summer, winter alleviates, and also has people not heal all the year round.Tinea pedis infectivity, easily recur, clinical manifestation is skin erosion, ulcer, blister sample, pruritus etc., the serious work affecting people and rest.
The pathogenesis of beriberi is: beriberi system is by contagion.Due to the palm, sole of the foot epidermis cell substitute the time long, cutin thickness, sweat gland is many, again without sebaceous gland, and biped often wears footgear, airtight, sweat evaporation difficulty, makes it local temperature high, high humidity, the normal impregnated deliquescing of horny layer, epidermis acid-base value changes, then for conk creates good condition.In addition, Personal hygiene custom is bad, and the footgear of contact patient, glove, shared slippers, towel and bathing pool etc., be then easy to infected.Dermatophytosis is usually through the publilc baths polluted, the floor of edge of pool, bath towel, public slippers, foot basin and infecting.
At present the effective medicine of generally recognized as safe is still lacked at present for tinea pedis.
Involved by external application Chinese medicine of the present invention, the present Research of medical material is as follows:
Fructus Xanthii
[source] this product is the fruit of the drying and ripening band involucre of feverfew Herba Xanthii XanthiumsibiricumPatr..
[function cures mainly] falls apart wind, pain relieving, damp eliminating, parasite killing.
Herba Ecliptae
[source] this product is the dry aerial parts of feverfew Eclipta prostrata EcliptaprostrataL..
[function cures mainly] removing heat from blood, hemostasis, the kidney invigorating, tonifying YIN.
Herba Scutellariae Barbatae
[source] is the herb of labiate Herba Scutellariae Barbatae.
[function cures mainly] heat-clearing and toxic substances removing, blood stasis dispelling diuresis.
Flos Campsis
[source] is the flower of Bignoniaceae plant Radix campsis.
[function cures mainly] clearing away heat and cooling blood; Blood stasis-eliminating and stagnation-dissipating; Dispelling wind for relieving itching.
Flos Magnoliae
The alabastrum that [source] is Magnoliacea plant Flos Magnoliae or Magnolia denudata.
[function cures mainly] dispels the wind, sensible.
Radix Cynanchi Paniculati
[source] this product is asclepiadaceae Cynanchum plant Radix Cynanchi Paniculati Cynanchumpaniculatum(Bge.) the dry root and rhizome of Kitag..
[function cures mainly] dispels the wind removing dampness, antalgesic-antipruritic.
Herba Centellae
[source] this product is samphire Herba Centellae Centellaasiatica(L.) the dry herb of Urb..
[function cures mainly] clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.
Hickory Leaves
[source] medical material Ji Yuan: be the leaf of juglandaceae plant Semen Caryae Cathayensis.
[function cures mainly] heat-clearing and toxic substances removing; Killing parasites for relieving itching.
Fructus Mori
[source] this product is the dry fruit ear of moraceae plants Mulberry MorusalbaL..
[function cures mainly] tonifying liver, kidney tonifying, relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and grows liquid.
Cacumen Platycladi
[source] this product is Cupressaceae plant Cacumen Platycladi Platycladusorientalis(L.) the dry branch tip and leaf of Franco.
[function cures mainly] removing heat from blood, hemostasis, wind-damp dispelling, loose toxic swelling.
Herba Mimosae Pudicae
The herb of [source] pulse family Mimosa plant Herba Mimosae Pudicae MimosapudicaL..
[function cures mainly] removing pathogenic heat from blood and toxic substance from the body; Clearing away heat-damp and promoting diuresis; Tranquillizing and allaying excitement.
Herba Incarvilleae sinensis
[source] this product is the dry herb of Bignoniaceae plant Radix Incarvilleae compactae IncarvillacompactaMaxim..
[function cures mainly] regulating menstruation and activating blood, wind-damp dispelling, antiinflammatory profit ear, beneficial arteries and veins.
Summary of the invention
The present invention aims to provide a kind of externally-applied medicinal composition for the treatment of tinea pedis, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing tinea pedis.
In order to achieve the above object, the present invention is by the following technical solutions:
A kind of externally-applied medicinal composition for the treatment of tinea pedis, it is characterized by, make unguentum by the raw material of following parts by weight: Fructus Xanthii 5 parts, Herba Ecliptae 10 parts, Herba Scutellariae Barbatae 10 parts, Flos Campsis 5 parts, Flos Magnoliae 3 parts, Radix Cynanchi Paniculati 12 parts, Herba Centellae 15 parts, Hickory Leaves 10 parts, 5 parts, Fructus Mori, Cacumen Platycladi 4 parts, Herba Mimosae Pudicae 15 parts, Herba Incarvilleae sinensis 5 parts.
Chinese medicine of the present invention is unguentum, after being cleaned up by each raw material, makes unguentum according to a conventional method, spreads on affected part outward and makes it fully absorb, with afterwash.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
1, physical data
Inventor collects the out-patient of 123 routine tinea pedis altogether between in July ,-2015 in January, 2015, age 23-46 year, the course of disease 2 months-16 months.Be divided at random: treatment group 89 example, blank group 34 example.The two groups of data such as age, state of an illness there was no significant differences, have comparability.
2, diagnostic criteria
Clinical manifestation is play vesicle, decortication or skin whitening between toe to wet soft, and also can occur erosion or pachyderma, coarse, cracking, and can spread to the sufficient sole of the foot and edge, play is itched.Can accompany local suppuration, red and swollen, pain, inguinal lymphadenopathy, even forms the secondary infection such as shank erysipelas and cellulitis.
Medically usually, divide three types by beriberi: erosive type, vesicle, squama keratinization type beriberi.
1. erosive type: be apt to occur between the 3rd and the four, four and five toe.From the beginning of moist between toe, dipping turns white, and after dry desquamation, peels off rotten to the corn face that scurf is moistening, flushing or with breach, oddly itches, easy secondary infection.　
2. vesicle: be apt to occur in sufficient edge, vola portion.From the beginning of being the full phlysis of wall thickness, the be fused into bulla had, bleb liquid is transparent, around without blush.Consciously very to itch, after scratching, often cause erysipelas, lymphangitis etc. because of secondary infection.　
3. squama keratinization type: be apt to occur in heel, sufficient edge.Because fungal infection causes xerosis cutis, cutin slightly thick, desquamation, easily chap.This type is without vesicle and suppuration, and the course of disease is slow, and how not healing, Most patients is transformed by erosive type, vesicle throughout the year.
3, test method
3.1 treatment groups use external-applied ointment of the present invention, are cleaned in affected part and dry, get appropriate ointment uniform application in affected part, and be massaged into ointment and absorb completely and clean, every 8 hours are once, within 5 days, are 1 course for the treatment of, 2 ~ 3 courses for the treatment of of continuous use, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
3.2 blank groups use clean water foot affected part, and every 8 hours once; Within 5 days, be 1 course for the treatment of, continuous 2 ~ 3 courses for the treatment of.
4, criterion of therapeutical effect and therapeutic outcome
4.1 criterion of therapeutical effect
With reference to State Administration of Traditional Chinese Medicine " disease of tcm Standardization of diagnosis and curative effect "
Recovery from illness: clinical symptom disappearance after treatment, vitamin B1 deficiency is fully recovered, and half a year is without recurrence;
Take a turn for the better: clinical symptoms is obviously improved, and vitamin B1 deficiency is progressively recovered;
Invalid: clinical part transference cure or without change, do not reach improvement standard person.
4.2 treatment statistical results are in table 1.
Table 1 liang group comparitive study
Group n Recovery from illness Take a turn for the better Invalid Total effective rate (%) Untoward reaction example
Treatment group 89 31（34.8%） 48（53.9%） 10（11.2%） 88.8% 0
Blank group 34 0（0.0%） 3（8.8%） 31（91.2%） 8.8% 0
For proving that the present invention has good curative effect, enumerate model case as follows:
1, fourth ×, man, 37 years old, patient main suit has suffered from beriberi for many years, has had vesicle, decortication phenomenon, occur rotten to the corn, cracking time serious between toe, and can spread to the sufficient sole of the foot and edge, play is itched, and once uses the beriberi dispelling medicines such as beriberi liquor to have no radical cure, give external application Chinese medicine of the present invention treatment subsequently, after smearing a course for the treatment of, above-mentioned vesicle, decortication symptom obviously take a turn for the better to some extent, continuous with recovering normal after two courses for the treatment of, check display no abnormality seen subsequently, do not recur so far.
2, all ××s, man, 42 years old, main suit suffered from beriberi one year, often feels that between toe, pruritus unbearably, abnormal flavour is had after motion, local horny layer of epidermis is macerated and is turned white, and exposes the rotten to the corn face of cerise, go to local hospital to be diagnosed as tinea pedis by routine examination subsequently after exfoliation, hospital gives and zinci undecylenatis compositum external medication, and symptom is not substantive to some extent to be alleviated.After give external application Chinese medicine of the present invention treatment, after smearing a course for the treatment of, beriberi and tinea pedis phenomenon takes a turn for the better to some extent, and after continuing to smear two courses for the treatment of, state of an illness rehabilitation is complete, and so far without recurring.
3, woods ×, man, 32 years old, patient likes motion, often to motion in summer, abnormal flavour is seriously particularly evident, heel pruritus, once multi-medicament obstinate was used, go to local hospital to be diagnosed as tinea pedis by routine examination subsequently, hospital gives conventional liquid medicine medicine and treats, and symptom is not alleviated to some extent, after give external application Chinese medicine of the present invention treatment, after smearing a course for the treatment of, above-mentioned pruritus, abnormal flavour symptom obviously take a turn for the better to some extent, continue and recover normal after smearing two courses for the treatment of, check display no abnormality seen subsequently, do not recur so far.
Visible, the present invention adopts the formula of science and suitable proportioning, with clearing away heat and expelling wind, dissipating blood stasis for subsidence of swelling, dampness removing to stop itchin, removing toxic substances parasite killing for therapeutic rules, adopts between each medicine and cooperatively interacts, synergism, made external application Chinese medicine medicine can safe and effective treatment tinea pedis.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Specific embodiment 1
Take: Fructus Xanthii 5 grams, Herba Ecliptae 10 grams, Herba Scutellariae Barbatae 10 grams, Flos Campsis 5 grams, Flos Magnoliae 3 grams, Radix Cynanchi Paniculati 12 grams, Herba Centellae 15 grams, Hickory Leaves 10 grams, 5 grams, Fructus Mori, Cacumen Platycladi 4 grams, Herba Mimosae Pudicae 15 grams, Herba Incarvilleae sinensis 5 grams, above-mentioned raw materials is cleaned up, put into lapping apparatus pulverization, make unguentum by Oleum sesami furnishing pasty state or other conventional methods, normal 1 day unguentum consumption must be met.
Usage and dosage: affected part is cleaned and dries, get appropriate ointment uniform application in affected part, and be massaged into ointment and absorb completely and clean, once, be used for the treatment of tinea pedis in every 8 hours.

Claims (1)

1. treat the externally-applied medicinal composition of tinea pedis for one kind, it is characterized by, make unguentum by the raw material of following parts by weight: Fructus Xanthii 5 parts, Herba Ecliptae 10 parts, Herba Scutellariae Barbatae 10 parts, Flos Campsis 5 parts, Flos Magnoliae 3 parts, Radix Cynanchi Paniculati 12 parts, Herba Centellae 15 parts, Hickory Leaves 10 parts, 5 parts, Fructus Mori, Cacumen Platycladi 4 parts, Herba Mimosae Pudicae 15 parts, Herba Incarvilleae sinensis 5 parts.
CN201610020206.XA 2016-01-13 2016-01-13 External medical composition for treating tinea pedis Pending CN105477069A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105998262A (en) * 2016-05-25 2016-10-12 王忠喜 Foot-bath salt with odor-removing and itching-relieving effects and preparation method thereof
CN107496799A (en) * 2017-09-28 2017-12-22 临汾市碧丰霖农业科技开发有限公司 A kind of Chinese medicine for being used to treat athlete's foot

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1282608A (en) * 1999-07-29 2001-02-07 刘常武 Medicine 'Pifuning'- for treating skin disease

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1282608A (en) * 1999-07-29 2001-02-07 刘常武 Medicine 'Pifuning'- for treating skin disease

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105998262A (en) * 2016-05-25 2016-10-12 王忠喜 Foot-bath salt with odor-removing and itching-relieving effects and preparation method thereof
CN107496799A (en) * 2017-09-28 2017-12-22 临汾市碧丰霖农业科技开发有限公司 A kind of Chinese medicine for being used to treat athlete's foot

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Application publication date: 20160413