CN103734472B - Feed additive with motherwort herb extract and preparation method of feed additive - Google Patents
Feed additive with motherwort herb extract and preparation method of feed additive Download PDFInfo
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- CN103734472B CN103734472B CN201310753633.5A CN201310753633A CN103734472B CN 103734472 B CN103734472 B CN 103734472B CN 201310753633 A CN201310753633 A CN 201310753633A CN 103734472 B CN103734472 B CN 103734472B
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Abstract
The invention discloses a feed additive with motherwort herb extract and a preparation method of the feed additive. The feed additive adopts the motherwort herb extract and a carrier as materials; the motherwort herb extract is prepared by adopting ultrasonic-assisted water extraction method. In the preparation process of the feed additive, the material waste is less, the content of active components in the extract is high, the extract yield is high, and the benefit to improving the feed effect and reducing the production cost is achieved; the prepared feed additive has good adjusting function for endless lochia and retained fetal membranes and the like after delivery of female animals.
Description
Technical field
The invention belongs to Chinese herbal feed field, be specifically related to a kind of motherwort herb extract feed additive and preparation method thereof.
Background technology
Along with the raising of the propelling of aquaculture process of industrialization, the popularization of breeding and raise competence, a large amount of uses of antibiotic growth promotion medicine, and the continuous increase of various stress, the diarrhoea that various virus, bacillary and non-bacterial cause, have loose bowels, the symptom such as various respiratory tract disease is increasing.Along with the continuous increase of virus, resistance, the Large-scale intrusion of various bacterium, virus causes the outburst of disease.The blue otopathy generally occurred in China, nameless high-fever, various colpitis, endometritis, postpartum retention of afterbirth, lochiorrhagia, various respiratory tract, sow postpartum is without the level of production and the economic benefit of milk or disease had a strong impact on a lot of plant of China such as milk is few.The threat of plant field is increased day by day.Therefore in order to cater to an urgent demand of following nuisanceless, green, ecological animal husbandry, a kind of effective antibiotic medicine substitute is needed to break this persistent ailment, protection plant interests, protection of the environment.
Motherwort is the dry aerial parts of Labiatae mother wort plant Leonurusheterophyllus Sweet.Beginning of being used as medicine sees Shennong's Herbal, and be classified as top grade, history tree is all on the books.Motherwort has the effects such as promoting blood circulation for regulating menstruation, eliminate blood stasis and promote tissue regeneration, diuresis, detumescence, and be China's conventional Chinese medicine at present, long-term application practice shows that it is safe and effective, has larger Development volue and Research Significance.But, for its value as feed use and the correlative study of effect, have not yet to see report.
Summary of the invention
The object of the invention is to the deficiency overcoming the existence of above-mentioned prior art, a kind of motherwort herb extract feed additive and preparation method thereof is provided.
The object of the invention is to be achieved through the following technical solutions:
First aspect, the present invention relates to a kind of motherwort herb extract feed additive, and described feed addictive is with Leonurus extract and carrier for raw material, and described Leonurus extract adopts the preparation of ultrasonic assistant water extraction and obtains.
Preferably, the weight ratio of described Leonurus extract and carrier is 2 ~ 4: 6 ~ 8.
Preferably, described carrier is one or more in attapulgite, pine needle meal and maltodextrin.
Second aspect, the present invention relates to a kind of preparation method of above-mentioned motherwort herb extract feed additive, described method comprises the steps:
A, by motherwort pretreatment, pulverizing, add ethanolic solution dipping 3 ~ 5h; Add in ultrasonic extractor, ultrasonic extraction 35 ~ 50min under room temperature; Extract and terminate, filter, obtain filtrate and solid residue a; Reduction vaporization removes the ethanol in described filtrate, obtains the first extract;
Add 8 times of water gagings in B, described solid residue a, boil 4 ~ 6h, steam pressure 0.4 ~ 0.7MPa, filter, obtain the second extract and solid residue b;
Add 6 times of water gagings in C, described solid residue b, boil 1 ~ 5h, steam pressure 1.5 ~ 1.7MPa, filter, obtain the 3rd extract and solid residue c;
D, by described first, second and third extract mixing, concentrated, obtain medicinal extract; Medicinal extract enters spray dryer, EAT 180 DEG C, and leaving air temp 70 ~ 90 DEG C, obtains Leonurus extract dry powder;
E, described Leonurus extract dry powder to be mixed with carrier, obtain described motherwort herb extract feed additive.
Preferably, described pretreatment, pulverizing are specially: by the natural drying of motherwort leaf, removal of impurities, 60 DEG C of dry 6h, and pulverizing, crossing aperture is the sieve of 0.5 ~ 0.6mm.Particle diameter is too small, and motherwort powder easily swims in above feed liquid, affects extraction effect; Particle diameter is excessive, and extraction efficiency reduces more.
Preferably, the consumption of described ethanolic solution is: add ethanolic solution 10 ~ 15ml in every gram of motherwort; In described ethanolic solution, the concentration of ethanol is 75wt% ~ 85wt%.The concentration of ethanolic solution and consumption have considerable influence to yield of extract and active component recovery rate, when ethanolic solution consumption is brought up to a certain degree, (concentration is 85wt%, consumption is add 15ml in every gram of motherwort) after, the consumption increasing ethanolic solution again has no significant effect yield of extract of the present invention and active component recovery rate, for the comprehensive consideration of cost and effect, in every gram of motherwort, add ethanolic solution 10 ~ 15ml; In described ethanolic solution, the concentration of ethanol is 75wt% ~ 85wt% is optimised process.
Preferably, during described ultrasonic extraction, supersonic frequency is 110 ~ 120KHz.
Preferably, add acetic acid in step B and regulate water pH value to be 6.5, add saturated NaOH in step C and regulate water pH value to be 8.5.
Preferably, the mixture of the attapulgite of described carrier to be weight ratio be 1: 0.3 ~ 0.5:2 ~ 3, pine needle meal and maltodextrin.
Compared with prior art, the present invention has following beneficial effect:
1, feed addictive of the present invention has good regulatory function to dam prolonged lochia, retention of afterbirth etc.;
2, in feed addictive preparation technology of the present invention, wastage of material is few, active component content is high in extract, yield of extract is high, is conducive to the raising of feed efficiency and the reduction of production cost;
3, natural, noresidue, have no drug resistance, have no side effect.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in detail.Following examples will contribute to those skilled in the art and understand the present invention further, but not limit the present invention in any form.It should be pointed out that to those skilled in the art, without departing from the inventive concept of the premise, some distortion and improvement can also be made.These all belong to protection scope of the present invention.
embodiment 1
The present embodiment relates to a kind of motherwort herb extract feed additive; Its preparation specifically comprises the steps:
Step one, by the natural drying of motherwort leaf, removal of impurities, 60 DEG C of dry 6h, pulverize, cross aperture be the sieve of 0.6mm, add ethanolic solution 12ml according in every gram of motherwort, add 80wt% ethanolic solution dipping 4h; Add in ultrasonic extractor, ultrasonic extraction 45min under the condition of room temperature, 115KHz; Extract and terminate, filter, obtain filtrate and solid residue a; Reduction vaporization removes the ethanol in described filtrate, obtains the first extract;
Add 8 times of water gagings in step 2, described solid residue a, boil 5h, steam pressure 0.5MPa, filter, obtain the second extract and solid residue b;
Add 6 times of water gagings in step 3, described solid residue b, boil 3h, steam pressure 1.6MPa, filter, obtain the 3rd extract and solid residue c;
Step 4, by the mixing of described first, second and third extract, be concentrated into D=0.6 ~ 1.2, obtain medicinal extract; Medicinal extract enters spray dryer, EAT 180 DEG C, and leaving air temp 80 DEG C (can be selected from arbitrary value in 70 ~ 90 DEG C), obtains Leonurus extract dry powder;
Step 5, described Leonurus extract dry powder and carrier (weight ratio be the attapulgite of 1: 0.5: 3, the mixture of pine needle meal and maltodextrin) to be mixed, obtain described motherwort herb extract feed additive; Wherein, the weight ratio of Leonurus extract and carrier is 1: 3.
comparative example 1
This comparative example relates to a kind of motherwort herb extract feed additive; Its preparation specifically comprises the steps:
Step one, by the natural drying of motherwort leaf, removal of impurities, 60 DEG C of dry 6h, pulverize, cross aperture be the sieve of 0.6mm; Loaded by raw material in alcohol extracting tank, add the 80wt% ethanol of 8 times of weight, boil 5 hours, steam pressure is 0.7MPa, alcohol reflux; Filter after first time alcohol extracting, obtain the first filtrate and the first filter residue respectively; Wherein, the first filtrate is by reduced pressure concentration tank recovery ethanol, until the ethanol <60% reclaimed stops reclaiming, the continuation of the first filtrate concentrates to obtain concentrate;
Step 2, the first filter residue add the 80wt% ethanol of 8 times of weight for the second time, boil 5 hours, steam pressure 0.7MPa, alcohol reflux, until the ethanol <60% reclaimed stops reclaiming, filter, obtain the second filtrate and the second filter residue respectively;
Step 3, the second filter residue add 6 times of weight water, boil 3 hours, and steam pressure is 1.4MPa, filter, and obtain the 3rd filtrate and the 3rd filter residue respectively, discard the 3rd filter residue;
Step 4, concentrate, the second filtrate, the 3rd filtrate mixed and is concentrated into D=0.6 ~ 1.2, obtaining medicinal extract; Medicinal extract enters spray dryer, EAT 180 DEG C, and leaving air temp 80 DEG C, obtains Leonurus extract dry powder;
Step 5, Leonurus extract dry powder mix with carrier (weight ratio be the attapulgite of 1: 0.5: 3, the mixture of pine needle meal and maltodextrin), obtain described motherwort herb extract feed additive; Wherein, the weight ratio of Leonurus extract and carrier is 1: 3.
embodiment 2
The object of the present embodiment is to consider the impact on dry cream rate and active component recovery rate of pH value in the water extraction step after ultrasonic extraction.The preparation of the present embodiment is with embodiment 1, and institute's difference is: add acetic acid in step 2 respectively and regulate water pH value to be 5.5,6.0,6.5, adds saturated NaOH respectively and regulates water pH value to be 8.0,8.5,9.0, form 9 experimental group in step 3; The step 2 that experimental group 1 ~ 9 is corresponding in turn to, the pH value of three are respectively 5.5,8.0, and 5.5,8.5,5.5,9.0,6.0,8.0,6.0,8.5,6.0,9.0,6.5,8.0,6.5,8.5,6.5,9.0.
With motherwort medicinal material 100g, contrast test is carried out to the present embodiment, embodiment 1 and comparative example 1; Specific as follows:
Dry cream rate measures: respectively above-mentioned 9 experimental group and the mixing of first, second and third extract of embodiment 1 gained are concentrated into 500ml, measures 20ml and puts in moisture determination instrument and carry out moisture determination, calculate the dry cream rate of extract according to moisture content value.
Motherwort total alkaloid measures: measure according to AAS (China's coastal port annex VB); In each group of concentrate recorded, in total alkaloid content and motherwort raw material, the ratio of total alkaloid content is the TA rate of transform.
Test result is as shown in table 1:
Table 1
From above-mentioned table 1, add acetic acid and regulate water pH value to be 6.5 in step 2, the dry cream rate and the active component recovery rate that add extract when saturated NaOH regulates water pH value to be 8.5 in step 3 are best.
embodiment 3
The present embodiment relates to a kind of motherwort herb extract feed additive; Its preparation is with embodiment 1, and institute's difference is:
Step one, excessively aperture are the sieve of 0.5mm, add ethanolic solution 10ml according in every gram of motherwort, add the ethanolic solution dipping 5h of 85wt%; Ultrasonic extraction 35min under the condition of 110KHz;
Step 2, boil 4h, steam pressure 0.4MPa;
Step 3, boil 5h, steam pressure 1.7MPa.
embodiment 4
The present embodiment relates to a kind of motherwort herb extract feed additive; Its preparation is with embodiment 1, and institute's difference is:
Step one, add ethanolic solution 15ml according in every gram of motherwort, add the ethanolic solution dipping 3h of 75wt%; Ultrasonic extraction 50min under the condition of 120KHz;
Step 2, boil 6h, steam pressure 0.7MPa;
Step 3, boil 1h, steam pressure 1.5MPa.
embodiment 5
The object of the present embodiment is that the selection investigating carrier is on the impact of Leonurus extract feed.Embodiment 1 is led in the preparation of the present embodiment, and institute's difference is: carrier selects attapulgite respectively, pine needle meal, maltodextrin, the pine needle meal of 1: 1 and maltodextrin, and the pine needle meal of 1: 1 and maltodextrin remember into experimental group a, b, c, d, e.
Carry out contrast test in fight pasture, Lou Tang town, Jiading District in Shanghai City to embodiment 1,3,4,5 and comparative example 1, experimental animal adopts and is bred as later stage DLY ternary pigs, and spice eats, and feed per ton adds 600g.Experimental result is as shown in table 2:
Table 2
As shown in Table 2, suitable carrier select can work in coordination with and play the effect of Leonurus extract.Leonurus extract feed of the present invention has better enhancing animal body immunologic function, and the effect of disease-resistant growth-promoting, can reduce the swinery genital diseases incidence of disease, improves survival rate.
Above specific embodiments of the invention are described.It is to be appreciated that the present invention is not limited to above-mentioned particular implementation, those skilled in the art can make various distortion or amendment within the scope of the claims, and this does not affect flesh and blood of the present invention.
Claims (5)
1. the preparation method of a motherwort herb extract feed additive, described feed addictive with Leonurus extract and carrier for raw material, it is characterized in that, described Leonurus extract adopts the preparation of ultrasonic assistant water extraction and obtains, and described preparation method comprises the steps:
A, by motherwort pretreatment, pulverizing, add ethanolic solution dipping 3 ~ 5h; Add in ultrasonic extractor, ultrasonic extraction 35 ~ 50min under room temperature; Extract and terminate, filter, obtain filtrate and solid residue a; Reduction vaporization removes the ethanol in described filtrate, obtains the first extract;
Add 8 times of water gagings in B, described solid residue a, add acetic acid and regulate water pH value to be 6.5, boil 4 ~ 6h, steam pressure 0.4 ~ 0.7MPa, filter, obtain the second extract and solid residue b;
Add 6 times of water gagings in C, described solid residue b, add saturated NaOH and regulate water pH value to be 8.5, boil 1 ~ 5h, steam pressure 1.5 ~ 1.7MPa, filter, obtain the 3rd extract and solid residue c;
D, by described first, second and third extract mixing, concentrated, obtain medicinal extract; Medicinal extract enters spray dryer, EAT 180 DEG C, and leaving air temp 70 ~ 90 DEG C, obtains Leonurus extract dry powder;
E, described Leonurus extract dry powder to be mixed with carrier, obtain described motherwort herb extract feed additive.
2. the preparation method of motherwort herb extract feed additive as claimed in claim 1, is characterized in that, described pretreatment, pulverizing are specially: by the natural drying of motherwort leaf, removal of impurities, 60 DEG C of dry 6h, and pulverizing, crossing aperture is the sieve of 1.0 ~ 1.2mm.
3. the preparation method of motherwort herb extract feed additive as claimed in claim 1, it is characterized in that, the consumption of described ethanolic solution is: add ethanolic solution 10 ~ 15ml in every gram of motherwort; In described ethanolic solution, the concentration of ethanol is 75wt% ~ 85wt%.
4. the preparation method of motherwort herb extract feed additive as claimed in claim 1, it is characterized in that, during described ultrasonic extraction, supersonic frequency is 110 ~ 120KHz.
5. the preparation method of motherwort herb extract feed additive as claimed in claim 1, is characterized in that, the mixture of the attapulgite of described carrier to be weight ratio be 1:0.3 ~ 0.5:2 ~ 3, pine needle meal and maltodextrin.
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| CN106036084A (en) * | 2015-12-31 | 2016-10-26 | 上海朝翔生物技术有限公司 | Plant additive capable of preventing animals from having cracked hoofs and preparation method of plant additive |
| CN108850542A (en) * | 2018-06-19 | 2018-11-23 | 河北农业大学 | It is a kind of for repairing the feed addictive of egg fowl fallopian tubal |
| CN110447746A (en) * | 2019-09-11 | 2019-11-15 | 胡玉涛 | A kind of Poria cocos coffee beverage and its production method |
| CN112753889B (en) * | 2020-12-31 | 2023-05-09 | 内江师范学院 | Motherwort mildew inhibitor, preparation method and application thereof in fish feed |
| CN114504058A (en) * | 2022-03-01 | 2022-05-17 | 吉林省农业科学院 | Efficient composite mildew inhibitor for feed and preparation method thereof |
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| CN101524114A (en) * | 2009-01-19 | 2009-09-09 | 汪鲲 | Egg modified feed additive of plant polysaccharide and flavonoid extracts |
| CN102144708A (en) * | 2010-02-08 | 2011-08-10 | 上海朝翔生物技术有限公司 | Motherwort herb extract feed additive and preparation method thereof |
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