CN103734472A - Feed additive with motherwort herb extract and preparation method of feed additive - Google Patents
Feed additive with motherwort herb extract and preparation method of feed additive Download PDFInfo
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- CN103734472A CN103734472A CN201310753633.5A CN201310753633A CN103734472A CN 103734472 A CN103734472 A CN 103734472A CN 201310753633 A CN201310753633 A CN 201310753633A CN 103734472 A CN103734472 A CN 103734472A
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Abstract
The invention discloses a feed additive with motherwort herb extract and a preparation method of the feed additive. The feed additive adopts the motherwort herb extract and a carrier as materials; the motherwort herb extract is prepared by adopting ultrasonic-assisted water extraction method. In the preparation process of the feed additive, the material waste is less, the content of active components in the extract is high, the extract yield is high, and the benefit to improving the feed effect and reducing the production cost is achieved; the prepared feed additive has good adjusting function for endless lochia and retained fetal membranes and the like after delivery of female animals.
Description
Technical field
The invention belongs to Chinese herbal feed field, be specifically related to a kind of motherwort herb extract feed additive and preparation method thereof.
Background technology
Raising along with the propelling of aquaculture process of industrialization, the popularization of breeding and raise competence, a large amount of uses of antibiotic growth promotion medicine, and the continuous increase of various stress, various virus, the diarrhoea that bacillary and non-bacterial causes, have loose bowels, the symptom such as various respiratory tract disease is increasing.Along with the continuous increase of virus, resistance, the Large-scale intrusion of various bacteriums, virus causes the outburst of disease.The blue otopathy generally occurring in China, nameless high-fever, various colpitis, endometritis, postpartum retention of afterbirth, lochiorrhagia, various respiratory tract, sow postpartum is without milk or the level of production and the economic benefit of disease the had a strong impact on a lot of plants of China such as milk is few.Threat to plant field increases day by day.Therefore in order to cater to an urgent demand of following nuisanceless, green, ecological animal husbandry, need a kind of effective antibiotic medicine substitute to break this persistent ailment, protection plant interests, protection of the environment.
Motherwort is the dry aerial parts of Labiatae mother wort plant Leonurusheterophyllus Sweet.Be used as medicine and begin to see < < Sheng Nong's herbal classic > >, classify as top gradely, successive dynasties book on Chinese herbal medicine is all on the books.Motherwort has the effects such as promoting blood circulation for regulating menstruation, eliminate blood stasis and promote tissue regeneration, diuresis, detumescence, is China's conventional Chinese medicine at present, and long-term application practice shows that it is safe and effective, has larger exploitation value and Research Significance.Yet the value of using as feed for it and the correlative study of effect, have not yet to see report.
Summary of the invention
The object of the invention is to overcome the deficiency that above-mentioned prior art exists, a kind of motherwort herb extract feed additive and preparation method thereof is provided.
The object of the invention is to be achieved through the following technical solutions:
First aspect, the present invention relates to a kind of motherwort herb extract feed additive, and it is raw material that described feed addictive be take Leonurus extract and carrier, described Leonurus extract be adopt the preparation of ultrasonic wave auxiliary water formulation and.
Preferably, the weight ratio of described Leonurus extract and carrier is 2～4: 6～8.
Preferably, described carrier is one or more in attapulgite, pine needle meal and maltodextrin.
Second aspect, the present invention relates to a kind of preparation method of above-mentioned motherwort herb extract feed additive, and described method comprises the steps:
A, by motherwort pretreatment, pulverizing, add ethanolic solution dipping 3～5h; Add in ultrasonic extractor ultrasonic extraction 35～50min under room temperature; Extract and finish, filter, obtain filtrate and solid residue a; Reduction vaporization is removed the ethanol in described filtrate, obtains the first extract;
In B, described solid residue a, add 8 times of water gagings, boil 4～6h, steam pressure 0.4～0.7MPa, filters, and obtains the second extract and solid residue b;
In C, described solid residue b, add 6 times of water gagings, boil 1～5h, steam pressure 1.5～1.7MPa, filters, and obtains the 3rd extract and solid residue c;
D, by described first, second and third extract mix, concentrated, obtain medicinal extract; Medicinal extract enters spray dryer, 180 ℃ of EATs, and 70～90 ℃ of leaving air temps, obtain Leonurus extract dry powder;
E, described Leonurus extract dry powder is mixed with carrier, obtain described motherwort herb extract feed additive.
Preferably, described pretreatment, pulverizing are specially: motherwort leaf is natural drying, removal of impurities, 60 ℃ of dry 6h, pulverize, cross the sieve that aperture is 0.5～0.6mm.Particle diameter is too small, and motherwort powder easily swims in feed liquid top, affects extraction effect; Particle diameter is excessive, and extraction efficiency reduces more.
Preferably, the consumption of described ethanolic solution is: in every gram of motherwort, add ethanolic solution 10～15ml; In described ethanolic solution, the concentration of ethanol is 75wt%～85wt%.The concentration of ethanolic solution and consumption have considerable influence to yield of extract and active component recovery rate, when ethanolic solution consumption is brought up to a certain degree, (concentration is 85wt%, consumption is to add 15ml in every gram of motherwort) afterwards, the consumption that increases again ethanolic solution has no significant effect yield of extract of the present invention and active component recovery rate, for the comprehensive consideration of cost and effect, in every gram of motherwort, add ethanolic solution 10～15ml; In described ethanolic solution, the concentration of ethanol is that 75wt%～85wt% is optimised process.
Preferably, during described ultrasonic extraction, supersonic frequency is 110～120KHz.
Preferably, in step B, adding acetic acid adjusting water pH value is 6.5, and in step C, adding saturated NaOH adjusting water pH value is 8.5.
Preferably, described carrier is that weight ratio is the mixture of attapulgite, pine needle meal and the maltodextrin of 1: 0.3～0.5:2～3.
Compared with prior art, the present invention has following beneficial effect:
1, feed addictive of the present invention has good regulatory function to dam prolonged lochia, retention of afterbirth etc.;
2, in feed addictive preparation technology of the present invention, wastage of material is few, active component content is high in extract, yield of extract is high, is conducive to the raising of feed efficiency and the reduction of production cost;
3, natural, noresidue, have no drug resistance, have no side effect.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is described in detail.Following examples will contribute to those skilled in the art further to understand the present invention, but not limit in any form the present invention.It should be pointed out that to those skilled in the art, without departing from the inventive concept of the premise, can also make some distortion and improvement.These all belong to protection scope of the present invention.
embodiment 1
The present embodiment relates to a kind of motherwort herb extract feed additive; Its preparation specifically comprises the steps:
Step 1, motherwort leaf is natural drying, removal of impurities, 60 ℃ of dry 6h, pulverize, cross the sieve that aperture is 0.6mm, according to adding ethanolic solution 12ml in every gram of motherwort, add the ethanolic solution dipping 4h of 80wt%; Add in ultrasonic extractor ultrasonic extraction 45min under the condition of room temperature, 115KHz; Extract and finish, filter, obtain filtrate and solid residue a; Reduction vaporization is removed the ethanol in described filtrate, obtains the first extract;
In step 2, described solid residue a, add 8 times of water gagings, boil 5h, steam pressure 0.5MPa, filters, and obtains the second extract and solid residue b;
In step 3, described solid residue b, add 6 times of water gagings, boil 3h, steam pressure 1.6MPa, filters, and obtains the 3rd extract and solid residue c;
Step 4, described first, second and third extract is mixed, is concentrated into D=0.6～1.2, obtain medicinal extract; Medicinal extract enters spray dryer, 180 ℃ of EATs, and 80 ℃ of leaving air temps (can be selected from arbitrary value in 70～90 ℃), obtain Leonurus extract dry powder;
Step 5, described Leonurus extract dry powder is mixed with carrier (mixture of the attapulgite that weight ratio is 1: 0.5: 3, pine needle meal and maltodextrin), obtain described motherwort herb extract feed additive; Wherein, the weight ratio of Leonurus extract and carrier is 1: 3.
comparative example 1
This comparative example relates to a kind of motherwort herb extract feed additive; Its preparation specifically comprises the steps:
Step 1, motherwort leaf is natural drying, removal of impurities, 60 ℃ of dry 6h, pulverize, cross the sieve that aperture is 0.6mm; Raw material is packed in alcohol extracting tank, add the 80wt% ethanol of 8 times of weight, boil 5 hours, steam pressure is 0.7MPa, alcohol reflux; After alcohol extracting, filter for the first time, obtain respectively the first filtrate and the first filter residue; Wherein, the first filtrate is passed through reduced pressure concentration tank and is reclaimed ethanol, until the ethanol <60% reclaiming stops reclaiming, the continuation of the first filtrate concentrates to obtain concentrate;
Step 2, the first filter residue add the 80wt% ethanol of 8 times of weight for the second time, boil 5 hours, and steam pressure 0.7MPa, alcohol reflux, until the ethanol <60% reclaiming stops reclaiming, filters, and obtains respectively the second filtrate and the second filter residue;
Step 3, the second filter residue add 6 times of weight water, boil 3 hours, and steam pressure is 1.4MPa, filter, and obtain respectively the 3rd filtrate and the 3rd filter residue, discard the 3rd filter residue;
Step 4, concentrate, the second filtrate, the 3rd filtrate mixed and is concentrated into D=0.6～1.2, obtaining medicinal extract; Medicinal extract enters spray dryer, 180 ℃ of EATs, and 80 ℃ of leaving air temps, obtain Leonurus extract dry powder;
Step 5, Leonurus extract dry powder and mix with carrier (mixture of the attapulgite that weight ratio is 1: 0.5: 3, pine needle meal and maltodextrin), obtain described motherwort herb extract feed additive; Wherein, the weight ratio of Leonurus extract and carrier is 1: 3.
embodiment 2
The object of the present embodiment is to consider the impact of pH value on dry cream rate and active component recovery rate in ultrasonic extraction water extraction step afterwards.The preparation of the present embodiment is with embodiment 1, and institute's difference is: in step 2, adding respectively acetic acid adjusting water pH value is 5.5,6.0,6.5, and in step 3, adding respectively saturated NaOH adjusting water pH value is 8.0,8.5,9.0, forms 9 experimental group; Experimental group 1～9 successively corresponding step 2, three pH value is respectively 5.5,8.0,5.5,8.5,5.5,9.0,6.0,8.0,6.0,8.5,6.0,9.0,6.5,8.0,6.5,8.5,6.5,9.0.
With motherwort medicinal material 100g, the present embodiment, embodiment 1 and comparative example 1 are carried out to contrast test; Specific as follows:
Dry cream rate is measured: respectively will above-mentioned 9 experimental group and first, second and third extract of embodiment 1 gained mix and be concentrated into 500ml, measure 20ml and put in moisture determination instrument and carry out moisture determination, according to the dry cream rate of moisture content value calculating extract.
Motherwort total alkaloid is measured: according to AAS (Chinese pharmacopoeia version appendix VB in 2005), measure; Record respectively to organize in concentrate the ratio of total alkaloid content in total alkaloid content and motherwort raw material be the TA rate of transform.
Test result is as shown in table 1:
Table 1
From above-mentioned table 1, in step 2, adding acetic acid adjusting water pH value is 6.5, adds dry cream rate and active component recovery rate that saturated NaOH adjusting water pH value is 8.5 o'clock extracts best in step 3.
embodiment 3
The present embodiment relates to a kind of motherwort herb extract feed additive; Its preparation is with embodiment 1, and institute's difference is:
Step 1, the sieve that aperture is 0.5mm excessively, according to adding ethanolic solution 10ml in every gram of motherwort, add the ethanolic solution dipping 5h of 85wt%; Ultrasonic extraction 35min under the condition of 110KHz;
Step 2, boil 4h, steam pressure 0.4MPa;
Step 3, boil 5h, steam pressure 1.7MPa.
embodiment 4
The present embodiment relates to a kind of motherwort herb extract feed additive; Its preparation is with embodiment 1, and institute's difference is:
Step 1, according to adding ethanolic solution 15ml in every gram of motherwort, add the ethanolic solution dipping 3h of 75wt%; Ultrasonic extraction 50min under the condition of 120KHz;
Step 2, boil 6h, steam pressure 0.7MPa;
Step 3, boil 1h, steam pressure 1.5MPa.
embodiment 5
The impact of the selection that the object of the present embodiment is to investigate carrier on Leonurus extract feed.The logical embodiment 1 of preparation of the present embodiment, institute's difference is: carrier is selected respectively attapulgite, pine needle meal, maltodextrin, the pine needle meal of 1: 1 and maltodextrin, the pine needle meal of 1: 1 and maltodextrin, remember into experimental group a, b, c, d, e.
In fight pasture, Lou Tang town, Jiading District in Shanghai City, embodiment 1,3,4,5 and comparative example 1 are carried out to contrast test, experimental animal adopts and is bred as later stage DLY ternary pigs, and spice is edible, and feed per ton adds 600g.Experimental result is as shown in table 2:
Table 2
As shown in Table 2, suitable carrier select can work in coordination with performance Leonurus extract effect.Leonurus extract feed of the present invention has better enhancing animal body immunologic function, and the effect of disease-resistant growth-promoting can reduce the swinery genital diseases incidence of disease, improves survival rate.
Above specific embodiments of the invention are described.It will be appreciated that, the present invention is not limited to above-mentioned specific implementations, and those skilled in the art can make various distortion or modification within the scope of the claims, and this does not affect flesh and blood of the present invention.
Claims (9)
1. a motherwort herb extract feed additive, it is raw material that described feed addictive be take Leonurus extract and carrier, it is characterized in that, described Leonurus extract be adopt the preparation of ultrasonic wave auxiliary water formulation and.
2. motherwort herb extract feed additive as claimed in claim 1, is characterized in that, the weight ratio of described Leonurus extract and carrier is 2～4: 6～8.
3. motherwort herb extract feed additive as claimed in claim 1, is characterized in that, described carrier is one or more in attapulgite, pine needle meal and maltodextrin.
4. a preparation method for motherwort herb extract feed additive as claimed in claim 1, is characterized in that, described method comprises the steps:
A, by motherwort pretreatment, pulverizing, add ethanolic solution dipping 3～5h; Add in ultrasonic extractor ultrasonic extraction 35～50min under room temperature; Extract and finish, filter, obtain filtrate and solid residue a; Reduction vaporization is removed the ethanol in described filtrate, obtains the first extract;
In B, described solid residue a, add 8 times of water gagings, boil 4～6h, steam pressure 0.4～0.7MPa, filters, and obtains the second extract and solid residue b;
In C, described solid residue b, add 6 times of water gagings, boil 1～5h, steam pressure 1.5～1.7MPa, filters, and obtains the 3rd extract and solid residue c;
D, by described first, second and third extract mix, concentrated, obtain medicinal extract; Medicinal extract enters spray dryer, 180 ℃ of EATs, and 70～90 ℃ of leaving air temps, obtain Leonurus extract dry powder;
E, described Leonurus extract dry powder is mixed with carrier, obtain described motherwort herb extract feed additive.
5. the preparation method of motherwort herb extract feed additive as claimed in claim 4, is characterized in that, described pretreatment, pulverizing are specially: motherwort leaf is natural drying, removal of impurities, 60 ℃ of dry 6h, pulverize, cross the sieve that aperture is 1.0～1.2mm.
6. the preparation method of motherwort herb extract feed additive as claimed in claim 4, is characterized in that, the consumption of described ethanolic solution is: in every gram of motherwort, add ethanolic solution 10～15ml; In described ethanolic solution, the concentration of ethanol is 75wt%～85wt%.
7. the preparation method of motherwort herb extract feed additive as claimed in claim 4, is characterized in that, during described ultrasonic extraction, supersonic frequency is 110～120KHz.
8. the preparation method of motherwort herb extract feed additive as claimed in claim 4, is characterized in that, in step B, adding acetic acid adjusting water pH value is 6.5, and in step C, adding saturated NaOH adjusting water pH value is 8.5.
9. the preparation method of motherwort herb extract feed additive as claimed in claim 4, is characterized in that, described carrier is that weight ratio is the mixture of attapulgite, pine needle meal and the maltodextrin of 1: 0.3～0.5:2～3.
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| CN106071243A (en) * | 2015-12-31 | 2016-11-09 | 上海朝翔生物技术有限公司 | Prevent plant additive of animal cracked feet and preparation method thereof |
| CN108850542A (en) * | 2018-06-19 | 2018-11-23 | 河北农业大学 | It is a kind of for repairing the feed addictive of egg fowl fallopian tubal |
| CN110447746A (en) * | 2019-09-11 | 2019-11-15 | 胡玉涛 | A kind of Poria cocos coffee beverage and its production method |
| CN112753889A (en) * | 2020-12-31 | 2021-05-07 | 内江师范学院 | Motherwort mildew preventive, preparation method and application in fish feed |
| CN114504058A (en) * | 2022-03-01 | 2022-05-17 | 吉林省农业科学院 | Efficient composite mildew inhibitor for feed and preparation method thereof |
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| CN114504058A (en) * | 2022-03-01 | 2022-05-17 | 吉林省农业科学院 | Efficient composite mildew inhibitor for feed and preparation method thereof |
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