CN1037322C - Dispensation of Chinese herbs oral liquid adjuvant - Google Patents
Dispensation of Chinese herbs oral liquid adjuvant Download PDFInfo
- Publication number
- CN1037322C CN1037322C CN 92114412 CN92114412A CN1037322C CN 1037322 C CN1037322 C CN 1037322C CN 92114412 CN92114412 CN 92114412 CN 92114412 A CN92114412 A CN 92114412A CN 1037322 C CN1037322 C CN 1037322C
- Authority
- CN
- China
- Prior art keywords
- oral liquid
- liquid adjuvant
- beta
- schardinger dextrin
- dispensation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to oral liquid adjuvant of Chinese herbal medicines, which has the functions of antipyresis, detoxication and sedation. The oral liquid adjuvant comprises belta-cyclodextrin, cane sugar, menthol and water as the rest. The present invention has the advantages of good taste and no effect on the stability of main medicines.
Description
The present invention relates to beta-schardinger dextrin-and be used to prepare a kind of Chinese herbal medicine oral liquid QINGKAILING KOUFUYE with heat-clearing and toxic substances removing, calm sedative action.
QINGKAILING, " new medicine and pharmacology magazine " 1975 the 8th, 9 phases have been reported its injection and preparation method thereof, on the basis of injection, stevioside, Mentholum have been added, change oral liquid into, and obtained new drug and produced certification, produce according to ministry standard WS2-23 (X-14)-88.The adjuvant of the QINGKAILING KOUFUYE of applicant's Mingxing Pharmaceutical Factory, Guangzhou employing at present is stevioside 0.36%, Mentholum 0.0132% (weight/volume percent), and surplus is moisture.This oral liquid mouthfeel that this adjuvant prescription is made is poor, and patient is difficult to accept, and bitter, fishy smell weighs, and influential to the quality stability of principal agent.
Purpose of the present invention is exactly poor in order to overcome the made oral liquid mouthfeel of this adjuvant prescription, to the influential shortcoming of the quality stability of principal agent, adopts beta-schardinger dextrin-in QINGKAILING KOUFUYE, makes mouthfeel good, especially increases principal agent quality stability.
The present invention is achieved in that and gets beta-schardinger dextrin-, and sucrose is in the molten water, promptly.
The content of beta-schardinger dextrin-of the present invention can be 0.2～1.0%, sucrose 5～38% (weight/volume percent), and all the other are water.
The present invention can also add 0.005%～0.05% Mentholum.
Embodiment 1, gets 0.5 gram beta-schardinger dextrin-, and 30 gram sucrose add in 100 ml waters.
Embodiment 2, get 0.5 gram beta-schardinger dextrin-, 30 gram sucrose, and 0.01 gram Mentholum adds in 100 ml waters.
Get the oral liquid that oral liquid that embodiment 1, embodiment 2 adjuvants make and supplementary material are made, randomly draw 142 people, carry out the mouthfeel investigation, its statistical result is as follows:
| Sample is imitated the product fruit | Supplementary material lot number 900313-15 | Embodiment 1 lot number 900329-1 | Embodiment 2 lot number 900412-1 | |
| Think that mouthfeel is good, better | Number | 25 | 127 | 128 |
| Percentage ratio (%) | 17.6 | 90.1 | 90.1 | |
| Think that mouthfeel is poor | Number | 117 | 14 | 14 |
| Percentage ratio (%) | 82.4 | 9.9 | 9.9 | |
Each is a collection of to get oral liquid that oral liquid that supplementary material makes and embodiment 1 make, with its main constituent baicalin is testing index, adopt acute destructive testing, according to the Arrhenius formula, measure it and drop to for 90% time, the result shows that the factory of oral liquid above 2 years that embodiment 1 makes is responsible for the phase, and the factory that adopts supplementary material not reach 2 years is responsible for the phase.
| Supplementary material (lot number 880504) | Embodiment 1 (lot number 900404-1) |
| 12 months | 28 months |
Consider that Mentholum is to the quality stability did not influence of principal agent, so do not investigate the stability experiment of embodiment 2 among the embodiment 2.
Beta-schardinger dextrin-of the present invention adds in the QINGKAILING KOUFUYE, makes mouthfeel good, especially increases principal agent quality stability.
Claims (3)
1. beta-schardinger dextrin-is used to prepare QINGKAILING KOUFUYE.
2. beta-schardinger dextrin-according to claim 1 is used to prepare QINGKAILING KOUFUYE, it is characterized in that beta-schardinger dextrin-content in drug solution is 0.2～1.0% weight/volume percent.
3. beta-schardinger dextrin-according to claim 1 is used to prepare QINGKAILING KOUFUYE, it is characterized in that beta-schardinger dextrin-content in drug solution is 0.5% weight/volume percent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92114412 CN1037322C (en) | 1992-12-08 | 1992-12-08 | Dispensation of Chinese herbs oral liquid adjuvant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92114412 CN1037322C (en) | 1992-12-08 | 1992-12-08 | Dispensation of Chinese herbs oral liquid adjuvant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1088113A CN1088113A (en) | 1994-06-22 |
| CN1037322C true CN1037322C (en) | 1998-02-11 |
Family
ID=4946916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 92114412 Expired - Lifetime CN1037322C (en) | 1992-12-08 | 1992-12-08 | Dispensation of Chinese herbs oral liquid adjuvant |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1037322C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1101184C (en) * | 1999-04-12 | 2003-02-12 | 远达药业集团哈尔滨一洲制药有限公司 | Process for preparing medical particles Qingkailing by wrapping chololic acid and animal extract with cyclodextrin |
| CN1939424B (en) * | 2006-09-26 | 2012-05-23 | 河南福森药业有限公司 | Preparation process of Rhizoma corydalis analgetic oral liquid |
-
1992
- 1992-12-08 CN CN 92114412 patent/CN1037322C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1088113A (en) | 1994-06-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C15 | Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993) | ||
| OR01 | Other related matters | ||
| C56 | Change in the name or address of the patentee |
Owner name: GUANGZHOU MINGXING PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME OR ADDRESS: MINGXING PHARMACEUTICAL FACTORY, GUANGZHOU |
|
| CP03 | Change of name, title or address |
Address after: 510250 No. 48 Industrial Avenue, Guangzhou, Guangdong, Henan Patentee after: Guizhou Mingxing Pharmaceutical Co., Ltd. Address before: 510250 No. 48 Industrial Avenue, Guangzhou, Guangdong, Henan Patentee before: Mingxing Pharmaceutical Factory |
|
| ASS | Succession or assignment of patent right |
Owner name: GUANGZHOU BAIYUNSHAN MINGXING PHARMACEUTICAL CO., Free format text: FORMER OWNER: GUANGZHOU MINGXING PHARMACEUTICAL CO., LTD. Effective date: 20060303 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20060303 Address after: 510250 No. 48 Industrial Avenue, Guangzhou, Guangdong, Henan Patentee after: Guangzhou Baiyun Shan Ming Xing Pharmaceutical Co., Ltd. Address before: 510250 No. 48 Industrial Avenue, Guangzhou, Guangdong, Henan Patentee before: Guizhou Mingxing Pharmaceutical Co., Ltd. |
|
| C17 | Cessation of patent right | ||
| CX01 | Expiry of patent term |
Expiration termination date: 20121208 Granted publication date: 19980211 |