CN103720704A - Compound levamisole hydrochloride injection and preparation method thereof - Google Patents
Compound levamisole hydrochloride injection and preparation method thereof Download PDFInfo
- Publication number
- CN103720704A CN103720704A CN201410015570.8A CN201410015570A CN103720704A CN 103720704 A CN103720704 A CN 103720704A CN 201410015570 A CN201410015570 A CN 201410015570A CN 103720704 A CN103720704 A CN 103720704A
- Authority
- CN
- China
- Prior art keywords
- injection
- parts
- levamisole
- hydrochloric acid
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a compound levamisole hydrochloride injection. Every 100 parts by weight of injection contains components in parts by weight: 3-5 parts of levamisole hydrochloride, 4-6 parts of astragalus polysaccharide, 15-20 parts of ethanol, 20-30 parts of propylene glycol, and the balance of water for injection. A preparation method of the compound levamisole hydrochloride injection comprises the following steps: (1) taking a proper amount of water for injection, sequentially adding the levamisole hydrochloride and the astragalus polysaccharide, adding the other substance after one substance is dissolved completely, and stirring to dissolve completely; and (2) sequentially adding the ethanol and the propylene glycol with prescription dosage into the solution obtained in step 1, mixing evenly, adjusting the pH value of the mixed liquor, adding the water for injection into the solution to the prescription dosage, mixing, filtering, sub-packaging, potting and sterilizing at 115-126 DEG C for 25-35 minutes. Due to the combination of traditional Chinese and western medicines, and the joint action of the levamisole hydrochloride and the astragalus polysaccharide, the compound levamisole hydrochloride injection provided by the invention can effectively improve the livestock and poultry immunity, reduce the morbidity, reduce drug residues and improve the quality of livestock and poultry products, and has a special effect on low immunity of livestock and poultry caused by the parasitic disease.
Description
Technical field
The present invention relates to field of veterinary, a kind of compound hydrochloric acid levamisole injection and preparation method thereof is provided.
Background technology
Immunosuppressive disease is the common disease of plant, often causes that growth of animals or poultry is obstructed, vaccine immunity failed, various diseases is concurrent or secondary infection, causes large quantities of poultry dead or superseded, causes huge economic loss.Particularly the poultry such as cattle, sheep, pig, chicken are subject to parasitic infection and cause undergrowth, and efficiency of feed utilization is low, resistance reduces, and cause breeding enterprise economic benefit to reduce.
Levamisole hydrochloride is wide spectrum conventional during veterinary clinic and animal produce, efficient, low toxicity anthelmintic.Research is found, it is except having function for expelling pests, also there is immunoregulation effect, there is the phagocytosis that strengthens segmented cell, macrophage, promote the effect such as synthetic of cytophagous migration, leukocytic chemotaxis, T lymphocyte nucleic acid-protein, propagation, maturation that can Promote immunity cell, strengthen that it is engulfed, Chemotaxis Function, and induction body produces various cytokines; Improve complement activity, enhancing body macrophage function, improves antibody and produces level, can be used for anti-inflammation, antiviral, the inhibition tumor of animal and promotes the aspects such as growth.
Astragalus polysaccharides is the macromolecular compound of Chinese medicine astragalus, has many-sided activity.Research shows that astragalus polysaccharides can strengthen animal anti-stress effect, improves animal immune ability, thereby reaches the resistance against diseases of animal.
The present invention is take astragalus polysaccharides and levamisole hydrochloride as basis, prepare a kind of compound injection, by Chinese medicine and western medicine combination, improve poultry anti-stress effect and immunocompetence, reduce Expectancy, can reduce again the dosage of medicine, reduce drug residue, improve the quality of animal products, for clinical inhibitive ability of immunity epidemic disease provides effectively preventing medicine, the especially immunosuppressive disease of parasite initiation and secondary.
Summary of the invention
The object of the invention is to overcome above-mentioned deficiency provides a kind of compound hydrochloric acid levamisole injection and preparation method thereof, is mainly used in prevention and the treatment of immunosuppressive disease, thereby improves poultry body function.
Object of the present invention is achieved through the following technical solutions:
A kind of compound hydrochloric acid levamisole injection, mainly contains the component of following weight parts: 3 ~ 5 parts of levamisole hydrochlorides, 4 ~ 6 parts of astragalus polysaccharidess in the injection of every 100 parts of weight portions.
Above-mentioned compound hydrochloric acid levamisole injection, also comprises the component of following weight portion: 15 ~ 20 parts of ethanol, 20 ~ 30 parts of propylene glycol, surplus is water for injection.
Above-mentioned compound hydrochloric acid levamisole injection, contains following component: 3 parts of levamisole hydrochlorides, 4 parts of astragalus polysaccharidess, 15 parts of ethanol, 20 parts of propylene glycol, surplus is water for injection in the injection of every 100 parts of weight portions.
Above-mentioned compound hydrochloric acid levamisole injection, the component that contains following weight in every 100 parts of weight portion injection: 4 parts of levamisole hydrochlorides, 5 parts of astragalus polysaccharidess, 17.5 parts of ethanol, 25 parts of propylene glycol, surplus is water for injection.
Above-mentioned compound hydrochloric acid levamisole injection, the component that contains following weight in every 100 parts of weight portion injection: 5 parts of levamisole hydrochlorides, 6 parts of astragalus polysaccharidess, 20 parts of ethanol, 30 parts of propylene glycol, surplus is water for injection.
The preparation method of above-mentioned compound hydrochloric acid levamisole injection, it comprises the following steps:
(1) get appropriate water for injection, add successively levamisole hydrochloride and astragalus polysaccharides, after a kind of substance dissolves is complete, add again another kind of material, be stirred to and dissolve completely, standby;
(2), in the solution of step 1 gained, add successively ethanol and the propylene glycol of recipe quantity, mix homogeneously; With hydrochloric acid solution, adjusting pH of mixed is 3.0-4.0, adds water for injection to recipe quantity in solution, stirs 25-35min, filter, and subpackage, embedding, in 115-126 ℃ of sterilizing 25-30 min, makes compound hydrochloric acid levamisole injection.
The preparation method of above-mentioned compound hydrochloric acid levamisole injection, it is 3.5 left and right that described step 2 is adjusted pH of mixed with hydrochloric acid solution, adds water for injection to recipe quantity in solution, stir 30min, filter subpackage, embedding, makes compound hydrochloric acid levamisole injection in 121 ℃ of sterilizing 30 min.
Advantage of the present invention is Chinese medicine and western medicine combination, and the synergy of levamisole hydrochloride and astragalus polysaccharides can effectively improve immunity of livestock, reduce prevalence, reduce drug residue, improve the quality of animal products, the immunity of livestock that parasitic disease is caused lowly has specially good effect.
The specific embodiment
Below in conjunction with specific embodiment, the inventive method is further elaborated, should be understood that following examples cause restriction to protection scope of the present invention never in any form.
Embodiment 1
The prescription of compound hydrochloric acid levamisole injection is: in every 100 grams of injection, contain following component: levamisole hydrochloride 3g, astragalus polysaccharides 4g, ethanol 15g, propylene glycol 20g, surplus is water for injection.
The preparation method of compound hydrochloric acid levamisole injection is as follows:
(1) get appropriate water for injection, add successively levamisole hydrochloride and astragalus polysaccharides, after a kind of substance dissolves is complete, add again another kind of material, be stirred to and dissolve completely, standby;
(2), in the solution of step 1 gained, add successively ethanol and the propylene glycol of recipe quantity, mix homogeneously; With hydrochloric acid solution, adjusting pH of mixed is 3.5 left and right, injects water to recipe quantity, stirs 30min, filter, and subpackage, embedding, in 121 ℃ of sterilizing 30 min.
Embodiment 2
The prescription of compound hydrochloric acid levamisole injection is: in every 100 grams of injection, contain following component: levamisole hydrochloride 4g, astragalus polysaccharides 5g, ethanol 17.5g, propylene glycol 25g, surplus is water for injection.
The preparation method of compound hydrochloric acid levamisole injection is as example 1.
Embodiment 3
The prescription of compound hydrochloric acid levamisole injection is: in every 100 grams of injection, contain following component: levamisole hydrochloride 5g, astragalus polysaccharides 6g, ethanol 20g, propylene glycol 30g, surplus is water for injection.
The preparation method of compound hydrochloric acid levamisole injection is as example 1.
Embodiment 4
The prescription of compound hydrochloric acid levamisole injection is: in every 100 grams of injection, contain following component: levamisole hydrochloride 3.5g, astragalus polysaccharides 4.2g, ethanol 15.5g, propylene glycol 21g, surplus is water for injection.
The preparation method of compound hydrochloric acid levamisole injection is as follows:
(1) get appropriate water for injection, add successively levamisole hydrochloride and astragalus polysaccharides, after a kind of substance dissolves is complete, add again another kind of material, be stirred to and dissolve completely, standby,
(2), in the solution of step 1 gained, add successively ethanol and the propylene glycol of recipe quantity, mix homogeneously; With hydrochloric acid solution, adjusting pH of mixed is 3.4 left and right, injects water to recipe quantity, stirs 25min, filter, and subpackage, embedding, in 115 ℃ of sterilizing 25 min.
Embodiment 5
The prescription of compound hydrochloric acid levamisole injection is: in every 100 grams of injection, contain following component: levamisole hydrochloride 4.5g, astragalus polysaccharides 5.5g, ethanol 18g, propylene glycol 28g, surplus is water for injection.
The preparation method of compound hydrochloric acid levamisole injection is as follows:
(1) get appropriate water for injection, add successively levamisole hydrochloride and astragalus polysaccharides, after a kind of substance dissolves is complete, add again another kind of material, be stirred to and dissolve completely, standby,
(2), in the solution of step 1 gained, add successively ethanol and the propylene glycol of recipe quantity, mix homogeneously; With hydrochloric acid solution, adjusting pH of mixed is 3.7 left and right, injects water to recipe quantity, stirs 34min, filter, and subpackage, embedding, in 125 ℃ of sterilizing 33 min.
Embodiment 6 clinical practices
1, experimental animal
Choose 60 of ill one-tenth pigs, body weight is at 75 kg ~ 100kg.
2, trial drug
Compound hydrochloric acid levamisole injection, levamisole hydrochloride injection.
3, test method
At random 90 ill one-tenth pigs are divided into 3 groups, wherein first group is blank group, is left intact; Second group is administration matched group, by operation instruction, and the levamisole hydrochloride injection that injection is bought, after 4 days, repeated drug taking is once; The 3rd group is test group, injects medicine compound hydrochloric acid levamisole injection of the present invention, the injection making with embodiments of the invention 3, and dosage is 0.004 g ~ 0.006 g/kg b.w., after 4 days, repeated drug taking is once.Medication was added up therapeutic effect after 7 days.Wherein:
Invalid: refer to after 7 days, ill one-tenth pig symptom is not improved, number of parasites is unchanged or increase.
Effective: refer to after 7 days, ill one-tenth pig symptom has certain improvement, number of parasites reduces or disappears.
Cure: refer to after 7 days, ill one-tenth pig symptom is improved, and number of parasites disappears.
The relative weight gain rate: refer to medicine matched group or the rate of body weight gain of test group to the ill one-tenth of blank group pig after 7 days.
| Numbering | Group | Invalid number | Effective number | Cure a number | The relative weight gain rate |
| 1 | Blank group | / | / | / | / |
| 2 | Medicine matched group | 4 | 26 | 24 | 72.5% |
| 3 | Test group | 1 | 29 | 28 | 83.3% |
Result of the test shows: compound hydrochloric acid levamisole injection of the present invention can effectively be treated the one-tenth pig that suffers from parasitic disease, and effective percentage reaches 96.7%, and cure rate reaches 93.3%, illustrates that Chinese medicine and western medicine is in conjunction with the curative effect that can improve injection.
Claims (7)
1. a compound hydrochloric acid levamisole injection, is characterized in that: the component that mainly contains following weight parts in the injection of every 100 parts of weight portions: 3 ~ 5 parts of levamisole hydrochlorides, 4 ~ 6 parts of astragalus polysaccharidess.
2. compound hydrochloric acid levamisole injection according to claim 1, is characterized in that: the component that also comprises following weight portion: 15 ~ 20 parts of ethanol, 20 ~ 30 parts of propylene glycol, surplus is water for injection.
3. compound hydrochloric acid levamisole injection according to claim 2, it is characterized in that: in the injection of every 100 parts of weight portions, contain following component: 3 parts of levamisole hydrochlorides, 4 parts of astragalus polysaccharidess, 15 parts of ethanol, 20 parts of propylene glycol, surplus is water for injection.
4. compound hydrochloric acid levamisole injection according to claim 2, it is characterized in that: the component that contains following weight in every 100 parts of weight portion injection: 4 parts of levamisole hydrochlorides, 5 parts of astragalus polysaccharidess, 17.5 parts of ethanol, 25 parts of propylene glycol, surplus is water for injection.
5. compound hydrochloric acid levamisole injection according to claim 2, it is characterized in that: the component that contains following weight in every 100 parts of weight portion injection: 5 parts of levamisole hydrochlorides, 6 parts of astragalus polysaccharidess, 20 parts of ethanol, 30 parts of propylene glycol, surplus is water for injection.
6. according to the preparation method of the compound hydrochloric acid levamisole injection described in any one in claim 2-5, it comprises the following steps:
(1) get appropriate water for injection, add successively levamisole hydrochloride and astragalus polysaccharides, after a kind of substance dissolves is complete, add again another kind of material, be stirred to and dissolve completely, standby;
(2), in the solution of step 1 gained, add successively ethanol and the propylene glycol of recipe quantity, mix homogeneously; With hydrochloric acid solution, adjusting pH of mixed is 3.0-4.0, adds water for injection to recipe quantity in solution, stirs 25-35min, filter, and subpackage, embedding, in 115-126 ℃ of sterilizing 25-30 min, makes compound hydrochloric acid levamisole injection.
7. the preparation method of compound hydrochloric acid levamisole injection according to claim 6, it is characterized in that: it is 3.5 left and right that described step 2 hydrochloric acid solution is adjusted pH of mixed, in solution, add water for injection to recipe quantity, stir 30min, filter, subpackage, embedding, makes compound hydrochloric acid levamisole injection in 121 ℃ of sterilizing 30 min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410015570.8A CN103720704A (en) | 2014-01-14 | 2014-01-14 | Compound levamisole hydrochloride injection and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410015570.8A CN103720704A (en) | 2014-01-14 | 2014-01-14 | Compound levamisole hydrochloride injection and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103720704A true CN103720704A (en) | 2014-04-16 |
Family
ID=50445167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410015570.8A Pending CN103720704A (en) | 2014-01-14 | 2014-01-14 | Compound levamisole hydrochloride injection and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103720704A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107432929A (en) * | 2016-05-27 | 2017-12-05 | 华南农业大学 | Animal composite immune reinforcing agent and application and the method for determining the reinforcing agent best composition content |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1850148A (en) * | 2006-05-19 | 2006-10-25 | 天津生机集团有限公司 | Medicine for increasing bird's immunity and treating immunity-inhibiting diseases, and preparing medicine therefor |
| CN101297815A (en) * | 2007-10-31 | 2008-11-05 | 天津生机集团有限公司 | Powder combined with Chinese medicament and western medicament for improving immunity of chicken and preparation thereof |
| CN101612118A (en) * | 2009-07-23 | 2009-12-30 | 天津生机集团股份有限公司 | Porcine compound astragalus polysaccharide injection and preparation method thereof |
-
2014
- 2014-01-14 CN CN201410015570.8A patent/CN103720704A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1850148A (en) * | 2006-05-19 | 2006-10-25 | 天津生机集团有限公司 | Medicine for increasing bird's immunity and treating immunity-inhibiting diseases, and preparing medicine therefor |
| CN101297815A (en) * | 2007-10-31 | 2008-11-05 | 天津生机集团有限公司 | Powder combined with Chinese medicament and western medicament for improving immunity of chicken and preparation thereof |
| CN101612118A (en) * | 2009-07-23 | 2009-12-30 | 天津生机集团股份有限公司 | Porcine compound astragalus polysaccharide injection and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 张云茜: "兽用中药注射剂辅料有哪些", 《北京牧业》, no. 13, 15 July 2008 (2008-07-15), pages 26 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107432929A (en) * | 2016-05-27 | 2017-12-05 | 华南农业大学 | Animal composite immune reinforcing agent and application and the method for determining the reinforcing agent best composition content |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101417018B (en) | Preparation method of animal injection capable of clearing away the heat-evil and expelling superficial evils, cooling blood and relieving dysentery | |
| CN103720704A (en) | Compound levamisole hydrochloride injection and preparation method thereof | |
| CN102920719A (en) | Compound veterinary medicine preparation for treating avian enteritis type colibacillosis | |
| CN101297813B (en) | Compound niacin norfloxacin injection for animals and preparation thereof | |
| CN101642460A (en) | Compound solution of diclazuril for curing avian coccidium infection and preparation method thereof | |
| CN102078598B (en) | Injection for preventing and treating porcine viral diseases and preparation method thereof | |
| CN103432136A (en) | Composition for treating salpingitis of chicken and preparation method of composition | |
| CN101653448B (en) | Veterinary compound terramycin injection and preparation method thereof | |
| CN107174644B (en) | Traditional Chinese medicine composition for treating cad pigs | |
| CN105770603A (en) | Compound traditional Chinese veterinary medicinal granule for treating improper eating induced indigestion of livestock and poultry | |
| CN101297858B (en) | Oral liquid for treating infection by avian viruses mixed with salmonella and preparation | |
| CN102846681A (en) | Medicament for treating livestock diarrhea | |
| CN106491674A (en) | A kind of CHUANXINLIAN ZHUSHEYE containing high-load andrographolide and preparation method thereof | |
| CN101966245B (en) | Compound injection for curing viral diseases in livestock and poultry and preparation method thereof | |
| CN105231053A (en) | Feed nutrition additive | |
| CN107898841B (en) | Medicine for preventing and treating chicken coccidiosis and preparation method and application thereof | |
| KR102258773B1 (en) | An animal feed form with poultry productivity improvement | |
| CN108371139B (en) | Chicken breeding method | |
| CN108261513A (en) | Poultry Chinese medicine composition of getting fat resisting stress and preparation method thereof | |
| CN106689790A (en) | Feed additive for preventing and treating colibacillosis of egg-laying hens | |
| CN105267590A (en) | Natural plant additive for backup breeding boars of Min pig and preparation method | |
| CN106071133A (en) | A kind of feed for goat and preparation method thereof | |
| CN104187139A (en) | Additive of complete feed | |
| CN105192431A (en) | Feed for recovery of female rabbit after delivery | |
| CN104186991A (en) | Lactalbumin feed additive |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20140416 |