CN103705623A - Application of semi-bionic extraction method in eliminating precipitate in liquid traditional Chinese medicinal preparation - Google Patents
Application of semi-bionic extraction method in eliminating precipitate in liquid traditional Chinese medicinal preparation Download PDFInfo
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- CN103705623A CN103705623A CN201310699732.XA CN201310699732A CN103705623A CN 103705623 A CN103705623 A CN 103705623A CN 201310699732 A CN201310699732 A CN 201310699732A CN 103705623 A CN103705623 A CN 103705623A
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Abstract
The invention relates to application of a semi-bionic extraction method in eliminating precipitate in a liquid traditional Chinese medicinal preparation for treating angiitis and a method for preparing the liquid traditional Chinese medicinal preparation for treating angiitis. In the process of preparing the liquid traditional Chinese medicinal preparation, a semi-bionic extraction method is applied, the precipitate in the liquid traditional Chinese medicinal preparation for treating angiitis can be effectively eliminated, and little precipitate occurs in a product, so that the stability of the preparation is improved, the quality is table, and the taking taste is excellent.
Description
Technical field
The invention belongs to field of traditional Chinese, relate to a kind of extracting technique of Chinese medicine, relate in particular to semi-bionic extraction sedimentary application in eliminating the vasculitic liquid preparation of Chinese medicine for the treatment of.
Background technology
Liquid preparation of Chinese medicine is scattered in system because being colloidal state containing small particle, with resting period prolongation and merging gradually, from medium, separates out; Some compositions produces the reactions such as oxidation, polymerization, occurs muddy or precipitates, and mouthfeel when having affected the outward appearance of liquid preparation of Chinese medicine and patient and taking, even lessens the curative effect.Modern preparation process generally takes to add suspending agent or solubilizing agent, prolongation time of repose refilters, with centrifugation, replaces natural sedimentation, adopts ultrafiltration to replace the methods such as filtration.
Semi-bionic extraction is proposed by people such as Zhang Shengwang at home the earliest, that whole medicine organon is combined with molecular medicine organon, from biopharmaceutical angle, simulation oral administration and medicine, through the principle of gastrointestinal tract transhipment, are a kind of new extraction process of the Chinese medicine preparation design through digestive tract administration.Be about to spice and first use the acid extraction of certain pH, continue with the potass extraction of certain pH, extracting solution filters respectively, concentrates, and makes preparation.Because extraction method condition can not be completely identical with people's concrete conditions in the establishment of a specific crime for this reason, only " half is bionical ", therefore claim " semi-bionic extraction ".Semi-bionic extraction can embody the comprehensive function feature of tcm clinical practice medication, meets the principle that oral drugs absorb through gastrointestinal tract transhipment.The extract obtaining is compared with conventional water extract-alcohol precipitation extract, and the composition of acquisition is more complete, better efficacy.
Thromboangiitis obliterans is one of peripheral arterial occlusive disease common type, and this disease disability rate is high, and easily recurrence, has a strong impact on patient's quality of life and work, causes heavy burden to patient family and society.Be used for the treatment of vasculitic liquid preparation of Chinese medicine and storing and often occurring the wild effects such as liquid layered, precipitation, medicinal liquid change color during clinical use, also have user to reflect to take mouthfeel poor, have the deficiencies such as foreign body sensation, affected the compliance of medication.
Summary of the invention
The object of the invention is the technical problem that will solve for above, provide a kind of and can effectively eliminate sedimentary method in the vasculitic liquid preparation of Chinese medicine for the treatment of.
For reaching above object, the present invention is applied to eliminate precipitate in liquid preparation of Chinese medicine by semi-bionic extraction, and described liquid preparation of Chinese medicine is for being used for the treatment of vasculitic liquid preparation of Chinese medicine.
Preferably, the Chinese medicine ingredients in described liquid preparation of Chinese medicine is comprised of following medical material: Millettia Speciosa 2 weight portions, Radix Rehmanniae Preparata 2 weight portions, Radix Angelicae Sinensis 1 weight portion, Radix Achyranthis Bidentatae 1 weight portion, Caulis Spatholobi 2 weight portions, Herba Hedyotidis Diffusae 1 weight portion, Radix Zanthoxyli 1 weight portion, Rhizoma Anemones Raddeanae 1 weight portion.
Wherein, Millettia Speciosa is the root of pulse family Millettia plant beautiful millettia Millettia specisoa Champ., and nature and flavor are sweet, flat.Main effect tonify deficiency lung moistening, strong muscle is active.
Radix Rehmanniae Preparata is that the tuber of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa is concocted and formed through processing, and nature and flavor are sweet, tepor.Return liver, kidney channel.The main effect YIN nourishing of enriching blood, beneficial essence is filled out marrow.
When being classified as the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels., nature and flavor sweet, acrid, warm.Return liver, the heart, spleen channel.Main effect is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Radix Achyranthis Bidentatae is the dry root of amaranthaceous plant Radix Achyranthis Bidentatae Achyranthes bidentata Blume., and nature and flavor are bitter, sour, flat.Return liver, kidney channel.Main effect invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.
Caulis Spatholobi is the dry rattan of leguminous plant spatholobus suberectus (Caulis Sargentodoxae, Radix seu Caulis Verntilaginis Leiocarpae, SANYE Caulis Spatholobi, nine layers of wind) Spatholobus suberectusDunn.Nature and flavor are bitter, sweet, temperature.Return liver, kidney channel.Main effect is enriched blood, invigorates blood circulation, and dredging collateral.
Herba Hedyotidis Diffusae is the herb of Rubiaceae plants of Hedyotis Herba Hedyotidis Diffusae Hedyotis diffusa Willd.Nature and flavor are sweet, light, cool.Return stomach, large intestine, small intestine meridian.Main effect is heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain
Radix Zanthoxyli is root or the branch and leaf of rutaceae Radix Zanthoxyli Zanthoxylum nitidum (Roxb.) DC., and nature and flavor are arduous, and temperature is slightly poisonous.Main effect dispelling wind and removing obstruction in the collateral, removing dampness to relieve pain, subduing swelling and detoxicating.
Rhizoma Anemones Raddeanae is the dry rhizome of ranunculaceae plant anemone raddeana Regel Anemone raddeana Regel.Nature and flavor are pungent, heat; Poisonous.Return spleen channel.Main effect is wind-damp dispelling, subduing inflammation.
The invention also discloses a kind ofly for eliminating treatment vasculitic liquid preparation of Chinese medicine sedimentary method, its step is as follows:
The vasculitic Chinese medicine composition for the treatment of is ground into coarse powder, the water soaking of pH=3.5 that adds 8 times of volumes supersound extraction 1 hour after 0.5 hour, extracting liquid filtering is standby to container; Medicinal residues continue to add the pH=7.0 water of 8 times of volumes, supersound extraction 1 hour, and extracting liquid filtering is standby to container; Medicinal residues continue to add the pH=8.5 water of 8 times of volumes, supersound extraction 1 hour, and extracting liquid filtering is standby to container; Merge the filtrate of extracting for three times; Be evaporated to and contain the concentrated solution that crude drug amount is 0.66g/ml, fill, sterilizing, obtains.
Preferably, described Chinese medicine composition is composed of the following components: Millettia Speciosa 2 weight portions, Radix Rehmanniae Preparata 2 weight portions, Radix Angelicae Sinensis 1 weight portion, Radix Achyranthis Bidentatae 1 weight portion, Caulis Spatholobi 2 weight portions, Herba Hedyotidis Diffusae 1 weight portion, Radix Zanthoxyli 1 weight portion, Rhizoma Anemones Raddeanae 1 weight portion.
The present invention is in preparing the process of liquid preparation of Chinese medicine, applied semi-bionic extraction, effectively eliminated the precipitate being used for the treatment of in vasculitic liquid preparation of Chinese medicine, the less appearance precipitation of product, makes preparation stability raising, steady quality, takes good mouthfeel.
The specific embodiment
Below in conjunction with specific embodiment, technical scheme of the present invention is described in further detail, but protection scope of the present invention is not limited in following examples.
Embodiment 1
By following formula, weigh each component: Millettia Speciosa 12g, Radix Rehmanniae Preparata 12g, Radix Angelicae Sinensis 6g, Radix Achyranthis Bidentatae 6g, Caulis Spatholobi 12g, Herba Hedyotidis Diffusae 6g, Radix Zanthoxyli 6g, Rhizoma Anemones Raddeanae 6g, above-mentioned pulverizing medicinal materials is become to coarse powder, the water soaking of pH=3.5 that adds 8 times of volumes supersound extraction 1 hour after 0.5 hour, extracting liquid filtering is standby to container; Medicinal residues continue to add the pH=7.0 water of 8 times of volumes, supersound extraction 1 hour, and extracting liquid filtering is standby to container; Medicinal residues continue to add the pH=8.5 water of 8 times of volumes, supersound extraction 1 hour, and extracting liquid filtering is standby to container; Merge the filtrate of extracting for three times; Be evaporated to and contain the concentrated solution that crude drug amount is 0.66g/ml, fill, sterilizing, obtains.
Adopt the technique of embodiment 1, prepared altogether 3 batches.
Reference examples
Water decocting preparation technique routinely, the pulverizing medicinal materials of separately getting the formula ratio in embodiment 1 becomes coarse powder, adds appropriate water boiling and extraction 3 times, each 1.5 hours, merge 3 times extracting solution, filter the concentrated solution that it is 0.66g/ml that filtrate decompression is concentrated into containing crude drug amount, fill, sterilizing, obtains.3 batches have been prepared altogether.
Stability test
The liquid preparation of Chinese medicine of above each batch being placed 6 months under normal temperature condition, respectively randomly drawed 20 bottles and observe precipitation situation, there is the bottle number of precipitation in record, and its result is as following table.
Result shows: adopt mixture prepared by half bionic artistic can greatly reduce the phenomenon that occurs precipitation, thereby mouthfeel is taken in stability and the improvement that can improve preparation.
The test of pesticide effectiveness
According to clarifying a diagnosis about the diagnostic criteria of superficial thrombophlebitis in < < peripheral vascular disease Chinese and western medicine diagnostics > >.Outpatient service and inpatient be totally 167 examples, extremity superficial thrombophlebitis 94 examples wherein, and migration superficial thrombophlebitis 31 examples, breast stomach wall superficial thrombophlebitis 42 examples, minimum 20 years old of age, maximum 74 years old, male 95 examples, female's 72 examples, the shortest 1d of the course of disease, the longest 3 years.Acute stage (vein scleroma or be streak, around red and swollen heat pain) 122 examples, chronic phase (vein scleroma or be streak, without obvious tenderness, local skin is left over pigmentation) 45 examples.Be divided at random two groups.Treatment group 88 examples wherein, matched group 79 examples, between two groups, the physical data such as age, the course of disease, the state of an illness is through check no significant difference.
Therapeutic Method
Matched group: acute stage is given oral aspirin, antibiotics, nonsteroidal antiinflammatory drug, vitamin C, compound recipe bromelain sheet etc., and chronic phase is given In Rutin Compound Tablets, Radix Notoginseng total glucosides tablet etc.
Treatment group: add on the basis of matched group and use embodiment 1 gained liquid preparation of Chinese medicine oral, each 50ml, every day 2 times; 15d is 1 course for the treatment of, after the 5d of interval, carries out the next course for the treatment of.
Criterion of therapeutical effect is formulated with reference to < < peripheral vascular disease Chinese and western medicine diagnostics > >.Recovery from illness: local red and swollen heat pain and firmly rope bar disappear, and non-pigment is calm, it is normal that body temperature and leukocyte recover, nothing recurrence in 1 year; Effective: the disappearance of swelling and ache, rope bar does not absorb completely, has pigmentation, nothing recurrence in half a year; Effective: swell and ache and alleviate, have tenderness, rope bar exists, without dwindling; Invalid: above symptom and sign is without change, or outbreak repeatedly.Therapeutic outcome is in Table 1.
Curative effect comparison after each group treatment of table 1
Through check, in each course of disease group, treatment group and matched group are through X 2 test, and V2 value is respectively 9.08,9.01,8.06, equal P<0.05, and treatment group and matched group have difference.In each course of disease group, treatment group curative effect is better than matched group, and the course of disease is shorter, and curative effect is better.Treatment group total effective rate 95.45%, matched group total effective rate 74.68%.
Visible, the effects such as vasculitic liquid preparation of Chinese medicine can play antibacterial bacteriostatic, suppresses thrombosis and extension, thrombus, anticoagulant, expander that are used for the treatment of of prepared in accordance with the method for the present invention, to vasculitic clinical efficacy better and without hemorrhage fraud.
Claims (4)
1. semi-bionic extraction sedimentary application in eliminating liquid preparation of Chinese medicine, described liquid preparation of Chinese medicine is for being used for the treatment of vasculitic liquid preparation of Chinese medicine.
2. application according to claim 1, the Chinese medicine ingredients in described liquid preparation of Chinese medicine is comprised of following medical material: Millettia Speciosa 2 weight portions, Radix Rehmanniae Preparata 2 weight portions, Radix Angelicae Sinensis 1 weight portion, Radix Achyranthis Bidentatae 1 weight portion, Caulis Spatholobi 2 weight portions, Herba Hedyotidis Diffusae 1 weight portion, Radix Zanthoxyli 1 weight portion, Rhizoma Anemones Raddeanae 1 weight portion.
3. for eliminating the sedimentary method of the vasculitic liquid preparation of Chinese medicine for the treatment of, its step is as follows:
The vasculitic Chinese medicine composition for the treatment of is ground into coarse powder, the water soaking of pH=3.5 that adds 8 times of volumes supersound extraction 1 hour after 0.5 hour, extracting liquid filtering is standby to container; Medicinal residues continue to add the pH=7.0 water of 8 times of volumes, supersound extraction 1 hour, and extracting liquid filtering is standby to container; Medicinal residues continue to add the pH=8.5 water of 8 times of volumes, supersound extraction 1 hour, and extracting liquid filtering is standby to container; Merge the filtrate of extracting for three times; Be evaporated to and contain the concentrated solution that crude drug amount is 0.66g/ml, fill, sterilizing, obtains.
4. method according to claim 3, described Chinese medicine composition is composed of the following components: Millettia Speciosa 2 weight portions, Radix Rehmanniae Preparata 2 weight portions, Radix Angelicae Sinensis 1 weight portion, Radix Achyranthis Bidentatae 1 weight portion, Caulis Spatholobi 2 weight portions, Herba Hedyotidis Diffusae 1 weight portion, Radix Zanthoxyli 1 weight portion, Rhizoma Anemones Raddeanae 1 weight portion.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106266343A (en) * | 2016-08-31 | 2017-01-04 | 山东沃华医药科技股份有限公司 | A kind of preparation method of dispersing brain blood |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1122243A (en) * | 1995-08-16 | 1996-05-15 | 岳泰出 | Medicinal powder for eliminating embolism and invigorating blood circulation |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1122243A (en) * | 1995-08-16 | 1996-05-15 | 岳泰出 | Medicinal powder for eliminating embolism and invigorating blood circulation |
Non-Patent Citations (5)
| Title |
|---|
| 仲晓宁: "白头翁汤方药半仿生提取法的实验研究", 《中国硕士论文全文数据库》, 15 September 2009 (2009-09-15), pages 16 * |
| 广州市中医医院脉管炎病区: "血管闭塞性脉管炎疼痛的原因及处理", 《新医药通讯1976年第6期》, 31 December 1976 (1976-12-31), pages 8 - 10 * |
| 张兆旺，等: ""半仿生提取法"的特点与应用", 《世界科学技术-中药现代化》, vol. 2, no. 1, 28 February 2000 (2000-02-28), pages 35 - 38 * |
| 李顺宁: "脉复生对动脉硬化闭塞症患者血脂及炎症细胞因子的影响", 《中国优秀硕士学位论文全文数据库（医药卫生科技辑）》, 31 October 2011 (2011-10-31), pages 10 * |
| 蔡延渠，等: "新型提取联用技术在中药提取中的应用进展", 《中成药》, vol. 33, no. 5, 31 May 2011 (2011-05-31), pages 863 - 866 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106266343A (en) * | 2016-08-31 | 2017-01-04 | 山东沃华医药科技股份有限公司 | A kind of preparation method of dispersing brain blood |
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