CN103702692B - 用于具有得自植物结构转化的分层组织结构的“承重”骨替代物的植入体 - Google Patents
用于具有得自植物结构转化的分层组织结构的“承重”骨替代物的植入体 Download PDFInfo
- Publication number
- CN103702692B CN103702692B CN201180064219.2A CN201180064219A CN103702692B CN 103702692 B CN103702692 B CN 103702692B CN 201180064219 A CN201180064219 A CN 201180064219A CN 103702692 B CN103702692 B CN 103702692B
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- China
- Prior art keywords
- shell
- bone
- bone substitute
- hydroxyapatite
- timber
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/501—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/10—Ceramics or glasses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ceramic Engineering (AREA)
- Materials Engineering (AREA)
- Composite Materials (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Cultivation Of Plants (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Abstract
Description
Claims (21)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI2010A002070 | 2010-11-08 | ||
IT002070A ITMI20102070A1 (it) | 2010-11-08 | 2010-11-08 | Impianti per sostituzioni ossee "load bearing" ad architettura gerarchicamente organizzata derivante dalla trasformazione di strutture vegetali |
PCT/IB2011/054980 WO2012063201A1 (en) | 2010-11-08 | 2011-11-08 | The present invention relates to a bone substitute comprising a core based on hydroxyapatite (ha), obtained from at least one porous wood, or based on collagen fibres and hydroxyapatite, and a shell, based on hydroxyapatite (ha) or silicon carbide (sic), obtained from at least one wood having a lower porosity than the at least one wood of the core. the porous wood has a total porosity of between 60% and 95%, preferably between 65% and 85%, and it is selected from amongst the choices of rattan, pine, abachi and balsa wood. the wood of the shell has a porosity of between 20% and 60%, preferably between 30% and 50%. the bone substitute is utilized for the substitution and regeneration of bone, preferably for bones subjected to mechanical loads, such as long bones of the leg and arm, preferably the tibia, metatarsus, femur, humerus or radius. |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103702692A CN103702692A (zh) | 2014-04-02 |
CN103702692B true CN103702692B (zh) | 2015-11-25 |
Family
ID=43742685
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201180064219.2A Active CN103702692B (zh) | 2010-11-08 | 2011-11-08 | 用于具有得自植物结构转化的分层组织结构的“承重”骨替代物的植入体 |
Country Status (16)
Country | Link |
---|---|
US (1) | US9326948B2 (zh) |
EP (1) | EP2637709B1 (zh) |
CN (1) | CN103702692B (zh) |
AU (1) | AU2011328893B2 (zh) |
CA (1) | CA2830483C (zh) |
DK (1) | DK2637709T3 (zh) |
ES (1) | ES2539703T3 (zh) |
HK (1) | HK1196786A1 (zh) |
HU (1) | HUE026305T2 (zh) |
IT (1) | ITMI20102070A1 (zh) |
PL (1) | PL2637709T3 (zh) |
PT (1) | PT2637709E (zh) |
RU (1) | RU2585958C2 (zh) |
SI (1) | SI2637709T1 (zh) |
SM (1) | SMT201500151B (zh) |
WO (1) | WO2012063201A1 (zh) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2750605C (en) | 2009-01-23 | 2019-01-22 | Royal College Of Surgeons In Ireland | Layered scaffold suitable for osteochondral repair |
TWI517866B (zh) * | 2012-11-05 | 2016-01-21 | Far Eastern New Century Corp | Porous bone filling material |
CN103170011B (zh) * | 2013-04-10 | 2014-06-18 | 浙江大学 | 一种生物陶瓷原位包覆的镁人工骨及其制备方法 |
CN103961742A (zh) * | 2014-05-14 | 2014-08-06 | 常州大学 | 含有益离子的磷酸钙多孔支架的制备方法 |
US10290234B2 (en) * | 2015-01-19 | 2019-05-14 | Ammolite Biomodels Inc. | Simulated bone materials and methods of making same |
ITUB20152939A1 (it) * | 2015-08-06 | 2017-02-06 | Consiglio Nazionale Ricerche | Processo per produrre grandi scaffold porosi in 3D realizzati in idrossiapatite attiva ottenuta tramite trasformazione biomorfica di strutture naturali? |
ITUB20152962A1 (it) * | 2015-08-06 | 2017-02-06 | Consiglio Nazionale Ricerche | Grandi scaffold porosi in 3D realizzati in idrossiapatite attiva ottenuta tramite trasformazione biomorfica di strutture naturali |
UA125283C2 (uk) | 2015-08-06 | 2022-02-16 | Ґрінбоун Орто С.Р.Л. | Великі пористі тривимірні каркасні структури, отримані з активного гідроксіапатиту шляхом біоморфного перетворення природних структур та процес їх отримання |
CN105536072B (zh) * | 2015-10-22 | 2018-06-12 | 上海纳米技术及应用国家工程研究中心有限公司 | 一种锶、铁掺杂羟基磷灰石胶原纤维复合支架材料及制备方法 |
KR101981704B1 (ko) * | 2017-05-31 | 2019-05-24 | 한국생산기술연구원 | 동결 주조법을 이용한 다공성 세라믹 지지체 제조방법 및 이에 의해 제조된 다공성 세라믹 지지체 |
US20200368027A1 (en) | 2018-01-02 | 2020-11-26 | Cartiheal (2009) Ltd. | Implantation Tool and Protocol for Optimized Solid Substrates Promoting Cell and Tissue Growth |
CN111249523B (zh) * | 2020-03-10 | 2021-07-13 | 四川大学 | 仿骨复合材料支架及其制备方法 |
CN112402695B (zh) * | 2020-11-27 | 2022-09-20 | 南方科技大学 | 一种取向结构的原位矿化仿生骨水凝胶复合材料及其制备方法和应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1447104A1 (en) * | 2003-02-05 | 2004-08-18 | Consiglio Nazionale Delle Ricerche | Process to synthetize artificial bone tissue, artificial bone tissue obtained by such a process and use thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5522894A (en) * | 1984-12-14 | 1996-06-04 | Draenert; Klaus | Bone replacement material made of absorbable beads |
IT1318663B1 (it) | 2000-08-02 | 2003-08-27 | Mediolanum Farmaceutici Srl | Membrane di collagene a due facce di cui una organizzata a livellomacromolecolare. |
ES2187371B1 (es) | 2001-10-11 | 2004-09-16 | Universidad De Sevilla | Procedimiento para la fabricacion de ceramicas de carburo de silicio a partir de precursores vegetales. |
EP1642599B1 (en) * | 2003-05-26 | 2010-12-01 | HOYA Corporation | Porous composite containing calcium phosphate and process for producing the same |
ITMI20050343A1 (it) | 2005-03-04 | 2006-09-05 | Fin Ceramica Faenza S R L | Sostituto cartilagineo e osteocindrale comprendente una struttura multistrato e relativo impiego |
ITMI20051966A1 (it) * | 2005-10-18 | 2007-04-19 | C N R Consiglio Naz Delle Ri C | Una idrossiapatite plurisostituita ed il relativo composito con un polimero naturale e-o sintetico loro preparazione e usi |
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2010
- 2010-11-08 IT IT002070A patent/ITMI20102070A1/it unknown
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2011
- 2011-11-08 HU HUE11794855A patent/HUE026305T2/en unknown
- 2011-11-08 CA CA2830483A patent/CA2830483C/en active Active
- 2011-11-08 AU AU2011328893A patent/AU2011328893B2/en active Active
- 2011-11-08 RU RU2013127019/15A patent/RU2585958C2/ru active
- 2011-11-08 WO PCT/IB2011/054980 patent/WO2012063201A1/en active Application Filing
- 2011-11-08 PL PL11794855T patent/PL2637709T3/pl unknown
- 2011-11-08 EP EP11794855.4A patent/EP2637709B1/en active Active
- 2011-11-08 ES ES11794855.4T patent/ES2539703T3/es active Active
- 2011-11-08 SI SI201130501T patent/SI2637709T1/sl unknown
- 2011-11-08 US US13/884,123 patent/US9326948B2/en active Active
- 2011-11-08 CN CN201180064219.2A patent/CN103702692B/zh active Active
- 2011-11-08 DK DK11794855.4T patent/DK2637709T3/en active
- 2011-11-08 PT PT117948554T patent/PT2637709E/pt unknown
-
2014
- 2014-10-09 HK HK14109864.8A patent/HK1196786A1/zh unknown
-
2015
- 2015-06-26 SM SM201500151T patent/SMT201500151B/xx unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1447104A1 (en) * | 2003-02-05 | 2004-08-18 | Consiglio Nazionale Delle Ricerche | Process to synthetize artificial bone tissue, artificial bone tissue obtained by such a process and use thereof |
Non-Patent Citations (2)
Title |
---|
Biomorphous porous hydroxyapatite-ceramics from rattan (Calamus Rotang);Christiane Eichenseer等;《Journal of Materials Science》;20090823;第21卷(第1期);第131页左栏第1段至133页左栏第2段 * |
From wood to bone: multi-step process to convert wood hierarchical structures into biomimetic hydroxyapatite scaffolds for bone tissue engineering;Anna Tampieri等;《Journal of Materials Chemistry》;20090615;第19卷;第4973页左栏第1段至第4974页左栏末段 * |
Also Published As
Publication number | Publication date |
---|---|
AU2011328893B2 (en) | 2016-04-14 |
DK2637709T3 (en) | 2015-07-13 |
AU2011328893A1 (en) | 2013-07-04 |
WO2012063201A8 (en) | 2013-07-04 |
WO2012063201A1 (en) | 2012-05-18 |
US9326948B2 (en) | 2016-05-03 |
EP2637709A1 (en) | 2013-09-18 |
HUE026305T2 (en) | 2016-06-28 |
CA2830483A1 (en) | 2012-05-18 |
CA2830483C (en) | 2019-04-02 |
EP2637709B1 (en) | 2015-04-08 |
SMT201500151B (it) | 2015-09-07 |
RU2013127019A (ru) | 2014-12-20 |
PL2637709T3 (pl) | 2015-10-30 |
RU2585958C2 (ru) | 2016-06-10 |
ITMI20102070A1 (it) | 2012-05-09 |
US20140134258A1 (en) | 2014-05-15 |
ES2539703T3 (es) | 2015-07-03 |
SI2637709T1 (sl) | 2015-08-31 |
HK1196786A1 (zh) | 2014-12-24 |
CN103702692A (zh) | 2014-04-02 |
PT2637709E (pt) | 2015-07-28 |
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Effective date of registration: 20201211 Address after: Italy Ravenna Patentee after: Green bone osser Ltd. Address before: Rome Italy Patentee before: CONSIGLIO NAZIONALE DELLE RICERCHE |
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