CN103690788B - A kind of Chinese medicine composition for the treatment of acute radiodermatitis - Google Patents
A kind of Chinese medicine composition for the treatment of acute radiodermatitis Download PDFInfo
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- CN103690788B CN103690788B CN201310722825.XA CN201310722825A CN103690788B CN 103690788 B CN103690788 B CN 103690788B CN 201310722825 A CN201310722825 A CN 201310722825A CN 103690788 B CN103690788 B CN 103690788B
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Abstract
The invention discloses a kind of Chinese medicine composition for the treatment of acute radiodermatitis.Theory of Chinese medical science thinks that its property of lonizing radiation belongs to heat, easy damaged human body, and radiodermatitis is that pyretic toxicity crosses Sheng, and fire-toxin accumulates and steams in skin, caused by the corruption of intenseness of heat meat.The present invention select there is clearing heat, detoxicating, dispelling dampness, removing heat from blood nourishes blood, the Chinese medicine Herba Crotalariae Ferrugineae of removing the necrotic tissue and promoting granulation, Herba Artemisiae Scopariae, Herba Stellariae Saxatilis, Cortex Alni Lanatae, Rhizoma Tupistrae Chinensis, Herba abutili indici, Fructus seu semen ulmi pumilae, Caulis Polygoni Multiflori, Herba Linderniae anagallis, Herba Cleisostomatis scolopendrifolii, Herb Polygoni Chinensis, Herba Lysimachiae Circaeoidis, decoction is made by I institute Drug Manufacturing Room, through clinical trial, total effective rate reaches 97.1%, obviously be better than 76.5% of matched group, evident in efficacy.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition for the treatment of acute radiodermatitis.
Background technology
Radiodermatitis (radiodermatitis) is because lonizing radiation (mainly β and gamma-rays and x-ray) irradiate the mucocutaneous inflammatory injury caused.Primary disease is mainly seen in the radiocurable patient of acceptance and is engaged in radiation work and protects tight person.Acute radiodermatitis often causes due to the heavy dose of radiation exposure of one or many, even if but sensitive subjects dosage is not very big also can fall ill.This disease of western medical treatment takes antibiotic or corticosteroid hormone as the case may be, and therapeutic effect is general, and has certain side effect.Radiotherapy is interrupted and treatment time prolongation can reduce therapeutic effect again.Chinese medicine prevention acute radiodermatitis not only curative effect certainly, to have no side effect but also cheap, for raising body toleration, reduce the incidence rate of radiodermatitis, alleviating pain, there is significant curative effect wound healing aspect.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of acute radiodermatitis.Theory of Chinese medical science thinks that its property of lonizing radiation belongs to heat, easy damaged human body, and radiodermatitis is that pyretic toxicity crosses Sheng, and fire-toxin accumulates and steams in skin, caused by the corruption of intenseness of heat meat, thus produces the symptom such as desquamation, ulcer, belongs to " eczema ", " herpes simplex " of the traditional Chinese medical science.Treatment on should select there is clearing heat, detoxicating, dispelling dampness, removing heat from blood nourishes blood, the medicine of removing the necrotic tissue and promoting granulation effect.
The object of the invention is to be achieved through the following technical solutions, the Chinese medicine composition of this treatment acute radiodermatitis is made up of the Chinese medicine of following weight portion: Herba Crotalariae Ferrugineae 25-50 part, Herba Artemisiae Scopariae 15-25 part, Herba Stellariae Saxatilis 10-15 part, Cortex Alni Lanatae 12-16 part, Rhizoma Tupistrae Chinensis 13-15 part, Herba abutili indici 50-60 part, Fructus seu semen ulmi pumilae 7-15 part, Caulis Polygoni Multiflori 15-20 part, Herba Linderniae anagallis 15-25 part, Herba Cleisostomatis scolopendrifolii 25-35 part, Herb Polygoni Chinensis 15-30 part, Herba Lysimachiae Circaeoidis 5-9 part.
Preferred: Herba Crotalariae Ferrugineae 35 parts, Herba Artemisiae Scopariae 20 parts, Herba Stellariae Saxatilis 12 parts, Cortex Alni Lanatae 14. parts, Rhizoma Tupistrae Chinensis 14 parts, Herba abutili indici 55 parts, Fructus seu semen ulmi pumilae 10 parts, Caulis Polygoni Multiflori 17 parts, Herba Linderniae anagallis 20 parts, Herba Cleisostomatis scolopendrifolii 30 parts, Herb Polygoni Chinensis 20 parts, 7 parts, Herba Lysimachiae Circaeoidis.
Above-mentioned Chinese medicine decocting is made decoction by preparation method.
Fang Zhong: Herba Crotalariae Ferrugineae, Herba Artemisiae Scopariae clearing heat, purging intense-heat; Cortex Alni Lanatae, Herba Stellariae Saxatilis liver heat removing relieve dizziness, high fever, infantile convulsions, epilepsy, etc., and suppressing the hyperactive liver relieves inflammation or internal heat; Rhizoma Tupistrae Chinensis nourishing YIN to lower pathogenic fire; Herba abutili indici, Fructus seu semen ulmi pumilae clearing away heat-damp and promoting diuresis; Caulis Polygoni Multiflori promoting blood circulation by removing wind, eliminating stasis to stop pain; Herba Linderniae anagallis clearing heat for detumescence, relieving stranguria by diuresis, controls wind heat ophthalmalgia; Herba Cleisostomatis scolopendrifolii heat-clearing and toxic substances removing; Herb Polygoni Chinensis clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body; Herba Lysimachiae Circaeoidis detumescence and promoting granulation, eliminating stasis to stop pain, cooling blood for hemostasis.
Clinical data
1. physical data patient 68 example, is my Out-patient Department and inpatient, is diagnosed as acute radiodermatitis after diagnosing.Be divided into treatment group and each 34 examples of matched group at random.Treatment group man 14 example, female 20 example, 41.8 years old mean age; Matched group man 13 example, female 21 example, 42.9 years old mean age.Protopathy is mainly nasopharyngeal carcinoma, hypopharyngeal cancer, oral cancer etc., and before some patients radiotherapy, row primary tumor is performed the operation and/or the clear art of neck.All patients all adopt German Siemens linear accelerator PrimuseE type 6MV-X line and 8MeV-electric wire to treat.The clinical factors such as two groups of patient ages, sex, histological type analyze not statistically significant (P > 0.05), have comparability.
2. diagnostic criteria (1) local once or be repeatedly subject in the short time (a few days) accumulated dose be greater than 5Gy irradiate.(2) clinical manifestation can divide three degree, I degree: initial reaction is erythema, latent phase 2 ~ 6 weeks, crisis symptom be erythema, depilation, reference dose is 5Gy; II degree: initial reaction is erythema, feeling of numbness, latent phase 1 ~ 3 week, crisis symptom have secondary erythema, ollicles, blister, reference dose is 10Gy; III degree: initial reaction is erythema, feeling of numbness, pruritus, edema, latent phase a few hours ~ 10 days, crisis symptom have ulcer, necrosis, reference dose is 15Gy.
3. Therapeutic Method two groups of patients all give conventional skin care, keep local clean, dry.Matched group uses moist expose burn ointment, dexamethasone mixed liquor or gentian violet routinely, and wound surface exposes.Treatment group takes Chinese medicine composition of the present invention, take Herba Crotalariae Ferrugineae 35g, Herba Artemisiae Scopariae 20g, Herba Stellariae Saxatilis 12g, Cortex Alni Lanatae 14g, Rhizoma Tupistrae Chinensis 14g, Herba abutili indici 55g, Fructus seu semen ulmi pumilae 10g, Caulis Polygoni Multiflori 17g, Herba Linderniae anagallis 20g, Herba Cleisostomatis scolopendrifolii 30g, Herb Polygoni Chinensis 20g, Herba Lysimachiae Circaeoidis 7g, decocting becomes decoction, every order potion, dividing and sooner or later take for 2 times, 5th is 1 course for the treatment of.
4. criterion of therapeutical effect is effective: wound secretion obviously reduces, and pain obviously alleviates, and 3d ~ 5d wound surface is cured completely; Effective: after treatment, secretions reduces gradually, and wound surface reduces gradually, and pain symptom alleviates to some extent, and wound surface 6d ~ 14d cures.Invalid: treatment more than 15d symptom is without being clearly better, and local is oozed out companion's purulent secretion and increased, and need treat by other treatment method.
5. therapeutic effect treats observe the curative effect after 3 courses for the treatment of.In treatment group 34 example, wherein effective 19 examples (55.9%), effective 14 examples (41.2%), invalid 1 example (2.9%), total effective rate is 97.1%; In matched group 34 example, wherein effective 10 examples (29.4%), effective 16 examples (47.1%), invalid 8 examples (23.5%), total effective rate is 76.5%.Two groups of total effective rate comparing differences have significant (P < 0.05), and treatment group therapeutic effect is obviously better than matched group.
Detailed description of the invention
Embodiment one: take Herba Crotalariae Ferrugineae 35g, Herba Artemisiae Scopariae 20g, Herba Stellariae Saxatilis 12g, Cortex Alni Lanatae 14g, Rhizoma Tupistrae Chinensis 14g, Herba abutili indici 55g, Fructus seu semen ulmi pumilae 10g, Caulis Polygoni Multiflori 17g, Herba Linderniae anagallis 20g, Herba Cleisostomatis scolopendrifolii 30g, Herb Polygoni Chinensis 20g, Herba Lysimachiae Circaeoidis 7g, becomes decoction by above-mentioned Chinese medicine decocting.
Embodiment two: take Herba Crotalariae Ferrugineae 50g, Herba Artemisiae Scopariae 15g, Herba Stellariae Saxatilis 15g, Cortex Alni Lanatae 12g, Rhizoma Tupistrae Chinensis 15g, Herba abutili indici 50g, Fructus seu semen ulmi pumilae 15g, Caulis Polygoni Multiflori 15g, Herba Linderniae anagallis 25g, Herba Cleisostomatis scolopendrifolii 25g, Herb Polygoni Chinensis 30g, Herba Lysimachiae Circaeoidis 5g, becomes decoction by above-mentioned Chinese medicine decocting.
Embodiment three: take Herba Crotalariae Ferrugineae 25g, Herba Artemisiae Scopariae 25g, Herba Stellariae Saxatilis 10g, Cortex Alni Lanatae 16g, Rhizoma Tupistrae Chinensis 13g, Herba abutili indici 60g, Fructus seu semen ulmi pumilae 7g, Caulis Polygoni Multiflori 20g, Herba Linderniae anagallis 15g, Herba Cleisostomatis scolopendrifolii 35g, Herb Polygoni Chinensis 15g, Herba Lysimachiae Circaeoidis 9g, becomes decoction by above-mentioned Chinese medicine decocting.
Claims (2)
1. treat a Chinese medicine composition for acute radiodermatitis, it is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Herba Crotalariae Ferrugineae 25-50 part, Herba Artemisiae Scopariae 15-25 part, Herba Stellariae Saxatilis 10-15 part, Cortex Alni Lanatae 12-16 part, Rhizoma Tupistrae Chinensis 13-15 part, Herba abutili indici 50-60 part, Fructus seu semen ulmi pumilae 7-15 part, Caulis Polygoni Multiflori 15-20 part, Herba Linderniae anagallis 15-25 part, Herba Cleisostomatis scolopendrifolii 25-35 part, Herb Polygoni Chinensis 15-30 part, Herba Lysimachiae Circaeoidis 5-9 part.
2. a kind of Chinese medicine composition for the treatment of acute radiodermatitis according to claim 1, is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Herba Crotalariae Ferrugineae 35 parts, Herba Artemisiae Scopariae 20 parts, Herba Stellariae Saxatilis 12 parts, Cortex Alni Lanatae 14. parts, Rhizoma Tupistrae Chinensis 14 parts, Herba abutili indici 55 parts, Fructus seu semen ulmi pumilae 10 parts, Caulis Polygoni Multiflori 17 parts, Herba Linderniae anagallis 20 parts, Herba Cleisostomatis scolopendrifolii 30 parts, Herb Polygoni Chinensis 20 parts, 7 parts, Herba Lysimachiae Circaeoidis.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101019918A (en) * | 2007-03-08 | 2007-08-22 | 贵州大学 | Natural antibiotic composition extracted from rust-colored crotalaria herb and its extraction process |
| CN101116691A (en) * | 2007-08-29 | 2008-02-06 | 北京艺信堂医药研究所 | Chinese traditional medicine composition for treating neurodermatitis |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101019918A (en) * | 2007-03-08 | 2007-08-22 | 贵州大学 | Natural antibiotic composition extracted from rust-colored crotalaria herb and its extraction process |
| CN101116691A (en) * | 2007-08-29 | 2008-02-06 | 北京艺信堂医药研究所 | Chinese traditional medicine composition for treating neurodermatitis |
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Effective date of registration: 20170511 Address after: 226100, No. 588, Jinyang Road, Yue Yue town, Haimen, Jiangsu, Nantong Patentee after: Haimen Yue Yue Textile Co., Ltd. Address before: 276400 Linyi health center, Yishui, Shandong, China, Yishui Central Hospital, No. 17, Patentee before: Zou Guangdong |