CN102626470B - Medicine for treating acne - Google Patents
Medicine for treating acne Download PDFInfo
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- CN102626470B CN102626470B CN2012101379891A CN201210137989A CN102626470B CN 102626470 B CN102626470 B CN 102626470B CN 2012101379891 A CN2012101379891 A CN 2012101379891A CN 201210137989 A CN201210137989 A CN 201210137989A CN 102626470 B CN102626470 B CN 102626470B
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Abstract
The invention discloses a medicine for treating acne, which is used for solving the problems that western medicine treatment is long in process, large in side effect and apt to reoccur and is prepared by fructus forsythiae, honeysuckle, Chinese violet, golden cypress, Sargassum, Sargent gloryvine, astragali radix, root of common peony and fructus kochiae. The medicine is used for treating acne, can reduce sebum secretion of sebaceous glands, restrains growth of bacteria in folliculus pili, reduces cutaneous inflammation reaction, promotes absorbing and diffusion of red and swollen nodules of folliculus pili portions, and achieves satisfied curative effects clinically. The medicine for treating acne is rigorous in compatibility of medicines, scientific, reasonable, low in cost, good in curative rate, short in course of treatment, convenient to use and not apt to reoccur and can be used for treating acne.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to the Chinese medicine composition of Acne treatment.
Background technology
Acne is the chronic inflammatory disease dermatoses of a kind of hair follicle and sebaceous gland, frequently-occurring disease is in adolescence, modern medicine study thinks that acne is under the condition of inherited genetic factors, and two the aspect factors of effect of the microorganisms such as corynebacterium acnes in (especially the dihydrotestosterone in skin histology is increased) and follicular orifice cause because androgen secretion increases.The traditional Chinese medical science thinks that face nose and thoracic dorsal subordinate lung, the reason that causes acne are to be hindered due to the skin by wind and heat in the lung meridian; Or because of surfeit delicious food, greasy, maror, the taste intrinsic heat, damp and hot interior life, fumigate in face and form.Medically acne being there is no to effective Therapeutic Method at present, is mainly to use the western medicines such as tetracycline, metronidazole, tretinoin, exists uncertain therapeutic efficacy to cut, and the course for the treatment of is long, the defects such as large, the easy recurrence of side effect.
Summary of the invention
The medicine that the purpose of this invention is to provide a kind of Acne treatment, exist the length course for the treatment of, side effect problem large, that easily recur to solve western medicine.
Pharmaceutical formulation of the present invention forms as follows by weight:
Fructus Forsythiae 9-15 part, Flos Lonicerae 15-30 part (under rear), Herba Violae 9-15 part, Cortex Phellodendri 9-15 part,
Sargassum 9-15 part, Caulis Sargentodoxae 9-15 part, Radix Astragali 15-30 part, Radix Paeoniae Rubra 9-15 part and Fructus Kochiae 6-12 part.
Pharmaceutical formulation composition of the present invention is preferably by weight:
12 parts of Fructus Forsythiaes, 24 parts of Flos Loniceraes, 12 parts of Herba Violaes, 12 parts of Cortex Phellodendris,
9 parts of 12 parts of Sargassums, 12 parts of Caulis Sargentodoxaes, 24 parts of Radix Astragali, 12 parts of Radix Paeoniae Rubra and the Fructus Kochiae.
The preparation method step of the medicine of Acne treatment of the present invention is as follows: get Fructus Forsythiae, Herba Violae, Cortex Phellodendri, Sargassum, Caulis Sargentodoxae, Radix Astragali, Radix Paeoniae Rubra and the Fructus Kochiae, the cold water soak 30 minutes that adds 4～5 times, Chinese medicine, decoct and after 30 minutes, Flos Lonicerae is added, decocted again 5 minutes, dry in the air cool after, filter and use plastic bag sealing sterilization packaging, every bag of 300ml.
Using method of the present invention: every day potion, sooner or later each is once.Serveing on 10 days is a course for the treatment of, per month 1 course for the treatment of, treats 1～3 month.
Fructus Forsythiae, Flos Lonicerae, Herba Violae heat-clearing and toxic substances removing in medicine of the present invention, cool loose wind and heat in the lung meridian, mass dissipating and swelling eliminating are monarch drug altogether; Cortex Phellodendri heat clearing and damp drying, eliminating fire and detoxication, Caulis Sargentodoxae heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation are ministerial drug altogether; Radix Astragali benefiting QI for strengthening the superficies, expelling pus and toxin by strengthening QI, Sargassum hard masses softening and resolving, Radix Paeoniae Rubra clearing away heat and cooling blood, eliminating stasis to stop pain are adjuvant drug altogether; Fructus Kochiae clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching, draw wet descending altogether for making medicine.All medicines share, and play the effect of heat-clearing and toxic substances removing, dampness dampness removing, hard masses softening and resolving, QI invigorating evacuation of pus.Be used for Acne treatment, can reduce the sebum secretion of sebaceous gland, suppress the growth of antibacterial in hair follicle, alleviate the scytitis reaction, promote the absorption of the red and swollen tuberosity in hair follicle position to dissipate, obtained clinically satisfied curative effect.
Compatibility of the present invention is rigorous, scientific and reasonable, and expense is low, and good effect, short treating period are easy to use, is difficult for recurrence.
The acute toxicity test of Chinese prescription
One, experiment material
Animal: Kunming mouse is provided by Lanzhou University's zoopery center, and body weight is 18～22g, the male and female dual-purpose.
Medicine: this Chinese prescription decocts slowly after half an hour with hydrology fire that to be concentrated into 200 ml standby.
Two, method:
Mtd test
20 of mices, experiment the previous day, water is can't help in fasting overnight, under the condition of 20 ± 2 ℃ of room temperatures, gastric infusion twice in 24 hours, dosage is 0.5 ml/ time, one week of observation after administration.
Mice in 30 minutes, slightly has discomfort after administration as a result, and it shows as mice and has loose bowels, and hunchbacked phenomenon recovers rapidly normal subsequently, and quieter, and in two weeks of Continuous Observation, mice all survives, and cuts open inspection, and naked eyes examine main inner internal organs, no abnormality seen.
Three, conclusion:
According to the requirement of Chinese medicine toxicological study, mice, can accept the maximum volume under Cmax, carry out mtd test.Mice is all survivals within the observation period, have no overt toxicity, show that this poison of drug is very little, clinical use safety.
Clinical trial
1. physical data
Selected 150 routine cases are and at my Out-patient Department, are diagnosed as the patient of acne year January January to 2011 calendar year 2001, and the age is between 13 years old～30 years old.20 examples within the course of disease 1 year, l～2 year 49 examples, 2～4 years 56 examples, 35 examples more than 4 years.Mostly once with Chinese and western drugs, treated poor effect, or easily recurrence.
2. diagnostic criteria
Canonical reference Pill Sburv and international improvement acne staging, Zhao distinguish show " clinical dermatology " second edition.
Acne vulgaris diagnostic criteria pubarche morbidity, be apt to occur in the flourishing position of face, upper breast and back sebaceous gland, symmetrical.Skin lesion is hair follicle pimple, black acne, pustule, tuberosity, cyst and cicatrix, with seborrhea, is chronic process.
3. clinical weight classification
Slightly: main skin lesion is blackhead, is distributed to multiplely, and the inflammatory pimple is distributed.Several 10～30 of total focus.
Lighter moderate: main skin lesion is acne, and pimple and the potentiality pustule of moderate quatity are arranged, and several 31～50 of total focus, be confined to face.
Heavier moderate: main skin lesion is for deeply at the struvite pimple of property and pustule, and always focus is several 50～100, and tuberosity<3, betide face, cervical region, chest and back.
Severe: skin lesion for deeply at the struvite pimple of property and pustule, total focus number > 100, tuberosity/cyst > 3, easily form cicatrix, betide above the waist.
4. Therapeutic Method
Potion clear water decoction every day, sooner or later respectively once.Serveing on 10 days was 1 cycle, and per month 1 cycle, treating for 2～March is 1 course for the treatment of.
5. clinical efficacy
5.1 efficacy assessment standard
Computing formula: { integration before (integration after integration before treatment-treatment) ÷ treatment } * 100%
Clinical recovery: skin lesion disappears, or only leaves over a little pigmentation, transference cure, and integrated value reduces >=95%.
Produce effects: the skin lesion major part disappears, and symptom obviously alleviates, and integrated value reduces >=70%.
Effectively: skin lesion partly disappears, doing well,improving, and integrated value reduces >=50%.
Invalid: skin lesion disappears not obvious, or clinical symptoms is counter sees deterioration, and integrated value reduces less than 50%.
5.2 therapeutic outcome
In order to 3 courses for the treatment of of upper Regimen Chemotherapy, treatment 150 routine acne patients, cure rate 81.33%, effective percentage 96.66%.Follow up a case by regular visits to not recurrence in a year, the treatment situation sees the following form:
The clinical research result shows: evident in efficacy with this Treated with Chinese Decoction acne, and have no side effect.
The specific embodiment:
Embodiment 1
Get Fructus Forsythiae 9g, Herba Violae 9g, Cortex Phellodendri 9g, Sargassum 9g, Caulis Sargentodoxae 9g, Radix Astragali 15g, Radix Paeoniae Rubra 9g and Fructus Kochiae 6g, the cold water soak of 4～5 times 30 minutes that adds above-mentioned Chinese medicine, decocted 30 minutes, add Flos Lonicerae 15g to decoct again 5 minutes, dry in the air cool after, filter and use plastic bag sealing sterilization packaging, every bag of 300ml.
Every bag of 300ml, 2～3 bags of potions, potion on the one, divide and take for 2～3 times, avoids pungent raw food greasy, and 10 is a course for the treatment of.
Embodiment 2
Get Fructus Forsythiae 12g, Herba Violae 12g, Cortex Phellodendri 12g, Sargassum 12g, Caulis Sargentodoxae 12g, Radix Astragali 24g, Radix Paeoniae Rubra 12g and Fructus Kochiae 9g, the cold water soak of 4～5 times 30 minutes that adds above-mentioned Chinese medicine, decocted about 30 minutes, the 24g Flos Lonicerae is added and decocts 5 minutes again, dry in the air cool after, filter and use plastic bag sealing sterilization packaging, every bag of 300ml.
Every bag of 300ml, 2～3 bags of potions, potion on the one, divide and take for 2～3 times, avoids pungent raw food greasy, and 10 is a course for the treatment of.
Embodiment 3
Get Fructus Forsythiae 15g, Herba Violae 15g, Cortex Phellodendri 15g, Sargassum 15g, Caulis Sargentodoxae 15g, Radix Astragali 30g, Radix Paeoniae Rubra 15g and Fructus Kochiae 12g, the cold water soak of 4～5 times 30 minutes that adds above-mentioned Chinese medicine, decocted about 30 minutes, the 30g Flos Lonicerae is added and decocts 5 minutes again, dry in the air cool after, filter and use plastic bag sealing sterilization packaging, every bag of 300ml.
Every bag of 300ml, 2～3 bags of potions, potion on the one, divide and take for 2～3 times, avoids pungent raw food greasy, and 10 is a course for the treatment of.
Above-described embodiment can Acne treatment, and by contrast, the effect of embodiment 2 is best.
Claims (2)
1. the medicine of an Acne treatment is characterized in that this medicine made by the crude drug of following weight ratio:
Fructus Forsythiae 9-15 part, Flos Lonicerae 15-30 part, Herba Violae 9-15 part, Cortex Phellodendri 9-15 part, Sargassum 9-15 part, Caulis Sargentodoxae 9-15 part, Radix Astragali 15-30 part, Radix Paeoniae Rubra 9-15 part and Fructus Kochiae 6-12 part.
2. according to the medicine of claim 1, it is characterized in that the crude drug for preparing this medicine consists of:
9 parts of 12 parts of Fructus Forsythiaes, 24 parts of Flos Loniceraes, 12 parts of Herba Violaes, 12 parts of Cortex Phellodendris, 12 parts of Sargassums, 12 parts of Caulis Sargentodoxaes, 24 parts of Radix Astragali, 12 parts of Radix Paeoniae Rubra and the Fructus Kochiae.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101379891A CN102626470B (en) | 2012-05-07 | 2012-05-07 | Medicine for treating acne |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101379891A CN102626470B (en) | 2012-05-07 | 2012-05-07 | Medicine for treating acne |
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| Publication Number | Publication Date |
|---|---|
| CN102626470A CN102626470A (en) | 2012-08-08 |
| CN102626470B true CN102626470B (en) | 2013-11-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012101379891A Expired - Fee Related CN102626470B (en) | 2012-05-07 | 2012-05-07 | Medicine for treating acne |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813989A (en) * | 2004-11-09 | 2006-08-09 | 谢有珠 | Chinese herbal medicine for quickly eliminating acne without scar |
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2012
- 2012-05-07 CN CN2012101379891A patent/CN102626470B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1813989A (en) * | 2004-11-09 | 2006-08-09 | 谢有珠 | Chinese herbal medicine for quickly eliminating acne without scar |
Non-Patent Citations (2)
| Title |
|---|
| 王冬梅.钱文燕教授治疗寻常性痤疮临床经验撷要.《辽宁中医药大学硕士学位论文》.2010,第7、20页. |
| 钱文燕教授治疗寻常性痤疮临床经验撷要;王冬梅;《辽宁中医药大学硕士学位论文》;20100630;第7、20页 * |
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| CN102626470A (en) | 2012-08-08 |
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