CN103687853B - 新型双氨基喹啉化合物及其制备的药物组合物和它们的用途 - Google Patents

新型双氨基喹啉化合物及其制备的药物组合物和它们的用途 Download PDF

Info

Publication number
CN103687853B
CN103687853B CN201280032260.6A CN201280032260A CN103687853B CN 103687853 B CN103687853 B CN 103687853B CN 201280032260 A CN201280032260 A CN 201280032260A CN 103687853 B CN103687853 B CN 103687853B
Authority
CN
China
Prior art keywords
compound
cancer
bases
pharmaceutical composition
purposes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201280032260.6A
Other languages
English (en)
Chinese (zh)
Other versions
CN103687853A (zh
Inventor
R·K·阿玛拉瓦迪
J·温克勒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Publication of CN103687853A publication Critical patent/CN103687853A/zh
Application granted granted Critical
Publication of CN103687853B publication Critical patent/CN103687853B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201280032260.6A 2011-04-29 2012-04-26 新型双氨基喹啉化合物及其制备的药物组合物和它们的用途 Expired - Fee Related CN103687853B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161480641P 2011-04-29 2011-04-29
US61/480,641 2011-04-29
PCT/US2012/035251 WO2012149186A2 (en) 2011-04-29 2012-04-26 Novel bisaminoquinoline compounds, pharmaceutical compositions prepared therefrom and their use

Publications (2)

Publication Number Publication Date
CN103687853A CN103687853A (zh) 2014-03-26
CN103687853B true CN103687853B (zh) 2017-12-08

Family

ID=47073068

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280032260.6A Expired - Fee Related CN103687853B (zh) 2011-04-29 2012-04-26 新型双氨基喹啉化合物及其制备的药物组合物和它们的用途

Country Status (7)

Country Link
US (4) US20140050696A1 (enExample)
EP (1) EP2702054B1 (enExample)
JP (1) JP6162687B2 (enExample)
CN (1) CN103687853B (enExample)
AU (1) AU2012249646B2 (enExample)
CA (1) CA2841452C (enExample)
WO (1) WO2012149186A2 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2841452C (en) 2011-04-29 2021-04-13 The Trustees Of The University Of Pennsylvania Novel bisaminoquinoline compounds, pharmaceutical compositions prepared therefrom and their use
CA3217159A1 (en) 2013-02-01 2014-08-07 Wellstat Therapeutics Corporation Substituted quinazolin-4-amine compounds and pharmaceutical compositions thereof having anti-inflammatory, antifungal, antiparasitic and anticancer activity
WO2014147531A2 (en) * 2013-03-19 2014-09-25 Mahesh Kandula Compositions and methods for the treatment of cancer
WO2015133280A1 (ja) * 2014-03-03 2015-09-11 公立大学法人名古屋市立大学 抗マラリア活性化合物及び抗マラリア薬
CN106794184A (zh) * 2014-06-02 2017-05-31 黄奇英 抗药性癌症的治疗方法
WO2016011022A1 (en) * 2014-07-14 2016-01-21 The Cleveland Clinic Foundation Substituted thioxanthenone autophagy inhibitors
EP3177595B1 (en) 2014-08-08 2021-02-24 The Trustees Of The University Of Pennsylvania Asymmetric bisaminoquinolines and bisaminoquinolines with varied linkers as autophagy inhibitors for cancer and other therapy
WO2016111957A1 (en) * 2015-01-06 2016-07-14 Albert Einstein College Of Medicine, Inc. Chloroquinoline triazole compounds, composition and uses
EP3283463B1 (en) 2015-04-17 2021-01-20 The Trustees Of The University Of Pennsylvania Dimeric quinacrine derivatives as autophagy inhibitors for cancer therapy
WO2016175264A1 (ja) * 2015-04-28 2016-11-03 カルナバイオサイエンス株式会社 抗マラリア活性を有する新規ヘテロアリール誘導体
WO2016196393A2 (en) * 2015-05-29 2016-12-08 Presage Biosciences, Inc. Autophagy-inhibiting compounds and uses thereof
CN107007606B (zh) * 2016-02-04 2021-10-26 南京舒鹏生物科技有限公司 一种用于干燥综合症预防及治疗的药物及其组合
US11040027B2 (en) 2017-01-17 2021-06-22 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
US12343339B2 (en) 2019-05-24 2025-07-01 The Trustees Of The University Of Pennsylvania Bisaminoquinolines and bisaminoacridines compounds and methods of their use
EP4031543A4 (en) * 2019-09-18 2023-09-27 The Regents Of The University Of California BIAMINOCINOLINES AND NANOFORMULATIONS FOR THE TREATMENT OF CANCER
CN110559449B (zh) * 2019-10-22 2022-09-02 长治医学院 一种聚棉酚前药胶束及其制备方法
WO2021142065A1 (en) 2020-01-10 2021-07-15 Reyoung Corporation Acridin-9-yl-amine, quinolin-9-yl-amine, 1 -amino-9h-thioxanthene-9-one and benzo[b][1,5]naphthyri din-10-yl-amine derivatives as autophagy inhibitors for treating cancer
CN115252615B (zh) * 2022-09-14 2023-10-24 重庆医药高等专科学校 一种含有防己诺林-7-丙酸酯与parp-1抑制剂的药物组合物
CN118576596A (zh) * 2023-03-01 2024-09-03 中国科学院上海药物研究所 Lys01或其盐在制备Kir4.1钾离子通道抑制剂中的应用
CN120309536A (zh) * 2024-06-28 2025-07-15 中山大学 桥连双喹啉化合物及其制备方法与应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993007126A1 (en) * 1991-10-03 1993-04-15 Board Of Regents Of The University Of Nebraska Antimalarial bisquinolines

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2816893A (en) * 1957-12-17 Improvements in or relating to
GB726568A (en) * 1952-03-12 1955-03-23 Rhone Poulenc Sa Improvements in or relating to quinoline derivatives
DE1169948B (de) * 1961-06-06 1964-05-14 Dr Hans Carl Stark Verfahren zur Herstellung von antibakteriell wirksamen N, N'-Alkylen-1, 1'-alkylen-bis-(4-aminochinolinium-halogeniden)
LU43783A1 (enExample) * 1962-06-22 1963-07-22
GB9612829D0 (en) * 1996-06-19 1996-08-21 Univ London Potassium channel blockers
US5756517A (en) * 1996-10-25 1998-05-26 Bayer Aktiengesellschaft Use of bisquinoline compounds in the treatment of cerebral disorders
FR2796021B1 (fr) 1999-07-05 2001-10-19 Peugeot Citroen Automobiles Sa Poutre de pare-chocs pour vehicules automobiles
EP1408991A4 (en) * 1999-06-30 2004-04-21 Scott Cordray NOSE SPRAY BASED ON SALT SEA
US7183413B2 (en) 2003-04-11 2007-02-27 Taigen Biotechnology Aminoquinoline compounds
US7574340B2 (en) * 2003-09-08 2009-08-11 The United States Of America As Represented By The Secretary Of The Army Small molecules and a pharmacophore model for inhibition of botulinum toxin and methods of making and using thereof
EP1856247B1 (en) * 2005-01-19 2016-05-04 The Trustees of The University of Pennsylvania Regulation of autophagy and cell survival
WO2007097450A1 (ja) 2006-02-27 2007-08-30 Nagoya City University 抗マラリア活性化合物、及びそれを有効成分とする抗マラリア薬
CN101224207A (zh) * 2007-10-12 2008-07-23 中国科学院上海有机化学研究所 具有诱导自吞噬治疗错误折叠蛋白聚集所致疾病的药物及其筛选方法
WO2011115555A1 (en) * 2010-03-16 2011-09-22 Ge Healthcare Bio-Sciences Ab System for improved delivery of gene modulating compounds
CA2841452C (en) 2011-04-29 2021-04-13 The Trustees Of The University Of Pennsylvania Novel bisaminoquinoline compounds, pharmaceutical compositions prepared therefrom and their use
EP3177595B1 (en) 2014-08-08 2021-02-24 The Trustees Of The University Of Pennsylvania Asymmetric bisaminoquinolines and bisaminoquinolines with varied linkers as autophagy inhibitors for cancer and other therapy
US20160168699A1 (en) 2014-12-12 2016-06-16 Asm Ip Holding B.V. Method for depositing metal-containing film using particle-reduction step
EP3283463B1 (en) 2015-04-17 2021-01-20 The Trustees Of The University Of Pennsylvania Dimeric quinacrine derivatives as autophagy inhibitors for cancer therapy

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993007126A1 (en) * 1991-10-03 1993-04-15 Board Of Regents Of The University Of Nebraska Antimalarial bisquinolines

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Antiplasmodial Activity and Cytotoxicity of Bis-, Tris-, and Tetraquinolines with Linear or Cyclic Amino Linkers;Sophie Girault, et.al.;《J. Med. Chem.》;20010427;第44卷(第11期);第1658-1665页 *
Bisquinolines. 2. Antimalarial N,N-Bis(7-chloroquinolin-4-yl)heteroalkanediamines;Jonathan L. Vennerstrom. et.al.;《J. Med. Chem.》;19980925;第41卷(第22期);第4360-4364页 *

Also Published As

Publication number Publication date
JP6162687B2 (ja) 2017-07-12
CN103687853A (zh) 2014-03-26
US20170166530A1 (en) 2017-06-15
US11591298B2 (en) 2023-02-28
US20160168099A1 (en) 2016-06-16
WO2012149186A3 (en) 2013-01-03
AU2012249646A1 (en) 2014-02-27
WO2012149186A2 (en) 2012-11-01
US10047052B2 (en) 2018-08-14
CA2841452C (en) 2021-04-13
US20200071272A1 (en) 2020-03-05
JP2014513101A (ja) 2014-05-29
WO2012149186A9 (en) 2013-02-21
US20140050696A1 (en) 2014-02-20
EP2702054A4 (en) 2014-11-05
AU2012249646B2 (en) 2017-06-08
EP2702054A2 (en) 2014-03-05
CA2841452A1 (en) 2012-11-01
EP2702054B1 (en) 2018-10-24

Similar Documents

Publication Publication Date Title
CN103687853B (zh) 新型双氨基喹啉化合物及其制备的药物组合物和它们的用途
US11639335B2 (en) Asymmetric bisaminoquinolines and bisaminoquinolines with varied linkers as autophagy inhibitors for cancer and other therapy
US10774047B2 (en) Dimeric quinacrine derivatives as autophagy inhibitors for cancer therapy
JP5922584B2 (ja) 結腸および胃の腺癌の処置に使用のための３−（インドリル）−または３−（アザインドリル）−４−アリールマレイミド誘導体
US20230348419A1 (en) Biaminoquinolines and nanoformulations for cancer treatment
JP5693970B2 (ja) ベンゾフェナントリジン構造を有する抗腫瘍薬およびそれらを含有する製剤
EP2513089A1 (en) 3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment
AU2017283653A1 (en) Porphyrin compounds and compositions useful for treating cancer
AU2015240775B2 (en) Sigma-2 receptor ligand drug conjugates as antitumor compounds, methods of synthesis and uses thereof
US20190231793A1 (en) Use of harringtonines in the treatment of breast cancer, in particular triple-negative breast cancer
HK1190718A (en) Novel bisaminoquinoline compounds, pharmaceutical compositions prepared therefrom and their use
WO2007139497A1 (en) Levoglucosenone derivatives for the treatment of disorders such as cancer, autoimmune diseases and heart diseases.
WO2016111957A1 (en) Chloroquinoline triazole compounds, composition and uses
KR20060007368A (ko) Ｎ-(3-클로로-1ｈ-인돌-7-일)-4-설파모일벤젠설폰아미드를포함하는 약제 조성물 및 세포 증식 억제제
HK1195907A1 (zh) 取代的2，3-二氢咪唑并[1，2-c]喹唑啉盐

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1190718

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1190718

Country of ref document: HK

CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20171208