CN103656326B - One treats bronchitic medicine - Google Patents

Abstract

The invention discloses one and treat bronchitic medicine, it is characterized in that, described medicine is made up of the Chinese medicine of following weight portion: Radix Asteris 4-14g, Rhizoma Cynanchi Stauntonii 6-12g, Semen Armeniacae Amarum 6-12g, Rhizoma Phragmitis 4-14g, mustard fringe 4-14g, Radix Glycyrrhizae 6-12g, Radix Scrophulariae 4-14g, Semen Lepidii (Semen Descurainiae) 3-7g, Cortex Magnoliae Officinalis 4-14g, Herba Asari 6-12g, Lignum Aquilariae Resinatum 3-7g, Semen Trigonellae 6-12g.The present invention has gentle lung qi dispersing, antitussive reduces phlegm, relieving the exterior syndrome falls apart heresy, relieving cough and asthma, dispelling wind are regulated the flow of vital energy, Xin Liang leads off, effect of heat clearing away YIN nourishing, each component complements each other, jointly reach cough-relieving, reduce phlegm, the effectiveness of antiinflammatory, effectively can eliminate the cough that bronchitis brings, many symptoms such as abundant expectoration, thoroughly eradicate bronchitis.<pb pnum="1" />

Description

One treats bronchitic medicine

Technical field

The present invention relates to the field of Chinese medicines, specifically, relate to one and treat bronchitic medicine.

Background technology

Bronchitis is common with old people, refers to the chronic nonspecific inflammation of trachea-bronchial epithelial cell mucosa and surrounding tissue thereof, clinically with cough, expectoration or with the chronic process of panting for feature.The state of an illness is slow progress generally, easy recurrent exerbation, Chang Jifa obstructive emphysema, even pulmonary hypertension, pulmonary heart disease, is a kind of commonly encountered diseases of serious harm people ' s health.Bronchitis Etiological is that the defense function of bronchial mucosa is low, and the repeated infection of virus and antibacterial, defines the chronic nonspecific inflammation of bronchial mucosa.When there's a sudden fall in temperature, under respiratory tract small blood vessel spasm ischemia, defense function, degradation is beneficial to pathogenic, the chronic stimulations such as smog dust, atmosphere pollution also can be fallen ill, smoking makes the variation of bronchospasm, mucosa, ciliary movement reduces, mucous secretion increases advantageous infectivity, and intolerance factors also has certain relation.

The bronchitic medicine of current treatment is a lot, but offer limited effectiveness, and these medicines need long-term taking, once stop using, the state of an illness will recur.But long-term taking can bring a lot of side effect.

Summary of the invention

The technical problem to be solved in the present invention overcomes above-mentioned defect, provides a kind of good effect, instant effect and the bronchitic medicine of the treatment had no side effect.

For solving the problem, the technical solution adopted in the present invention is:

One treats bronchitic medicine, it is characterized in that, described medicine is made up of following Chinese medicinal components:

Radix Asteris 4-14g, Rhizoma Cynanchi Stauntonii 6-12g, Semen Armeniacae Amarum 6-12g, Rhizoma Phragmitis 4-14g, mustard fringe 4-14g, Radix Glycyrrhizae 6-12g, Radix Scrophulariae 4-14g, Semen Lepidii (Semen Descurainiae) 3-7g, Cortex Magnoliae Officinalis 4-14g, Herba Asari 6-12g, Lignum Aquilariae Resinatum 3-7g, Semen Trigonellae 6-12g.

Improve as one, described medicine is made up of following Chinese medicinal components:

Radix Asteris 9g, Rhizoma Cynanchi Stauntonii 9g, Semen Armeniacae Amarum 9g, Rhizoma Phragmitis 9g, mustard fringe 9g, Radix Glycyrrhizae 9g, Radix Scrophulariae 9g, Semen Lepidii (Semen Descurainiae) 5g, Cortex Magnoliae Officinalis 9g, Herba Asari 9g, Lignum Aquilariae Resinatum 5g, Semen Trigonellae 9g.

Optionally, described medicine is made up of following Chinese medicinal components:

Radix Asteris 4g, Rhizoma Cynanchi Stauntonii 6g, Semen Armeniacae Amarum 6g, Rhizoma Phragmitis 4g, mustard fringe 4g, Radix Glycyrrhizae 6g, Radix Scrophulariae 4g, Semen Lepidii (Semen Descurainiae) 3g, Cortex Magnoliae Officinalis 4g, Herba Asari 6g, Lignum Aquilariae Resinatum 3g, Semen Trigonellae 6g.

Optionally, described medicine is made up of following Chinese medicinal components:

Radix Asteris 14g, Rhizoma Cynanchi Stauntonii 12g, Semen Armeniacae Amarum 12g, Rhizoma Phragmitis 14g, mustard fringe 14g, Radix Glycyrrhizae 12g, Radix Scrophulariae 14g, Semen Lepidii (Semen Descurainiae) 7g, Cortex Magnoliae Officinalis 14g, Herba Asari 12g, Lignum Aquilariae Resinatum 7g, Semen Trigonellae 12g.

Wherein:

Radix Asteris has effect of nourishing the lung to keep the adverse QI downward, preventing phlegm from forming and stopping coughing, cures mainly cough, deficiency of the lung chronic cough, consumptive lung disease lung abscess, coughs vomiting bloody pus, dysuria, breath with cough for abundant expectoration, new chronic cough is coughed, the asthma of chronic cough hemoptysis, chronic cough.

Rhizoma Cynanchi Stauntonii has effect of lowering the adverse-rising QI to resolve phlegm, cough-relieving, and for the disease such as cough with copious phlegm, asthma, this product slightly warm in nature and not dry strong, is longer than and eliminates the phlegm, fall lung qi with flat cough with asthma, no matter belonging to cold and belonging to heat, Exogenous and internal injuries, chronic cough of newly coughing all available it.

Semen Armeniacae Amarum has expelling phlegm for arresting cough, relievings asthma, effect of intestine moistening, cures mainly exogenous cough, dyspnea with fullness of the chest, sore throat, the dry constipation of breast.

Rhizoma Phragmitis has effect of clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis, for calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.

Mustard fringe has effect of induce sweat loose wind, rash, for flu, headache, measles, rubella, skin infection from the beginning of.

Radix Glycyrrhizae treating disorders in five ZANG-organs six internal organs cold and heat pathogen, hard muscles and bones, longue meat, times strength, removing toxic substances, for a long time clothes are made light of one's life by commiting suicide and are prolonged life.Life pathogenic fire purging is hot, ripe use falls apart exterior cold, go pharyngalgia, except pathogenic heat, slow healthy energy, yin nourishing blood, tonifying the spleen and stomach, lung moistening.

Radix Scrophulariae has effect of clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing, and Radix Scrophulariae cures mainly that pathogenic warmth is joined the army, constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus are hindered in the pericardium that caves in, maculae caused by violent heat pathogen, consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin.

Semen Lepidii (Semen Descurainiae) has eliminating the pathogens from the lung sending down the abnormal ascending QI, eliminating phlegm and relieving asthma, inducing diuresis to remove edema, let out effect by heresy, cure mainly sputum stop up the dyspnea and cough with excessive sputum of lung, lung abscess, edema, breast abdomen hydrops, dysuria, chronic pulmonary heart disease, heart failure breathe heavily swollen, scrofula tuberculosis.

Cortex Magnoliae Officinalis has circulation of qi promoting removing food stagnancy, dampness except effect that is full, lowering the adverse QI to relieve asthma, cures mainly stagnation of QI due to dyspepsia, abdominal distention constipation, retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea, expectorant stops up QI rising in reverse order, fullness in the chest is breathed with cough.

Herba Asari have dispel the wind, cold expelling, Hang Shui, the effect of having one's ideas straightened out, cure mainly the diseases such as air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia.

Lignum Aquilariae Resinatum has effect of sending down the abnormal ascending QI warming middle-JIAO, warming the kidney improving inspiration by invigorating kidney-QI, pants, vomits singultus, abdominal distention, waist knee joint cold caused by deficiency, large intestine constipation due to insufficiency, urine qi stranguria, man's cold sperm for QI rising in reverse order.

Semen Trigonellae has effect of kidney-replenishing, dispelling cold and dampness, cures mainly colic of cold type, the abdomen side of body distension, the disturbance of lower legs due to pathogenic cold and dampness, the soreness of waist of suffering from a deficiency of the kidney, sexual impotence.

The present invention has gentle lung qi dispersing, antitussive reduces phlegm, relieving the exterior syndrome falls apart heresy, relieving cough and asthma, dispelling wind are regulated the flow of vital energy, Xin Liang leads off, effect of heat clearing away YIN nourishing, each component complements each other, jointly reach cough-relieving, reduce phlegm, the effectiveness of antiinflammatory, effectively can eliminate the cough that bronchitis brings, many symptoms such as abundant expectoration, thoroughly eradicate bronchitis.

Detailed description of the invention

Embodiment 1: one treats bronchitic medicine, described medicine is made up of following Chinese medicinal components:

Radix Asteris 9g, Rhizoma Cynanchi Stauntonii 9g, Semen Armeniacae Amarum 9g, Rhizoma Phragmitis 9g, mustard fringe 9g, Radix Glycyrrhizae 9g, Radix Scrophulariae 9g, Semen Lepidii (Semen Descurainiae) 5g, Cortex Magnoliae Officinalis 9g, Herba Asari 9g, Lignum Aquilariae Resinatum 5g, Semen Trigonellae 9g.

Embodiment 2: one treats bronchitic medicine, described medicine is made up of following Chinese medicinal components:

Radix Asteris 4g, Rhizoma Cynanchi Stauntonii 6g, Semen Armeniacae Amarum 6g, Rhizoma Phragmitis 4g, mustard fringe 4g, Radix Glycyrrhizae 6g, Radix Scrophulariae 4g, Semen Lepidii (Semen Descurainiae) 3g, Cortex Magnoliae Officinalis 4g, Herba Asari 6g, Lignum Aquilariae Resinatum 3g, Semen Trigonellae 6g.

Embodiment 3: one treats bronchitic medicine, described medicine is made up of following Chinese medicinal components:

Radix Asteris 14g, Rhizoma Cynanchi Stauntonii 12g, Semen Armeniacae Amarum 12g, Rhizoma Phragmitis 14g, mustard fringe 14g, Radix Glycyrrhizae 12g, Radix Scrophulariae 14g, Semen Lepidii (Semen Descurainiae) 7g, Cortex Magnoliae Officinalis 14g, Herba Asari 12g, Lignum Aquilariae Resinatum 7g, Semen Trigonellae 12g.

In above-described embodiment, each component is made the step of decoct and is: selection by weight, soak 30 minutes, decoct 1 hour, filtering medicinal residues obtain medicinal liquid decoct.Instructions of taking is once-a-day, and taking before sleep after supper, five days is a course for the treatment of.

Zoopery is selected to further illustrate the property of medicine of medicine of the present invention:

Each laboratory mouse is 50, male and female half and half, random point five groups, often organizes ten.The experimental result obtained is as follows:

(1) antibacterial

Antibacterial experiment in vitro method is adopted to evaluate this medicine to the suppression or the killing action that cause the antibacterial of respiratory tract infection in experiment.The experimental strain of this experiment selects totally 100 strains of 5 kinds of antibacterials, comprises staphylococcus aureus, staphylococcus epidermidis, bacillus pyocyaneus, Klebsiella pneumoniae, each 20 strains of proteus vulgaris.Above bacterial strain is Clinical isolation.Whole strain all carries out conventional method qualification, and it is 1 × 10 that above-mentioned each bacterium is diluted to concentration respectively ⁵cFU/ml is for subsequent use.Quality-control strains is staphylococcus aureus ATCC25922 and bacillus pyocyaneus ATCC27853, and Quality-control strains being diluted to final concentration is 1 × 10 ⁵cFU/ml is for subsequent use.Adopt doubling dilution according to the antibacterial effective range of prerun medicine this medicine distilled water diluted respectively be mixed with final concentration be respectively 0.8352,1.272,2.98,6.9,13.7,30.1,57.9,121.3,234.1,473.3,931.7, the pastille agar plate culture medium of 1868.8g/ml, for subsequent use.More than operate and all aseptically carry out.The bacterium liquid multiple spot diluted inoculation instrument is inoculated into respectively above-mentioned respectively containing the agar plate media surface of variable concentrations medicine, the pastille BAP culture medium of beta hemolytic streptococcus containing 10% defiber Sanguis caprae seu ovis, cultivate 18h, be the minimal inhibitory concentration (MIC) of this medicine without the least concentration of contained drug in the plate of bacterial growth for 37 DEG C.The results are shown in Table 1, in tested 5 kind of 100 strain clinical strains, result shows, the effect of this medicine to staphylococcus aureus, staphylococcus epidermidis and klebsiella pneumoniae is stronger, illustrate that this medicine has the antibacterial playing respiratory tract infection to suppress preferably or killing action, also have certain inhibitory action to proteus vulgaris and bacillus pyocyaneus, but effect is more weak.As shown in Table 1, this medicine also has good inhibitory action to 2 strain Quality-control strains.

This medicine of table one is on the impact of 5 kind of 102 strain antibacterial

(2) cough-relieving

By strong aqua ammonia nebulization, evaluate the antitussive action of this medicine.White mice divides 5 groups, i.e. normal saline group, drug control group, each one group of this Medications Example 1, embodiment 2, embodiment 3, continuous gastric infusion 3d, drug control group adopts ZHENKELING 6.2ml/kg administration, after 3d administration 40min, white mice is put in 1000ml closed glass container, spray into ammonia with ultrasound atomizer and excite white mice to cough, occur contraction of abdominal muscle with white mice simultaneously, contracting breast, opening one's mouth, is cough standard, and record draws coughs white mice cough number of times in incubation period and 5min.The results are shown in Table two.This Medications Example 1, embodiment 2, embodiment 3 all can make that white mice cough latent period obviously extends, number of times of coughing obviously reduces, all statistical significance is had with blank group comparing difference, and in certain dose-effect relationship, show that this medicine has good antitussive action.

This medicine of table two on white mice ammonia draw cough impact ( ± s, n=10)

(3) reduce phlegm

By observing the impact of this medicine on white mice phenol red output, evaluate the resolve phlegm effect of this medicine.White mice divides 5 groups, is respectively this Medications Example 1, embodiment 2, embodiment 3, and drug control group and blank group, be disposable gastric infusion, and matched group is given and waited capacity distilled water, and drug control group adopts ammonium chloride drug treatment.After administration 1h, give the phenol red normal saline solution of mice by intraperitoneal injection 5% respectively, the every 20g body weight 0.5ml of volume injected, after injecting phenol red 30min, cervical dislocation puts to death white mice, is separated trachea, inserts syringe, connect to prick and fix, with 5% sodium bicarbonate lavation white mice trachea-bronchial epithelial cell, continuous 4 times, each 0.5ml, collect irrigating solution, measure absorbance with 722 type spectrophotometers at wavelength 546nm place, obtain the phenol red output of every white mice according to standard curve, compare between organizing.The results are shown in Table three.This Medications Example 1, embodiment 2 and embodiment 3 all can make white mice phenol red output increase, and all have statistical significance, and in certain dose-effect relationship, illustrate that this medical instrument has good phlegm-dispelling functions with blank group comparing difference.

This medicine of table three on the impact of white mice phenol red output ( ± s, n=10)

Group	Phenol red concentration (mg/ml)
		Blank group	1.34±0.21
Embodiment 1	2.66±0.54
		Embodiment 2	2.45±0.43

Embodiment 3	2.97±0.46
		Ammonium chloride (1.0g/kg)	2.82±0.61

Model case: in through curing with this prescription 200 routine patients, wherein man 102 example, female 98 example is the course of disease the shortest half a year, the longest 11 years.

Efficacy determination: adopt recovery from illness, effective, effective, invalid 4 grade standards.

Therapeutic outcome statistics is in table four

Table four

The effective percentage for the treatment of of the present invention after one week is 86.5%, and the effective percentage after treatment surrounding is 99%.

Claims (4)

1. treat a bronchitic medicine, it is characterized in that, described medicine is made up of following Chinese medicinal components:

Radix Asteris 4-14g, Rhizoma Cynanchi Stauntonii 6-12g, Semen Armeniacae Amarum 6-12g, Rhizoma Phragmitis 4-14g, mustard fringe 4-14g, Radix Glycyrrhizae 6-12g, Radix Scrophulariae 4-14g, Semen Lepidii (Semen Descurainiae) 3-7g, Cortex Magnoliae Officinalis 4-14g, Herba Asari 6-12g, Lignum Aquilariae Resinatum 3-7g, Semen Trigonellae 6-12g.

2. one according to claim 1 treats bronchitic medicine, it is characterized in that, described medicine is made up of following Chinese medicinal components:

Radix Asteris 9g, Rhizoma Cynanchi Stauntonii 9g, Semen Armeniacae Amarum 9g, Rhizoma Phragmitis 9g, mustard fringe 9g, Radix Glycyrrhizae 9g, Radix Scrophulariae 9g, Semen Lepidii (Semen Descurainiae) 5g, Cortex Magnoliae Officinalis 9g, Herba Asari 9g, Lignum Aquilariae Resinatum 5g, Semen Trigonellae 9g.

3. one according to claim 1 treats bronchitic medicine, it is characterized in that, described medicine is made up of following Chinese medicinal components:

Radix Asteris 4g, Rhizoma Cynanchi Stauntonii 6g, Semen Armeniacae Amarum 6g, Rhizoma Phragmitis 4g, mustard fringe 4g, Radix Glycyrrhizae 6g, Radix Scrophulariae 4g, Semen Lepidii (Semen Descurainiae) 3g, Cortex Magnoliae Officinalis 4g, Herba Asari 6g, Lignum Aquilariae Resinatum 3g, Semen Trigonellae 6g.

4. one according to claim 1 treats bronchitic medicine, it is characterized in that, described medicine is made up of following Chinese medicinal components:

Radix Asteris 14g, Rhizoma Cynanchi Stauntonii 12g, Semen Armeniacae Amarum 12g, Rhizoma Phragmitis 14g, mustard fringe 14g, Radix Glycyrrhizae 12g, Radix Scrophulariae 14g, Semen Lepidii (Semen Descurainiae) 7g, Cortex Magnoliae Officinalis 14g, Herba Asari 12g, Lignum Aquilariae Resinatum 7g, Semen Trigonellae 12g.