CN103655882A - Traditional Chinese medicine composition for treating hepatitis C and preparation method of composition - Google Patents
Traditional Chinese medicine composition for treating hepatitis C and preparation method of composition Download PDFInfo
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- CN103655882A CN103655882A CN201310701469.3A CN201310701469A CN103655882A CN 103655882 A CN103655882 A CN 103655882A CN 201310701469 A CN201310701469 A CN 201310701469A CN 103655882 A CN103655882 A CN 103655882A
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Abstract
The invention relates to traditional Chinese medicine composition, and particularly provides traditional Chinese medicine composition for treating hepatitis C. The traditional Chinese medicine composition comprises the components in parts by weight as follows: 2-6 parts of radix bupleuri, 1-3 parts of scutellaria baicalensis, 1-3 parts of wild chrysanthemums, 1-3 parts of radix sophorae flavescentis, 1-3 parts of astragalus membranaceus, 1-3 parts of schisandra chinensis, 1-3 parts of common peony roots, 1-3 parts of red-rooted salvia roots, 1-3 parts of liquorice and 1-3 parts of abrus cantoniensis hance. The traditional Chinese medicine composition has functions of heat clearing, dampness drying, heat purging, toxin removing, blood circulation promoting to remove blood stasis, body resistance strengthening and evil eliminating, can remove virus residuals in livers out of bodies, can circulate blocked vessels in the livers, can nourish hepatic cells, can promote gradual regeneration of the hepatic cells, can realize normalization of liver functions, and is safe to take and free from toxic and side effects.
Description
Technical field
The present invention relates to Chinese medicine composition, specifically, relate to a kind of Chinese medicine composition for the treatment of hepatitis C and preparation method thereof.
Background technology
Hepatitis C, referred to as hepatitis C, hepatitis C, is a kind of viral hepatitis being caused by infection with hepatitis C virus.Conventional interferon has certain curative effect to hepatitis C at present, but stablizes response rate only at 15%-20%, and side effect is large, relapse rate is high.Antiviral drugs can only suppress virus development and increase immunity, and direct kill virus.In the face of difficult and complicated illness, because Chinese medicine is not only symptomatic treatment, more emphasize the wholistic therapy scheme of mediation, balance, therefore, the Chinese medicine of inventing a kind of effective, safe treatment hepatitis C is very possible.
Summary of the invention
In order to solve problems of the prior art, the object of this invention is to provide a kind of Chinese medicine composition for the treatment of hepatitis C and preparation method thereof.
In order to realize the object of the invention, first the present invention provides a kind of Chinese medicine composition for the treatment of hepatitis C, and described Chinese medicine composition comprises the composition of following weight parts: Radix Bupleuri 2-6 part, Radix Scutellariae 1-3 part, Flos Chrysanthemi Indici 1-3 part, Radix Sophorae Flavescentis 1-3 part, Radix Astragali 1-3 part, Radix Schisandrae Bicoloris 1-3 part, Radix Paeoniae Rubra 1-3 part, Radix Salviae Miltiorrhizae 1-3 part, Radix Glycyrrhizae 1-3 part, Herba Abri 1-3 part.
As preferably, described Chinese medicine composition comprises the composition of following weight parts: 4 parts of Radix Bupleuri, 2 parts of Radix Scutellariaes, 2 parts of Flos Chrysanthemi Indicis, 2 parts of Radix Sophorae Flavescentiss, 2 parts of the Radixs Astragali, 2 parts of Radix Schisandrae Bicoloriss, 2 parts of Radix Paeoniae Rubra, 2 parts of Radix Salviae Miltiorrhizaes, 2 parts, Radix Glycyrrhizae, 1 part of Herba Abri.
Wherein, described Radix Schisandrae Bicoloris is processed with wine Radix Schisandrae Bicoloris.
Each composition is by weight as proportioning above, when producing, can increase or reduce according to corresponding proportion, as large-scale production, can take kilogram is unit, Huo Yidunwei unit, small-scale production also can be take milligram as unit, weight can increase or reduce, but the constant rate of weight proportion between each composition.
In Chinese medicine composition of the present invention:
Radix Bupleuri: expelling pathogenic factors from the exterior expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.
Radix Scutellariae: heat clearing and damp drying, eliminating fire and detoxication.
Flos Chrysanthemi Indici: heat-clearing and toxic substances removing; Dispelling wind suppressing the hyperactive liver.
Radix Sophorae Flavescentis: heat clearing and damp drying, extensive use and multiple humidifier fever.
The Radix Astragali: invigorating QI to consolidate the body surface resistance diuresis granulation promoting.
Radix Schisandrae Bicoloris (processed with wine): the nourishing kidney of astringing the lung, the arresting sweating that promotes the production of body fluid, arresting seminal emission antidiarrheal.
Radix Paeoniae Rubra: clots absorbing, pain relieving, removing heat from blood, detumescence.
Radix Salviae Miltiorrhizae: blood circulation promoting and blood stasis dispelling, calming heart and tranquilizing mind.
Radix Glycyrrhizae: heat-clearing and toxic substances removing, expelling phlegm for arresting cough.
Herba Abri: clearing away heat-damp and promoting diuresis, eliminating stasis to stop pain.
In the present invention's prescription, Radix Bupleuri reaches the heresy of few sun thoroughly, discongests the stasis of mechanism of qi, is principal agent; Radix Scutellariae, Radix Sophorae Flavescentis, Herba Abri, Flos Chrysanthemi Indici heat clearing and damp drying, eliminating fire and detoxication clearing away the heat in SHAO YANG is hot and suffocating, is accessory drugs; Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, calming heart and tranquilizing mind, during the Radix Astragali, Fructus Schisandrae Chinensis, Radix Glycyrrhizae QI invigorating are adjusted, strengthening vital QI to eliminate pathogenic factors, is adjuvant drug altogether.All medicines share, can treating SHAO YANG disease by mediations, can depressed liver-energy dispersing and QI regulating close stomach again.
The present invention also provides a kind of method of preparing described Chinese medicine composition, is specially: according to proportioning, take described ten taste compositions, decoct with water 2 times, each 2 hours, collecting decoction, filtered, and filtrate is concentrated into the clear paste that relative density is 1.25-1.35 at 50 ℃.
The present invention also provides a kind of Chinese medicine preparation, and described preparation is made separately by above-mentioned Chinese medicine composition or is comprised of described Chinese medicine composition and pharmaceutically acceptable carrier.
Described pharmaceutically acceptable carrier is one or more in sucrose, dextrin, water or dehydrated alcohol.
Described Chinese medicine preparation is granule, tablet, pill, capsule, electuary, oral liquid, soft extract, syrup or mixture.
As preferably, described Chinese medicine preparation is granule.
The present invention also provides the method for preparing above-mentioned Chinese medicine preparation granule, and described method is for getting 10 parts of Chinese medicine compositions, 2 parts of cane sugar powders, and 1 part, dextrin, granulation, dry, obtain.
The present invention further provides the application in the medicine of preparation treatment hepatitis C of described Chinese medicine composition or Chinese medicine preparation.
Beneficial effect of the present invention is:
Chinese medicine composition of the present invention has following curative effect:
1, heat clearing and damp drying, eliminating fire and detoxication, removes external by liver inner virus residue.
2, blood circulation promoting and blood stasis dispelling, strengthening vital QI to eliminate pathogenic factors, gets through liver internal congestion blood vessel, makes hepatocyte obtain nutrition, promotes that hepatocyte regenerates gradually, reaches liver function normalization.
3, take safety, have no side effect.
The specific embodiment
Following examples are used for illustrating the present invention, but are not used for limiting the scope of the invention.
Embodiment 1 granule
In the present embodiment, Chinese medicine composition comprises following composition:
Radix Bupleuri 666g, Radix Scutellariae 333g, Flos Chrysanthemi Indici 333g, Radix Sophorae Flavescentis 333g, Radix Astragali 333g, Radix Schisandrae Bicoloris (processed with wine) 333g, Radix Paeoniae Rubra 333g, Radix Salviae Miltiorrhizae 333g, Radix Glycyrrhizae 166g, Herba Abri 166g.
The preparation method of the Chinese medicine preparation of the present embodiment comprises:
1) according to said ratio, take described ten taste compositions, decoct with water 2 times, each 2 hours, collecting decoction, filtered, and filtrate is concentrated into the clear paste that relative density is 1.25-1.35 at 50 ℃.
2) get above-mentioned clear paste 1000g, cane sugar powder 200g, dextrin 100g, granulation, dry, make 1000g and get final product.
Embodiment 2 granules
In the present embodiment, Chinese medicine composition comprises following composition:
Radix Bupleuri 200g, Radix Scutellariae 100g, Flos Chrysanthemi Indici 300g, Radix Sophorae Flavescentis 300g, Radix Astragali 100g, Radix Schisandrae Bicoloris (processed with wine) 300g, Radix Paeoniae Rubra 100g, Radix Salviae Miltiorrhizae 100g, Radix Glycyrrhizae 300g, Herba Abri 300g.
The preparation method of the Chinese medicine preparation of the present embodiment comprises:
1) according to said ratio, take described ten taste compositions, decoct with water 2 times, each 2 hours, collecting decoction, filtered, and filtrate is concentrated into the clear paste that relative density is 1.25-1.35 at 50 ℃.
2) get above-mentioned clear paste 1000g, cane sugar powder 200g, dextrin 100g, granulation, dry, make 1000g and get final product.
Embodiment 3 granules
In the present embodiment, Chinese medicine composition comprises following composition:
Radix Bupleuri 600g, Radix Scutellariae 300g, Flos Chrysanthemi Indici 100g, Radix Sophorae Flavescentis 100g, Radix Astragali 300g, Radix Schisandrae Bicoloris (processed with wine) 100g, Radix Paeoniae Rubra 300g, Radix Salviae Miltiorrhizae 300g, Radix Glycyrrhizae 100g, Herba Abri 100g.
The preparation method of the Chinese medicine preparation of the present embodiment comprises:
1) according to said ratio, take described ten taste compositions, decoct with water 2 times, each 2 hours, collecting decoction, filtered, and filtrate is concentrated into the clear paste that relative density is 1.25-1.35 at 50 ℃.
2) get above-mentioned clear paste 1000g, cane sugar powder 200g, dextrin 100g, granulation, dry, make 1000g and get final product.
Embodiment 4 granules
In the present embodiment, Chinese medicine composition comprises following composition:
Radix Bupleuri 500g, Radix Scutellariae 200g, Flos Chrysanthemi Indici 100g, Radix Sophorae Flavescentis 200g, Radix Astragali 300g, Radix Schisandrae Bicoloris (processed with wine) 100g, Radix Paeoniae Rubra 300g, Radix Salviae Miltiorrhizae 200g, Radix Glycyrrhizae 200g, Herba Abri 100g.
The preparation method of the Chinese medicine preparation of the present embodiment comprises:
1) according to said ratio, take described ten taste compositions, decoct with water 2 times, each 2 hours, collecting decoction, filtered, and filtrate is concentrated into the clear paste that relative density is 1.25-1.35 at 50 ℃.
2) get above-mentioned clear paste 1000g, cane sugar powder 200g, dextrin 100g, granulation, dry, make 1000g and get final product.
Test example 1
The present invention treats chronic hepatitis C 90 examples and sums up
1. diagnosis and grouping
Treat chronic hepatitis C 90 examples year October in October, 2005 to 2012, clinical diagnosis all meets in March, 2004 26 Chinese Medical Association hepatopathy credit meeting and lemology is combined the diagnostic criteria of formulation with parasitology branch.Be divided at random treatment group (A group) 60 examples, male 34 examples wherein, female's 26 examples, 33 years old mean age, average course of disease 10 years.Matched group (B group) 30 examples, male 16 examples wherein, female's 14 examples, 31 years old mean age, average course of disease 10.5, two groups of patients conveniently have comparability (P>0.05) in sexually transmitted disease (STD), age, the course of disease
2. Therapeutic Method:
Granule described in the A group employing embodiment of the present invention 1, each 10g, every day 2 times, sooner or later respectively once.
B group adopts interferon-ALPHA 2a(FUKANGTAI) 300Wan unit, intramuscular injection, 1 times/day.Treatment time is 6 months
3. result
Before and after table 1. liang group patient treatment, (6 months) HCV-RNA and anti-HCV change relatively
P
1>0.05；P
2<0.05
The treatment of hepatitis C, HCV-RNA can be used as lasting effectively unique independent parameter (56 pages of combination of Chinese and Western medicine hepatopathy magazine 2002-12-1 phases of volume), and Chinese medicine composition of the present invention is remarkable to the chronic hepatitis c HCV-RNA effect of turning out cloudy.Described in embodiment of the present invention 2-4, granule has above-mentioned curative effect too.
Although above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements, all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (10)
1. a Chinese medicine composition for the treatment of hepatitis C, it is characterized in that, described Chinese medicine composition comprises the composition of following weight parts: Radix Bupleuri 2-6 part, Radix Scutellariae 1-3 part, Flos Chrysanthemi Indici 1-3 part, Radix Sophorae Flavescentis 1-3 part, Radix Astragali 1-3 part, Radix Schisandrae Bicoloris 1-3 part, Radix Paeoniae Rubra 1-3 part, Radix Salviae Miltiorrhizae 1-3 part, Radix Glycyrrhizae 1-3 part, Herba Abri 1-3 part.
2. Chinese medicine composition according to claim 1, it is characterized in that, described Chinese medicine composition comprises the composition of following weight parts: 4 parts of Radix Bupleuri, 2 parts of Radix Scutellariaes, 2 parts of Flos Chrysanthemi Indicis, 2 parts of Radix Sophorae Flavescentiss, 2 parts of the Radixs Astragali, 2 parts of Radix Schisandrae Bicoloriss, 2 parts of Radix Paeoniae Rubra, 2 parts of Radix Salviae Miltiorrhizaes, 2 parts, Radix Glycyrrhizae, 1 part of Herba Abri.
3. Chinese medicine composition according to claim 1 and 2, is characterized in that, described Radix Schisandrae Bicoloris is processed with wine Radix Schisandrae Bicoloris.
4. a method of preparing Chinese medicine composition described in claim 1-3 any one, is characterized in that, described method is: according to proportioning, take described ten taste compositions, decoct with water 2 times, each 2 hours, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.25-1.35 at 50 ℃.
5. a Chinese medicine preparation, is characterized in that, described Chinese medicine preparation is made separately or is comprised of described Chinese medicine composition and pharmaceutically acceptable carrier by the Chinese medicine composition described in claim 1-3 any one.
6. Chinese medicine preparation according to claim 5, is characterized in that, described pharmaceutically acceptable carrier is one or more in sucrose, dextrin, water or dehydrated alcohol.
7. Chinese medicine preparation according to claim 6, is characterized in that, described Chinese medicine preparation is granule, tablet, pill, capsule, electuary, oral liquid, soft extract, syrup or mixture.
8. Chinese medicine preparation according to claim 7, is characterized in that, described Chinese medicine preparation is granule.
9. the method for preparing Chinese medicine preparation described in claim 8, is characterized in that, described method is for getting 10 parts of Chinese medicine compositions, 2 parts of cane sugar powders, and 1 part, dextrin, granulation, dry, obtain.
10. the application of the Chinese medicine preparation described in the Chinese medicine composition described in claim 1-3 any one or claim 5-8 any one in the medicine of preparation treatment hepatitis C.
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| CN101757433A (en) * | 2009-11-02 | 2010-06-30 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating acute hepatitis and preparation method thereof |
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| CN103341134A (en) * | 2013-07-21 | 2013-10-09 | 华菊 | Chinese medicine composition for treating viral hepatitis and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1101281C (en) * | 1998-09-01 | 2003-02-12 | 王铁砚 | Treating method for urban garbage and special equipment |
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- 2013-12-18 CN CN201310701469.3A patent/CN103655882B/en active Active
Patent Citations (5)
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|---|---|---|---|---|
| CN1101281A (en) * | 1994-03-15 | 1995-04-12 | 赵壁修 | Preparation of ke'ao Jiugan Lin |
| CN101112591A (en) * | 2007-08-04 | 2008-01-30 | 李五堂 | Medicine for treating cirrhosis and production process thereof |
| CN101757433A (en) * | 2009-11-02 | 2010-06-30 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating acute hepatitis and preparation method thereof |
| CN102178875A (en) * | 2011-04-18 | 2011-09-14 | 赵云龙 | Traditional Chinese pill used for treating liver disease |
| CN103341134A (en) * | 2013-07-21 | 2013-10-09 | 华菊 | Chinese medicine composition for treating viral hepatitis and preparation method thereof |
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