CN103655882B - Traditional Chinese medicine composition for treating hepatitis C and preparation method of composition - Google Patents
Traditional Chinese medicine composition for treating hepatitis C and preparation method of composition Download PDFInfo
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Abstract
The invention relates to traditional Chinese medicine composition, and particularly provides traditional Chinese medicine composition for treating hepatitis C. The traditional Chinese medicine composition comprises the components in parts by weight as follows: 2-6 parts of radix bupleuri, 1-3 parts of scutellaria baicalensis, 1-3 parts of wild chrysanthemums, 1-3 parts of radix sophorae flavescentis, 1-3 parts of astragalus membranaceus, 1-3 parts of schisandra chinensis, 1-3 parts of common peony roots, 1-3 parts of red-rooted salvia roots, 1-3 parts of liquorice and 1-3 parts of abrus cantoniensis hance. The traditional Chinese medicine composition has functions of heat clearing, dampness drying, heat purging, toxin removing, blood circulation promoting to remove blood stasis, body resistance strengthening and evil eliminating, can remove virus residuals in livers out of bodies, can circulate blocked vessels in the livers, can nourish hepatic cells, can promote gradual regeneration of the hepatic cells, can realize normalization of liver functions, and is safe to take and free from toxic and side effects.
Description
Technical field
The present invention relates to Chinese medicine composition, specifically, relate to a kind of Chinese medicine composition for the treatment of hepatitis C and preparation method thereof.
Background technology
Hepatitis C, referred to as hepatitis C, hepatitis C, is a kind of viral hepatitis caused by infection with hepatitis C virus.Interferon conventional at present has certain curative effect to hepatitis C, but stablizes response rate only at 15%-20%, and side effect is large, relapse rate is high.Antiviral drugs can only suppress viral progression and increase immunity, and can not direct kill virus.In the face of difficult and complicated illness, because Chinese medicine is not only symptomatic treatment, more emphasize the wholistic therapy scheme being in harmonious proportion, balancing, therefore, the Chinese medicine inventing a kind of effective, safe treatment hepatitis C is very possible.
Summary of the invention
In order to solve problems of the prior art, the object of this invention is to provide a kind of Chinese medicine composition for the treatment of hepatitis C and preparation method thereof.
In order to realize the object of the invention, first the present invention provides a kind of Chinese medicine composition for the treatment of hepatitis C, and described Chinese medicine composition comprises the composition of following weight parts: Radix Bupleuri 2-6 part, Radix Scutellariae 1-3 part, Flos Chrysanthemi Indici 1-3 part, Radix Sophorae Flavescentis 1-3 part, Radix Astragali 1-3 part, Radix Schisandrae Bicoloris 1-3 part, Radix Paeoniae Rubra 1-3 part, Radix Salviae Miltiorrhizae 1-3 part, Radix Glycyrrhizae 1-3 part, Herba Abri 1-3 part.
As preferably, described Chinese medicine composition comprises the composition of following weight parts: Radix Bupleuri 4 parts, Radix Scutellariae 2 parts, Flos Chrysanthemi Indici 2 parts, Radix Sophorae Flavescentis 2 parts, the Radix Astragali 2 parts, Radix Schisandrae Bicoloris 2 parts, Radix Paeoniae Rubra 2 parts, Radix Salviae Miltiorrhizae 2 parts, 2 parts, Radix Glycyrrhizae, Herba Abri 1 part.
Wherein, described Radix Schisandrae Bicoloris is processed with wine Radix Schisandrae Bicoloris.
Each composition is by weight as proportioning above, can increase according to corresponding proportion when producing or reduce, as large-scale production can by kilogram in units of, or in units of ton, small-scale production also can in units of milligram, weight can increase or reduce, but the constant rate of weight proportion between each composition.
In Chinese medicine composition of the present invention:
Radix Bupleuri: expelling pathogenic factors from the exterior expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.
Radix Scutellariae: heat clearing and damp drying, eliminating fire and detoxication.
Flos Chrysanthemi Indici: heat-clearing and toxic substances removing; Dispelling wind suppressing the hyperactive liver.
Radix Sophorae Flavescentis: heat clearing and damp drying, extensive use and multiple humidifier fever.
The Radix Astragali: invigorating QI to consolidate the body surface resistance diuresis granulation promoting.
Radix Schisandrae Bicoloris (processed with wine): nourishing kidney of astringing the lung, promote the production of body fluid arresting sweating, arresting seminal emission antidiarrheal.
Radix Paeoniae Rubra: clots absorbing, pain relieving, removing heat from blood, detumescence.
Radix Salviae Miltiorrhizae: blood circulation promoting and blood stasis dispelling, calming heart and tranquilizing mind.
Radix Glycyrrhizae: heat-clearing and toxic substances removing, expelling phlegm for arresting cough.
Herba Abri: clearing away heat-damp and promoting diuresis, eliminating stasis to stop pain.
In prescription of the present invention, Radix Bupleuri reaches the heresy of few sun thoroughly, discongests the stasis of mechanism of qi, is principal agent; Radix Scutellariae, Radix Sophorae Flavescentis, Herba Abri, Flos Chrysanthemi Indici heat clearing and damp drying, eliminating fire and detoxication clearing away the heat in SHAO YANG is hot and suffocating, is accessory drugs; Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, calming heart and tranquilizing mind, during the Radix Astragali, Fructus Schisandrae Chinensis, Radix Glycyrrhizae QI invigorating are adjusted, strengthening vital QI to eliminate pathogenic factors is adjuvant drug altogether.All medicines share, can treating SHAO YANG disease by mediation, depressed liver-energy dispersing and QI regulating can close stomach again.
Present invention also offers a kind of method preparing described Chinese medicine composition, be specially: take described ten taste compositions according to proportioning, decoct with water 2 times, each 2 hours, collecting decoction, filter, at 50 DEG C, filtrate is concentrated into the clear paste that relative density is 1.25-1.35.
Present invention also offers a kind of Chinese medicine preparation, described preparation is made up separately of above-mentioned Chinese medicine composition or is made up of described Chinese medicine composition and pharmaceutically acceptable carrier.
Described pharmaceutically acceptable carrier is one or more in sucrose, dextrin, water or dehydrated alcohol.
Described Chinese medicine preparation is granule, tablet, pill, capsule, electuary, oral liquid, soft extract, syrup or mixture.
As preferably, described Chinese medicine preparation is granule.
Present invention also offers the method preparing above-mentioned Chinese medicine preparation granule, described method is for getting Chinese medicine composition 10 parts, and cane sugar powder 2 parts, 1 part, dextrin, makes granule, dry, to obtain final product.
Invention further provides described Chinese medicine composition or the application of Chinese medicine preparation in the medicine of preparation treatment hepatitis C.
Beneficial effect of the present invention is:
Chinese medicine composition of the present invention has following curative effect:
1, heat clearing and damp drying, eliminating fire and detoxication, by outside liver inner virus residue purged body.
2, blood circulation promoting and blood stasis dispelling, strengthening vital QI to eliminate pathogenic factors, gets through liver internal congestion blood vessel, makes hepatocyte obtain nutrition, promotes that hepatocyte regenerates gradually, reaches liver function normalization.
3, take safety, have no side effect.
Detailed description of the invention
Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.
Embodiment 1 granule
In the present embodiment, Chinese medicine composition comprises following composition:
Radix Bupleuri 666g, Radix Scutellariae 333g, Flos Chrysanthemi Indici 333g, Radix Sophorae Flavescentis 333g, Radix Astragali 333g, Radix Schisandrae Bicoloris (processed with wine) 333g, Radix Paeoniae Rubra 333g, Radix Salviae Miltiorrhizae 333g, Radix Glycyrrhizae 166g, Herba Abri 166g.
The preparation method of the Chinese medicine preparation of the present embodiment comprises:
1) take described ten taste compositions according to said ratio, decoct with water 2 times, each 2 hours, collecting decoction, filter, at 50 DEG C, filtrate is concentrated into the clear paste that relative density is 1.25-1.35.
2) get above-mentioned clear paste 1000g, cane sugar powder 200g, dextrin 100g, makes granule, dry, makes 1000g and get final product.
Embodiment 2 granule
In the present embodiment, Chinese medicine composition comprises following composition:
Radix Bupleuri 200g, Radix Scutellariae 100g, Flos Chrysanthemi Indici 300g, Radix Sophorae Flavescentis 300g, Radix Astragali 100g, Radix Schisandrae Bicoloris (processed with wine) 300g, Radix Paeoniae Rubra 100g, Radix Salviae Miltiorrhizae 100g, Radix Glycyrrhizae 300g, Herba Abri 300g.
The preparation method of the Chinese medicine preparation of the present embodiment comprises:
1) take described ten taste compositions according to said ratio, decoct with water 2 times, each 2 hours, collecting decoction, filter, at 50 DEG C, filtrate is concentrated into the clear paste that relative density is 1.25-1.35.
2) get above-mentioned clear paste 1000g, cane sugar powder 200g, dextrin 100g, makes granule, dry, makes 1000g and get final product.
Embodiment 3 granule
In the present embodiment, Chinese medicine composition comprises following composition:
Radix Bupleuri 600g, Radix Scutellariae 300g, Flos Chrysanthemi Indici 100g, Radix Sophorae Flavescentis 100g, Radix Astragali 300g, Radix Schisandrae Bicoloris (processed with wine) 100g, Radix Paeoniae Rubra 300g, Radix Salviae Miltiorrhizae 300g, Radix Glycyrrhizae 100g, Herba Abri 100g.
The preparation method of the Chinese medicine preparation of the present embodiment comprises:
1) take described ten taste compositions according to said ratio, decoct with water 2 times, each 2 hours, collecting decoction, filter, at 50 DEG C, filtrate is concentrated into the clear paste that relative density is 1.25-1.35.
2) get above-mentioned clear paste 1000g, cane sugar powder 200g, dextrin 100g, makes granule, dry, makes 1000g and get final product.
Embodiment 4 granule
In the present embodiment, Chinese medicine composition comprises following composition:
Radix Bupleuri 500g, Radix Scutellariae 200g, Flos Chrysanthemi Indici 100g, Radix Sophorae Flavescentis 200g, Radix Astragali 300g, Radix Schisandrae Bicoloris (processed with wine) 100g, Radix Paeoniae Rubra 300g, Radix Salviae Miltiorrhizae 200g, Radix Glycyrrhizae 200g, Herba Abri 100g.
The preparation method of the Chinese medicine preparation of the present embodiment comprises:
1) take described ten taste compositions according to said ratio, decoct with water 2 times, each 2 hours, collecting decoction, filter, at 50 DEG C, filtrate is concentrated into the clear paste that relative density is 1.25-1.35.
2) get above-mentioned clear paste 1000g, cane sugar powder 200g, dextrin 100g, makes granule, dry, makes 1000g and get final product.
Test example 1
The present invention treats chronic hepatitis C 90 example and sums up
1. diagnosis and grouping
Treat chronic hepatitis C 90 example year October in October, 2005 to 2012, clinical diagnosis all meets Chinese Medical Association's hepatopathy credit meeting on March 26th, 2004 and lemology combines the diagnostic criteria of formulation with parasitology branch.The random treatment group (A group) 60 that is divided into is routine, wherein man 34 example, female 26 example, 33 years old mean age, average course of disease 10 years.Matched group (B group) 30 example, wherein man 16 example, female 14 example, 31 years old mean age, average course of disease 10.5, two groups of patients conveniently have comparability (P>0.05) in sexually transmitted disease (STD), age, the course of disease
2. Therapeutic Method:
A group adopts granule described in the embodiment of the present invention 1, each 10g, every day 2 times, sooner or later respectively once.
B group adopts Interferon a2a (FUKANGTAI) 3,000,000 unit, intramuscular injection, 1 times/day.Treatment time is 6 months
3. result
Before and after table 1. liang group patient treatment, (6 months) HCV-RNA and HCV-Ab IgG change are compared
P
1>0.05;P
2<0.05
The treatment of hepatitis C, HCV-RNA can be used as lasting effectively unique independent parameter (combination of Chinese and Western medicine hepatopathy magazine 2002-12 rolls up-1 phase 56 pages), and Chinese medicine composition of the present invention to be turned out cloudy Be very effective to chronic hepatitis c HCV-RNA.Granule described in embodiment of the present invention 2-4 has above-mentioned curative effect too.
Although above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (10)
1. treat the Chinese medicine composition of hepatitis C for one kind, it is characterized in that, described Chinese medicine composition is made up of the composition of following weight parts: Radix Bupleuri 2-6 part, Radix Scutellariae 1-3 part, Flos Chrysanthemi Indici 1-3 part, Radix Sophorae Flavescentis 1-3 part, Radix Astragali 1-3 part, Radix Schisandrae Bicoloris 1-3 part, Radix Paeoniae Rubra 1-3 part, Radix Salviae Miltiorrhizae 1-3 part, Radix Glycyrrhizae 1-3 part, Herba Abri 1-3 part.
2. Chinese medicine composition according to claim 1, it is characterized in that, described Chinese medicine composition is made up of the composition of following weight parts: Radix Bupleuri 4 parts, Radix Scutellariae 2 parts, Flos Chrysanthemi Indici 2 parts, Radix Sophorae Flavescentis 2 parts, the Radix Astragali 2 parts, Radix Schisandrae Bicoloris 2 parts, Radix Paeoniae Rubra 2 parts, Radix Salviae Miltiorrhizae 2 parts, 2 parts, Radix Glycyrrhizae, Herba Abri 1 part.
3. Chinese medicine composition according to claim 1 and 2, is characterized in that, described Radix Schisandrae Bicoloris is processed with wine Radix Schisandrae Bicoloris.
4. prepare a method for Chinese medicine composition described in any one of claim 1-3, it is characterized in that, described method is: take described ten taste compositions according to proportioning, decoct with water 2 times, each 2 hours, collecting decoction, filter, at 50 DEG C, filtrate is concentrated into the clear paste that relative density is 1.25-1.35.
5. a Chinese medicine preparation, is characterized in that, described Chinese medicine preparation is made up separately of the Chinese medicine composition described in any one of claim 1-3 or is made up of described Chinese medicine composition and pharmaceutically acceptable carrier.
6. Chinese medicine preparation according to claim 5, is characterized in that, described pharmaceutically acceptable carrier is one or more in sucrose, dextrin, water or dehydrated alcohol.
7. Chinese medicine preparation according to claim 6, is characterized in that, described Chinese medicine preparation is granule, tablet, pill, capsule, electuary, oral liquid, soft extract, syrup or mixture.
8. Chinese medicine preparation according to claim 7, is characterized in that, described Chinese medicine preparation is granule.
9. prepare the method for Chinese medicine preparation described in claim 8, it is characterized in that, described method is for getting Chinese medicine composition 10 parts, and cane sugar powder 2 parts, 1 part, dextrin, makes granule, dry, to obtain final product.
10. the application in the medicine of preparation treatment hepatitis C of the Chinese medicine composition described in any one of claim 1-3 or the Chinese medicine preparation described in any one of claim 5-8.
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CN1101281A (en) * | 1994-03-15 | 1995-04-12 | 赵壁修 | Preparation of ke'ao Jiugan Lin |
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CN1101281C (en) * | 1998-09-01 | 2003-02-12 | 王铁砚 | Treating method for urban garbage and special equipment |
CN101112591A (en) * | 2007-08-04 | 2008-01-30 | 李五堂 | Medicine for treating cirrhosis and production process thereof |
CN101757433A (en) * | 2009-11-02 | 2010-06-30 | 泰一和浦(北京)中医药研究院有限公司 | Traditional Chinese medicine composition for treating acute hepatitis and preparation method thereof |
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