CN103655745B - A kind of pharmaceutical composition for the treatment of burn and scald - Google Patents
A kind of pharmaceutical composition for the treatment of burn and scald Download PDFInfo
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- CN103655745B CN103655745B CN201310691385.6A CN201310691385A CN103655745B CN 103655745 B CN103655745 B CN 103655745B CN 201310691385 A CN201310691385 A CN 201310691385A CN 103655745 B CN103655745 B CN 103655745B
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- elephants
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- scald
- burn
- giant knotweed
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Abstract
The present invention discloses a kind of pharmaceutical composition for the treatment of burn and scald, said composition is made up through extracting of flavour of a drug such as elephants-foot, iron holly bark, bitter tree, giant knotweeds, has good anti-inflammation, pain relieving, myogenic function, and it is easy to use, evident in efficacy and without obvious adverse reaction, be easy to be accepted by patient.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of have anti-inflammation, pain relieving, the raw myofunctional externally-applied medicinal composition that is used for the treatment of burn and scald.
Background technology
Burn, scald accident often occur, main outer with burn and scald medicine treatment, have multiple on the market at present about the medicine for the treatment of burn and scald. Doctor trained in Western medicine mainly adopts the antibacterials such as antibiotic to treat, preventing that effect is remarkable aspect trauma surface infestation, but it exists treatment time long, stay more afterwards the problems such as scar, and Chinese Traditional Medicine is aspect treatment burn and scald, except overcoming the problem of western medical treatment existence, also there is its unique result for the treatment of. At present conventional have MEIBAO SHIRUN SHAOSHANG GAO, ice king ointment for treating burn and scald, a jingwanhong soft plaster ointment for scald, obvious to burn and scald curative effect, but because it is ointment medicine, when medication, to be coated with thicklyer, can disturb the observation surface of a wound, and while changing dressings, need to first remove residual ointment, could again add medicine to, otherwise left drug can affect drug effect, even can cause wound inflammation.
The present invention is a kind of water-based Chinese medicine composition, except having good anti-inflammation, wound healing effect, compares with traditional ointment medicine, also has obvious advantage: change dressings simple, patient is painful few; The medicine film that aqueous pharmaceutical forms at the surface of a wound does not have thickness, is beneficial to the variation of observing the surface of a wound. Scald or the scald patient of adult face for child, aqueous pharmaceutical is selected especially preferably.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of have anti-inflammation, pain relieving, the raw myofunctional externally-applied medicinal composition that is used for the treatment of burn and scald.
For solving the problems of the technologies described above, the present invention is achieved by the following technical solutions:
Treat an externally-applied medicinal composition for empyrosis, made by the bulk drug of following weight portion: 1～20 part of elephants-foot, 1～10 part of iron holly bark, 1～10 part, bitter tree, 1～10 part of giant knotweed.
Treat an externally-applied medicinal composition for empyrosis, made by the bulk drug of following weight portion: 1～10 part of elephants-foot, 1～5 part of iron holly bark, 1～5 part, bitter tree, 1～5 part of giant knotweed.
Treat an externally-applied medicinal composition for empyrosis, made by the bulk drug of following weight portion: 2 parts of elephants-foot, 1 part of iron holly bark, 1 part, bitter tree, 1 part of giant knotweed.
The preparation method of the externally-applied medicinal composition that above-mentioned treatment is burnt, scalded is: get elephants-foot, iron holly bark, bitter tree, giant knotweed, impurity elimination respectively, clean, boiling 1～3 time, each 1～3 hour, filter merging filtrate, be concentrated into 300～1000ml, add appropriate anticorrisive agent, to obtain final product.
Using method: clean after the surface of a wound, liquid is evenly applied to affected part.
Each raw material of pharmaceutical composition of the present invention, elephants-foot clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body, anti-inflammation, analgesia; Iron holly bark is clearing heat and detoxicating, dampness removing pain relieving, anti-inflammation; Bitter tree is clearing heat and detoxicating, and clearing damp is anti-infective; Giant knotweed dampness removing removing jaundice, clearing heat and detoxicating, blood stasis removing analgesic, anti-infective; Four medicines mutually 5 have anti-inflammation, pain relieving, myogenic, clearing heat and detoxicating effect, its scientific formulation, rationally. The present invention is externally applied drug, is directly applied to affected part when use, does not need to wrap up, and is beneficial to the variation of observing the surface of a wound. Through clinical trial, can alleviate the pain that burn and scald brings, wound healing, resume speed is fast, rear preventing from scar.
By reading description and appending claims below, can understand better these and other feature, aspect and advantage of the present invention.
Detailed description of the invention
Although this description by particularly pointing out and knowing that claimed claims of the present invention draw a conclusion, should be believed following explanation and will understand better the present invention.
Except as otherwise noted, all actual contents based on this composition of all percentages, ratio and the content of related composition herein, and solvent, filler or other material that can combine with these compositions not included in commercially available prod.
As used herein, word " preferably " and variant refer to embodiment of the present invention that specific beneficial effect can be provided under specific environment. But other embodiment can be also preferred under identical or other environment. In addition, the detailed description of one or more preferred embodiments does not represent that other embodiment is useless, and is not intended to get rid of from category of the present invention other embodiment.
Raw material
Elephants-foot is the root and rhizome of gentianaceae plant rough gentian (GentianascabraBge.) or three flower rough gentian (GentianatrifloraPall.). Its bitter, cold in nature, " Chinese pharmacopoeia " one of version in 1977 is carried " clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body ". Modern pharmacological research shows, elephants-foot also has anti-inflammation, analgesic activity, and Pseudomonas aeruginosa, typhoid bacillus, staphylococcus aureus etc. are had to obvious inhibitory action.
Iron holly bark is the dry bark of holly plant ilexrotunda IlexrotundaThLmb.. Its bitter, cold in nature, " Chinese pharmacopoeia " one of version in 2010 is carried " clearing heat-fire, dampness removing pain relieving ", " Guangxi book on Chinese herbal medicine a collection of selected materials ": " clearing heat and detoxicating, swelling and pain relieving. Cure mainly ... eczema, paddy-field dermatitis, burn and scald. " modern pharmacological research shows, iron holly bark also has anti-inflammation, analgesic effect.
Bitter tree, is quassia quassia Picrasm, dry branch and the leaf of aquassioides (D.Don) Benn.. Its bitter, cold in nature, " Chinese pharmacopoeia " one of version in 2010 is carried " clearing heat and detoxicating, Eradicates is wet ", " Zhejiang medicinal plant will ": " heat-clearing and damp-drying drug ... control carbuncle furuncle sore outward, mange, scalds. " modern clinical research shows, bitter tree is used for the treatment of inflammation disease, reaches 90% to cutization pyogenic infection is efficient.
Bitter cane is dry rhizome and the root of polygonaceae plant giant knotweed PolygonumcuspidatumSieb.etZucc.. Its mildly bitter flavor, cold nature, one of " Chinese pharmacopoeia " version in 2010 is carried " dampness removing removing jaundice, clearing heat and detoxicating, blood stasis removing analgesic ", " Guizhou side's medicine among the people collection ": " astringing to arrest bleeding. Burn is controlled in external application ". Modern clinical research shows, bitter cane have impervious go out, effect of anti-shock, anti-infective, pain relieving, promoting blood circulation and hemostasis, be used for the treatment of burn, analgesic effect is definite, does not stay scar after more, and has no adverse reaction.
Prescription
The pharmaceutical composition for the treatment of burn and scald of the present invention, is made up of the bulk drug of following weight portion: 1～20 part of elephants-foot, 1～10 part of iron holly bark, 1～10 part, bitter tree, 1～10 part of giant knotweed.
In order to send better beneficial effect, i.e. balance between " anti-infective, pain palliation efficacy " and " production cost ", is preferably made up of the bulk drug of following weight portion: 1～10 part of elephants-foot, 1～5 part of iron holly bark, 1～5 part, bitter tree, 1～5 part of giant knotweed. More preferably made by the bulk drug of following weight portion: 2 parts of elephants-foot, 1 part of iron holly bark, 1 part, bitter tree, 1 part of giant knotweed.
Preparation method
The pharmaceutical composition for the treatment of burn and scald of the present invention, its preparation method is:
Get elephants-foot, iron holly bark, bitter tree, giant knotweed, impurity elimination respectively, clean, boiling 1～3 time, each 1～3 hour, filter, merging filtrate, is concentrated into 300～1000ml, adds appropriate anticorrisive agent, to obtain final product.
Embodiment
The following example has further described and has proved the embodiment in the scope of the invention. These embodiment are only illustrative, but not limit the scope of the invention, because its many modification are possible in the situation that not deviating from the spirit and scope of the invention.
Embodiment 1
Composition of raw materials: elephants-foot 200g, iron holly bark 100g, bitter tree 100g, giant knotweed 100g
Preparation method: get elephants-foot, iron holly bark, bitter tree, giant knotweed, impurity elimination respectively, clean, boiling 2 times, each 1.5 hours, filter, merging filtrate, is concentrated into 500ml, adds appropriate anticorrisive agent, to obtain final product.
Embodiment 2
Composition of raw materials: elephants-foot 100g, iron holly bark 100g, bitter tree 100g, giant knotweed 100g
Preparation method: get elephants-foot, iron holly bark, bitter tree, giant knotweed, impurity elimination respectively, clean, boiling 3 times, each 1 hour, filter, merging filtrate, is concentrated into 300ml, adds appropriate anticorrisive agent, to obtain final product.
Embodiment 3
Composition of raw materials: elephants-foot 2000g, iron holly bark 100g, bitter tree 100g, giant knotweed 1000g
Preparation method: get elephants-foot, iron holly bark, bitter tree, giant knotweed, impurity elimination respectively, clean, boiling 1 time, each 3 hours, filter, merging filtrate, is concentrated into 1000ml, adds appropriate anticorrisive agent, to obtain final product.
Embodiment 4
Composition of raw materials: elephants-foot 300g, iron holly bark 500g, bitter tree 100g, giant knotweed 200g
Preparation method: get elephants-foot, iron holly bark, bitter tree, giant knotweed, impurity elimination respectively, clean, boiling 2 times, each 2 hours, filter, merging filtrate, is concentrated into 800ml, adds appropriate anticorrisive agent, to obtain final product.
Embodiment 5
Composition of raw materials: elephants-foot 1000g, iron holly bark 600g, bitter tree 300g, giant knotweed 500g
Preparation method: get elephants-foot, iron holly bark, bitter tree, giant knotweed, impurity elimination respectively, clean, boiling 3 times, each 1 hour, filter, merging filtrate, is concentrated into 700ml, adds appropriate anticorrisive agent, to obtain final product.
Embodiment 6
Composition of raw materials: elephants-foot 800g, iron holly bark 400g, bitter tree 500g, giant knotweed 700g
Preparation method: get elephants-foot, iron holly bark, bitter tree, giant knotweed, impurity elimination respectively, clean, boiling 2 times, each 2 hours, filter, merging filtrate, is concentrated into 900ml, adds appropriate anticorrisive agent, to obtain final product.
Embodiment 7
Composition of raw materials: elephants-foot 400g, iron holly bark 1000g, bitter tree 400g, giant knotweed 200g
Preparation method: get elephants-foot, iron holly bark, bitter tree, giant knotweed, impurity elimination respectively, clean, boiling 2 times, each 2.5 hours, filter, merging filtrate, is concentrated into 600ml, adds appropriate anticorrisive agent, to obtain final product.
Embodiment 8
Composition of raw materials: elephants-foot 500g, iron holly bark 100g, bitter tree 1000g, giant knotweed 300g
Preparation method: get elephants-foot, iron holly bark, bitter tree, giant knotweed, impurity elimination respectively, clean, boiling 3 times, each 1 hour, filter, merging filtrate, is concentrated into 400ml, adds appropriate anticorrisive agent, to obtain final product.
The investigation of product clinical efficacy
1. case-data
Collect altogether case 53 examples, wherein male 31 examples, female's 22 examples; 18 years old～63 years old age, average 26 years old; Burn and scald area is all less than 10%TBSA, is light degree Ⅱ burn and scald.
2. methods for the treatment of
Get the liquid that embodiment 1 raw material is made, wounds is evenly applied to affected part by liquid after cleaning, and every day 3～4 times, without dressing, does not generally do bubble and punctures discharge opeing.
3. curative effect determinate standard
(1) cure surface of a wound incrustation, naturally come off.
(2) the effective surface of a wound heals substantially, and fraction incrustation does not come off.
(3) the effectively most of healing of the surface of a wound, fraction is not healed, and still has and oozes out or fester.
(4) the invalid surface of a wound oozes out manyly, has purulent secretion.
4. result
52 routine pain all can alleviate, without using anodyne, all without cicatrization. 2 examples are cured in medication for 7 days, effective 15 examples, and effective 28 examples, total effective rate is 84.9%; Treat and within 10 days, cure 5 examples, effective 23 examples, effective 22 examples, invalid 3 examples, total effective rate is 94.3%; Treat and within 14 days, cure 6 examples, effective 37 examples, effective 9 examples, invalid 1 example, it is 98.1% that total effective rate reaches.
Claims (3)
1. an externally-applied medicinal composition for the treatment of burn and scald, is characterized in that, is made up of the bulk drug of following weight portion: 1～20 part of elephants-foot, 1～10 part of iron holly bark, 1～10 part, bitter tree, 1～10 part of giant knotweed.
2. externally-applied medicinal composition as claimed in claim 1, is characterized in that, is made up of the bulk drug of following weight portion: 1～10 part of elephants-foot, 1～5 part of iron holly bark, 1～5 part, bitter tree, 1～5 part of giant knotweed.
3. externally-applied medicinal composition as claimed in claim 1, is characterized in that, is made up of the bulk drug of following weight portion: 2 parts of elephants-foot, 1 part of iron holly bark, 1 part, bitter tree, 1 part of giant knotweed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201310691385.6A CN103655745B (en) | 2013-12-17 | 2013-12-17 | A kind of pharmaceutical composition for the treatment of burn and scald |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310691385.6A CN103655745B (en) | 2013-12-17 | 2013-12-17 | A kind of pharmaceutical composition for the treatment of burn and scald |
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| CN103655745A CN103655745A (en) | 2014-03-26 |
| CN103655745B true CN103655745B (en) | 2016-05-18 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1171259A (en) * | 1996-12-06 | 1998-01-28 | 董庭君 | Chinese medicine for curing burn and traumatic wound and its production method |
| CN101181528A (en) * | 2007-11-14 | 2008-05-21 | 武汉理工大学 | Compound giant knotweed burn film coating agent and preparation method thereof |
| CN102764345A (en) * | 2012-08-08 | 2012-11-07 | 董世贤 | Basil-bluegum ointment for curing burns and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101326162B1 (en) * | 2009-10-01 | 2013-11-07 | 재단법인 제주테크노파크 | Anti-inflammatory Composition |
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2013
- 2013-12-17 CN CN201310691385.6A patent/CN103655745B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1171259A (en) * | 1996-12-06 | 1998-01-28 | 董庭君 | Chinese medicine for curing burn and traumatic wound and its production method |
| CN101181528A (en) * | 2007-11-14 | 2008-05-21 | 武汉理工大学 | Compound giant knotweed burn film coating agent and preparation method thereof |
| CN102764345A (en) * | 2012-08-08 | 2012-11-07 | 董世贤 | Basil-bluegum ointment for curing burns and preparation method thereof |
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| CN103655745A (en) | 2014-03-26 |
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Address after: 530007, 56 Garden Avenue, Nanning, the Guangxi Zhuang Autonomous Region Applicant after: GUANGXI HOUDE DAJIANKANG INDUSTRY Co.,Ltd. Address before: 530007, 56 Garden Avenue, Nanning, the Guangxi Zhuang Autonomous Region Applicant before: Guangxi Boke Pharmaceutical Co.,Ltd. |
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Address after: 530007 No. 56, Keyuan Avenue, Nanning, Guangxi Zhuang Autonomous Region Patentee after: Guangxi Houde Pharmaceutical Co.,Ltd. Address before: 530007 No. 56, Keyuan Avenue, Nanning, Guangxi Zhuang Autonomous Region Patentee before: GUANGXI HOUDE DAJIANKANG INDUSTRY Co.,Ltd. |