CN103655537A - Oleaceran在治疗促进小肠蠕动药物中的应用 - Google Patents
Oleaceran在治疗促进小肠蠕动药物中的应用 Download PDFInfo
- Publication number
- CN103655537A CN103655537A CN201310643744.0A CN201310643744A CN103655537A CN 103655537 A CN103655537 A CN 103655537A CN 201310643744 A CN201310643744 A CN 201310643744A CN 103655537 A CN103655537 A CN 103655537A
- Authority
- CN
- China
- Prior art keywords
- oleaceran
- small intestine
- application
- intestine peristalsis
- promoting small
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- XEOIJMSRWFEZRQ-HXUWFJFHSA-N oleaceran Natural products COc1cccc2c1CO[C@@]23Oc4cc(C)cc5ccc(O)c3c45 XEOIJMSRWFEZRQ-HXUWFJFHSA-N 0.000 title claims abstract description 37
- 230000008855 peristalsis Effects 0.000 title claims abstract description 17
- 239000003814 drug Substances 0.000 title claims abstract description 12
- 210000000813 small intestine Anatomy 0.000 title abstract description 7
- 230000001737 promoting effect Effects 0.000 title abstract 5
- 230000000968 intestinal effect Effects 0.000 claims description 15
- 150000001875 compounds Chemical class 0.000 claims description 13
- 230000000144 pharmacologic effect Effects 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 3
- 238000002474 experimental method Methods 0.000 abstract description 3
- 238000002360 preparation method Methods 0.000 description 7
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 5
- 241000187180 Streptomyces sp. Species 0.000 description 3
- 239000003610 charcoal Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 125000003003 spiro group Chemical group 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000001187 pylorus Anatomy 0.000 description 2
- 206010009944 Colon cancer Diseases 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000001141 propulsive effect Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310643744.0A CN103655537B (zh) | 2013-12-04 | 2013-12-04 | Oleaceran在治疗促进小肠蠕动药物中的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310643744.0A CN103655537B (zh) | 2013-12-04 | 2013-12-04 | Oleaceran在治疗促进小肠蠕动药物中的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103655537A true CN103655537A (zh) | 2014-03-26 |
CN103655537B CN103655537B (zh) | 2015-11-25 |
Family
ID=50295100
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310643744.0A Expired - Fee Related CN103655537B (zh) | 2013-12-04 | 2013-12-04 | Oleaceran在治疗促进小肠蠕动药物中的应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103655537B (zh) |
-
2013
- 2013-12-04 CN CN201310643744.0A patent/CN103655537B/zh not_active Expired - Fee Related
Non-Patent Citations (1)
Title |
---|
RITESH RAJU等: "Oleaceran: a novel spiro[isobenzofuran-1,2"-naptho[1,8-bc]furan]isolated from a terrestrial streptomyces sp.", 《ORGANIC LETTERS》, vol. 15, no. 14, 26 June 2013 (2013-06-26), pages 3487 - 3489 * |
Also Published As
Publication number | Publication date |
---|---|
CN103655537B (zh) | 2015-11-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN105412066A (zh) | 化合物在制备治疗促进小肠蠕动药物中的应用 | |
CN103655537A (zh) | Oleaceran在治疗促进小肠蠕动药物中的应用 | |
CN102885807B (zh) | Aphanamixoid A在制备促进小肠蠕动药物中的应用 | |
CN103432138A (zh) | 化合物在制备治疗促进小肠蠕动药物中的应用 | |
CN103372021B (zh) | Chukrasone A在制备促进小肠蠕动药物中的应用 | |
CN103536591A (zh) | Neonectrolide A在制备治疗促进小肠蠕动药物中的应用 | |
CN105287491A (zh) | Kendomycin A在制备治疗促进小肠蠕动药物中的应用 | |
CN103301109A (zh) | 化合物在制备治疗促进小肠蠕动药物中的应用 | |
CN103479645A (zh) | Kadcoccitones A在制备治疗促进小肠蠕动药物中的应用 | |
CN103463112A (zh) | Phyllanthoid A在制备治疗促进小肠蠕动药物中的应用 | |
CN103462981A (zh) | Spirooliganones B在制备治疗促进小肠蠕动药物中的应用 | |
CN105267208A (zh) | Strigol在制备治疗促进小肠蠕动药物中的应用 | |
CN106265637A (zh) | Linderolide H在制备治疗促进小肠蠕动药物中的应用 | |
CN103462949A (zh) | Scopariusins在制备治疗促进小肠蠕动药物中的应用 | |
CN103027922A (zh) | Houttuynoid E在制备促进小肠蠕动药物中的应用 | |
CN103446097B (zh) | Incarviatone A在制备促进小肠蠕动药物中的应用 | |
CN103463048A (zh) | Lycojaponicumin A在促进小肠蠕动药物中的应用 | |
CN103372003B (zh) | Chukrasone B在制备促进小肠蠕动药物中的应用 | |
CN103446124B (zh) | Lycojaponicumin B在制备促进小肠蠕动药物中的应用 | |
CN102872029B (zh) | Gypensapogenin B在制备促进小肠蠕动药物中的应用 | |
CN105412079A (zh) | Penicillactones B在制备治疗促进小肠蠕动药物中的应用 | |
CN103446149A (zh) | Lycojaponicumin C在促进小肠蠕动药物中的应用 | |
CN110092806B (zh) | 附子中具有镇痛作用的c19二萜生物碱糖苷及其用途 | |
CN105287516A (zh) | Streptospirole在制备治疗促进小肠蠕动药物中的应用 | |
CN103340848A (zh) | Nardoaristolones A在制备治疗促进小肠蠕动药物中的应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: NANJING ZHENGLIANG PHARMACEUTICAL TECHNOLOGY CO., Free format text: FORMER OWNER: CHANGZHOU COLLECTION MEDICAL INSTRUMENT CO., LTD. Effective date: 20150420 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 213000 CHANGZHOU, JIANGSU PROVINCE TO: 211200 NANJING, JIANGSU PROVINCE |
|
TA01 | Transfer of patent application right |
Effective date of registration: 20150420 Address after: Qingfeng Village Yong Yang town of Lishui County of Nanjing City, Jiangsu province 211200 Green Village building 301 room 22 Applicant after: Nanjing Zhengliang Medical Technology Co.,Ltd. Address before: 213000 West -256-1, building 4, West Taihu international wisdom garden, Wujin Economic Development Zone, Jiangsu, Changzhou Applicant before: CHANGZHOU KELIXIN MEDICAL DEVICES CO., LTD. |
|
C41 | Transfer of patent application or patent right or utility model | ||
CB03 | Change of inventor or designer information |
Inventor after: Xu Li Inventor before: Chen Jun |
|
COR | Change of bibliographic data | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20151021 Address after: 266000 Ningxia Road, Shandong, China, No. 308, No. Applicant after: Qingdao University Address before: Qingfeng Village Yong Yang town of Lishui County of Nanjing City, Jiangsu province 211200 Green Village building 301 room 22 Applicant before: Nanjing Zhengliang Medical Technology Co.,Ltd. |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151125 Termination date: 20161204 |