CN103463048A - Lycojaponicumin A在促进小肠蠕动药物中的应用 - Google Patents
Lycojaponicumin A在促进小肠蠕动药物中的应用 Download PDFInfo
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- CN103463048A CN103463048A CN2013104367655A CN201310436765A CN103463048A CN 103463048 A CN103463048 A CN 103463048A CN 2013104367655 A CN2013104367655 A CN 2013104367655A CN 201310436765 A CN201310436765 A CN 201310436765A CN 103463048 A CN103463048 A CN 103463048A
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- lycojaponicumin
- small intestine
- medicaments
- promoting
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- 230000008855 peristalsis Effects 0.000 title claims abstract description 21
- 239000003814 drug Substances 0.000 title claims abstract description 15
- 230000001737 promoting effect Effects 0.000 title claims abstract description 10
- WGVQKABRYXBLGW-WUZBVLBZSA-N (1R,2S,5S,7S,10S,13S)-7-hydroxy-7-methyl-17-oxa-14-azapentacyclo[12.2.1.02,10.02,13.05,10]heptadecane-3,9-dione Chemical compound O=C([C@@]12CC3)C[C@@](C)(O)C[C@H]1CC(=O)[C@@]12[C@H]3N2CC[C@H]1O2 WGVQKABRYXBLGW-WUZBVLBZSA-N 0.000 title abstract description 20
- 210000000813 small intestine Anatomy 0.000 title abstract description 7
- 150000001875 compounds Chemical class 0.000 claims abstract description 13
- 230000000968 intestinal effect Effects 0.000 claims description 16
- 229930185194 lycojaponicumin Natural products 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 abstract description 12
- 238000002474 experimental method Methods 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 3
- 230000000144 pharmacologic effect Effects 0.000 abstract description 3
- 239000003610 charcoal Substances 0.000 description 4
- 235000010489 acacia gum Nutrition 0.000 description 3
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 3
- 238000012449 Kunming mouse Methods 0.000 description 2
- 241000927897 Lycopodium japonicum Species 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000001187 pylorus Anatomy 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000001141 propulsive effect Effects 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201310436765.5A CN103463048B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin A在制备促进小肠蠕动药物中的应用 |
Applications Claiming Priority (1)
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CN201310436765.5A CN103463048B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin A在制备促进小肠蠕动药物中的应用 |
Publications (2)
Publication Number | Publication Date |
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CN103463048A true CN103463048A (zh) | 2013-12-25 |
CN103463048B CN103463048B (zh) | 2015-08-19 |
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Family Applications (1)
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CN201310436765.5A Expired - Fee Related CN103463048B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin A在制备促进小肠蠕动药物中的应用 |
Country Status (1)
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CN (1) | CN103463048B (zh) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103059043A (zh) * | 2011-10-24 | 2013-04-24 | 中国医学科学院药物研究所 | 伸筋草碱a-c、其制法和其药物组合物与用途 |
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2013
- 2013-09-23 CN CN201310436765.5A patent/CN103463048B/zh not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103059043A (zh) * | 2011-10-24 | 2013-04-24 | 中国医学科学院药物研究所 | 伸筋草碱a-c、其制法和其药物组合物与用途 |
Non-Patent Citations (2)
Title |
---|
WANG XIAOJING等: "Nine new lycopodine-type alkaloids from Lycopodium japonicum", 《TETRAHEDRON》, vol. 69, 13 May 2013 (2013-05-13), pages 6234 - 6240 * |
XIAO-JING WANG,ET AL.: "Lycojaponicumin A-C,Three Alkaloids with an Unprecedented Skeleton from Lycopodium japonicum", 《ORGANIC LETTERS》, vol. 14, no. 10, 8 May 2012 (2012-05-08), pages 2614 - 2617, XP055066237, DOI: 10.1021/ol3009478 * |
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Publication number | Publication date |
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CN103463048B (zh) | 2015-08-19 |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CP02 | Change in the address of a patent holder | ||
CP02 | Change in the address of a patent holder |
Address after: Tiefu iron rich street Pizhou city 221331 Jiangsu city of Xuzhou Province Patentee after: Nanjing Guangkangxie Biomedical Technology Co., Ltd. Address before: Metro Technology Building No. 69 Olympic Avenue in Jianye District of Nanjing city in Jiangsu province 210019 01 5 storey buildings Patentee before: Nanjing Guangkangxie Biomedical Technology Co., Ltd. |
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CB03 | Change of inventor or designer information |
Inventor after: Lu Hongxian Inventor before: Jiang Chunping Inventor before: Wang Hui |
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CB03 | Change of inventor or designer information | ||
TR01 | Transfer of patent right |
Effective date of registration: 20180103 Address after: 535000 the Guangxi Zhuang Autonomous Region, Qinzhou, Qinnan District Building Street, No. 9 Patentee after: Qinzhou Industry Research Institute Address before: Tiefu iron rich street Pizhou city 221331 Jiangsu city of Xuzhou Province Patentee before: Nanjing Guangkangxie Biomedical Technology Co., Ltd. |
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TR01 | Transfer of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150819 Termination date: 20180923 |
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CF01 | Termination of patent right due to non-payment of annual fee |