CN103638405A - Ephedra and bitter apricot kernel cough capsule and preparation technology thereof - Google Patents
Ephedra and bitter apricot kernel cough capsule and preparation technology thereof Download PDFInfo
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Abstract
The invention relates to an ephedra and bitter apricot kernel cough capsule. The capsule is prepared from the following raw materials in parts by weight: 700-1100 parts of ephedra, 500-800 parts of bitter apricot kernel, 1500-2000 parts of honeysuckle, 500-800 parts of fritillaria cirrhosa, 500-800 parts of radix stemonae, 500-800 parts of platycodon grandiflorum and 400-600 parts of liquorice. The ephedra and bitter apricot kernel cough capsule has the characteristics of being high in bioavailability, quick to release, small in toxic and side effects, high in drug content, small in dose, and convenient to carry.
Description
Technical field
The present invention relates to a kind ofly have antitussive, eliminate the phlegm, relieving asthma, the medicine for acute and chronic bronchitis and the symptom such as pant, relates in particular to a kind of Maxing Zhike Capsules and preparation technology thereof.
Background technology
Cough, excessive phlegm, pant and bronchitis etc. is all a kind of more common disease clinically, though there are in the market some related indication medicines for treatment, itself or therapeutic effect are not obvious, or side effect is larger, does not reach desirable therapeutic effect.Chinese patent CN 1634476A has announced a kind of Chinese ephedra and almond containing cough stopping dripping pills and preparation method thereof, take numb Fructus Pruni, Semen Armeniacae Amarum, Gypsum Fibrosum and Radix Glycyrrhizae Preparata as main component.National drug standards WS-10757(ZD-0757)-2002 have announced formula and the extraction process of Maxing Cough Syrup, fill a prescription as numb Fructus Pruni, Semen Armeniacae Amarum, Gypsum Fibrosum and Radix Glycyrrhizae Preparata, sucrose and sorbic acid.Above preparation all derives from " MAXINGSHIGAN TANG " in ancient prescription Zhang Zhongjing < < Treatise on Febrile Diseases > >, after taking, exist that disintegration time is long, dissolution is low, it is poor to absorb, liver sausage first pass effect and the problem such as bioavailability is low, thereby affect the performance of drug effect, also directly affect therapeutic effect.Therefore, answer the market demand, need badly develop a kind of dissolution high, absorb strong, bioavailability is high, toxic and side effects is littlely used for the treatment of cough, excessive phlegm, pant and the medicine of the symptom such as bronchitis.
Summary of the invention
It is high that technical problem to be solved by this invention is to provide a kind of bioavailability, discharges fast, toxic and side effects is little, medicament contg is high, taking dose is little, portable Maxing Zhike Capsules.
Another technical problem to be solved by this invention is to provide the preparation technology of this Maxing Zhike Capsules.
For addressing the above problem, a kind of Maxing Zhike Capsules of the present invention, is characterized in that: this capsule is made by the raw material of following weight parts: Herba Ephedrae 700 ~ 1100, Semen Armeniacae Amarum 500 ~ 800, Flos Lonicerae 1500 ~ 2000, Bulbus Fritillariae Cirrhosae 500 ~ 800, the Radix Stemonae 500 ~ 800, Radix Platycodonis 500 ~ 800, Radix Glycyrrhizae 400 ~ 600.
The preparation technology of a kind of Maxing Zhike Capsules as above, comprises the following steps:
(1) by proportioning, weigh;
(2) the water that adds 4 ~ 12 times of its quality after Semen Armeniacae Amarum being deoiled according to a conventional method, is supersound extraction 30 ~ 50min under 60 ~ 80 ℃, the power condition that is 200 ~ 400W in temperature, filters, and obtains filtrate A;
(3) Herba Ephedrae, Flos Lonicerae, Bulbus Fritillariae Cirrhosae, the Radix Stemonae, Radix Platycodonis, Radix Glycyrrhizae are crushed to 10 orders after mixing, obtain mixture, then in this mixture, add the water of 6 ~ 10 times of its quality, in temperature, it is supersound extraction 2 times under 50 ~ 75 ℃, the power condition that is 100 ~ 500W, each extraction time is 60 ~ 80min, filter, obtain liquor B;
(4) by after described filtrate A and the merging of described liquor B, in temperature, be that under 50 ~ 70 ℃, the pressure condition that is 0.06 ~ 0.08MPa, to be evaporated to relative density be 1.10 ~ 1.15 extractum, this extractum is spray-dried adds according to a conventional method adjuvant to constant weight, mix, granulation incapsulates.
Described step (4) in spray-dired condition refer to that inlet temperature is 110 ~ 140 ℃, temperature of outgoing air is 60 ~ 75 ℃, charging total amount is 800 ~ 1000kg/h.
Described step (4) in adjuvant be any one in starch, mannitol, lactose, micropowder silica gel, microcrystalline Cellulose, Pulvis Talci, magnesium stearate, glyceryl monostearate.
It is oral that this preparation adopts, 3 times on the one, one time 2.
The present invention compared with prior art has the following advantages:
1, pharmacodynamic experiment: make positive control drug with similar drugs eliminating phlegm and stopping cough granule, Maxingshigan ball, make negative control with normal saline.
1.1 antitussive actions:
Select 40 of male guinea pigs, be divided into 4 groups, each organizes continuous ig administration 7 d of Cavia porcellus, after last 1 administration 1 h, in thorax binding, be connected in the pressure transducer of Biological Signal Collecting System, adopt citric acid to cause guinea pig cough's model, in comprehensive statistics 10 min, cough number of times, the cough latent period of Cavia porcellus, the results are shown in Table 1.
Table 1 respectively organize guinea pig cough's number of times and the comparison of cough latent period measurement result (
)
Note: a and normal saline group be P≤0.05 relatively; B and eliminating phlegm and stopping cough groups of grains be P≤0.05 relatively; C and Maxingshigan ball group be P≤0.05 relatively.
1.2 phlegm-dispelling functions:
Get 40 of mices, male and female half and half, are divided into 4 groups at random, and group technology and dosage are in Table 2.Each organizes respectively gastric infusion 4 days of mice, once a day, each 0.2ml, after last administration 30 minutes, the phenol red liquid 10ml/kg of lumbar injection 5% (about 0.2ml), put to death mice after 30 minutes.Separated trachea is also cut, and puts into 2ml normal saline, adds 1mol/LNaOH0.1ml, surveys absorbance in 546nm wavelength place.By phenol red liquid standard curve, calculate phenol red content, the results are shown in Table 2.
Table 2 on the impact of the phenol red excretion amount of trachea (
)
Note: a and normal saline group be P≤0.05 relatively; B and eliminating phlegm and stopping cough groups of grains be P≤0.05 relatively; C and Maxingshigan ball group be P≤0.05 relatively.
1.3 antiasthmatic effects:
Get 40 of Baby guinea pigs, be divided at random 4 groups, each organizes Cavia porcellus difference gastric infusion 7 days, once a day, and each 1ml, after last administration 1 hour, each Mus is placed in respectively in glass flask, with 400mmHg pressure, sprays into 0.1% histamine phosphate and 2% acecoline mixed liquor volume than 1:1) 25 seconds, observe and record drawing of Cavia porcellus and breathe heavily incubation period and (from spraying, start to asthma attack, breathing is the devil, until the time of twitching and falling).The results are shown in Table 3.
Table 3 on the impact of Cavia porcellus antiasthmatic effect (
)
Note: a and normal saline group be P≤0.05 relatively; B and eliminating phlegm and stopping cough groups of grains be P≤0.05 relatively; C and Maxingshigan ball group be P≤0.05 relatively.
1.4 conclusions:
Table 1 shows that 3 administration groups and normal saline group more all have obvious antitussive action (P<0.05), and Maxing Zhike Capsules group is being better than eliminating phlegm and stopping cough granule aspect the number of times index of coughing, and cough latent period is better than Maxingshigan ball group.Table 2 shows that 3 administration groups and normal saline group more all have obvious phlegm-dispelling functions, though between 3 administration groups without significant difference, from the data of phenol red excretion amount, the curative effect of Maxing Zhike Capsules is slightly better than another two groups.Table 3 shows that 3 administration groups all have obvious antiasthmatic effect, compares P<0.05 with normal saline group, and the effect that Maxing Zhike Capsules treatment is relievingd asthma is better than eliminating phlegm and stopping cough granule, Maxingshigan ball (P<0.05).Therefore, Chinese ephedra and almond containing cough stopping of the present invention is in cough-relieving, aspect all card curative effects of eliminating the phlegm, relieving asthma, and general curative effect is obviously better than positive controls.
2, by different dosage form is investigated to discovery disintegration, be obviously better than Chinese ephedra and almond containing cough stopping sheet and Maxingshigan ball (referring to table 4) disintegration of preparation Maxing Zhike Capsules of the present invention.
Table 4 different dosage form is investigated disintegration
3, because the present invention is enteric coated capsule preparation, can make the direct location of medicine be released to small intestinal and enter circulation for absorption, therefore, can avoid the first pass effect of liver, reach the effect of slow release prolongation of effect, thereby improved the performance of drug effect; Simultaneously, medicine in capsule is directly filled in softgel shell with graininess, so dispersion rapidly, stripping and absorption in small intestinal, its bioavailability is higher than other dosage form, there is the features such as dissolution is high, absorption is strong, bioavailability is high, toxic and side effects is little, and can cover the bad stability of smelling taste, improving medicine of medicine.
4, the present invention is with low cost, easy to implement, have with short production cycle, process equipment is simple, the few feature of adjuvant easy to operate, used.
The specific embodiment
embodiment 1a Maxing Zhike Capsules, this capsule is made by the raw material of following weight parts: Herba Ephedrae 700g, Semen Armeniacae Amarum 500g, Flos Lonicerae 1500g, Bulbus Fritillariae Cirrhosae 500g, Radix Stemonae 500g, Radix Platycodonis 500g, Radix Glycyrrhizae 400g.
The preparation technology of this Maxing Zhike Capsules, comprises the following steps:
(1) by proportioning, weigh.
(2) the water that adds 4 ~ 12 times of its quality after Semen Armeniacae Amarum being deoiled according to a conventional method, is supersound extraction 30 ~ 50min under 60 ~ 80 ℃, the power condition that is 200 ~ 400W in temperature, filters, and obtains filtrate A.
(3) Herba Ephedrae, Flos Lonicerae, Bulbus Fritillariae Cirrhosae, the Radix Stemonae, Radix Platycodonis, Radix Glycyrrhizae are crushed to 10 orders after mixing, obtain mixture, then in this mixture, add the water of 6 ~ 10 times of its quality, in temperature, it is supersound extraction 2 times under 50 ~ 75 ℃, the power condition that is 100 ~ 500W, each extraction time is 60 ~ 80min, filter, obtain liquor B.
(4) by after filtrate A and liquor B merging, in temperature, be that under 50 ~ 70 ℃, the pressure condition that is 0.06 ~ 0.08MPa, to be evaporated to relative density be 1.10 ~ 1.15 extractum, this extractum is spray-dried adds according to a conventional method adjuvant to constant weight, mixes, and granulation incapsulates.
Wherein: spray-dired condition refers to that inlet temperature is 110 ~ 140 ℃, and temperature of outgoing air is 60 ~ 75 ℃, and charging total amount is 800 ~ 1000kg/h.
Adjuvant is any one in starch, mannitol, lactose, micropowder silica gel, microcrystalline Cellulose, Pulvis Talci, magnesium stearate, glyceryl monostearate.
embodiment 2a Maxing Zhike Capsules, this capsule is made by the raw material of following weight parts: Herba Ephedrae 1100g, Semen Armeniacae Amarum 800g, Flos Lonicerae 2000g, Bulbus Fritillariae Cirrhosae 800g, Radix Stemonae 800g, Radix Platycodonis 800g, Radix Glycyrrhizae 600g.
The preparation technology of this Maxing Zhike Capsules is same
embodiment 1.
embodiment 3a Maxing Zhike Capsules, this capsule is made by the raw material of following weight parts: Herba Ephedrae 800g, Semen Armeniacae Amarum 600g, Flos Lonicerae 1600g, Bulbus Fritillariae Cirrhosae 600g, Radix Stemonae 600g, Radix Platycodonis 600g, Radix Glycyrrhizae 500g.
The preparation technology of this Maxing Zhike Capsules is same
embodiment 1.
embodiment 4a Maxing Zhike Capsules, this capsule is made by the raw material of following weight parts: Herba Ephedrae 800g, Semen Armeniacae Amarum 700g, Flos Lonicerae 1700g, Bulbus Fritillariae Cirrhosae 700g, Radix Stemonae 700g, Radix Platycodonis 700g, Radix Glycyrrhizae 500g.
The preparation technology of this Maxing Zhike Capsules is same
embodiment 1.
embodiment 5a Maxing Zhike Capsules, this capsule is made by the raw material of following weight parts: Herba Ephedrae 900g, Semen Armeniacae Amarum 650g, Flos Lonicerae 1800g, Bulbus Fritillariae Cirrhosae 650g, Radix Stemonae 650g, Radix Platycodonis 650g, Radix Glycyrrhizae 450g.
The preparation technology of this Maxing Zhike Capsules is same
embodiment 1.
embodiment 6a Maxing Zhike Capsules, this capsule is made by the raw material of following weight parts: Herba Ephedrae 1000g, Semen Armeniacae Amarum 750g, Flos Lonicerae 1900g, Bulbus Fritillariae Cirrhosae 750g, Radix Stemonae 750g, Radix Platycodonis 750g, Radix Glycyrrhizae 550g.
The preparation technology of this Maxing Zhike Capsules is same
embodiment 1.
Claims (4)
1. a Maxing Zhike Capsules, is characterized in that: this capsule is made by the raw material of following weight parts: Herba Ephedrae 700 ~ 1100, Semen Armeniacae Amarum 500 ~ 800, Flos Lonicerae 1500 ~ 2000, Bulbus Fritillariae Cirrhosae 500 ~ 800, the Radix Stemonae 500 ~ 800, Radix Platycodonis 500 ~ 800, Radix Glycyrrhizae 400 ~ 600.
2. the preparation technology of a kind of Maxing Zhike Capsules as claimed in claim 1, comprises the following steps:
(1) by proportioning, weigh;
(2) the water that adds 4 ~ 12 times of its quality after Semen Armeniacae Amarum being deoiled according to a conventional method, is supersound extraction 30 ~ 50min under 60 ~ 80 ℃, the power condition that is 200 ~ 400W in temperature, filters, and obtains filtrate A;
(3) Herba Ephedrae, Flos Lonicerae, Bulbus Fritillariae Cirrhosae, the Radix Stemonae, Radix Platycodonis, Radix Glycyrrhizae are crushed to 10 orders after mixing, obtain mixture, then in this mixture, add the water of 6 ~ 10 times of its quality, in temperature, it is supersound extraction 2 times under 50 ~ 75 ℃, the power condition that is 100 ~ 500W, each extraction time is 60 ~ 80min, filter, obtain liquor B;
(4) by after described filtrate A and the merging of described liquor B, in temperature, be that under 50 ~ 70 ℃, the pressure condition that is 0.06 ~ 0.08MPa, to be evaporated to relative density be 1.10 ~ 1.15 extractum, this extractum is spray-dried adds according to a conventional method adjuvant to constant weight, mix, granulation incapsulates.
3. the preparation technology of a kind of Maxing Zhike Capsules as claimed in claim 2, is characterized in that: described step (4) in spray-dired condition refer to that inlet temperature is 110 ~ 140 ℃, temperature of outgoing air is 60 ~ 75 ℃, charging total amount is 800 ~ 1000kg/h.
4. the preparation technology of a kind of Maxing Zhike Capsules as claimed in claim 2, is characterized in that: described step (4) in adjuvant be any one in starch, mannitol, lactose, micropowder silica gel, microcrystalline Cellulose, Pulvis Talci, magnesium stearate, glyceryl monostearate.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948884A (en) * | 2014-03-31 | 2014-07-30 | 泰州市兴东煤矿机械制造有限公司 | Method for preparing traditional Chinese medicine preparation for preventing respiratory diseases and used in mine |
| CN104225216A (en) * | 2014-10-08 | 2014-12-24 | 山东理工大学 | Chinese herbal preparation for treating children cough with lung heat |
| CN104225236A (en) * | 2014-10-08 | 2014-12-24 | 山东理工大学 | Chinese herbal medicine composition for treating cough with lung heat in children |
| CN104258230A (en) * | 2014-10-08 | 2015-01-07 | 山东理工大学 | Chinese medicinal composition for treating pediatric lung heat cough |
| CN104984034A (en) * | 2015-06-30 | 2015-10-21 | 覃洪质 | Cough-relieving capsule |
| CN105250843A (en) * | 2015-10-30 | 2016-01-20 | 王滋东 | Medicament for treating cough due to wind-heat evil |
| CN106963883A (en) * | 2016-01-14 | 2017-07-21 | 北京亚东生物制药有限公司 | A kind of Chinese medicine composition of relieving cough and asthma resolving sputum and preparation method thereof |
| CN108785581A (en) * | 2018-07-20 | 2018-11-13 | 谢猛 | One kind moistens the lung and relieve the cough oral solution and its preparation method and application of relievining asthma |
| CN113546143A (en) * | 2020-04-26 | 2021-10-26 | 孙传阁 | Pharmaceutical composition for treating chronic bronchitis asthma and preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948884A (en) * | 2014-03-31 | 2014-07-30 | 泰州市兴东煤矿机械制造有限公司 | Method for preparing traditional Chinese medicine preparation for preventing respiratory diseases and used in mine |
| CN104225216A (en) * | 2014-10-08 | 2014-12-24 | 山东理工大学 | Chinese herbal preparation for treating children cough with lung heat |
| CN104225236A (en) * | 2014-10-08 | 2014-12-24 | 山东理工大学 | Chinese herbal medicine composition for treating cough with lung heat in children |
| CN104258230A (en) * | 2014-10-08 | 2015-01-07 | 山东理工大学 | Chinese medicinal composition for treating pediatric lung heat cough |
| CN104984034A (en) * | 2015-06-30 | 2015-10-21 | 覃洪质 | Cough-relieving capsule |
| CN105250843A (en) * | 2015-10-30 | 2016-01-20 | 王滋东 | Medicament for treating cough due to wind-heat evil |
| CN106963883A (en) * | 2016-01-14 | 2017-07-21 | 北京亚东生物制药有限公司 | A kind of Chinese medicine composition of relieving cough and asthma resolving sputum and preparation method thereof |
| CN108785581A (en) * | 2018-07-20 | 2018-11-13 | 谢猛 | One kind moistens the lung and relieve the cough oral solution and its preparation method and application of relievining asthma |
| CN113546143A (en) * | 2020-04-26 | 2021-10-26 | 孙传阁 | Pharmaceutical composition for treating chronic bronchitis asthma and preparation method thereof |
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| CN103638405B (en) | 2016-01-20 |
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