CN103638329A - Medicine for treating diabetes mellitus and preparation method of medicine - Google Patents
Medicine for treating diabetes mellitus and preparation method of medicine Download PDFInfo
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Abstract
The invention discloses a medicine for treating diabetes mellitus and a preparation method of the medicine. The medicine is mainly prepared from radices trichosanthis, yam, schisandra chinensis, raw rehmannia, pangolin, achyranthes bidentata, fructus cnidii, cicada slough, radix polygonati officinalis and other medicines in a certain weight ratio. The medicine has the functions of promoting production of body fluid and moistening dryness, nourishing yin and tonifying kidney, is quick in response and good in curative effect when used for treating diabetes mellitus, and prevents relapse.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of diabetes and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Diabetes are one group and take the metabolic disease that hyperglycemia is feature.Hyperglycemia be due to defect of insulin secretion or its biological agent impaired, or both have concurrently and cause.The long-standing hyperglycemia of diabetes, will cause various tissues, particularly eye, kidney, heart, blood vessel, neurological chronic lesion, dysfunction.
The Therapeutic Method of diabetes mainly comprises Diet Therapy, exercise therapy and Western medicine Drug therapy at present, but there is no the method for radical cure diabetes, and western medicine DeGrain, recover slow, Therapeutic Method and be difficult to accurate assurance, even sometimes occur the problems such as untoward reaction.Therefore there is great demand to the Chinese medicine of rapid, effective treatment diabetes in people, up to now, also do not find about relevant report of the present invention.
Summary of the invention
The inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, has finally found the medicine of effective treatment diabetes, thereby has completed the present invention.
Object of the present invention is just to provide a kind of Chinese medicine composition of more effective treatment diabetes.
Another object of the present invention has just been to provide the preparation method of this Chinese medicine composition.
Medicine of the present invention selects Radix Trichosanthis, Rhizoma Dioscoreae, Fructus Schisandrae Chinensis, Radix Rehmanniae, Squama Manis, Radix Achyranthis Bidentatae, Fructus Cnidii, Periostracum Cicadae, Rhizoma Polygonati Odorati, Herba Dendrobii, Rhizoma Atractylodis, Radix Salviae Miltiorrhizae, Cortex Phellodendri, Radix Puerariae, Pericarpium Citri Reticulatae, Cortex Lycii, Fructus Rosae Laevigatae ten seven flavor medicine things to combine, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat glycosuria palindromia.Wherein select Radix Trichosanthis to be because its nature and flavor sweetness and bitterness acid is cool, enter lung, stomach warp, have and promote the production of body fluid, quench the thirst, pathogenic fire reducing, moisturizes, evacuation of pus, and the function of detumescence, controls calentura thirsty, quenches one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid complicated by anal fistula.Select Rhizoma Dioscoreae to be because its nature and flavor are sweet, flat, enter lung, spleen, kidney channel, there is spleen invigorating, tonifying the lung, reinforces the kidney, and the function of benefit essence, controls diarrhea due to hypofunction of the spleen, chronic dysentery, cough due to consumptive disease, quenches one's thirst, seminal emission, leukorrhagia, frequent micturition.Select Fructus Schisandrae Chinensis to be because its nature and flavor are sour, temperature, enters lung, kidney channel, astringes the lung, and nourishing kidney, promotes the production of body fluid, and receives antiperspirant, and the function of arresting seminal emission, controls the deficiency of the lung and breath with cough, and xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.Select Radix Rehmanniae to be because its nature and flavor are sweet, cold, GUIXIN, liver, kidney channel, have clearing away heat and cooling blood, yin nourishing, and the function of promoting the production of body fluid, controls calentura excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis, sends out speckle dermexanthesis.Select Squama Manis to be because its nature and flavor are salty, cool, enter liver, stomach warp, have the routed carbuncle of detumescence, search wind active, the function of the stimulating milk secretion of stimulating the menstrual flow, controls carbuncle skin ulcer swollen, anemofrigid-damp arthralgia, amenorrhea, galactostasis, external hemostasis.Select Radix Achyranthis Bidentatae to be because its nature and flavor sweetness and bitterness acid is flat, enter liver, kidney channel, dissipating blood stasis blood is used in life, and the function of subduing inflammation, controls gonorrhea, hematuria, amenorrhea ， mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis stomachache, sore throat, carbuncle, traumatic injury, ripe in invigorating the liver and kidney, bone and muscle strengthening, controls waist kneecap pain, spasm of the limbs, flaccidity syndrome and arthralgia syndrome.Select Fructus Cnidii to be because its nature and flavor are arduous, temperature, enters kidney, spleen channel, has warming the kidney to activate YANG, dispel the wind, and dampness, the function of parasite killing, controls impotence in male, scrotum pruritus due to damp pathogen, woman's leukorrhagia pudendal pruritus, cold uterus is infertile, rheumatic arthralgia, scabies eczema.Selecting Periostracum Cicadae is because its property sweet-salty, cool, enters lung, Liver Channel, has loose wind heat, and lung qi dispersing determine the function of convulsion, controls affection due to external wind and heat, cough hoarseness, and measles is thoroughly not smooth, rubella pruritus, little youngster shies Epilepsy, conjunctival congestion, cataracta, furuncle swelling toxin, tetanus.Select Rhizoma Polygonati Odorati to be because its nature and flavor are sweet, flat, enter lung, stomach warp, has yin nourishing, moisturizes, relieving restlessness, the function of quenching the thirst, controls calentura sun wound, cough, excessive thirst, deficient fever, rapid digestion of food is easily hungry, frequent micturition.Select Herba Dendrobii to be because its property slightly sweet flavor is micro-salty, cold, enter to have, lung, kidney channel, there is the stomach reinforcing of promoting the production of body fluid, the function of clearing away heat and nourishing YIN, controls consumption of body fluid caused by febrile disease, and xerostomia is tired drinks, deficiency-heat after being ill, it is dark that the moon is hindered order.Select Rhizoma Atractylodis to be because its nature and flavor are arduous, temperature, enters spleen, stomach warp, has spleen invigorating, dampness, and resolving depression, wards off dirty function, control the wet tired spleen of containing, asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting, has loose bowels, dysentery, malaria, phlegm retention, edema, seasonal epidemic pathogens flu, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia.Select Radix Salviae Miltiorrhizae to be because its nature and flavor are bitter, tepor, enters the heart, Liver Channel, has blood circulation and promoting silt, calming heart and tranquilizing mind, and evacuation of pus, the function of pain relieving, controls angina pectoris, menoxenia, dysmenorrhea, to close, metrorrhagia leukorrhagia ， mass in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.Select Cortex Phellodendri to be because its nature and flavor are bitter, cold, enter lung, stomach, kidney channel, there is nourishing YIN to lower pathogenic fire, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Select Radix Puerariae to be because its nature and flavor are sweet pungent, flat, enter spleen, stomach warp, there is yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, the function that relieving restlessness is quenched the thirst, cures the wound cold, warm, headache, stiffness of the nape, dysphoria with smothery sensation disappears and drinks, has loose bowels, dysentery, abnormal pigmentary deposit on the skin is examined not saturating, hypertension, angina pectoris, deafness.Select Pericarpium Citri Reticulatae to be because its nature and flavor are bitter, pungent, temperature, returns lung, spleen channel, has regulating qi-flowing for strengthening spleen, and the function of drying dampness to eliminate phlegm, controls fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Select Cortex Lycii to be because its nature and flavor are sweet, cold, enter lung, liver, kidney channel, there is heat clearing away, the function of removing heat from blood, controls asthenia hectic fever night sweat, and lung-heat cough with asthma is spitted blood, epistaxis, stranguria with blood, quenches one's thirst, hypertension, carbuncle, malignant boil.Select Fructus Rosae Laevigatae to be because its nature and flavor are sour and astringent, flat, enter kidney, bladder, large intestine channel, there is reinforcing the kidney and controlling nocturnal emission, the function of reducing urination and antidiarrheal, controls spermatorrhea, the enuresis, frequent micturition, insufficiency of the spleen dysentery, the deficiency of the lung is breathed with cough, spontaneous sweating, bone leaks leukorrhagia.
The specific embodiment
The drug dose of component of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Radix Trichosanthis 12-20g Rhizoma Dioscoreae 5-15g Fructus Schisandrae Chinensis 8-16g
Radix Rehmanniae 6-15g Squama Manis 5-12g Radix Achyranthis Bidentatae 6-15g
Fructus Cnidii 8-15g Periostracum Cicadae 2-12g Rhizoma Polygonati Odorati 10-20g
Herba Dendrobii 8-16g Rhizoma Atractylodis 10-20g Radix Salviae Miltiorrhizae 8-15g
Cortex Phellodendri 10-20g Radix Puerariae 12-22g Pericarpium Citri Reticulatae 15-25g
Cortex Lycii 12-20g Fructus Rosae Laevigatae 5-15g
Be preferably
Radix Trichosanthis 14g Rhizoma Dioscoreae 12g Fructus Schisandrae Chinensis 10g
Radix Rehmanniae 10g Squama Manis 12g Radix Achyranthis Bidentatae 10g
Fructus Cnidii 10g Periostracum Cicadae 10g Rhizoma Polygonati Odorati 15g
Herba Dendrobii 10g Rhizoma Atractylodis 12g Radix Salviae Miltiorrhizae 10g
Cortex Phellodendri 12g Radix Puerariae 15g Pericarpium Citri Reticulatae 18g
Cortex Lycii 15g Fructus Rosae Laevigatae 10g
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Radix Trichosanthis: choose decontamination, size block separately, saturating with blister approximately sixty percent, pulls out, and moistening is even to inside and outside humidity, and section, dries, or wash, and pulls out, shines extremely dryly, smashes into fritter;
2, Rhizoma Dioscoreae: choose clean impurity, be soaked in water while softening to Rhizoma Dioscoreae central part, pull out slightly and dry in the air, section is dried or dried;
3, Fructus Schisandrae Chinensis: sieve dedust bits, remove impurity, to put in food steamer and steam thoroughly, taking-up is dried;
4, Radix Rehmanniae: get crude drug, remove impurity, clean, slightly profit, cuts sheet, dry, and sieve removes chip;
5, Squama Manis: get the Squama Manis sheet of choosing clean, separately size, separately puts sand in pot and make popular, adds Squama Manis sheet, fries to heaving while being golden yellow, takes out, and sieve shakeout, cools;
6, Radix Achyranthis Bidentatae: choose decontamination, clean, soften, go reed, cutting, dries;
7, Fructus Cnidii: choose decontamination, sieve removes silt particle, cleans, and dries;
8, Periostracum Cicadae: choose decontamination, clean and dry;
9, Rhizoma Polygonati Odorati: remove impurity, clean earth, moistening is even to inside and outside humidity, and section, dries;
10, Herba Dendrobii: get dry Herba Dendrobii, saturating with approximately to eighty per cant of blister, stewing profit, removes undesirable root and black branch, and cutting, hits thin film, dries;
11, Rhizoma Atractylodis: choose decontamination, with blister to seven, most probably saturating, pull out, run through rear section, dry;
12, Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;
13, Cortex Phellodendri: choose decontamination, wash, pull out, run through, section or shredding, dry;
14, Radix Puerariae: choose decontamination, clean, be soaked in water, pull out, run through, section, dries in time;
15, Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, softens, and shredding, dries or cold drying, sieve dedust bits;
16, Cortex Lycii: choose decontamination and core, slightly wash, cutting, dries;
17, Fructus Rosae Laevigatae: choose decontamination, cut two lobes, water slightly soaks, and pulls out, removes residual burr after moistening, digs clean hair, core, dry.
Two, preparation
1, the Radix Trichosanthis of described weight, Rhizoma Dioscoreae, Fructus Schisandrae Chinensis, Radix Rehmanniae, Squama Manis, Radix Achyranthis Bidentatae, Fructus Cnidii, Periostracum Cicadae, Rhizoma Polygonati Odorati, Herba Dendrobii, Rhizoma Atractylodis, Radix Salviae Miltiorrhizae, Cortex Phellodendri, Radix Puerariae, Pericarpium Citri Reticulatae, Cortex Lycii, Fructus Rosae Laevigatae are decocted with water to secondary, add for the first time 6 times of amounts of water, intense fire decocts boiling 10 minutes, use again slow fire boiling 25 minutes, filter to obtain decoction liquor for the first time.
2, the medicinal residues after filtering are added to 4 times of amounts of water, decoct boiling, then use slow fire boiling 20 minutes, filter to obtain decoction liquor for the second time.
3, merge secondary decoction liquor, boil with high heat, then with slow fire boiling 10 minutes and get final product, decoction medicinal liquid is divided into 2 doses and takes.
Medicine of the present invention have promote the production of body fluid moisturize, the function of kidney nourishing and replenishing vital essence, be used for the treatment of diabetes instant effect, good effect, cure rate is high.
By test example, further set forth below the beneficial effect of medicine of the present invention, these tests comprise animal toxicity test and the clinical observation on the therapeutic effect test of medicine of the present invention.
The animal toxicity test of [test example 1] medicine of the present invention
Get 30 of West Germany rabbits, male and female dual-purpose, body weight 2.0-2.5kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Overdose test group is 25ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, and every day, secondary, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1, physical data
Accept out-patient's totally 100 examples for medical treatment, male's 54 examples, women's 46 examples.
2, diagnostic criteria
Patient's fasting glucose is more than or equal to 7.0 mM/ls, or two hours blood glucoses are more than or equal to 11.1 mM/ls and can make a definite diagnosis after the meal, comprise type Ⅰ diabetes mellitus and type Ⅱdiabetes mellitus.Type Ⅰ diabetes mellitus to show as age of onset light, mostly lower than 30 years old, onset is unexpected, the polydipsia polyuria polyphagia symptom of becoming thin is obvious, blood sugar level is high; Type Ⅱdiabetes mellitus is common in middle-aged and elderly people, and overweight people's sickness rate is high, often can be with hypertension, and the diseases such as dyslipidemia, arteriosclerosis.Insidious onset, early stage without any symptom, or only have slightly weak, thirsty.
3, Therapeutic Method
Select above-mentioned medicament, to patient, take, each serving with 1 dose, every day, morning and evening service once, 30 days was a course for the treatment of, took continuously two courses for the treatment of.
4, efficacy result (seeing the following form):
In above-mentioned treatment, by drug treatment of diabetic patient 100 examples of the present invention, effective 93 examples of result, obvious effective rate is 93%, 4 examples that take a turn for the better, and improvement rate is 4%, invalid 3 examples, total effective rate is 97%.
Claims (3)
1. a medicine for the treatment of diabetes, is characterized in that: it is to be made by the crude drug in following weight range:
Radix Trichosanthis 12-20g Rhizoma Dioscoreae 5-15g Fructus Schisandrae Chinensis 8-16g
Radix Rehmanniae 6-15g Squama Manis 5-12g Radix Achyranthis Bidentatae 6-15g
Fructus Cnidii 8-15g Periostracum Cicadae 2-12g Rhizoma Polygonati Odorati 10-20g
Herba Dendrobii 8-16g Rhizoma Atractylodis 10-20g Radix Salviae Miltiorrhizae 8-15g
Cortex Phellodendri 10-20g Radix Puerariae 12-22g Pericarpium Citri Reticulatae 15-25g
Cortex Lycii 12-20g Fructus Rosae Laevigatae 5-15g.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Radix Trichosanthis 14g Rhizoma Dioscoreae 12g Fructus Schisandrae Chinensis 10g
Radix Rehmanniae 10g Squama Manis 12g Radix Achyranthis Bidentatae 10g
Fructus Cnidii 10g Periostracum Cicadae 10g Rhizoma Polygonati Odorati 15g
Herba Dendrobii 10g Rhizoma Atractylodis 12g Radix Salviae Miltiorrhizae 10g
Cortex Phellodendri 12g Radix Puerariae 15g Pericarpium Citri Reticulatae 18g
Cortex Lycii 15g Fructus Rosae Laevigatae 10g.
3. according to the preparation method of medicine described in claim 1 or 2, it is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Radix Trichosanthis: choose decontamination, size block separately, saturating with blister approximately sixty percent, pulls out, and moistening is even to inside and outside humidity, and section, dries, or wash, and pulls out, shines extremely dryly, smashes into fritter;
(2) Rhizoma Dioscoreae: choose clean impurity, be soaked in water while softening to Rhizoma Dioscoreae central part, pull out slightly and dry in the air, section is dried or dried;
(3) Fructus Schisandrae Chinensis: sieve dedust bits, remove impurity, to put in food steamer and steam thoroughly, taking-up is dried;
(4) Radix Rehmanniae: get crude drug, remove impurity, clean, slightly profit, cuts sheet, dry, and sieve removes chip;
(5) Squama Manis: get the Squama Manis sheet of choosing clean, separately size, separately puts sand in pot and make popular, adds Squama Manis sheet, fries to heaving while being golden yellow, takes out, and sieve shakeout, cools;
(6) Radix Achyranthis Bidentatae: choose decontamination, clean, soften, go reed, cutting, dries;
(7) Fructus Cnidii: choose decontamination, sieve removes silt particle, cleans, and dries;
(8) Periostracum Cicadae: choose decontamination, clean and dry;
(9) Rhizoma Polygonati Odorati: remove impurity, clean earth, moistening is even to inside and outside humidity, and section, dries;
(10) Herba Dendrobii: get dry Herba Dendrobii, saturating with approximately to eighty per cant of blister, stewing profit, removes undesirable root and black branch, and cutting, hits thin film, dries;
(11) Rhizoma Atractylodis: choose decontamination, with blister to seven, most probably saturating, pull out, run through rear section, dry;
(12) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;
(13) Cortex Phellodendri: choose decontamination, wash, pull out, run through, section or shredding, dry;
(14) Radix Puerariae: choose decontamination, clean, be soaked in water, pull out, run through, section, dries in time;
(15) Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, softens, and shredding, dries or cold drying, sieve dedust bits;
(16) Cortex Lycii: choose decontamination and core, slightly wash, cutting, dries;
(17) Fructus Rosae Laevigatae: choose decontamination, cut two lobes, water slightly soaks, and pulls out, removes residual burr after moistening, digs clean hair, core, dry;
(2) preparation
(1) Radix Trichosanthis of described weight, Rhizoma Dioscoreae, Fructus Schisandrae Chinensis, Radix Rehmanniae, Squama Manis, Radix Achyranthis Bidentatae, Fructus Cnidii, Periostracum Cicadae, Rhizoma Polygonati Odorati, Herba Dendrobii, Rhizoma Atractylodis, Radix Salviae Miltiorrhizae, Cortex Phellodendri, Radix Puerariae, Pericarpium Citri Reticulatae, Cortex Lycii, Fructus Rosae Laevigatae are decocted with water to secondary, add for the first time 6 times of amounts of water, intense fire decocts boiling 10 minutes, use again slow fire boiling 25 minutes, filter to obtain decoction liquor for the first time;
(2) medicinal residues after filtering are added to 4 times of amounts of water, decoct boiling, then use slow fire boiling 20 minutes, filter to obtain decoction liquor for the second time;
(3) merge secondary decoction liquor, boil with high heat, then with slow fire boiling 10 minutes and get final product, decoction medicinal liquid is divided into 2 doses and takes.
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| CN201310671028.3A CN103638329B (en) | 2013-12-12 | 2013-12-12 | Medicine for treating diabetes mellitus and preparation method of medicine |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1686529A (en) * | 2005-05-20 | 2005-10-26 | 李素梅 | Ready prepared Chinese medicine for treating diabetes |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1686529A (en) * | 2005-05-20 | 2005-10-26 | 李素梅 | Ready prepared Chinese medicine for treating diabetes |
Non-Patent Citations (1)
| Title |
|---|
| 金建宁，等: "赵进喜治疗糖尿病经验", 《中医杂志》, vol. 54, no. 6, 31 March 2013 (2013-03-31), pages 526 - 528 * |
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