CN103599644A - Device for extracting paeonol - Google Patents
Device for extracting paeonol Download PDFInfo
- Publication number
- CN103599644A CN103599644A CN201310597610.XA CN201310597610A CN103599644A CN 103599644 A CN103599644 A CN 103599644A CN 201310597610 A CN201310597610 A CN 201310597610A CN 103599644 A CN103599644 A CN 103599644A
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- CN
- China
- Prior art keywords
- extraction chamber
- paeonol
- extraction
- extracting
- stainless steel
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- UILPJVPSNHJFIK-UHFFFAOYSA-N Paeonol Chemical compound COC1=CC=C(C(C)=O)C(O)=C1 UILPJVPSNHJFIK-UHFFFAOYSA-N 0.000 title claims abstract description 46
- YLTGFGDODHXMFB-UHFFFAOYSA-N isoacetovanillon Natural products COC1=CC=C(C(C)=O)C=C1O YLTGFGDODHXMFB-UHFFFAOYSA-N 0.000 title claims abstract description 23
- MLIBGOFSXXWRIY-UHFFFAOYSA-N paeonol Natural products COC1=CC=C(O)C(C(C)=O)=C1 MLIBGOFSXXWRIY-UHFFFAOYSA-N 0.000 title claims abstract description 23
- 238000000605 extraction Methods 0.000 claims abstract description 41
- 229910001220 stainless steel Inorganic materials 0.000 claims abstract description 7
- 239000010935 stainless steel Substances 0.000 claims abstract description 7
- 239000011148 porous material Substances 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 6
- 241000736199 Paeonia Species 0.000 abstract description 3
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract description 3
- 229930014626 natural product Natural products 0.000 abstract description 2
- 238000001914 filtration Methods 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000007789 gas Substances 0.000 description 6
- 239000007788 liquid Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 240000005001 Paeonia suffruticosa Species 0.000 description 2
- 235000003889 Paeonia suffruticosa Nutrition 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- 101800004538 Bradykinin Proteins 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010020843 Hyperthermia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102100035792 Kininogen-1 Human genes 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 238000006757 chemical reactions by type Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 230000036031 hyperthermia Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Extraction Or Liquid Replacement (AREA)
Abstract
The invention provides a device for extracting paeonol, and particularly relates to a device which is used for extracting the paeonol, and is capable of increasing the yield and the extraction rate, belonging to the technical field of natural product extraction. The device comprises an extraction chamber; the upper part of the extraction chamber is provided with an exhaust pipe; a return pipe is arranged in the middle of the exhaust pipe; the return pipe is connected to the bottom of the extraction chamber by a control valve; an outlet of the exhaust pipe is connected with the bottom of the extraction chamber by a filtering part; the return pipe is provided with a heating part; the filtering part is a porous stainless steel filter plate; the porous stainless steel filter plate has the average pore size of 0.5-1 micron. The device provided by the invention can be used for continuously extracting the paeonol of the root bark of peony, and the gas which is not coagulated flows back into the extraction chamber, so that the material can be more evenly distributed, and the effective components are well dissolved out; furthermore, the condensate water flows back into the extraction chamber, and the effective components in the condensate water can be recycled, so that the yield is increased.
Description
Technical field
The invention provides a kind of extraction element of Paeonol, particularly relate to a kind of Paeonol extraction element that improves yield and recovery rate, belong to natural product extracting technique field.
Background technology
Paeonol has analgesia, anti-inflammatory, antipyretic and suppress allergic effect.To pressing the pain due to the physics such as tail, acetic acid or chemical factor, there is obvious analgesic activity.Inflammatory reaction to by due to carrageenan, egg white, formaldehyde, histamine, serotonin, bradykinin, dimethylbenzene and endotoxin etc., has obvious inhibitory action.The hyperthermia that typhoid vaccine, triple vaccine etc. is caused, has obvious refrigeration function.All inhibited to II, III, IV allergic reaction type.
Paeonol is extract a kind of Chinese medicine out from the root skin of Chinese national flower peony.Paeonol is one of main component of the Chinese medicine root bark of tree peony, and content is about 2-3 %, belongs to volatile ingredient, can volatilize with aqueous vapor, adopts volatile oil extractor to extract Paeonol in experiment.Take root bark of tree peony medicinal material approximately 50 g and put in 1 L round-bottomed flask, add 600 mL water, put up device, 2 h are extracted in hot reflux, and collection distillate is cooled to room temperature, ice bath crystallization.
The extraction efficiency of this extracting method is low, and productive rate is few, is not suitable for suitability for industrialized production.
Summary of the invention
The object of the invention is: a kind of extraction element that is suitable for industrialization, serialization, high efficiency Paeonol is provided, and the technical scheme of employing is as follows:
An extraction element for Paeonol, the middle part that the top that includes ， extraction chamber, extraction chamber is provided with blast pipe, blast pipe is provided with return duct, and return duct is connected in the bottom of extraction chamber by control valve; The outlet of blast pipe is connected with the bottom of extraction chamber by a filter element.
As improvement of the present invention, on return duct, be provided with heater block.
As improvement of the present invention, described filter element is porous stainless steel filter.
As improvement of the present invention, the average pore size of described porous stainless steel filter is 0.5～1 micron.
beneficial effect
Extraction element provided by the invention, can to the root skin of peony, carry out the extraction of Paeonol to serialization, and utilize not solidifying gas backstreaming to extraction chamber, material is more evenly distributed, the better stripping of active ingredient, and by condensate return to extraction chamber, active ingredient is wherein reclaimed again, improved yield.
Accompanying drawing explanation
Fig. 1 is the structural representation that the invention provides Paeonol extraction element.
Wherein, 1, extraction chamber; 2, blast pipe; 3, return duct; 4, control valve; 5, heater block; 6, filter element.
The specific embodiment
As Fig. 1, a kind of extraction element of Paeonol, the middle part that the top that includes 1 ， extraction chamber 1, extraction chamber is provided with blast pipe 2, blast pipe 2 is provided with return duct 3, and return duct 3 is connected in the bottom of extraction chamber 1 by control valve 4; The outlet of blast pipe 2 is connected with the bottom of extraction chamber 1 by a filter element 6.On return duct 3, be provided with heater block 5.Described filter element 6 is porous stainless steel filters, and average pore size is 0.5～1 micron.
Below in conjunction with concrete extraction operating process, this device is further described.
First, in extraction chamber, put into moutan bark raw material, then add suitable quantity of water, start to heat, the water that distillation produces can be discharged along blast pipe, in the gas of distillation, also have a large amount of Paeonols and water vapour, after exhaust pipe flow, can slowly be condensed, after the Paeonol of crystallization being held back by filter element, in the liquid seeing through, also contain the uncrystallized Paeonol of some, if after discharge, can cause the loss of active ingredient, this part is back to extraction chamber through liquid and can improve yield.
In addition, because the middle part at blast pipe is provided with return duct, in needs, opening control valve can make a part of steam be back in extraction chamber, these gases can make the moutan bark in feed liquid produce violent motion, make to extract, dissolve more even, have improved further yield.By the unlatching size of adjusting control valve, can adjust the flow of reflux gas, in addition, in order to prevent occurring condensation of gas on return duct, preferably by heater block, gas be heated again, prevent condensation, improve gas-liquid mixed effect.
Through a large amount of engineering tests, the moutan bark raw material of every 1kg can extract the Paeonol of 15-20g, and purity is about 90%.
Claims (4)
1. the extraction element of a Paeonol, it is characterized in that: include extraction chamber (1), the middle part that the top of (1) is provided with blast pipe (2), blast pipe (2) in extraction chamber is provided with return duct (3), and return duct (3) is connected in the bottom of extraction chamber (1) by control valve (4); The outlet of blast pipe (2) is connected with the bottom of extraction chamber (1) by a filter element (6).
2. the extraction element of Paeonol according to claim 1, is characterized in that: on described return duct (3), be provided with heater block (5).
3. the extraction element of Paeonol according to claim 1, is characterized in that: described filter element (6) is porous stainless steel filter.
4. the extraction element of Paeonol according to claim 3, is characterized in that: the average pore size of described porous stainless steel filter is 0.5～1 micron.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310597610.XA CN103599644B (en) | 2013-11-22 | 2013-11-22 | Device for extracting paeonol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310597610.XA CN103599644B (en) | 2013-11-22 | 2013-11-22 | Device for extracting paeonol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103599644A true CN103599644A (en) | 2014-02-26 |
| CN103599644B CN103599644B (en) | 2015-07-15 |
Family
ID=50117944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310597610.XA Active CN103599644B (en) | 2013-11-22 | 2013-11-22 | Device for extracting paeonol |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103599644B (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1094987A (en) * | 1993-05-14 | 1994-11-16 | 中南民族学院 | A kind of method that is used for the solid thermal extraction |
| JP2000246004A (en) * | 1999-03-04 | 2000-09-12 | Miura Co Ltd | Extracting equipment |
| CN2762860Y (en) * | 2005-01-28 | 2006-03-08 | 云南昆船设计研究院 | Chinese medicine extractor |
| CN2880210Y (en) * | 2006-02-07 | 2007-03-21 | 内蒙古师范大学 | Heating extracting device of plant useful component |
| CN102489040A (en) * | 2011-12-06 | 2012-06-13 | 河南牧翔动物药业有限公司 | Forced reflux extraction tank and forced reflux extraction process |
| CN202724857U (en) * | 2012-03-14 | 2013-02-13 | 刘刚 | High-efficiency extraction thickener |
-
2013
- 2013-11-22 CN CN201310597610.XA patent/CN103599644B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1094987A (en) * | 1993-05-14 | 1994-11-16 | 中南民族学院 | A kind of method that is used for the solid thermal extraction |
| JP2000246004A (en) * | 1999-03-04 | 2000-09-12 | Miura Co Ltd | Extracting equipment |
| CN2762860Y (en) * | 2005-01-28 | 2006-03-08 | 云南昆船设计研究院 | Chinese medicine extractor |
| CN2880210Y (en) * | 2006-02-07 | 2007-03-21 | 内蒙古师范大学 | Heating extracting device of plant useful component |
| CN102489040A (en) * | 2011-12-06 | 2012-06-13 | 河南牧翔动物药业有限公司 | Forced reflux extraction tank and forced reflux extraction process |
| CN202724857U (en) * | 2012-03-14 | 2013-02-13 | 刘刚 | High-efficiency extraction thickener |
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| Publication number | Publication date |
|---|---|
| CN103599644B (en) | 2015-07-15 |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Jia Shuang Inventor before: Wang Xiangbing |
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| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170802 Address after: 066000, No. 127 village, wood well Township, Lulong County, Qinhuangdao, Hebei Patentee after: Jia Shuang Address before: No. D802 530 building 214135 Jiangsu New District of Wuxi city Taihu international science and Technology Park of University Science and Technology Park Qingyuan Road Patentee before: WUXI HEZHONG INFORMATION TECHNOLOGY Co.,Ltd. |
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| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20180803 Address after: 244000 No. 706-1 Changjiang Middle Road, Tongguan mountain, Tongling, Anhui Patentee after: TONGLING XIANGYIHE TRADE Co.,Ltd. Address before: 066000 No. 127, Avenue Village, Mu Jing Township, Lulong, Qinhuangdao, Hebei Patentee before: Jia Shuang |
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| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20221103 Address after: 221000 No.18, Yangshan Road, Xuzhou Economic Development Zone, Jiangsu Province Patentee after: JIANGSU YI SEA PHARMACEUTICAl Co.,Ltd. Address before: 244000 No. 706-1 Changjiang Middle Road, Tongguan mountain, Tongling, Anhui Patentee before: TONGLING XIANGYIHE TRADE Co.,Ltd. |