CN103599442A - Novel method for preparing pharyngitis tablet - Google Patents

Abstract

The invention provides a novel method for preparing a pharyngitis tablet. The method comprises the following steps: extracting adix isatidis, radix scrophulariae and radix stemonae in the original prescription through 60% ethyl alcohol, extracting flos farfarae twice through hot water, and covering oleum menthae with beta-cyclodextrin. The novel process has the advantages that the toxicity of alcohol soluble components in the flos farfarae can be reduced, and active ingredients can be more adequately extracted.

Description

A kind of new method of preparing Yanyan slice

Technical field

The present invention relates to Chinese medicine formulation art, is a kind of new technology of preparing Chinese medicine.

Background technology

Yanyan slice is the product that Jilin ten thousand logical Pharmaceutical Mei He industry limited company produces, and has nourishing YIN and moistening the lung, heat-clearing and toxic substances removing, clearing throat, the effect that antitussive is antipruritic.What its method for making adopted is that the standard No. that second Yanyan slice of < < ministry standard Traditional Chinese medicine historical preparation > > records is: the standard of WS3-B-0331-90.Original prescription and method for making are as follows:

[prescription]

[method for making]

Above 12 tastes, except Oleum menthae, Flos Farfarae is ground into fine powder, sieves; Ten tastes such as all the other Radix Scrophulariaes decoct with water secondary, and 3 hours for the first time, 2 hours for the second time, collecting decoction, standing 24 hours, get supernatant, be condensed into thick paste, mix with Common Coltsfoot Flower, dry, granulation, spray, with Oleum menthae, mixes, and is pressed into 1000, and sugar coating, obtains.

Radix Scrophulariae is the dry root of dicotyledon Scrophulariaceae Scrophulariaceae Radix Scrophulariae ScrophularianingpoensisHemsl..There is clearing away heat and cooling blood, eliminating fire and detoxication, the effect of YIN nourishing, cures mainly pathogenic warmth and joins the army, the pericardium that caves in, maculae caused by violent heat pathogen, constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus are hindered in consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin.Radix Scrophulariae is mainly containing alkaloid, saccharide, sterol (Phy-tosterol), aminoacid (left-handed agedoite L-Asparagine etc.), volatilization wet goods.Above composition is easy to be dissolved in ethanol more.

The Radix Stemonae is the dried root for Stemonaceae plant Radix Stemonae Stemona sessilifolia (Miq.) Miq., Radix stemonae japonicae Stemona japonica (Bl.) Miq. or radix stemonae tuberosae Stemona tuberosa Lour..There is nourishing the lung to arrest cough; The effect of parasite killing delousing, coughs for new chronic cough, pulmonary tuberculosis, pertussis, enterobiasis, body louse, tinea scabies.The Radix Stemonae is containing multiple alkaloid, sugar, lipid, protein, ash and acetic acid, formic acid, malic acid, succinic acid, oxalic acid etc.Above composition is easy to be dissolved in ethanol more.

Flos Farfarae coltsfoot is the alabastrum of Compositae coltsfoot, and property and flavor of peppery and warm, has nourishing the lung to keep the adverse QI downward, and the effect of the antitussive that reduces phlegm, mainly containing the sterols such as arnidiol and isomer faradiol, globulariacitrin, hyperin, triterpenoid saponin, tannin, wax, volatilization wet goods.Modern clinical research shows, it is poisoning that Flos Farfarae ethanol extract can cause mice, causes mad dry uneasiness, and respiratory stimulant, muscular tone, spasm, convulsions are dead.

Radix Isatidis is the root of cruciferae isatis (Isatis tinctoria L.) and careless Folium Isatidis (I.indigotica Fort.), has the effect of heat-clearing and toxic substances removing, removing heat from blood detumescence, sore-throat relieving.Radix Isatidis is containing the antibacterial substance of indigo glycoside (Indoxyl-β-glucoside), isatin (Isatin), indigo (Indigo), qingdainone (Qingdainone), daucosterol (Daucosterol), cupreol (β-Sitosterol), Radix Isatidis second element, the third element and fourth element and anti-Grain-positive and negative bacteria.Radix Isatidis is the highest with indirubin and the total nitrogen content of 60% alcohol reflux thing.(credit of Niu Yingwei ,Li state, optimizes the research of Extraction Technology of Radix Isatidis, < < China's New Products > > 20 phases in 2011).

Summary of the invention

The invention provides a kind of new method of preparing Yanyan slice, its positive beneficial effect is, the one, removed the toxicity of Alcohol soluble composition in Flos Farfarae; The 2nd, be conducive to the extraction of the alkaloids composition in Radix Scrophulariae, the Radix Stemonae; The 3rd, the extracts active ingredients such as indigo, indirubin in Radix Isatidis is more complete.Increase on the whole the extracted amount of effective ingredient, reduced the toxicity of Yanyan slice, better efficacy.

[prescription]

[method for making]

Above 12 tastes, get Radix Scrophulariae, the Radix Stemonae, Radix Isatidis and add 60% ethanol extraction secondary, and each 1 hour, merge extractive liquid,, filtered, and reclaims ethanol, is condensed into thick paste, standby; Get Radix Asparagi, Cortex Moutan, Radix Ophiopogonis, Flos Farfarae (system), Semen Oroxyli, Radix Rehmanniae, Fructus Canarii, Periostracum Cicadae eight taste medicines and decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction, was condensed into thick paste, standby; Separately get Oleum menthae, with beta-cyclodextrin inclusion compound, standby; Above two kinds of thick pastes mix, dry, add Benexate Hydrochloride, mix, and granulation, tabletting, coating, obtains.

Technique comparative illustration before and after improving:

1, in former technique, Radix Scrophulariae, the Radix Stemonae, Radix Isatidis take water extraction to extract, and after improving, use 60% ethanol extraction.The two effective ingredient of Radix Scrophulariae, the Radix Stemonae is all alkaloids composition, and alkaloid is easy to be dissolved in ethanol; The effective ingredient of Radix Isatidis is indigo and indirubin, and the dissolubility of these two kinds of compositions in ethanol, higher than dissolubility in water, is more conducive to the extracts active ingredients in medical material after improvement, reduced production cost.

2, in former technique, Flos Farfarae, for directly pulverizing and be used as medicine, is water extraction after improving.After improvement, can avoid the molten part noxious substance of alcohol in Flos Farfarae to be used as medicine, thereby reduce the toxicity of medicine.

3, in former technique, Oleum menthae, for directly spraying and be used as medicine, is used as medicine with beta-cyclodextrin inclusion compound after improvement, can reduce the loss in preparation process, thereby increase curative effect of medication.

Claims (1)

1. a method of preparing Yanyan slice, its raw material medicament preparation method is as follows:

[prescription]

[method for making]

Above 12 tastes, get Radix Scrophulariae, the Radix Stemonae, Radix Isatidis and add 60% ethanol extraction secondary, and each 1 hour, merge extractive liquid,, filtered, and reclaims ethanol, is condensed into thick paste, standby; Get Radix Asparagi, Cortex Moutan, Radix Ophiopogonis, Flos Farfarae (system), Semen Oroxyli, Radix Rehmanniae, Fructus Canarii, Periostracum Cicadae eight taste medicines and decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction, was condensed into thick paste, standby; Separately get Oleum menthae, with beta-cyclodextrin inclusion compound, standby; Above two kinds of thick pastes mix, dry, add Benexate Hydrochloride, mix, and granulation, tabletting, coating, obtains.