CN103599266B - 一种治疗溃疡性结肠炎的中药 - Google Patents
一种治疗溃疡性结肠炎的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗溃疡性结肠炎的中药，由以下重量配比的药材制备而成：草红藤18份、佛杜树12份、飞燕草16份、端哼8份、凤尾搜山虎20份、滇白芷14份、澄茄子14份、丰花草14份、防已10份、伏毛山豆根12份、翅子树12份、地血香果12份、大叶金锦香10份、东莨菪14份、多蕊蛇菰16份。临床实验证明，本发明能够安全有效治疗溃疡性结肠炎。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗溃疡性结肠炎的中药。
背景技术
溃疡性结肠炎是一种病因尚不十分清楚的结肠和直肠慢性非特异性炎症性疾病，病变局限于大肠黏膜及黏膜下层。病变多位于乙状结肠和直肠，也可延伸至降结肠，甚至整个结肠。病程漫长，常反复发作。本病见于任何年龄，但20～30岁最多见。目前认为炎性肠病的发病是外源物质引起宿主反应、基因和免疫影响三者相互作用的结果。最初表现可有许多形式。血性腹泻是最常见的早期症状。其他症状依次有腹痛、便血、体重减轻、里急后重、呕吐等。偶尔主要表现为关节炎，虹膜睫状体炎，肝功能障碍和皮肤病变。
对于溃疡性结肠炎目前尚缺少公认安全有效的治疗药物。
本发明中药所涉及药材的研究现状如下：
草红藤【来源】豆科宿苞豆属植物毛宿苞豆Shuteria pampaniniana Hand.-Mazz.，以全草入药。夏秋采收，洗净切段晒干。【功能主治】清热解毒，消肿。用于阑尾炎，乳腺炎，腮腺炎，肺结核咯血。
佛杜树【来源】大戟科佛杜树Jatropha podagrica Hook.，以全株入药。【功能主治】清热解毒，消肿止痛。主治毒蛇咬伤。
飞燕草【来源】为毛茛科植物飞燕草的根、种子。夏秋采集，洗净，鲜用。【功能主治】种子：有催吐、泻下作用；外用杀虫；治疥疮；头虱。主根：外用治跌打损伤。
端哼【来源】为葡萄科植物大叶火筒树的根或叶。秋、冬季采根，洗净，切片；夏、秋季采叶，洗净，切碎。鲜用或晒干。【功能主治】活血散瘀；愈溃生肌；清热解毒。主妇人乳房肿痛；乳汁分泌不畅；颊颈炎症肿庸；疮疡肿疖；溃疡久不收口；跌打损伤。
凤尾搜山虎【来源】为水龙骨科植物多羽节肢蕨的根茎。秋、科季采挖根茎，洗净，去须根，放火上燎去毛，刮去外皮，晒干，或片晒干。【功能主治】祛风活络；消积通便；降火；止痛；利尿。主风湿稻田骨痛；坐骨神经痛；骨折；食积腹胀；便秘；目赤；牙痛；头痛；小便不利；淋浊。
滇白芷【来源】为伞形科植物糙叶独活的根。7-10月茎叶枯黄时采挖，去其茎叶，洗净，晒干。【功能主治】祛风发表；散寒燥湿。主风寒感冒；头痛；咳顺；鼻渊；脘腹冷痛；风寒湿痹；寒湿带下；痛经；疮疡肿痛；风疹湿痒。
澄茄子【来源】为樟科植物山鸡椒的果实。【功能主治】温中止痛；行气活血；平喘；利尿。主脘腹冷痛；食积气胀；反胃呕吐；中暑吐泻；泄泻痢疾；寒疝腹痛；哮喘；寒湿水臌；小便不利；小便浑浊；疮疡肿毒；牙痛；寒湿痹痛；跌打损伤。
丰花草【来源】为草科植物丰花草的全草。夏。秋季采收(海南省全年均可采)，鲜用或晒干。【功能主治】活血祛瘀；消肿解毒。主跌打损伤；骨折；痈疽肿毒；毒蛇咬伤。
防已【来源】为防已科植物粉防已睥块根。秋季采挖，修去芦梢，洗净或刮去栓皮，切成长段，粗根剖为2-4瓣，晒干。【功能主治】利水消肿；祛风止痛。主水肿；小便不利；风湿痹痛；脚气肿痛；疥癣疮肿；高血压病。
伏毛山豆根【来源】豆科伏毛山豆根Euchresta strigillosa C. Y. Wu，以根入药。【功能主治】清热解毒，止痛。主治肠炎腹泻，腹胀，胃痛，咽喉痛。
翅子树（翅子木）【来源】为梧桐科植物翅子树的叶。夏、秋季采叶，鲜用。【功能主治】散瘀止血。主跌打肿痛；创伤出血。
地血香果【来源】为五味子科植物异型南五味子的果实。夏秋采收，除去果柄，晒干。【功能主治】益肾宁心；祛痰止咳。主肾虚腰痛；神经衰弱；支气管炎。
大叶金锦香【来源】为野牡丹科植物蚂蚁花的枝叶。全年均可采，洗净切段晒干。【功能主治】燥湿杀虫。主疥癣瘙痒。
东莨菪【来源】为茄科植物东莨菪的根茎。春、秋采挖，洗净，晒干。【功能主治】治饮食积滞，噎膈反胃。
多蕊蛇菰【来源】为蛇菰科植物多蕊蛇菰的全株。秋季采收。【功能主治】滋阴补肾。治血虚，出血，淋病。
发明内容
本发明旨在提供一种治疗溃疡性结肠炎的中药，通过选择合适的药材及其配比，达到安全有效治愈溃疡性结肠炎的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗溃疡性结肠炎的中药，其特征在于，由以下重量配比的药材制备而成：草红藤18份、佛杜树12份、飞燕草16份、端哼8份、凤尾搜山虎20份、滇白芷14份、澄茄子14份、丰花草14份、防已10份、伏毛山豆根12份、翅子树（翅子木）12份、地血香果12份、大叶金锦香10份、东莨菪14份、多蕊蛇菰16份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2010年11月-2012年4月间共收集112例溃疡性结肠炎的门诊患者，年龄25-42岁，病程1-5年。随机分为：治疗组85例，空白组27例。两组年龄、病情等资料无显著性差异，具有可比性。
2、试验方法
2.1治疗组口服本发明按照具体实施例1制得的胶囊，早晚各一次。疗程30天。
2.2空白组口服安慰剂胶囊，早晚各一次。疗程30天。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常，愈后观察三个月未见复发。好转：临床症状减轻，病情得到控制，实验室检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 总有效率(%) | 不良反应例 |
| 治疗组 | 85 | 21（24.7%） | 45（52.9%) | 19（22.4%) | 77.6% | 0 |
| 空白组 | 27 | 0 | 6（22.2%） | 21（77.8%） | 22.2% | 0 |
可见，本发明制得的药物能够安全有效治疗溃疡性结肠炎。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：草红藤18克、佛杜树12克、飞燕草16克、端哼8克、凤尾搜山虎20克、滇白芷14克、澄茄子14克、丰花草14克、防已10克、伏毛山豆根12克、翅子树（翅子木）12克、地血香果12克、大叶金锦香10克、东莨菪14克、多蕊蛇菰16克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗溃疡性结肠炎。口服，每日分早晚两次服用。
具体实施例2
称取：草红藤18克、佛杜树12克、飞燕草16克、端哼8克、凤尾搜山虎20克、滇白芷14克、澄茄子14克、丰花草14克、防已10克、伏毛山豆根12克、翅子树（翅子木）12克、地血香果12克、大叶金锦香10克、东莨菪14克、多蕊蛇菰16克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，粉碎，即得符合正常成人1天用量的散剂。
用于治疗溃疡性结肠炎。口服，每日分早晚两次服用。
具体实施例3
称取：草红藤18克、佛杜树12克、飞燕草16克、端哼8克、凤尾搜山虎20克、滇白芷14克、澄茄子14克、丰花草14克、防已10克、伏毛山豆根12克、翅子树（翅子木）12克、地血香果12克、大叶金锦香10克、东莨菪14克、多蕊蛇菰16克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人1天用量的颗粒剂。
用于治疗溃疡性结肠炎。口服，每日分早晚两次服用。
Claims (1)
1.一种治疗溃疡性结肠炎的中药，其特征在于，由以下重量配比的药材制备而成：草红藤18份、佛杜树12份、飞燕草16份、端哼8份、凤尾搜山虎20份、滇白芷14份、澄茄子14份、丰花草14份、防已10份、伏毛山豆根12份、翅子树12份、地血香果12份、大叶金锦香10份、东莨菪14份、多蕊蛇菰16份。
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