CN103599265B - A kind of compound traditional Chinese medicine for radiation protection - Google Patents
A kind of compound traditional Chinese medicine for radiation protection Download PDFInfo
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Abstract
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of compound traditional Chinese medicine for radiation protection.The invention discloses a kind of compound traditional Chinese medicine for radiation protection, it is characterized in that medicine of the present invention is prepared from by the component of following weight parts: Radix Astragali 21-62 part, Semen Vitis viniferae 1-8 part, Radix Et Caulis Acanthopanacis Senticosi 16-46 part, Rhizoma Dioscoreae 7-29 part, Semen Ziziphi Spinosae 1-7 part.The present invention compares with curative with other radiation protection existing, has obvious advantage and effect: the first, and drug use is convenient; The second, the existing Study On The Radioprotective of medicine, also has the effect of auxiliary radiation injury in treating; 3rd, medicine refine from conventional medical herbs among the people, good drug efficacy and having no side effect; 4th, raw materials used is China's common Chinese medicine material, widely distributed, cheap, is one of advantage of its following input Application and Development.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of compound traditional Chinese medicine for radiation protection and its production and use.
Background technology
Along with the development of science and technology, ionizing radiation has penetrated into the many fields in human being's production life, inevitably cause radiation damage to people, as the radiotherapy carried out malignant tumor patient clinically, personnel are subject in the radioactivity infringement of occupational irradiation personnel and space travel space radiation etc.
Radioprotectant (radioprotectors) refers to that body or a certain biosystem are subject to before and after ionization radiation irradiation, give certain substance in early days and alleviate its radiation damage, promote that it recovers, the compound (or medicine) with this effect is called radioprotectant.Modern main radioprotectant has: thioctic acid analog derivative, estrogens, calcium ion antagonist, bacterial toxins, cytokine, polysaccharide and Chinese medicine etc.
Natural drug becomes rapidly the new focus of radioprotector research with little, the resourceful advantage of its toxic and side effects.The traditional Chinese medical science thinks that many symptoms that acute radiation sickness their early stage shows are that excessive noxious heat causes, and antipyretic and antidotal type medicine has the effects such as antibacterial, antiviral, and can the immunologic function of enhancing body, also has Study On The Radioprotective.In fact, carry out research to some Chinese herbal medicine and the active component that is separated to from Chinese herbal medicine to find, there is heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, blood yiqi, yin nourishing rise white Chinese medicinal formulae and single medicinal material all has radiation resistance in various degree, such as, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Dioscoreae, Semen Ziziphi Spinosae, Radix Ginseng, Radix Angelicae Sinensis, T. gambasum, ligustrazine, Ganoderma etc. all have radiation resistance.At present, the research of Traditional Chinese Medicine Anti radiation aspect mainly rests in the aspect of single rich in nutrition medicine, but Chinese medicine compound is used for radioprotector report seldom.
Summary of the invention
The object of this invention is to provide that a kind of material combination is fewer but better, cost of manufacture is low, have Mi Gu granule, and determined curative effect, safe and reliable for protecting and treat the compound traditional Chinese medicine for radiation protection due to radiogenic leukopenia.
For achieving the above object, the invention discloses a kind of compound traditional Chinese medicine for radiation protection, it is characterized in that medicine of the present invention is prepared from (unit is weight portion) by following component:
Radix Astragali 21-62 Semen Vitis viniferae 1-8 Radix Et Caulis Acanthopanacis Senticosi 16-46 Rhizoma Dioscoreae 7-29 Semen Ziziphi Spinosae 1-7.
In embodiments, described compound traditional Chinese medicine for radiation protection, is characterized in that medicine of the present invention is prepared from (unit is weight portion) by following component:
Radix Astragali 21-62 Semen Vitis viniferae 1-8 Radix Et Caulis Acanthopanacis Senticosi 16-46 Rhizoma Dioscoreae 7-29 Semen Ziziphi Spinosae 1-7
Wherein, optimization formula is prepared from (unit is weight portion) by following component:
Radix Astragali 36-46 Semen Vitis viniferae 4-6 Radix Et Caulis Acanthopanacis Senticosi 32-38 Rhizoma Dioscoreae 13-17 Semen Ziziphi Spinosae 3-4
Optimum formula of the present invention is prepared from (unit is weight portion) by following component:
Radix Astragali 37-39 Semen Vitis viniferae 5-6 Radix Et Caulis Acanthopanacis Senticosi 36-38 Rhizoma Dioscoreae 15-17 Semen Ziziphi Spinosae 3-4.
On the other hand, the invention also discloses the preparation method of above-mentioned compound traditional Chinese medicine for radiation protection, it includes but not limited to the conventional method of oral preparation of Chinese traditional medicinal, such as, feed material medicine can be developed into powder mix homogeneously and make powder and take after mixing it with water, also above-mentioned unit medicine together decocting can be made water decoction;
Preferably, the preparation method of herbal mixture of the present invention, comprises the following steps:
A) get the Radix Astragali of described weight, Semen Vitis viniferae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Dioscoreae, Semen Ziziphi Spinosae are for subsequent use;
B) above-mentioned Chinese crude drug is decocted with water 2 times, each amount of water was advisable not have powder, collecting decoction, was condensed into the extractum that proportion is 1.35;
C) extractum adopts water extract-alcohol precipitation to staticize process or the process of enzyme calmnessization, concentrated, dry at 40-50 DEG C, obtained dry extract;
D) dry extract is broken into fine powder, with regard to the active component of preparation cost invention herbal mixture.
In above-mentioned preparation method, step b) in when decocting with water, first time adds water 8 times amount, and decocts 1.5 hours, add water 6 times amount for the second time, decocts 1 hour.
The active component of herbal mixture of the present invention can add various pharmaceutically acceptable customary adjuvant required when preparing different dosage form, as disintegrating agent, lubricant, adhesive etc. adopt conventional phamaceutical techniques to make the common oral formulations of any one, comprise capsule, liposome, granule, tablet, pill, powder, oral liquid etc.
The present invention compares with curative with other radiation protection existing, has obvious advantage and effect: the first, and drug use is convenient; The second, the existing Study On The Radioprotective of medicine, also has the effect of auxiliary radiation injury in treating; 3rd, medicine refine from conventional medical herbs among the people, good drug efficacy and having no side effect; 4th, raw materials used is China's common Chinese medicine material, widely distributed, cheap, is one of advantage of its following input Application and Development.
Accompanying drawing explanation
Fig. 1 .8.0Gy
60after Co gamma-rays irradiates, different time respectively organizes mouse survival rate;
Fig. 2. each group SOD in Mice Activity determination;
Fig. 3. each group mice MAD content detection.
Detailed description of the invention
Below in conjunction with specific embodiment, set forth the present invention further.These embodiments are only not used in for illustration of the present invention and limit the scope of the invention.The experimental technique of unreceipted actual conditions in the following example, the usually conveniently conditioned disjunction condition of advising according to manufacturer.Unless otherwise defined, all specialties used in literary composition and scientific words and one skilled in the art the same meaning be familiar with.In addition, any method similar or impartial to described content and material all can be applicable in the inventive method.The use that better implementation method described in literary composition and material only present a demonstration.
The prescription optimization experiment of embodiment 1 Chinese medicine compound
Hemopoietic tissue is to ionizing radiation very sensitive organization, and the radiation damage of hemopoietic system and the hematopoietic disorder brought thus are the key pathogenetic links of acute radiation sickness pathological change.Therefore, protection hemopoietic tissue is from radiation damage or alleviate degree of injury, is one of important research direction of radiation damage prevention and control field all the time.After hematopoietic cell raying damage, the quantity of leucocyte be reflected in peripheral blood routine acutely declines [Fan Ting, Lin Xinying; Zhao Yan; Deng. garlicin is to the auxiliary protection function [J] of mice radiation damage. environment and health magazine, 2004,24(9): 718-720].Therefore, this experimental selection peripheral hemogram is the pharmacodynamic index that prescription is optimized.
1, compound traditional Chinese medicine for radiation protection prescription and preparation
1.1 Chinese prescription
5 taste medicines (Radix Astragali, Semen Vitis viniferae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Dioscoreae, Semen Ziziphi Spinosae) are provided by Acetar Bio-tech Inc., according to the effective dose principle of single medicinal material in the Pharmacopoeia of the People's Republic of China and document, set each taste pharmaceutical quantities scope.Above-mentioned 5 factors are divided into 10 levels, utilize uniform Design software design to go out 10 prescription proportionings, according to pharmacodynamic experiment result, select optimal drug prescription (table 1).
Table 1 prescription proportioning (unit is weight portion)
1.2 preparation method
The preparation method of compound traditional Chinese medicine for radiation protection, comprises the following steps:
A) get the Radix Astragali of described weight, Semen Vitis viniferae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Dioscoreae, Semen Ziziphi Spinosae are for subsequent use;
B) above-mentioned Chinese crude drug is decocted with water 2 times, add water 8 times amount for the first time, decocts 1.5 hours, and add water 6 times amount for the second time, decocts 1 hour, collecting decoction, be condensed into the extractum that proportion is 1.35;
C) extractum adds 90%-95% ethanol and carries out precipitate with ethanol, reclaims ethanol and concentrated, dry at 40-50 DEG C, obtained dry extract;
D) dry extract is broken into fine powder, is the active component of each taste Chinese medicine.
E) mix according to the weight of herbal mixture prescription of the present invention and get final product.
2, effect experiment
2.1 experimental techniques:
Laboratory animal grouping and administration:
Healthy SPF level Kunming mouse, male, 120, be divided into 12 groups at random by body weight, often organize 10, that is: normal group, irradiation control group, prescription 1, prescription 2, prescription 3, prescription 4, prescription 5, prescription 6, prescription 7, prescription 8, prescription 9, prescription 10.Successive administration 14 days.
The foundation of model:
In administration the 7th day, except normal group, all the other are respectively organized mice and all adopt the irradiation of 60Co γ-source to set up Radiation damage models.During irradiation, mice puts special mouse cage restraint, carries out whole body single uniform irradiation under waking state.Radioactive source is 60Co γ-source, exposure dose rate 1.0Gy/min, and accumulative exposure dose is 6.5Gy.
Testing index:
Continue empirically design administration after irradiation, and in latter 3rd day, 7 days of irradiation, eye socket got blood, adds in EDTA-2Na anticoagulant tube, detects erythrocyte by blood-counter system, leukocyte, platelet.
3. result
3.1 according to latter 3rd day
Result is as shown in table 2, compares with normal group, and except prescription 5, other prescriptions all have significant difference (P<0.01).Prompting, modeling success.Compare with irradiation control group, the RBC of normal group and 10 prescription groups, WBC recover all there is significant difference (P<0.01), wherein only have the HGB of prescription 5 to improve and have significant difference (P<0.01).Display, the mice hemogram of gavage prescription 5 recovers the most comprehensive, and the protective effect of prescription 5 is the most obvious.
Table 2 irradiates the impact (n=10 of rear 3d mouse peripheral blood WBC, RBC and HGB;
)
Note: compare with normal group,
#: P<0.05;
##: P<0.01; Compare with irradiation control group,
*: P<0.05;
*: P<0.01.
3.2 according to latter 7th day
Result is as shown in table 3, compares with normal group, and except prescription 5, other prescriptions all have significant difference (P<0.01).Compare with irradiation control group, the RBC of normal group and 10 prescription groups, WBC, HGB all recover obvious, have significant difference (P<0.01).Prompting, the prescription of anti-spoke capsule has protective action to radiation damage, and wherein the mice hemogram of prescription 5 recovers minimum with normal group difference, and protective effect is the most obvious.
Table 3 irradiates the impact (n=10 of rear 7d mouse peripheral blood WBC, RBC and HGB;
)
Note: compare with normal group,
#: P<0.05;
##: P<0.01; Compare with irradiation control group,
*: P<0.05;
*: P<0.01.
This studies display, and in peripheral hemogram, 10 prescriptions of anti-spoke capsule all have protective action to radiation damage, and wherein the proportioning of No. 5 prescriptions is more reasonable, and drug effect is more obvious.
Embodiment 230 days survival assay
Method: 100 healthy cleaning grade Kunming mouses, 22 ± 2g, male and female half and half, are divided into model group at random, basic, normal, high dosed administration group and matched group (male and female sub-cage rearing).Except matched group, adopt
60co γ-source, single fraction irradiation, close rate 2.0Gy/min, absorbed dose 8.0Gy.Administration group is according to design dosage, and according to first 7 days and according to each administration every day in latter 7 day (prescription 5, lower same) 1 time, dosage is 165mg/kg body weight; Model group and matched group give commensurability normal saline.Record mouse survival situation, measures 30d survival rate.
Result: as Fig. 1.All dead according to latter 30 days model group, survival rate is 0, and basic, normal, high dosed administration group 30 days survival rates are respectively 50%, 62.75% and 75%.Illustrate that medicine of the present invention has good Study On The Radioprotective, mice can be improved according to latter 30 days survival rates.
Embodiment 3 acute toxicity testing
Method: 60 healthy cleaning grade Kunming mouses, 22 ± 2g, male and female half and half, are divided into basic, normal, high dosed administration group (male and female sub-cage rearing) at random.By 30 times of compounding pharmaceutical dosage of 30 days existence test consumptions, single-dose, conventional raising 15 days, record mouse survival situation, measures mortality rate.
Result: as table 4, clinical drug consumption of the present invention is 3g/ day, and Mouse oral maximum tolerated dose is 30.0g/kg body weight, is equivalent to 465.2 times of adult's quantity.Prompting, medicine of the present invention is without obvious acute toxicity.
Table 4 Mouse Acute Toxicity is tested
Embodiment 4 is on hemopoietic and immune impact
Method: 50 healthy cleaning grade Male Kunming strain mice, male and female half and half, 22 ± 2g, is divided into model group at random, basic, normal, high dosed administration group and matched group (male and female sub-cage rearing).Except matched group, adopt 60Co γ-source, single fraction irradiation, close rate 2.0Gy/min, absorbed dose 5.5Gy.Weigh according to rear 7d, leukocyte count is surveyed in eyeball blood sampling, and rear de-neck is put to death and surveyed Thymus and spleen index.
Result: as table 5; compare with matched group; after mice exposure; spleen index, thymus index and leukocyte count all have decline; but administration group compares with model group; spleen index, thymus index and leukocyte count all have obvious rising, point out medicine of the present invention to have protective effect to mouse hemopoietic and immune system.
Table 5 mouse spleen index, thymus index and leukocyte count (
)
Embodiment 5 is on the impact of reproductive system
Method: 50 healthy cleaning grade Male Kunming strain mice, 22 ± 2g, is divided into model group at random, basic, normal, high dosed administration group and matched group.Except matched group, adopt 60Co γ-source, single fraction irradiation, close rate 2.0Gy/min, absorbed dose 5.5Gy.Sperm count and rate of teratosperm is measured according to rear 3d, 7d and 14d.
Result: as table 6, according to rear photograph rear 3d, 7d and 14d, go up with the sperm count of the more each administration group of model group, rate of teratosperm obviously declines.Medicine of the present invention is described, has protective effect to by the reproductive system according to mice.
Table 6 mouse sperm number and rate of teratosperm (
n=10)
Embodiment 6 is on the impact of SOD in serum, MDA
Method: 50 healthy cleaning grade Male Kunming strain mice, male and female half and half, 22 ± 2g, is divided into model group at random, basic, normal, high dosed administration group and matched group (male and female sub-cage rearing).Except matched group, adopt 60Co γ-source, single fraction irradiation, close rate 2.0Gy/min, absorbed dose 5.5Gy.Active and the MDA content according to rear eyeball kit measurement mice serum SOD.
Result: as Fig. 2,3, compared with model group, in the equal mice serum of administration group, MDA content declines, and SOD activity raises.Illustrate that medicine of the present invention can reduce MDA content in mice serum, improve SOD active, there is oxidation resistance, body can be protected from the detrimental effect of radiation induced free radical.
The oral liquid preparation of embodiment 7 herbal mixture of the present invention
A) Radix Astragali 37.1g is got, Semen Vitis viniferae 5.6g, Radix Et Caulis Acanthopanacis Senticosi 37.1g, Rhizoma Dioscoreae 16.7g, Semen Ziziphi Spinosae 3.5g, for subsequent use;
B) decocted with water 2-3 time by above-mentioned Chinese crude drug, each amount of water was advisable not have powder, collecting decoction, was condensed into the extractum that proportion is 1.35;
C) extractum adopts precipitate with ethanol to staticize process, then concentrates: the extracting solution after filtration suitably concentrates again.Its concentrating degree, is generally advisable at 30 ~ 60ml daily to measure;
D) subpackage: before subpackage, adds the correctives of doses, antiseptic in liquid, after stirring, can carry out coarse filtration, fine straining, loads in aseptic, clean, dry dactylethrae or suitable container, sealing.
E), after subpackage, multiple sterilization (as boiling method, steaming process, pressure sintering etc.) is adopted to carry out sterilizing.
Oral liquid can be selected to add correctives and antiseptic as required.Conventional correctives has Mel, simple syrup, glycyrrhizic acid and stevioside etc.; Antiseptic has sorbic acid, benzoic acid and propanoic acid etc.
The granule of embodiment 8 herbal mixture of the present invention or tablet preparation
A) Radix Astragali 37.1g is got, Semen Vitis viniferae 5.6g, Radix Et Caulis Acanthopanacis Senticosi 37.1g, Rhizoma Dioscoreae 16.7g, Semen Ziziphi Spinosae 3.5g, for subsequent use;
B) decocted with water 2-3 time by above-mentioned Chinese crude drug, each amount of water was advisable not have powder, collecting decoction, was condensed into the extractum that proportion is 1.35, added 90%-95% ethanol and carried out precipitate with ethanol, reclaimed ethanol and concentrated, dry at 40-50 DEG C, obtained dry extract;
C) dry extract is broken into fine powder, adds ethanol as adhesive, adds starch and makes granule as filler.
The granule of embodiment 9 herbal mixture of the present invention or tablet preparation
A) Radix Astragali 37.1g is got, Semen Vitis viniferae 5.6g, Radix Et Caulis Acanthopanacis Senticosi 37.1g, Rhizoma Dioscoreae 16.7g, Semen Ziziphi Spinosae 3.5g, for subsequent use;
B) decocted with water 2-3 time by above-mentioned Chinese crude drug, each amount of water was advisable not have powder, collecting decoction, was condensed into the extractum that proportion is 1.35, added 90%-95% ethanol and carried out precipitate with ethanol, reclaimed ethanol and concentrated, dry at 40-50 DEG C, obtained dry extract;
C) dry extract is broken into fine powder, adds adjuvant and makes granule, tabletted after dry.
Scope of the present invention is not by the restriction of described specific embodiments, and described embodiment, only as the single example of illustrating various aspects of the present invention, also comprises method and the component of functional equivalent in the scope of the invention.In fact, except content as herein described, those skilled in the art can easily grasp multiple improvement of the present invention with reference to description above and accompanying drawing.Described improvement also falls within the scope of appended claims.Every section of list of references mentioned above is listed in herein as a reference all in full.
Claims (10)
1. a compound traditional Chinese medicine for radiation protection, is characterized in that it is prepared from by the component of following weight parts: Radix Astragali 21-62 part, Semen Vitis viniferae 1-8 part, Radix Et Caulis Acanthopanacis Senticosi 16-46 part, Rhizoma Dioscoreae 7-29 part, Semen Ziziphi Spinosae 1-7 part.
2. compound traditional Chinese medicine for radiation protection as claimed in claim 1, is characterized in that it is prepared from by the component of following weight parts: Radix Astragali 36-46 part, Semen Vitis viniferae 4-6 part, Radix Et Caulis Acanthopanacis Senticosi 32-38 part, Rhizoma Dioscoreae 13-17 part, Semen Ziziphi Spinosae 3-4 part.
3. compound traditional Chinese medicine for radiation protection as claimed in claim 1, is characterized in that it is prepared from by the component of following weight parts: Radix Astragali 37-39 part, Semen Vitis viniferae 5-6 part, Radix Et Caulis Acanthopanacis Senticosi 36-38 part, Rhizoma Dioscoreae 15-17 part, Semen Ziziphi Spinosae 3-4 part.
4. compound traditional Chinese medicine for radiation protection as claimed in claim 1, is characterized in that it is prepared from by the component of following weight parts: the Radix Astragali 37.1 parts, Semen Vitis viniferae 5.6 parts, Radix Et Caulis Acanthopanacis Senticosi 37.1 parts, Rhizoma Dioscoreae 16.7 parts, Semen Ziziphi Spinosae 3.5 parts.
5. the preparation method of compound traditional Chinese medicine for radiation protection as claimed in claim 1, comprises the following steps:
A) get the Radix Astragali of described weight, Semen Vitis viniferae, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Dioscoreae, Semen Ziziphi Spinosae are for subsequent use;
B) above-mentioned Chinese crude drug is decocted with water 2 times, each amount of water was advisable not have powder, collecting decoction, was condensed into the extractum that proportion is 1.35;
C) extractum adopts precipitate with ethanol process, concentrated and dry, obtained dry extract;
D) dry extract is broken into fine powder, is just prepared into the active component of compound traditional Chinese medicine for radiation protection described in claim 1.
6. preparation method as claimed in claim 5, is characterized in that described step b) in when decocting with water, first time adds water 8 times amount, and decocts 1.5 hours, add water 6 times amount for the second time, decocts 1 hour.
7. preparation method as claimed in claim 5, is characterized in that described step c) in, described precipitate with ethanol staticizes and is treated to extractum and adds 90%-95% ethanol and carry out precipitate with ethanol.
8. compound traditional Chinese medicine for radiation protection as claimed in claim 1, is characterized in that it is oral formulations.
9. compound traditional Chinese medicine for radiation protection as claimed in claim 8, is characterized in that described oral formulations is capsule, liposome, granule, tablet, pill, powder or oral liquid.
10. the purposes of compound traditional Chinese medicine for radiation protection as claimed in claim 1 in preparation radiation protection or auxiliary therapy medicine.
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| CN1644095A (en) * | 2005-01-11 | 2005-07-27 | 贵阳中医学院 | Health-care products with improving immunity and preventing radiative harm and production thereof |
| CN101697994A (en) * | 2009-11-09 | 2010-04-28 | 黑龙江省祖研北药科技开发有限责任公司 | Radiation-resistant and fatigue-resistant agent and preparation method thereof |
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| CN1644095A (en) * | 2005-01-11 | 2005-07-27 | 贵阳中医学院 | Health-care products with improving immunity and preventing radiative harm and production thereof |
| CN101697994A (en) * | 2009-11-09 | 2010-04-28 | 黑龙江省祖研北药科技开发有限责任公司 | Radiation-resistant and fatigue-resistant agent and preparation method thereof |
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| 中药抗辐射作用的研究进展;苌凤锦等;《安徽医药》;20111231;第15卷(第07期);902-905，第903页左栏第17-20行 * |
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